期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 86, 期 1, 页码 44-48出版社
WILEY
DOI: 10.1038/clpt.2009.35
关键词
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资金
- Prinses Beatrix Fonds
3,4-Diaminopyridine and pyridostigmine are widely used to treat Lambert-Eaton myasthenic syndrome (LEMS), either alone or in combination. 3,4-Diaminopyridine enhances the release of acetylcholine at the neuromuscular synapse, and pyridostigmine inhibits the degradation of this neurotransmitter. Although this could lead to a synergistic effect on neuromuscular transmission, no studies have compared the effects of these drugs in patients with LEMS. Therefore, we performed a placebo-controlled, double-dummy, double-blind, randomized, crossover study in nine patients with LEMS.
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