Article
Cardiac & Cardiovascular Systems
Andrea Dell'Amore, Martin Kalab, Archibald Sandford Miller, Giampiero Dolci, Valeria Liparulo, Farahnaz Sadegh Beigee, Lorenzo Rosso, Pia Ferrigno, Alessandro Pangoni, Marco Schiavon, Tommaso Bottio, Francesco Puma, Vladimir Lonsky, Federico Rea
Summary: The study reviewed the clinical indications and outcomes of sternal chondral allograft transplantation in 58 patients, demonstrating that it is a safe and effective method for reconstructing the anterior chest wall after sternectomy, with a 74% survival rate at 5 years.
ANNALS OF THORACIC SURGERY
(2021)
Article
Agronomy
Priscila Ines Ferreira, Guilherme Rech Cassanego, Paula Cristina Basso, Daniel Curvello de Mendonca Muller
Summary: This study reports cases of partial hemipelvectomy in seven dogs. Despite some complications, the overall quality of life in the dogs showed significant improvement, indicating that partial hemipelvectomy is beneficial for dogs with severe pelvic conditions.
Review
Medicine, General & Internal
Dimitrios Kitridis, Konstantinos Tsikopoulos, Panagiotis Givissis, Byron Chalidis
Summary: This study compares the clinical and radiological outcomes of percutaneous cannulated screw fixation (PCSF) and conventional plate fixation in the treatment of traumatic symphysis pubis diastasis (SPD), and analyzes the biomechanical effectiveness of PCSF. The results show that PCSF has advantages over conventional plate fixation in terms of operative time, intraoperative blood loss, and infection rate, without increasing the incidence of postoperative fixation failure and revision surgery. Biomechanical studies confirm the stability of PCSF. Therefore, PCSF should be considered as an effective and feasible alternative for the treatment of SPD when closed reduction is achievable.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Bulent Erol, Omer Sofulu, Evrim Sirin, Fevzi Saglam, Omer Buyuktopcu
Summary: The study showed that LUMiC(R) endoprosthesis provides good functional outcomes and durable reconstruction in periacetabular malignant tumors. Despite some complications, this method offers a stable pelvis in managing periacetabular malignancies.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Nellie V. V. Movtchan, Lyndsay A. A. Kandi, Chad M. M. Teven, Edward M. M. Reece, Alanna M. M. Rebecca
Summary: The fillet flap is a reliable option for reconstructing large deformities following oncologic resection. This study reviewed the medical records of eight patients who underwent fillet flap reconstruction and found that successful free fillet flap transfer is a difficult task to achieve. However, specific management strategies can improve the survival odds of the flap.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2022)
Article
Hematology
Yifan Pang, Ananth Charya, Michael B. Keller, Arlene Sirajuddin, Yi-Ping Fu, Noa G. Holtzman, Steven Z. Pavletic, Sean Agbor-Enoh
Summary: This study adapted the 2019 International Society for Heart and Lung Transplantation criteria to define novel phenotypes of pulmonary chronic graft-versus-host disease (PcGVHD) and compared its performance with the NIH criteria in identifying high-risk PcGVHD patients. The adapted criteria were found to be effective in identifying high-risk PcGVHD patients that were missed by the NIH criteria.
Article
Orthopedics
Sachin Allahabadi, Nirav K. Pandya
Summary: MPFL reconstruction using allograft tissue can be safely performed in pediatric and adolescent population with good outcomes at midterm follow-up, few complications, and a low rate of recurrent instability.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Surgery
Howard D. Wang, Annie Cho, Amy Quan, Zuhaib Ibrahim, Robin Yang, Jordan P. Steinberg, Richard J. Redett
Summary: This study found that there was no significant difference in infection/extrusion rates between pediatric patients who received only perioperative antibiotics (<= 24 hours) and those who were prescribed a course of postoperative antibiotics after tissue expander insertion surgery, suggesting that postoperative prophylactic antibiotics may be unnecessary in this population.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Review
Oncology
Athan G. Zavras, Michael P. Fice, Navya Dandu, Mohammed A. Munim, Matthew W. Colman
Summary: This study aimed to compare the effects of sacroiliac resection with and without reconstruction on complications, functional outcomes, and oncologic outcomes. The results showed that reconstruction after sacroiliac resection led to higher complication rates and poorer physical recovery. The systematic review suggested that patients without spinopelvic junction instability may have better outcomes without reconstruction.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Orthopedics
Baptiste Boukebous, Valerie Dumaine, Victoire Cladiere-Nassif, Philippe Anract, David Biau
Summary: This study aimed to comprehensively evaluate revisions and mortality rates in patients with malignant bone tumors around the knee. Among 248 patients who underwent surgery with three different prosthesis models, it was found that although there were improvements in prosthesis design, they did not significantly affect the overall mortality rates and implant revision rates in the patients.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2023)
Article
Orthopedics
Allison J. Rao, David M. Macknet, Casey R. Stuhlman, Nicholas C. Yeatts, David P. Trofa, Susan M. Odum, Bryan M. Saltzman, James E. Fleischli
