Article
Nutrition & Dietetics
Franka Neumer, Orenci Urraca, Joaquin Alonso, Jesus Palencia, Vicente Varea, Stephan Theis, Maria Rodriguez-Palmero, Jose Antonio Moreno-Munoz, Francisco Guarner, Gigi Veereman, Yvan Vandenplas, Cristina Campoy
Summary: This study demonstrates that supplementation with inulin-type prebiotic oligosaccharides in infant formula during the first year of life can beneficially modulate the infant gut microbiota towards higher Bifidobacterium levels and reduce the duration of infections.
Article
Chemistry, Multidisciplinary
Pieter Van den Abbeele, Cindy Duysburgh, Jonas Ghyselinck, Shellen Goltz, Yulia Berezhnaya, Thomas Boileau, Anke De Blaiser, Massimo Marzorati
Summary: Synbiotic combinations of BB-12 with fructans, especially low DP fructans, show promising effects on gastrointestinal health by increasing the growth of beneficial bacteria and reducing the numbers of harmful bacteria in the gut. Fermentation of fructans by BB-12 leads to increased production of acetate and lactate, contributing to a healthier gut environment.
APPLIED SCIENCES-BASEL
(2021)
Review
Nutrition & Dietetics
Anais Lemoine, Patrick Tounian, Karine Adel-Patient, Muriel Thomas
Summary: The first objective of infant formulas is to ensure the healthy growth of neonates and infants, as the sole complete food source during the first months of life when a child cannot be breastfed. Infant nutrition companies also aim to mimic breast milk's immuno-modulating properties in addition to providing nutrition. Probiotics like Streptococcus thermophilus, Lactobacillus reuteri DSM 17938, and prebiotics like fructo-oligosaccharides (FOSs) and human milk oligosaccharides (HMOs) are commonly added to infant formulas to promote the maturation of immunity and the microbiota.
Article
Gastroenterology & Hepatology
Rika Hirano, Mikiyasu Sakanaka, Kazuto Yoshimi, Naohisa Sugimoto, Syogo Eguchi, Yuko Yamauchi, Misaki Nara, Shingo Maeda, Yuta Ami, Aina Gotoh, Takane Katayama, Noriho Iida, Tamotsu Kato, Hiroshi Ohno, Satoru Fukiya, Atsushi Yokota, Mamoru Nishimoto, Motomitsu Kitaoka, Hiroyuki Nakai, Shin Kurihara
Summary: The study identified Gal-beta 1,4-Rha as a next-generation prebiotic candidate that selectively promotes the growth of beneficial bacteria like Bifidobacterium without stimulating the growth of other prominent bacteria and pathogens. This prebiotic was found to suppress the growth of the enteric pathogen Clostridioides difficile, indicating its potential for preventing infections and improving gut health.
Article
Biochemistry & Molecular Biology
Teja Klancic, Isabelle Laforest-Lapointe, Jolene Wong, Ashley Choo, Jodi E. Nettleton, Faye Chleilat, Marie-Claire Arrieta, Raylene A. Reimer
Summary: Pulsed antibiotic treatment early in life increases the risk of obesity, while co-administering prebiotics can reduce fat mass and improve metabolic health. Antibiotic treatment had negative effects on body weight and insulin sensitivity, which were reversed with prebiotic co-administration, especially in a sex-specific manner.
Article
Microbiology
Peter Philip James Jackson, Anisha Wijeyesekera, Robert Adrian Rastall
Summary: In vitro fermentation experiments showed that a combination of oligofructose and oligofructose/2' fucosyllactose can induce the production of neurotransmitters and organic acids. There is heterogeneity in the response to 2' fucosyllactose supplementation among donors, while fermentation with oligofructose can increase the numbers of Bifidobacterium, Lactobacillus, and Bacteroides in the gut.
FEMS MICROBIOLOGY ECOLOGY
(2023)
Review
Food Science & Technology
Valentina Ambrogi, Francesca Bottacini, Linqiu Cao, Bas Kuipers, Margriet Schoterman, Douwe van Sinderen
Summary: Galacto-oligosaccharides (GOS) are non-digestible oligosaccharides with diverse structures that have been extensively studied for their health-promoting effects. GOS have been reported to promote the growth of beneficial bacteria, inhibit pathogen adhesion, and improve gut barrier function. However, their industrial production still faces technological challenges.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Nina Sillner, Alesia Walker, Marianna Lucio, Tanja V. Maier, Monika Bazanella, Michael Rychlik, Dirk Haller, Philippe Schmitt-Kopplin
Summary: The early-life metabolome of the intestinal tract is strongly influenced by colonization of gut microbiota, which is in turn affected by nutrition, such as breast milk or formula. The fecal metabolites of breastfed and formula-fed infants show distinct differences, with breastfed infants having higher levels of unsaturated fatty acids and human milk oligosaccharides. The metabolite profiles of infants converge at the end of the first year coinciding with the introduction of solid foods.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Pediatrics
Lili Shen, Weihua Huang, Xuebing Xu, Li Wang, Qingyun Wang, Shengqi Li, Xuewei Yuan
Summary: The study showed that adding a high concentration of OPO to formula is beneficial for the growth and development of infants, as it reduces fecal fatty acid content, decreases crying frequency, increases length, and promotes fecal excretion.
