Article
Clinical Neurology
Arjan C. Y. Loenen, Marloes J. M. Peters, Raymond T. J. Bevers, Claus Schaffrath, Els van Haver, Vincent M. J. Cuijpers, Timo Rademakers, Bert van Rietbergen, Paul C. Willems, Jacobus J. Arts
Summary: This study compared bone ingrowth and segmental stability of lumbar interbody fusion using two different cage types in a preclinical ovine model. The results showed that the newly developed trussed titanium (TT) cages had more direct bone to implant contact and exhibited a more gradual increase in stability compared to conventional polyether ether ketone (PEEK) cages, which had higher bone volume over total volume.
Article
Materials Science, Multidisciplinary
Marcela Britto de Paiva, Giovana Sant'Ana Pegorin Brasil, Ana Laura Destro Chagas, Ana Paula Macedo, Junia Ramos, Joao Paulo Mardegan Issa, Ankit Gangrade, Juliana Ferreira Floriano, Guilherme Ferreira Caetano, Bingbing Li, Neda Farhadi, Kalpana Mandal, Mehmet Remzi Dokmeci, Vadim Jucaud, Rondinelli Donizetti Herculano, Antonio Carlos Shimano
Summary: Due to the difficulty and high cost of therapy for bony defects or post-traumatic diseases, guided bone regeneration using natural rubber latex and latex-collagen membranes has been explored as a viable solution in orthopedics. This study developed and characterized NRL and NRL-COL membranes, and evaluated their effects on bone regeneration in rat tibial lesions. Results showed that NRL-COL exhibited the best performance in terms of bone volume.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Critical Care Medicine
Xiang-Yu Ma, Hong Yuan, Dong Cui, Bing Liu, Tian-Yu Han, Hai-Long Yu, Da-Peng Zhou
Summary: This study reviewed a treatment strategy for segmental bone defects following open distal femur fractures. The use of a cylindrical titanium mesh cage in a 2-staged Masquelet technique showed satisfactory clinical outcomes.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Oncology
Jeyashanth Riju, Arun Paul, C. Ajit, Amit Jiwan Tirkey
Summary: In this study, a unique technique using lingual cortex mandibular plate as an alternative choice for free flap reconstruction was introduced and applied in six patients with oral cancer. The cosmetic and functional outcomes were acceptable, making it a potential alternative treatment strategy for anterior segmental defects.
INDIAN JOURNAL OF CANCER
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ezgi Yuceer-Cetiner, Nilufer Ozkan, Mehmet Emin Onger, Mustafa Yavuz Gulbahar, Metehan Keskin
Summary: This study compared different graft materials for reconstructing mandibular bone defects, finding that a combination of autograft and xenograft was more effective than using either alone or leaving the defects empty. Immunohistochemical and stereological results support the adoption of the induced membrane technique in humans for small segmental mandibular defect reconstruction.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Review
Immunology
Darel Martinez Bedoya, Valerie Dutoit, Denis Migliorini
Summary: CAR T cell therapy has shown significant progress in cancer immunotherapy, with promising results in hematological malignancies and challenges in solid tumors like GBM. Allogeneic CAR T cells may offer advantages over autologous T cells, potentially allowing for multivalent approaches and modification of the tumor microenvironment. Future advancements in genome editing tools could further enhance the effectiveness of allogeneic CAR T cells for the treatment of patients with GBM.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Darling Rojas-Canales, Stacey N. Walters, Daniella Penko, Daniele Cultrone, Jacqueline Bailey, Tatyana Chtanova, Jodie Nitschke, Julie Johnston, Svjetlana Kireta, Thomas Loudovaris, Thomas W. Kay, Tim R. Kuchel, Wayne Hawthorne, Philip J. O'Connell, Greg Korbutt, John E. Greenwood, Shane T. Grey, Chris J. Drogemuller, P. Toby Coates
Summary: A clinically proven biodegradable temporizing matrix (BTM) has been found to facilitate the formation of a well-vascularized intracutaneous neodermis within the skin, which improves the survival and functionality of transplanted islet cells. The experiments conducted on mice and pigs showed that BTM does not harm the viability and function of islet cells, and it can maintain the normal structure and function of the islets. BTM has the potential to become an alternative site for islet transplantation.
