Review
Medicine, Research & Experimental
Kyle P. P. Martin, Christine Grimaldi, Rolf Grempler, Steven Hansel, Sandeep Kumar
Summary: There is significant interest in antibody-based biotherapeutics due to their selectivity and desirable pharmacology. This study analyzed characteristics of 89 marketed antibody-based biotherapeutics approved between 1986 and mid-2020. The findings reveal major trends in their emergence as best-selling pharmaceuticals and provide insights for better drug discovery and development strategies.
Review
Clinical Neurology
Anna M. Schneider, Robert W. Regenhardt, Adam A. Dmytriw, Aman B. Patel, Joshua Adam Hirsch, Alastair M. Buchan
Summary: Despite advances in clinical diagnosis and increasing numbers of eligible patients for revascularisation, ischaemic stroke remains a significant public health concern. Recanalisation therapy alone is not sufficient, and successful translational attempts for cerebroprotection are lacking. Therefore, understanding the diverse cellular effects and complex pathophysiological cascade of ischaemic stroke, as well as developing new multimodal and multicellular cerebroprotective agents, is crucial for improving patient outcomes.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Pharmacology & Pharmacy
Hang-Ping Yao, Xiang-Min Tong, Ming-Hai Wang
Summary: Aberrant expression of the MET receptor has led to the development of SMKIs and TmAbs for targeted cancer therapy. While SMKIs have been approved for clinical application, conventional anti-MET TmAbs have faced setbacks and raised uncertainty about their usefulness. Novel MET targeted biotherapeutics, such as bispecific antibodies and ADCs, show great potential for cancer therapy in the future, according to evidence from preclinical and clinical studies.
DRUG DISCOVERY TODAY
(2021)
Review
Pharmacology & Pharmacy
Zhuzhu Wu, Yifei Bian, Tianjiao Chu, Yuman Wang, Shuai Man, Yongmei Song, Zhenguo Wang
Summary: This review summarizes the recent advances and challenges of anti-angiogenic agents in the treatment of melanoma, which has a high metastatic potential contributing to its high mortality. A comprehensive understanding of angiogenesis is crucial for the development of melanoma therapies.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Minghui Cong, Shenyu Tan, Simin Li, Lina Gao, Luqi Huang, Huang-Ge Zhang, Hongzhi Qiao
Summary: Plant extracellular vesicles (EVs) and exosome-like nanoparticles (ELNs) have emerged as important mediators of intercellular communication, with potential applications in biological processes regulation, disease prevention and treatment, and drug delivery. This review provides an overview of the development, techniques, biological activities, and clinical potential of plant EVs and ELNs, as well as the challenges and future directions in realizing their clinical transformation.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Rowan Sultan, Tessa O. van den Beukel, Michael O. Reumerman, Hester E. M. Daelmans, Hans Springer, Els Grijmans, Majon Muller, Milan C. Richir, Michiel A. van Agtmael, Jelle Tichelaar
Summary: With the aging population, the prevalence of comorbid disorders and polypharmacy is rising, calling for regular medication reviews to prevent adverse events. A study showed that an interprofessional student-run medication review program can enhance prescribing practices and medication safety in geriatric outpatient clinics.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Infectious Diseases
Semra Palic, Josh H. Beijnen, Thomas P. C. Dorlo
Summary: This review provides an update on the recent developments in the clinical pharmacology of miltefosine, including a discussion on its pharmacokinetics and pharmacodynamics, as well as the current dosing regimens.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Editorial Material
Medicine, General & Internal
Katherine E. Goodman, Adam M. Rodman, Daniel J. Morgan
Summary: The U.S. government has recently focused on ensuring the safety of clinical decision support algorithms for clinical use. The next important task is to educate physicians on effectively utilizing these algorithms.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Yang Yang, Yuqing Ren, Wei Song, Bohong Yu, Hongzhuo Liu
Summary: Hydrogels are widely used in the biomedical field, but selecting appropriate functional materials and design strategies for optimizing their biological performance remains challenging. This review outlines the principles of hydrogel system functionality, explores the relationship between basic properties of hydrogels and biological functions, and discusses the prospects of advanced applications. The principles and understanding presented in this article will facilitate the improvement of therapeutic performance and the development of functional biomaterials.
MATERIALS & DESIGN
(2022)
Article
Respiratory System
Ruben Andujar-Espinosa, Lourdes Salinero-Gonzalez, Fatima Illan-Gomez, Manuel Castilla-Martinez, Chunshao Hu-Yang, Francisco Jose Ruiz-Lopez
Summary: The study aimed to assess the efficacy of vitamin D supplementation in improving asthma control in adult patients with asthma and vitamin D deficiency. The intervention group receiving calcifediol showed significant clinical improvement in asthma control and quality of life compared to the control group receiving a placebo. Further research is needed to evaluate long-term efficacy and safety.
Review
Pharmacology & Pharmacy
Courtney V. Fletcher, Shetty Ravi Dyavar, Arpan Acharya, Siddappa N. Byrareddy
Summary: Combination antiretroviral therapy (ART) can effectively suppress HIV levels, reduce transmission risk, lower mortality, and enhance quality of life for HIV-infected individuals. However, complete cure for HIV infection remains challenging due to the establishment of multiple reservoir sites within the body, which current treatments cannot eliminate.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Oncology
Fortunato Ciardiello, Davide Ciardiello, Giulia Martini, Stefania Napolitano, Josep Tabernero, Andres Cervantes
Summary: This review summarizes the progress in the clinical management of patients with metastatic colorectal cancer (mCRC) in the era of precision medicine. Molecular stratification, based on the current treatment algorithm, has been a significant step towards implementing more effective therapeutic approaches. Integrating tumor gene alterations with tumor and microenvironment gene and protein expression profiling, host immune competence, and applying dynamic changes to precision medicine-based continuum of care, could lead to the identification of individual prognostic and predictive parameters for choosing the most appropriate therapeutic program for each patient.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Review
Medical Laboratory Technology
Ales Kvasnicka, Lukas Najdekr, Dana Dobesova, Barbora Pisklakova, Eliska Ivanovova, David Friedecky
Summary: Lipidomics, a branch of metabolomics, provides unique information on the lipid profile in biological materials. It has been proven to be an effective tool in the discovery of biomarkers and understanding of pathobiochemistry in clinically focused studies. Despite being introduced nearly twenty years ago, only a few big data studies using clinical lipidomics have been published to date.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Ophthalmology
Chee Wai Wong, Josbert M. Metselaar, Gert Storm, Tina T. Wong
Summary: Ocular anterior segment inflammation is a medical issue that can lead to serious conditions if inadequately treated, with topical steroid eye-drops being the mainstay of treatment. However, drawbacks such as low bioavailability and poor patient compliance necessitate the development of alternative drug delivery systems to improve efficacy. Successes in clinical trials have shown that DDS like Dextenza and INVELTYS may replace traditional eye-drops for managing anterior segment inflammation.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Peripheral Vascular Disease
Gaetano Santulli, Fahimeh Varzideh, Imma Forzano, Scott Wilson, Luigi Salemme, Antonio de Donato, Angela Lombardi, Antonio Rainone, Luigi Nunziata, Stanislovas S. Jankauskas, Tullio Tesorio, Germano Guerra, Urna Kansakar, Pasquale Mone
Summary: SGLT2 inhibitors have beneficial effects on kidney and heart function, and they can improve physical and cognitive impairment in frail older adults.