Article
Medicine, General & Internal
Stephane Zuily, Benjamin Lefevre, Olivier Sanchez, Ombeline Empis de Vendin, Guillaume de Ciancio, Jean-Benoit Arlet, Lina Khider, Beatrice Terriat, Helene Greigert, Celine S. Robert, Guillaume Louis, Albert Trinh-Duc, Patrick Rispal, Sandrine Accassat, Guillaume Thiery, David Montani, Reza Azarian, Nicolas Meneveau, Simon Soudet, Raphael Le Mao, Francois Maurier, Vincent Le Moing, Isabelle Quere, Cecile M. Yelnik, Nicolas Lefebvre, Martin Martinot, Maxime Delrue, Ygal Benhamou, Florence Parent, Pierre-Marie Roy, Emilie Presles, Francois Goehringer, Patrick Mismetti, Laurent Bertoletti, Patrick Rossignol, Francis Couturaud, Denis Wahl, Nathalie Thilly, Silvy Laporte
Summary: This study investigated the effect of using weight-adjusted intermediate dose anticoagulation for preventing venous thromboembolism in COVID-19 patients. The results showed that the rate of thromboembolic events was slightly lower in the weight-adjusted dose group compared to the fixed-dose group, but the difference was not significant. Additionally, the weight-adjusted dose group had a twofold increased risk of major or clinically relevant nonmajor bleeding. Therefore, the study did not demonstrate the benefits of weight-adjusted intermediate dose anticoagulation for COVID-19 patients.
Article
Nursing
Yu Wang, Xin-Juan Wu, Yu-Fen Ma, Yuan Xu, Xiao-Jie Wang, Chen Zhu, Jing Cao, Jing Jiao, Ge Liu, Zhen Li, Ying Liu, Li-Yun Zhu
Summary: The study revealed that Chinese orthopaedic nurses have room for improvement in their knowledge of VTE and prophylactic practices, particularly in the proper use of prophylaxis, identification of risk factors, and understanding of symptoms. While pharmacological prophylaxis is widely used, the utilization of mechanical prophylaxis remains relatively low.
JOURNAL OF CLINICAL NURSING
(2021)
Article
Rehabilitation
Christina Draganich, Andrew Park, Mitch Sevigny, Susan Charlifue, David Coons, Michael Makley, Raul Alvarez, James Fenton, Jeffrey Berliner
Summary: This study aimed to determine the incidence of VTE in patients with brain injuries using ultrasonography and assess the risk of PE development and bleeding complications related to anticoagulation. The research found a high prevalence of VTEs in patients with moderate to severe brain injuries on admission to rehabilitation, but low complication rates from anticoagulation. Therefore, further prospective research is needed to validate these findings.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Surgery
Ahmed Mohammed Abdelsalam, Ahmed Mohammed Salah Eldeen ElAnsary, Mohammed Abdallah Salman, Sahar Abdelrahman Nassef, Hala Mostafa Elfergany, Hesham Ahmed Abou Aisha
Summary: This study aimed to evaluate the optimal regimen for VTE prophylaxis in bariatric procedures and reduce the incidence of perioperative VTE by using prophylactic anticoagulants. The results showed a significant decrease in postoperative VTE incidence in patients who received postoperative LMWH treatment.
WORLD JOURNAL OF SURGERY
(2021)
Article
Hematology
Aurelien Delluc, Waleed Ghanima, Michael J. Kovacs, Sudeep Shivakumar, Susan R. Kahn, Per Morten Sandset, Clive Kearon, Ranjeeta Mallick, Marc A. Rodger
Summary: This pilot trial demonstrates the feasibility of conducting a larger randomized controlled trial to determine the efficacy of adjuvant rosuvastatin for the secondary prevention of VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Surgery
Kirill Lobastov, Ekaterina Sautina, Eleanora Alencheva, Astanda Bargandzhiya, Ilya Schastlivtsev, Victor Barinov, Leonid Laberko, Grigoriy Rodoman, Valeriy Boyarintsev
Summary: The study showed that among patients with a Caprini score of >= 11, adjunctive use of IPC in addition to standard prophylaxis significantly reduced the incidence of asymptomatic venous thrombosis compared to standard prophylaxis alone.