Article
Nanoscience & Nanotechnology
Jing-Yang Chung, Zhang Li, Sarah A. Goodman, Jinkyu So, Govindo J. Syaranamual, Tara P. Mishra, Eugene A. Fitzgerald, Michel Bosman, Kenneth Lee, Stephen J. Pennycook, Silvija Gradecak
Summary: A new direct metal-organic chemical vapor deposition approach is demonstrated to grow In-rich InGaN quantum dots on Si substrates, leading to efficient long wavelength luminescence for white light emitting devices. The highly textured surface with V-pits allows localized high intensity red-shifted emission, opening up new pathways for solid-state white light emitting devices.
Article
Ophthalmology
Gege Xiao, Hanzhi Ben, Shaofeng Gu, Jing Hong
Summary: This study introduced the combination of deep anterior lamellar keratoplasty (DALK) with intralamellar tectonic patch graft to treat frank corneal perforation. The results showed that this method is a secure and effective alternative with reduced complications compared to conventional penetrating keratoplasty.
Article
Dentistry, Oral Surgery & Medicine
Bernardo Ottoni Braga Barreiro, Valesca Sander Koth, Patricia Sesterheim, Fernanda Goncalves Salum, Gabriel Ruebensam, Adolpho Herbert Augustin, Karen Cherubini
Summary: This study aimed to evaluate the effect of dentin matrix alone or combined with mesenchymal stromal cells (MSC) on postextraction alveolar bone regeneration. The results showed that the Dentin/MSC group had greater bone volume and higher expression of collagen type I and osteocalcin compared to the other groups. Therefore, the combination of dentin matrix and MSC can improve alveolar bone grafting.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Food Science & Technology
Joanna Katarzyna Banach, Ryszard Zywica, Malgorzata Grzywinska-Rapca, Mariola Grzybowska-Brzezinska
Summary: This research aimed to compare the impact of a conventional device and an alternative device on the quality of commercial turkey meat. The results showed that using the alternative device can reduce visible quality defects and improve the overall quality of the meat.
Review
Chemistry, Physical
Maria Pia Ferraz
Summary: This review summarizes the various materials used for bone defect replacement or repair in dentistry and oral and maxillofacial surgeries. Factors such as tissue viability, size, shape, and defect volume influence the choice of material. Autologous bone is the gold standard for bone grafting but has limitations. Alternatives include allografts, xenografts, and synthetic materials. Calcium-phosphate-based ceramics, especially hydroxyapatite, are commonly used due to their similarity to natural bone. This review aims to provide a comprehensive analysis of grafting materials in dentistry and discusses their properties, advantages, and challenges.
Article
Health Care Sciences & Services
Irina F. Dragan, Tanya Wright, Lucrezia Paterno Holtzman, Federico Ausenda, Umer Malik, Nawwaf Al-Hamoudi, Nadeem Karimbux, Mohammed Alasqah
Summary: This study evaluated the use of Omega-3 piscine acellular dermal matrix (OADM) as a soft tissue alternative in surgically created mucogingival defects. The results showed that the use of this alternative resulted in normal healing with minimal complications.
TECHNOLOGY AND HEALTH CARE
(2022)
Article
Medicine, General & Internal
Gianluca Mampieri, Tommaso Castroflorio, Andrea Conigliaro, Aldo Giancotti
Summary: Using aligners to camouflage missing canines during orthodontic treatment requires a good understanding of biomechanics, correct staging of dental movements, and strategic surgery planning to achieve optimal results.
CLINICAL CASE REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sohyun Park, Denny Chao, Keith E. Blackwell, Jay Jayanetti
Summary: This clinical report presents a new surgical modification for improving obturator function during maxillectomy. By performing vestibuloplasty and split thickness skin graft of the zygomaticoalveolar crest, a denture-bearing surface is created to enhance support and stability for the obturator prosthesis.