Summary: The study found that augmenting undersized HS ACL autograft with allograft did not show a difference in overall reoperation or revision of ACL failure. There was no clinically important difference in patient-reported outcomes between the hybrid autograft/allograft ACL reconstruction group and the control group.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Editorial Material
Orthopedics
Noel E. Palumbo, Matthew J. Matava
Summary: Meniscal allograft transplantation (MAT) is the reconstruction surgery of choice for patients who have undergone a complete or near-complete meniscectomy, with stable and well-aligned knees. While most patients see significant improvement in subjective outcomes, there is wide variability in how athletic patients are able to return to sports, with the most common complication being a recurrent meniscal tear.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Oncology
Hugo Otaola-Arca, Alfred Krebs, Hugo Bermudez, Raul Lyng, Marcelo Orvieto, Alberto Bustamante, Conrado Stein, Andres Labra, Marcela Schultz, Mario Fernandez
Summary: Robot-assisted partial nephrectomy (RAPN) for renal cell carcinoma (RCC) has been shown to result in excellent long-term survival and preserved renal function in most patients. The incidence of local and distant relapse is low in this large cohort.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Cell Biology
Zhuo Chen, Rama Natarajan
Summary: Inherent and acquired abnormalities in gene regulation due to genetics and epigenetics underlie many diseases including diabetes. Epigenetic changes are associated with complications of diabetes, and these changes persist even after restoration of normal blood sugar levels, known as metabolic memory. Epigenetic modifications provide a therapeutic opportunity to ameliorate cellular dysfunction and reverse metabolic memory.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Orthopedics
Surena Namdari, Thema Nicholson, Tyler J. Brolin, Jeffrey Lu, Joseph A. Abboud, Mark D. Lazarus
Summary: The study on complex and revision rotator cuff repairs with dermal allograft augmentation in 35 patients showed that double-row arthroscopic repair led to improved functional outcomes. Approximately half of patients experienced a failure of healing, which was associated with poorer functional results.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Clinical Neurology
Michiel E. R. Bongers, Paul T. Ogink, Katrina F. Chu, Anuj Patel, Brett Rosenthal, John H. Shin, Sang-Gil Lee, Francis J. Hornicek, Joseph H. Schwab
Summary: The study describes the surgical technique for spine reconstruction using free vascularized fibular grafts following total en bloc spondylectomy and reports the outcomes of 39 patients. The results show that the free vascularized fibular graft is an effective reconstruction technique, particularly in the cervicothoracic spine, but has high implant failure rates in the lumbar spine.
JOURNAL OF NEUROSURGERY-SPINE
(2021)
Article
Oncology
Kun Wang, Theodoros Michelakos, Bing Wang, Zikun Shang, Albert B. DeLeo, Zhenfeng Duan, Francis J. Hornicek, Joseph H. Schwab, Xinhui Wang
Summary: This study demonstrates that DSF/Cu can increase the radiosensitivity of chondrosarcoma stem cells, potentially providing better treatment outcomes for chondrosarcoma patients requiring radiotherapy.
Review
Orthopedics
Takashi Higuchi, Kentaro Igarashi, Hiromichi Oshiro, Kentaro Miyake, Norihiko Sugisawa, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Zhenfeng Duan, Francis J. Hornicek, Hiroyuki Tsuchiya, Robert M. Hoffman
Summary: The establishment of the osteosarcoma-PDOX model by the research team provides a better understanding for discovering effective therapies. The model more accurately replicates human tumors, offering opportunities to identify effective treatments.
Article
Multidisciplinary Sciences
Ahmad Al Shihabi, Ardalan Davarifar, Huyen Thi Lam Nguyen, Nasrin Tavanaie, Scott D. Nelson, Jane Yanagawa, Noah Federman, Nicholas Bernthal, Francis Hornicek, Alice Soragni
Summary: This study successfully established patient-derived organoids from chordoma tumor samples and identified potential therapeutic targets, providing new directions for chordoma treatment.
Article
Medicine, Research & Experimental
Xiaoyang Li, Dylan C. Dean, Jin Yuan, Thomas H. Temple, Jonathan C. Trent, E. Rosenberg Andrew, Yu Shengji, J. Hornicek Francis, Zhenfeng Duan
Summary: This study demonstrates that overexpression of CDK7 in synovial sarcoma is associated with advanced clinical stage and worse prognosis. Inhibition of CDK7 reduces cell growth and migration, and promotes apoptosis in synovial sarcoma. CDK7-specific cytotoxic agents show promise as novel treatment options for synovial sarcoma.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Walter Banfield, Myrsini Ioakeim-Ioannidou, Saveli Goldberg, Soha Ahmed, Joseph H. Schwab, Gregory M. Cote, Edwin Choy, John H. Shin, Francis J. Hornicek, Norbert J. Liebsch, Yen -Lin E. Chen, Shannon M. MacDonald, Thomas F. DeLaney
Summary: This study retrospectively reviewed the outcomes of high-dose proton-based definitive radiotherapy for newly diagnosed, unresected spinal and sacral chordomas. The results showed that high-dose definitive radiotherapy is an effective treatment option for medically inoperable or otherwise unresected mobile spine or sacrococcygeal chordomas.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Orthopedics
Juncheng Cui, Dylan Dean, Francis J. Hornicek, Guoliang Yi, Zhenfeng Duan
Summary: High expression of HMGA2 in osteosarcoma is associated with metastasis and shorter overall survival, serving as an independent predictor of poor prognosis. HMGA2 expression is predominantly nuclear and directly correlated with neoadjuvant chemoresistance.
