Article
Pathology
Thomas W. Bauer, Yaxia Zhang, Madeleine A. Gao, Bin Q. Lin, Matthew F. Koff
Summary: The study evaluated the inter-examiner repeatability of histopathologic grading methods in revision hip arthroplasty surgery, finding almost perfect inter-rater repeatability for individual factors and substantial agreement for the proposed major overall pattern. Correspondence analysis was able to identify individual features associated with the major pattern, facilitating evaluation of histopathologic tissue samples.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Orthopedics
Christian Klemt, Sakkadech Limmahakhun, Georges Bounajem, Christopher M. Melnic, Michael J. Harvey, Young-Min Kwon
Summary: This study reveals high complication and reoperation rates of recalled THAs at mid-term follow-up, with revision of modular taper corrosion THA and high-grade intraoperative tissue damage posing as risk factors for post-revision complications.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Orthopedics
Matthew F. Koff, Madeleine A. Gao, John P. Neri, Yu-Fen Chiu, Bin Q. Lin, Alissa J. Burge, Edwin Su, Douglas E. Padgett, Hollis G. Potter
Summary: The study found a higher proportion of ALTR or metallosis on MRI in patients with HRA compared with patients with CoP, even when patient self-assessed symptomatology of those with an ALTR or metallosis on MRI was not different than the absence of these features. MRI detected ALTRs in high-function patients, emphasizing that an annual clinical assessment dependent on survey or blood ion testing alone may not detect soft tissue complications.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2021)
Article
Orthopedics
Margaret A. Weber, Matthew J. Snyder, Kalain K. Workman, Margaret M. Sims, Clair N. Smith, Deepak Kumar, Akshay Daji, Camilo G. Borrero, Andrew C. Cordle, Anthony M. DiGioia, Brian R. Hamlin, Anton Y. Plakseychuk, Kenneth L. Urish
Summary: This study found that almost half of MoP THA ALTR cases were asymptomatic, cobalt levels could not differentiate between symptomatic and asymptomatic pseudotumor formation, and MRI characteristics of symptomatic and asymptomatic MoP ALTRs were similar.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Orthopedics
C. M. Lawrie, R. L. Barrack, R. M. Nunley
Summary: The study showed that young, active patients undergoing modular DM total hip arthroplasty had favorable clinical outcomes and metal ion levels at mid-term follow-up, with excellent overall survivorship and minimal concerns regarding corrosion and metal ion release.
BONE & JOINT JOURNAL
(2021)
Article
Orthopedics
Giorgio Perino, Ivan De Martino, Lingxin Zhang, Zhidao Xia, Jiri Gallo, Shonali Natu, David Langton, Monika Huber, Anastasia Rakow, Janosch Schoon, Enrique Gomez-Barrena, Veit Krenn
Summary: The histopathological examination of periprosthetic soft tissue and bone has helped identify and describe the morphological features of ALTR/ARMD. A uniform vocabulary and clarification of classification parameters are considered essential for meaningful interdisciplinary evaluation.