JOURNAL OF PROSTHETIC DENTISTRY
(2023)
Article
Engineering, Biomedical
Thomas Anijs, Sanne Eemers, Yukihide Minoda, David Wolfson, Nico Verdonschot, Dennis Janssen
Summary: This study validated postoperative bone response using finite element analysis and strain-adaptive remodeling theory in total knee arthroplasty. Similar trends were observed in bone remodeling between computational and clinical data in proximal regions, but large differences were found in distal regions. Further research is recommended to optimize bone remodeling distal to the tibial baseplate.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Biophysics
Corine E. Post, Thom Bitter, Adam Briscoe, Nico Verdonschot, Dennis Janssen
Summary: This computational study investigates the sensitivity of micromotions and interface gaps of a cementless PEEK femoral component to the interference fit and coefficient of friction. The study found that, besides the implant material, the micromotions and interface gaps of the implant were most sensitive to the interference fit. Compared to the cobalt-chrome femoral component, the PEEK femoral component generated higher micromotions and interface gaps when equal interference fit and friction values were applied.
JOURNAL OF BIOMECHANICS
(2022)
Article
Engineering, Biomedical
H. Dunning, N. Verdonschot, C. F. Buckens, D. Janssen, S. A. W. van de Groes
Summary: Accurate assessment of knee kinematics is crucial for understanding knee pathology and orthopaedic interventions. This study used a statistical shape model of the knee based on CT data and found that the patellar coordinate system is more sensitive to anatomical variation compared to the femoral and tibial coordinate systems.
MEDICAL ENGINEERING & PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Johnnidel Tabucol, Vera Geertruida Maria Kooiman, Marco Leopaldi, Tommaso Maria Brugo, Ruud Adrianus Leijendekkers, Gregorio Tagliabue, Vishal Raveendranathan, Eleonora Sotgiu, Pietro Benincasa, Magnus Oddsson, Nico Verdonschot, Raffaella Carloni, Andrea Zucchelli
Summary: Most biomechanical research has focused on level-ground walking, neglecting other conditions. This paper presents an ESR prosthesis with a spherical ankle joint that provides sagittal plane stiffness and flexibility in other planes. The performance of the prosthesis was evaluated quantitatively and qualitatively through testing and participant feedback.
APPLIED SCIENCES-BASEL
(2022)
Article
Medicine, General & Internal
Hao Chen, Na Zhao, Tao Tan, Yan Kang, Chuanqi Sun, Guoxi Xie, Nico Verdonschot, Andre Sprengers
Summary: This study proposes a method for automatic segmentation of knee bone and cartilage using a three-dimensional deep neural network. By adding adversarial loss and restoration network, the contextual information and resolution of the segmentation results can be improved while ensuring accuracy. Through evaluation and comparison, this method achieves good results in knee image segmentation tasks.
FRONTIERS IN MEDICINE
(2022)
Article
Orthopedics
Robin Atallah, David Reetz, Nico Verdonschot, Marinus de Kleuver, Jan Paul M. Frolke, Ruud A. Leijendekkers
Summary: This study compared two groups of patients with transfemoral amputation treated with different surgical techniques and implant designs, and found that changes to treatment can reduce the incidence of soft tissue infections and stoma-related complications. However, the use of a shallower stoma and titanium implant was associated with an increased risk of surgical site infections before stoma creation. Serious complications such as deep implant infection were rare in both groups during the 2-year follow-up period.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Review
Engineering, Biomedical
Vera G. M. Kooiman, Eline S. van Staveren, Ruud A. Leijendekkers, Jaap H. Buurke, Nico Verdonschot, Erik C. Prinsen, Vivian Weerdesteyn
Summary: This review examines the characteristics, protocols, aims, and outcome measures used during prosthesis prototype testing on individuals with a transfemoral amputation. The results indicate significant variations in research protocols and outcome measures, highlighting the need for a core set of reported characteristics, testing protocols, and outcome measures to evaluate prosthetic developments.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Orthopedics
T. G. van Tienen, B. van Minnen, K. C. Defoort, P. J. Emans, S. A. W. van de Groes, N. Verdonschot, L. M. Jutten, R. W. E. Pikaart, P. J. C. Heesterbeek
Summary: This study evaluated the effects of a polycarbonate anatomical meniscus prosthesis system on knee pain in patients with post-meniscectomy pain syndrome, and found that the prosthesis led to impaired knee function and had serious adverse events. However, one patient showed improvement with the prosthesis still in place.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Oncology
Florieke Eggermont, Yvette van der Linden, Nico Verdonschot, Edwin Dierselhuis, Steven Ligthert, Thom Bitter, Paulien Westhoff, Esther Tanck
Summary: Patients with femoral metastases are at risk of fractures, and preventing fractures is crucial for mobility and quality of life. The BOS score is an objective tool to assess fracture risk in femoral bone metastases and aids physicians and patients in making more informed treatment decisions.