ORTHOPAEDIC SURGERY
(2022)
Article
Oncology
Akash A. Shah, Santiago A. Lozano-Calderon, Emily A. Berner, William G. Austen, Jonathan M. Winograd, Howard Y. Park, Nicholas M. Bernthal, Brooke M. Crawford, Francis J. Hornicek
Summary: This retrospective cohort study analyzed 28 patients who underwent reconstruction employing a pedicled vastus lateralis flap after wide resection of primary sacropelvic malignancies. The study found that even in a cohort with high baseline risk for wound complications, the use of a pedicled vastus lateralis flap is a safe reconstructive option.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Robert L. Walker, Francis J. Hornicek, Zhenfeng Duan
Summary: This review summarizes recent enhancements and improvements made to generate useful chordoma models and discusses their applications in drug discovery and precision medicine.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Oncology
Yang Wen, Fan Tang, Chongqi Tu, Francis Hornicek, Zhenfeng Duan, Li Min
Summary: This review discusses the use of immune checkpoint inhibitors (ICIs) in the treatment of osteosarcoma and their related mechanisms. Osteosarcoma treatment has had limited progress over the years, but the advent of ICIs provides a new therapeutic strategy. The current mechanisms of resistance to ICIs therapy in osteosarcoma are summarized, along with strategies to improve their efficacy and potential predictive biomarkers.
Review
Biotechnology & Applied Microbiology
Huali Ye, Xin Hu, Yang Wen, Chongqi Tu, Francis Hornicek, Zhenfeng Duan, Li Min
Summary: Exosomes play an important role in the tumor microenvironment of sarcoma, promoting cancer progression and metastasis through mediating cellular communications. Due to their unique characteristics, exosomes are regarded as potential biomarkers and vehicles for diagnosis and treatment of sarcoma.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell Biology
Lucia Casadei, Patricia Sarchet, Fernanda Costas C. de Faria, Federica Calore, Giovanni Nigita, Sayumi Tahara, Luciano Cascione, Martin Wabitsch, Francis J. Hornicek, Valerie Grignol, Carlo M. Croce, Raphael E. Pollock
Summary: EVs have emerged as an important player in tumor initiation, progression, and metastasis. Detection of EV cargoes remains a challenge, and this study demonstrates the potential of using ultrasensitive ISH to examine embedded EVs as substrates for detecting DNA amplification, providing a more direct visualization of DNA targets.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Review
Orthopedics
David S. Constantinescu, William Pavlis, Juan J. Lizardi, Jonathan Weinerman, Thomas M. Best, Francis J. Hornicek, Seth D. Dodds
Summary: The purpose of this review was to analyze the types of questions in the Orthopaedic In-Training Examination. The study found that musculoskeletal trauma had the highest number of questions, and residents should focus on clinical management topics and primary journal sources for studying.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2023)
Article
Pathology
Stefan C. Halvorsen, Yair Benita, Megan Hopton, Brooke Hoppe, Hilmar O. Gunnlaugsson, Parimal Korgaonkar, Charles R. Vanderburg, G. Petur Nielsen, Nicole Trepanowski, Jaime H. Cheah, Matthew P. Frosch, Joseph H. Schwab, Andrew E. Rosenberg, Francis J. Hornicek, Slim Sassi
Summary: This study compared the gene expression profiles of chordoma and notochord, and found consistency between the two, identifying a 12-gene diagnostic signature for chordoma. The TBXT/TGF-B/SOX6/SOX9 pathway was hyperactivated in the tumor, suggesting that chondrogenesis-related pathways play a key role in chordoma development. This research provided the first molecular connection between notochord and chordoma and identified potential therapeutic targets.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Review
Cell Biology
Michael G. G. Rizzo, Thomas M. M. Best, Johnny Huard, Marc Philippon, Francis Hornicek, Zhenfeng Duan, Anthony J. J. Griswold, Lee D. D. Kaplan, Joshua M. M. Hare, Dimitrios Kouroupis
Summary: Osteoarthritis (OA) is the leading cause of disability among the elderly and is increasingly affecting younger individuals. Recent advancements in understanding the pathology of OA have led to the identification of potential therapeutic approaches targeting specific molecular pathways, such as inflammation and cellular senescence. Stem cell therapies and senolytics show promise in controlling patient symptoms and slowing disease progression.