Article
Ophthalmology
Don S. Minckler, Donald J. Brown, Angele Nalbandian, Donny W. Suh
Summary: This study investigated orthograde axonal transport of amyloid precursor protein (APP-A4) in the retina and lamina cribrosa (LC) portion of the optic nerve in abusive head trauma (AHT) suspects using immunohistochemistry. The findings revealed the accumulation of APP-A4 in LC and suggested that intraocular pressures be recorded and addressed in these patients.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Medicine, General & Internal
Aniello Maiese, Francesca Iannaccone, Andrea Scatena, Zoe Del Fante, Antonio Oliva, Paola Frati, Vittorio Fineschi
Summary: Abusive head trauma is often misdiagnosed, with no definitive signs for diagnosis in children. Reliable diagnostic tools, including circumstantial evidence, clinical history, radiological examinations, and autopsy, are crucial for accurate diagnosis. Histological examination of eye and brain tissues post-autopsy is important for correlating findings with symptoms observed in living patients.
Review
Biochemistry & Molecular Biology
Rahul M. Nikam, Heidi H. Kecskemethy, Vinay V. R. Kandula, Lauren W. Averill, Sigrid A. Langhans, Xuyi Yue
Summary: Abusive head trauma (AHT) is a leading cause of death in children under 2 years old. Animal models can provide valuable information on the biochemical effects and cellular changes in AHT, but have limitations in replicating the exact brain changes and clinical translatability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Luciana Porto, Marco Baz Bartels, Jonas Zwaschka, Se-Jong You, Christoph Polkowski, Julian Luetkens, Christoph Endler, Matthias Kieslich, Elke Hattingen
Summary: The study showed that neuroradiologists are more accurate in interpreting MRI in cases of suspected AHT compared to non-neuroradiologists. Neuroradiologists demonstrate higher levels of sensitivity and positive predictive value in the diagnosis of AHT, and are more precise in differential diagnosis and assessment than non-neuroradiologists.
Article
Pediatrics
Enrica Macorano, Mattia Gentile, Giandomenico Stellacci, Mariano Manzionna, Federica Mele, Mariagrazia Calvano, Mirko Leonardelli, Stefano Duma, Giovanni De Gabriele, Alessandro Cristalli, Raffaella Minella, Aldo Di Fazio, Francesco Introna
Summary: This paper presents a new entity of Abusive Head Trauma, called 'Compressed Baby Head', through a case study of child abuse. The uniqueness of this case deserves the attention of experts, the scientific community, as well as medical professionals such as pediatricians and resuscitators. They need to know how to properly manage similar complex clinical cases and ensure protection for abused infants and children.
Article
Family Studies
James Anderst, Shannon Carpenter, Terra Frazier, Brian Appavu, Michael Noetzel, Lauren A. Beslow, Mukta Sharma
Summary: The study found that in children with CSVT, most of those who had SDH also had independent risk factors for SDH. The results of this study do not support the hypothesis that CSVT causes SDH.
CHILD ABUSE & NEGLECT
(2021)
Review
Medicine, General & Internal
Matteo Antonio Sacco, Saverio Gualtieri, Lucia Tarda, Pietrantonio Ricci, Isabella Aquila
Summary: Abusive head trauma (AHT) is a serious global public health problem, and its diagnosis is complex, often resulting in missed or false diagnoses. Proper and timely recognition is essential to prevent recurrence of AHT and to conduct forensic investigations.
Article
Family Studies
Katelyn M. Even, Kent P. Hymel, Veronica Armijo-Garcia, Matthew Musick, Kerri Weeks, Suzanne B. Haney, Mark Marinello, Bruce E. Herman, Terra N. Frazier, Christopher L. Carroll, Menglu Liang, Ming Wang
Summary: The study found that subcortical injury is strongly associated with the diagnosis of abusive head trauma (AHT), historical inaccuracies concerning abuse, traumatic extracranial injuries, and increased severity of illness.
CHILD ABUSE & NEGLECT
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Boaz Karmazyn, Thomas A. Reher, Nucharin Supakul, Drew A. Streicher, Neud Kiros, Nicklaus Diggins, S. Gregory Jennings, George J. Eckert, Roberta A. Hibbard, Rupa Radhakrishnan
Summary: This study evaluated the importance of whole-spine MRI in children with suspected AHT, and the results showed that whole-spine MRI commonly reveals additional injuries in the thoracolumbar spine.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Clinical Neurology
Deveney Franklin, Chhitij Tiwari, Carlos Zamora, Randaline Barnett, Alice Woolard, Sheng-Che Hung, Molly Berkoff, Carolyn Quinsey
Summary: The aim of the study was to compare the performance of RS-MRI protocol combined with skull radiography versus CT for the detection of skull fractures, scalp hematomas, and intracranial hemorrhage in patients with abusive head trauma. The combination imaging showed promising results with high sensitivity and specificity for detecting skull fractures and intracranial hemorrhages. The presence of scalp hematoma on RS-MRI was found to be associated with concurrent skull fractures, although the sensitivity varied among radiologists.
NEUROSURGICAL REVIEW
(2023)
Article
Pediatrics
Adam J. Oates, Jai Sidpra, Kshitij Mankad
Summary: Abusive head trauma can have devastating consequences for children and society, leading to death or severe long-term effects. Caring for such children puts a significant financial burden on society, highlighting the importance of recognizing abusive head trauma.
PEDIATRIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Spencer Kriss, James Morris, Vesna Martich
Summary: The study aimed to assess the incidence of pediatric skull fractures contacting cranial sutures in abusive versus accidental trauma. It found that skull fractures contacting cranial sutures are common in both abusive and accidental pediatric head trauma, but contacting two or more sutures is significantly more associated with abusive injuries than accidental ones.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Family Studies
Kent P. Hymel, Wouter Karst, Mark Marinello, Bruce E. Herman, Terra N. Frazier, Christopher L. Carroll, Veronica Armijo-Garcia, Matthew Musick, Kerri Weeks, Suzanne B. Haney, Afshin Pashai, Ming Wang
Summary: This study compared the screening performances of PediBIRN-4 CDR and the simplified 3-variable CDR for AHT in PICU settings. The results showed that the simplified 3-variable CDR performed better in screening accuracy and served as a good predictor of the results of patients' subsequent completed abuse evaluations.
CHILD ABUSE & NEGLECT
(2022)
Article
Pediatrics
Kshitij Mankad, Jai Sidpra, Adam J. Oates, Alistair Calder, Amaka C. Offiah, Arabinda Choudhary
Summary: Abusive head trauma (AHT) is identified as the primary cause of child abuse-related deaths in children under 5. Research suggests that infants in contact with suspected AHT cases are at higher risk of abuse, highlighting the need for standardized screening methods and further consensus on the topic.
PEDIATRIC RADIOLOGY
(2021)
Review
Neurosciences
Gaia Cartocci, Vittorio Fineschi, Martina Padovano, Matteo Scopetti, Maria Camilla Rossi-Espagnet, Costanza Gianni
Summary: AHT is the leading cause of fatal head injuries in children under 2 years old, characterized by a complex diagnosis and requiring a multidisciplinary approach. MRI plays a crucial role in identifying AHT signs, especially in the absence of external detectable lesions.