FRONTIERS IN PEDIATRICS
(2021)
Article
Nutrition & Dietetics
John C. C. Wallingford, Pernille Neve Myers, Cynthia M. M. Barber
Summary: A study found that adding 2'FL to infant formula did not affect infant growth or adverse events. However, the formula-fed group showed higher microbial richness and diversity after 16 weeks compared to the breastfed group. Additionally, the addition of 2'FL resulted in changes in certain microbial metabolic modules, similar to breastfed infants.
FRONTIERS IN NUTRITION
(2022)
Review
Food Science & Technology
Lynn E. Ferro, Liana N. Crowley, Kyle Bittinger, Elliot S. Friedman, Jessica E. Decker, Kathryn Russel, Sarah Katz, Jae Kyeom Kim, Jillian C. Trabulsi
Summary: This review systematically evaluated the impact of pre-, pro-, or synbiotic supplementation in infant formula on the gastrointestinal microbiota. The results showed that supplementation with prebiotics and synbiotics increased fecal Bifidobacterium levels, but the effects of probiotic supplementation were not significant. In addition, the effects of supplementation on fecal Clostridium levels were inconsistent, and probiotic supplementation had no significant impact on fecal pH and stool consistency.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Jean-Pierre Chouraqui
Summary: Human milk oligosaccharides (HMOs) are being investigated as a novel food source with potential health benefits for infant immunity and gut health. However, limited controlled clinical trials have been conducted on a few HMOs, requiring more research to confirm the necessity of routine supplementation in formulas.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Nutrition & Dietetics
Tomas Cerdo, Alicia Ruiz, Inmaculada Acuna, Ana Nieto-Ruiz, Estefania Dieguez, Natalia Sepulveda-Valbuena, Mireia Escudero-Marin, Jose Antonio Garcia-Santos, Maria Garcia-Ricobaraza, Florian Herrmann, Jose Antonio Moreno-Munoz, Roser De Castellar, Jesus Jimenez, Antonio Suarez, Cristina Campoy
Summary: This study compared the development of gut microbiota in infants and found that different enterotypes were associated with age and feeding type. The use of a new formula was associated with significantly higher language scores in infants at 12 months of age, while at 4 years of age, the neurodevelopmental outcomes were similar to those of breastfed infants.
CLINICAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Riley L. Hughes, David A. Alvarado, Kelly S. Swanson, Hannah D. Holscher
Summary: This comprehensive review examines the prebiotic effects of inulin-type fructans (ITF) on the intestinal microbiota and health in healthy human adults. The review finds that ITF promote the growth of beneficial bacteria such as Bifidobacterium, Lactobacillus, and Faecalibacterium prausnitzii, and have positive effects on intestinal barrier function, laxation, insulin sensitivity, lipid profile, mineral absorption, and satiety. However, there is a lack of discussion on the effects of ITF chain length and individual factors on its efficacy.
ADVANCES IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Elvira Estorninos, Rachel B. Lawenko, Eisel Palestroque, Norbert Sprenger, Jalil Benyacoub, Guus A. M. Kortman, Jos Boekhorst, Jodi Bettler, Colin Cercamondi, Bernard Berger
Summary: The study found that infant formula supplemented with oligosaccharides can improve gut microbiota and enhance intestinal immunity. Compared to the control group, the oligosaccharide-supplemented formula had a strong bifidogenic effect, reduced fecal pathogens, and improved intestinal immune response.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Behavioral Sciences
Caroline M. Taylor, Susan M. Wernimont, Kate Northstone, Pauline M. Emmett
Article
Behavioral Sciences
Caroline M. Taylor, Kate Northstone, Susan M. Wernimont, Pauline M. Emmett
Article
Nutrition & Dietetics
Caroline M. Taylor, Kate Northstone, Susan M. Wernimont, Pauline M. Emmett
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2016)
Article
Gastroenterology & Hepatology
Giuseppe Puccio, Philippe Alliet, Cinzia Cajozzo, Elke Janssens, Giovanni Corsello, Norbert Sprenger, Susan Wernimont, Delphine Egli, Laura Gosoniu, Philippe Steenhout
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2017)
Article
Chemistry, Analytical
Susan M. Wernimont, Robin J. Thompson, Scott L. Mickelsen, Spencer C. Smith, Isabella C. Alvarenga, Kathy L. Gross
Article
Genetics & Heredity
Susan M. Wernimont, Andrew G. Clark, Patrick J. Stover, Martin T. Wells, Augusto A. Litonjua, Scott T. Weiss, J. Michael Gaziano, Katherine L. Tucker, Andrea Baccarelli, Joel Schwartz, Valentina Bollati, Patricia A. Cassano
BMC MEDICAL GENETICS
(2011)
Article
Nutrition & Dietetics
Susan M. Wernimont, Farbod Raiszadeh, Patrick J. Stover, Eric B. Rimm, David J. Hunter, Wenbo Tang, Patricia A. Cassano
JOURNAL OF NUTRITION
(2011)
Article
Nutrition & Dietetics
Susan M. Wernimont, Andrew G. Clark, Patrick J. Stover, Martin T. Wells, Augusto A. Litonjua, Scott T. Weiss, J. Michael Gaziano, Pantel S. Vokonas, Katherine L. Tucker, Patricia A. Cassano
JOURNAL OF NUTRITION
(2012)