Article
Otorhinolaryngology
Lirit Levi, Galia Spectre, Ofir Nesichi, Avi Leader, Pia Raanani, Yonatan Reuven, Hilla Schindel, Thomas Shpitzer, Ella Reifen, Gideon Bachar, Aviram Mizrachi
Summary: The study aimed to modify the CRAM-based protocol for otolaryngology patients and evaluate the efficacy and safety. Among the 508 patients, only 1 developed deep vein thrombosis, with no cases of pulmonary embolism. The protocol adherence rate was 79% with an average follow-up time of 115 days. The results suggest that the novel protocol is effective and safe for VTE prevention in otolaryngology, though further validation through a larger-scale study is needed.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Multidisciplinary Sciences
Liu Lin, Pan Luo, Mingyi Yang, Jiachen Wang, Weikun Hou, Peng Xu
Summary: A bidirectional Mendelian randomization study found no causal relationship between the three classical lipids (LDL, HDL, and TGs) and venous thromboembolism (DVT and PE).
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Alex C. Spyropoulos, Mark Goldin, Dimitrios Giannis, Wassim Diab, Janice Wang, Sameer Khanijo, Andrea Mignatti, Eugenia Gianos, Marc Cohen, Gulru Sharifova, Jeet M. Lund, Alfonso Tafur, Paul A. Lewis, Kevin P. Cohoon, Husneara Rahman, Cristina P. Sison, Martin L. Lesser, Kanta Ochani, Nirav Agrawal, Judith Hsia, Victoria E. Anderson, Marc Bonaca, Jonathan L. Halperin, Jeffrey Weitz
Summary: Therapeutic-dose low-molecular-weight heparin reduces major thromboembolism and death in high-risk inpatients with COVID-19, with no significant effect observed in critically ill patients.
JAMA INTERNAL MEDICINE
(2021)
Review
Clinical Neurology
Maurizio Paciaroni, Giancarlo Agnelli, Andrea Alberti, Cecilia Becattini, Francesco Guercini, Giuseppe Martini, Rossana Tassi, Giovanna Marotta, Michele Venti, Monica Acciarresi, Maria Giulia Mosconi, Simona Marcheselli, Lara Fratticci, Cataldo D'Amore, Walter Ageno, Maurizio Versino, Maria Luisa De Lodovici, Federico Carimati, Alessandro Pezzini, Alessandro Padovani, Francesco Corea, Umberto Scoditti, Licia Denti, Tiziana Tassinari, Giorgio Silvestrelli, Alfonso Ciccone, Valeria Caso
Summary: In patients with acute ICH, the use of anticoagulants to prevent VTE was found to be safe but the overall evidence level was low due to the low number of patients included in randomized clinical trials.
EUROPEAN NEUROLOGY
(2021)
Article
Hematology
Mark Goldin, Dimitrios Giannis, Wassim Diab, Janice Wang, Sameer Khanijo, Gulru Sharifova, Marc Cohen, Jeet M. Lund, Andrea Mignatti, Eugenia Gianos, Alfonso Tafur, Paul A. Lewis, Kevin Cohoon, John M. Kittelson, Martin L. Lesser, Cristina P. Sison, Husneara Rahman, Kanta Ochani, William R. Hiatt, Rita A. Dale, Victoria E. Anderson, Marc Bonaca, Jonathan L. Halperin, Jeffrey I. Weitz, Alex C. Spyropoulos
Summary: The HEP-COVID trial aims to evaluate the efficacy and safety of therapeutic-dose low-molecular-weight heparin (LMWH) compared to prophylactic-dose LMWH for preventing VTE, ATE, and all-cause mortality in hospitalized COVID-19 patients. The study design includes a randomized, multicenter approach with a focus on patients with elevated D-dimer levels.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Critical Care Medicine
John W. Eikelboom, Sanjit S. Jolly, Emilie P. Belley-Cote, Richard P. Whitlock, Sumathy Rangarajan, Lizhen Xu, Laura Heenan, Shrikant Bangdiwala, Wadea M. Tarhuni, Mohamed Hassany, Anna Kontsevaya, William Harper, Sanjib Kumar Sharma, Patricio Lopez-Jaramillo, Antonio L. Dans, Lia M. Palileo-Villanueva, Alvaro Avezum, Prem Pais, Denis Xavier, Camilo Felix, Afzalhussein Yusufali, Renato D. Lopes, Otavio Berwanger, Zeeshan Ali, Sean Wasserman, Sonia S. Anand, Jackie Bosch, Shurjeel Choudhri, Michael E. Farkouh, Mark Loeb, Salim Yusuf
Summary: The ACT outpatient trial aimed to evaluate the effectiveness of colchicine and aspirin in preventing disease progression in community patients with COVID-19. The results showed no significant difference in the occurrence of major outcomes, such as hospitalization or death, between the colchicine and aspirin treatment groups compared to the control groups. The study also found that the colchicine group had more serious adverse events, but none of them led to discontinuation of the study interventions. There was no significant increase in serious adverse events in the aspirin group compared to the control group.