EFORT OPEN REVIEWS
(2021)
Article
Orthopedics
Akshay V. Daji, Kalain K. Workman, Charlie J. Yoo, Clair N. Smith, Deepak Kumar, Margaret A. Weber, Matthew J. Snyder, Kenneth L. Urish
Summary: This study found that patients who underwent revision total hip arthroplasty for adverse local tissue reactions (ALTR) experienced significant pain relief. Increased or decreased head-neck offset and magnetic resonance imaging findings did not significantly affect instability/dislocation. Increased serum cobalt and chromium levels did not predict complications, but a decreased cobalt-chromium ratio was associated with postoperative complications.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Brian J. McGrory
Summary: At 10-year follow-up, at least 22% of non-cemented total hip arthroplasties presented with symptomatic mechanically assisted crevice corrosion (MACC). Symptoms and adverse local tissue reactions were each present about one-half of the time, and 59% of those with documented MACC underwent revision surgery.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Pharmacology & Pharmacy
Asif Massud, Syed Azhar Syed Sulaiman, Nafees Ahmad, Muhammad Shafqat, Long Chiau Ming, Amer Hayat Khan
Summary: The management of drug-resistant tuberculosis patients is crucial to prevent adverse drug reactions, which may lead to a higher rate of loss to follow-up. This study conducted in Pakistan found a high frequency of adverse drug reactions among drug-resistant tuberculosis patients, but effective management strategies were implemented.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Felipe Eltit, Jake Noble, Manju Sharma, Niloufar Benam, Anne Haegert, Robert H. Bell, Felipe Simon, Clive P. Duncan, Donald S. Garbuz, Nelson Greidanus, Bassam A. Masri, Tony L. Ng, Rizhi Wang, Michael E. Cox
Summary: Adverse local tissue reactions (ALTRs) in failing metal hip implants are likely caused by CoCrMo corrosion, leading to aseptic necrosis and leukocyte infiltration of synovial tissue. Cobalt ions released by failing hip implants induce mitochondrial stress and cytokine secretion by synovial fibroblasts, initiating ALTR pathogenesis. The inflammatory factors secreted by cobalt-exposed synovial fibroblasts contribute to endothelial activation and monocyte migration in ALTR patients.
ACTA BIOMATERIALIA
(2021)
Review
Orthopedics
Liang Xiong, Evan J. Smith, Christian Klemt, Ameen Barghi, Anand Padmanabha, Young-Min Kwon
Summary: Evaluation of ALTR characteristics in patients with failed THA using MARS MRI can help predict intraoperative tissue necrosis and postoperative complications. The synovial composition of mixed and solid features, as well as abductor disruption, are the most relevant prognostic characteristics associated with tissue necrosis and revision surgery outcomes.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2021)
Article
Orthopedics
Liang Xiong, Evan J. Smith, Christian Klemt, Ameen Barghi, Anand Padmanabha, Young-Min Kwon
Summary: MARS MRI synovial composition including mixed and solid features and the presence of abductor disruption provide the best prognostic characteristics associated with intraoperative soft-tissue necrosis and revision surgery outcome. These prognostic characteristics on MRI may assist surgeons with improved criteria for intervention and preoperative patient counseling.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2021)
Article
Orthopedics
Felipe Eltit, Nissreen Mohammad, Indira Medina, Anne Haegert, Clive P. Duncan, Donald S. Garbuz, Nelson V. Greidanus, Bassam A. Masri, Tony L. Ng, Rizhi Wang, Michael E. Cox
Summary: In patients undergoing hip implants, adverse local tissue reactions (ALTRs) can occur, especially with metal-on-metal and metal-on-polyethylene prosthetics. Among these reactions, those dominated by lymphocytes show similar immune-related transcript profiles and cell signatures between MoM and MoP prosthetics, suggesting a common hypersensitivity pathogenesis in these cases.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Chemistry, Physical
Himanshu Sekhar Jena, Hannes Rijckaert, Chidharth Krishnaraj, Isabel Van Driessche, Pascal Van der Voort, Anna M. Kaczmarek
Summary: Zr-metal organic frameworks (MOFs) can be used for catalysis and serve as hosts for various upconverting nanoparticles, displaying excellent temperature-dependent luminescence properties. They can also function as stable and reusable catalysts.
CHEMISTRY OF MATERIALS
(2021)
Article
Orthopedics
B. A. Sophie Lipson, Nicholas R. Pagani, Michael A. Moverman, Richard N. Puzzitiello, Mariano E. Menendez, Eric L. Smith
Summary: This study examines the cost-effectiveness of extended oral antibiotic prophylaxis for preventing prosthetic joint infection (PJI) in high-risk patients undergoing total joint arthroplasty (TJA). The results suggest that this preventive measure is cost-effective at certain infection rates. However, the current evidence supporting this practice is limited, and the potential development of antimicrobial resistance should be considered.
JOURNAL OF ARTHROPLASTY
(2022)