Article
Neurosciences
Vera Kooiman, Lisanne Haket, Nico Verdonschot, Ruud Leijendekkers, Vivian Weerdesteyn
Summary: Comparative analysis between satisfied transfemoral socket-suspended prosthesis (SSP) users, satisfied transfemoral bone-anchored prosthesis (BAP) users, and able-bodied individuals (AB) revealed that SSP users had higher oxygen consumption and trunk dynamics compared to AB during walking. BAP users had intermediate results between SSP users and AB, but no significant differences were found. Greater trunk excursions were associated with higher oxygen consumption, while a higher degree of pistoning in SSP users was related to larger trunk dynamics. These findings suggest that evaluating CoM and trunk dynamics, as well as pistoning, could help determine the suitability of BAP for SSP users and potentially benefit a larger population.
Review
Orthopedics
Carl W. Imhauser, Andrew P. Baumann, Xiangyi (Cheryl) Liu, Jeffrey E. Bischoff, Nico Verdonschot, Benjamin J. Fregly, Shady S. Elmasry, Neda N. Abdollahi, Donald R. Hume, Nynke B. Rooks, Marco T. -Y. Schneider, William Zaylor, Thor F. Besier, Jason P. Halloran, Kevin B. Shelburne, Ahmet Erdemir
Summary: Stakeholders in the modeling and simulation community organized a workshop to discuss efforts to address irreproducibility focusing on the knee joint. Representatives from academia, industry, and regulatory bodies highlighted the need for reproducibility standards and open collaboration. Survey results showed strong support for increasing emphasis on computational modeling and identified individual laboratories and journals as key players in ensuring reproducible research. Thought leaders stressed the importance of data sharing and the credibility of computational models in advancing knee modeling and simulation.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Navid Soltanihafshejani, Thom Bitter, Nico Verdonschot, Dennis Janssen
Summary: This study used finite element analysis (FEA) to simulate the effects of postoperative bone density changes on the failure of tibial total knee arthroplasty (TKA) due to bone resorption. The results showed that postoperative bone loss significantly increased the risk of TKA loosening, especially in patients with poor bone quality. Additionally, the study examined the probability of medial or lateral subsidence of the implant and aimed to improve clinical implications.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Hans Dunning, S. A. W. van de Groes, C. F. Buckens, Mathias Prokop, Nico Verdonschot, Dennis Janssen
Summary: This study establishes normative knee kinematics of 100 healthy subjects using a fully automatic workflow, which can be used in clinics. The dynamic CT scans provide valuable information on the angles, rotation, and displacement of the knee joint during flexion and extension.
Article
Biotechnology & Applied Microbiology
Periklis Tzanetis, Rene Fluit, Kevin de Souza, Seonaid Robertson, Bart Koopman, Nico Verdonschot
Summary: Robotic-assisted total knee arthroplasty can achieve accurate implantation. This study demonstrates the feasibility of reproducing pre-diseased kinematics and ligament strains to optimize the position of knee components. By using a patient-specific musculoskeletal model and an optimization algorithm, the deviations between pre-diseased and post-operative kinematics and ligament strains were significantly reduced, providing valuable information for the pre-planning of robotic-assisted surgery.
BIOENGINEERING-BASEL
(2023)
Article
Orthopedics
Branco S. van Minnen, Albert J. van der Veen, Sebastiaan A. W. van de Groes, Nico J. J. Verdonschot, Tony G. van Tienen
Summary: The study aimed to investigate whether a flexible medial meniscus prosthesis is capable of sharing loads with the direct tibiofemoral cartilage contact and its effect on tibial pressure distribution after total meniscectomy. The second-generation prosthesis was found to share loads with the direct tibiofemoral contact and significantly reduce pressure on the medial tibial cartilage. These findings suggest that the prosthesis has the potential to relieve post-meniscectomy pain symptoms.
JOURNAL OF EXPERIMENTAL ORTHOPAEDICS
(2022)