LANCET RESPIRATORY MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ming-Yee Sun, Sonu M. M. Bhaskar
Summary: This article provides an updated overview of the therapeutic and preventive strategies for strokes in cancer settings, emphasizing the distinct challenges and the need for individualized diagnostic and treatment approaches. The strategies discussed include acute reperfusion therapy, anticoagulant therapy, antiplatelet therapy, and lifestyle management options. The article highlights the limited guidelines and evidence-based clinical management for cancer-related strokes and thromboembolisms, and offers future recommendations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Liqi Shu, Ekaterina Bakradze, Setareh Salehi Omran, James Giles, Jordan Amar, Nils Henninger, Marwa Elnazeir, Ava Liberman, Khadean Moncrieffe, Jenny Rotblat, Richa Sharma, Yee Cheng, Adeel S. Zubair, Alexis Simpkins, Grace Li, Justin Kung, Dezaray Perez, Mirjam R. Heldner, Adrian Scutelnic, Rascha Von Martial, Bernhard Siepen, Aaron Rothstein, Ossama Khazaal, David Do, Sami Al Kasab, Line Abdul Rahman, Eva A. Mistry, Deborah Kerrigan, Hayden Lafever, Thanh N. Nguyen, Piers Klein, Hugo J. Aparicio, Jennifer A. Frontera, Lindsey Kuohn, Shashank Agarwal, Christoph Stretz, Narendra Kala, Sleiman ElJamal, Allison Chang, Shawna Cutting, Fransisca Indraswari, Adam de Havenon, Varsha Muddasani, Teddy Wu, Duncan Wilson, Amre Nouh, Daniyal Asad, Abid Qureshi, Justin Moore, Pooja Khatri, Yasmin Aziz, Bryce Casteigne, Muhib Khan, Yao Cheng, Brian MacGrory, Martin Weiss, Dylan Ryan, Maria Cristina Vedovati, Maurizio Paciaroni, James Siegler, Scott Kamen, Siyuan Yu, Christopher Leon Guerrero, Eugenie Atallah, Gian Marco De Marchis, Alex Brehm, Tolga Dittrich, Marios Psychogios, Ronald Alvarado-Dyer, Tareq Kass-Hout, Shyam Prabhakaran, Tristan Honda, David Liebeskind, Karen Furie, Shadi Yaghi
Summary: This study aimed to identify predictors of recurrent venous thrombosis in patients with CVT. The study found that Black race, history of VTE, and the presence of one or more positive antiphospholipid antibodies were associated with recurrent venous thrombosis among patients with CVT.
Article
Hematology
Kristen M. Sanfilippo
Summary: Patients with hematologic malignancy have an increased risk of venous thromboembolism (VTE), especially in the first months after diagnosis. Risk varies depending on the type of leukemia, lymphoma, or multiple myeloma, with acute leukemia and aggressive lymphoma having higher risks. Risk prediction models are available but need further validation or improvement. Future efforts should focus on validating existing models, incorporating biomarkers, and evaluating the risk/benefit of thromboprophylaxis in high-risk patients.
THROMBOSIS RESEARCH
(2022)
Article
Engineering, Biomedical
Verena Gotta, Olivera Marsenic, Marc Pfister
Article
Pharmacology & Pharmacy
Kim Dao, Monia Guidi, Pascal Andre, Eric Giannoni, Sebastien Basterrechea, Wei Zhao, Aline Fuchs, Marc Pfister, Thierry Buclin, Chantal Csajka
PHARMACOLOGICAL RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Paola Mian, Karel Allegaert, Sigrid Conings, Pieter Annaert, Dick Tibboel, Marc Pfister, Kristel van Calsteren, John N. van den Anker, Andre Dallmann
CLINICAL PHARMACOKINETICS
(2020)
Article
Pharmacology & Pharmacy
Tarek A. Leil, Yasong Lu, Marion Bouillon-Pichault, Robert Wong, Miroslawa Nowak
Summary: This study conducted a model-based meta-analysis of RA drugs and found that most drugs had similar effects on Delta DAS28 in typical RA patient population, except tocilizumab which showed a significantly greater response at 24 weeks possibly due to its effect on interleukin-6. Factors like baseline DAS28, disease duration, percentage of male participants, and year of trial conduct had significant effects on the timing and magnitude of Delta DAS28 in control arms. Clinical trial simulations suggested that several drugs would have a high probability of showing a significant difference vs. control at Week 6 with small sample sizes.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Marie-Anne Burckhardt, Verena Gotta, Svetlana Beglinger, Luzia Renggli, Sara Bachmann, Melanie Hess, Katharina Rentsch, Marc Pfister, Gilbert Koch, Elizabeth A. Davis, Urs Zumsteg, Timothy W. Jones, Gabor Szinnai
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Pediatrics
Tamara van Donge, Aline Fuchs, Stephanie Leroux, Marc Pfister, Frederique Rodieux, Andrew Atkinson, Eric Giannoni, John van den Anker, Julia Bielicki
Summary: The study found that current neonatal amoxicillin dosing regimens struggle to meet the desired minimum inhibitory concentration and neurotoxicity targets. None of the regimens achieved the 90% target for bacteriostatic effect. Selecting optimal dosing regimens is challenging and may require novel trial designs combined with pharmacometric modeling and simulation.
Article
Hematology
Ravi Sarode, Katsuyuki Fukutake, Masahiro Yasaka, Michael A. Tortorici, Antoinette Mangione, Marc Pfister, Adam Cuker
Article
Pharmacology & Pharmacy
Cornelis Smit, Daniela Hofmann, Somphou Sayasone, Jennifer Keiser, Marc Pfister
Summary: Moxidectin population pharmacokinetics in S. stercoralis-infected adults was characterized using a pharmacometric approach, with simulations indicating similar exposure levels after fixed-dose and weight-based dosing strategies.
CLINICAL PHARMACOKINETICS
(2022)
Article
Infectious Diseases
Daniela Hofmann, Janneke M. Brussee, Jessica D. Schulz, Jean T. Coulibaly, Marc Pfister, Jennifer Keiser
Summary: This study developed a pharmacokinetic model for albendazole and its metabolites and identified optimal doses and treatment strategies. The efficacy of albendazole varied among individuals infected with different helminth species, highlighting the need for further research.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Uri Nahum, Julie Refardt, Irina Chifu, Wiebke K. Fenske, Martin Fassnacht, Gabor Szinnai, Mirjam Christ-Crain, Marc Pfister
Summary: This study utilized machine learning methods to assist in the differentiation between central diabetes insipidus (cDI) and primary polydipsia (PP), demonstrating high accuracy in distinguishing between these two conditions.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Pediatrics
Cornelis Smit, Aline G. J. Engbers, Samira Samiee-Zafarghandy, Tamara van Donge, Sinno H. P. Simons, Robert B. B. Flint, Marc Pfister, Catherijne A. J. Knibbe, John N. N. van den Anker
Summary: This study explores the mechanism behind the greater effectiveness of oral ibuprofen compared to intravenous ibuprofen in closing a patent ductus arteriosus. The results show that after oral dosing, the concentration of the biologically active S-enantiomer is lower for a significant portion of the dosing interval. The study also indicates that R- to S-conversion does not exceed 45%.
Article
Pharmacology & Pharmacy
Marije E. Otto, Marie-Anne Burckhardt, Gabor Szinnai, Marc Pfister, Verena Gotta
Summary: The study found that the secretion response of arginine vasopressin and aldosterone in pediatric patients during DKA treatment is different, indicating their potential as future markers for diagnosis, prognosis, and treatment monitoring in diabetic patients.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Dominic Stefan Braem, Uri Nahum, Andrew Atkinson, Gilbert Koch, Marc Pfister
Summary: Missing data poses challenges in clinical research, leading to loss of statistical power and potentially biased results. This study introduces two machine-learning methods for imputing missing covariate data in pharmacometric analyses. The results show that both traditional imputation approaches and machine-learning methods perform well in handling missing data situations.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Klervi Golhen, Michael Buettcher, Jonas Kost, Joerg Huwyler, Marc Pfister
Summary: The majority of therapeutics currently available are not suitable for pediatric patients, thus there is a need to develop child-friendly dosage forms. This review discusses the challenges and opportunities in the development of such dosage forms, including taste masking, tablet size, dose flexibility, excipient safety, and acceptability. It also explores the example of orally dispersible tablets (ODTs) as a child-friendly drug delivery strategy, utilizing inorganic particulate drug carriers as multifunctional excipients to address unique medical needs in infants and children while maintaining a favorable excipient safety and acceptability profile in these vulnerable patient populations.
Article
Pharmacology & Pharmacy
Verena Gotta, Sara Bachmann, Marc Pfister, Birgit Donner
Summary: An association was observed between nocturnal hypoglycemia and QT prolongation in children with type 1 diabetes. This pharmacometric analysis aimed to understand this association and determine other sources of QT variability quantitatively.
JOURNAL OF CLINICAL PHARMACOLOGY
(2023)