Article
Biochemistry & Molecular Biology
Yong-Ho Seo, Su-Hyun Hwang, Yu-Na Kim, Hyung-Joon Kim, Eun-Bin Bae, Jung-Bo Huh
Summary: The study aimed to investigate the bone regeneration efficiency of two-layer porcine-derived bone scaffolds composed of cancellous and cortical bones in a rabbit calvarial defect model. The results showed satisfactory bone regeneration efficiency in the cancellous and two-layer groups, while the cortical group exhibited poor bone regeneration. Further studies are needed to explore methods for regulating the ratio of cortical and cancellous bones in two-layer bones.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rui I. Falacho, Paulo J. Palma, Joana A. Marques, Maria H. Figueiredo, Francisco Caramelo, Isabel Dias, Carlos Viegas, Fernando Guerra
Summary: Collagenated porcine-derived bone graft materials have osteoconductive properties and different formulations can enhance bone regeneration. Results of a study on rabbit cancellous bone defects suggest that mp3 demonstrated significant differences compared to other materials, showing promising new bone formation.
Article
Multidisciplinary Sciences
Itsuki Michimoto, Kazuki Miyashita, Hidehisa Suzuyama, Keita Yano, Yasuyo Kobayashi, Kozue Saito, Mami Matsukawa
Summary: The transcranial Doppler method (TCD) is used to measure cerebral blood flow velocity and detect emboli by applying an ultrasound probe to different locations on the skull bone. Difficulties in TCD measurements in older women may be related to the cancellous bone structure in the skull bone.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Sarit Naishlos, Eran Zenziper, Helena Zelikman, Joseph Nissan, Shaked Mizrahi, Gavriel Chaushu, Shlomo Matalon, Liat Chaushu
Summary: The study evaluated esthetic results after augmentation of the anterior atrophic maxilla using cancellous bone-block allograft followed by implant placement and late loading. Results showed predictable esthetic outcome with long-term stability.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Biomedical
Lin Luo, Pengcheng Li, Haohao Ren, Zhengwen Ding, Yonggang Yan, Shuyang Li, Jie Yin
Summary: Xenogeneic bone has good biological activity, but overcoming immunogenicity while maintaining osteogenic abilities is challenging. By combining xenogeneic bone with poly amino acid (PAA), a new type of composite with bionics and low immunogenicity was obtained. Three composites of delipidized cancellous bone powder (DCBP) and PAA were designed and prepared by different methods, with DCBP/PAA EM showing the best cell proliferation and osteogenic differentiation in vitro.
BIOMEDICAL MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Wenhao Wang, Jiansen Lu, Ying Song, Chun Zeng, Yongkui Wang, Cheng Yang, Bin Huang, Yifan Dai, Jian Yang, Liangxue Lai, Liping Wang, Daozhang Cai, Xiaochun Bai
Summary: In this study, GTKO pig cancellous bone showed advantages in repairing femoral condyle bone defects and inhibiting xenotransplant rejection. Compared with WT pig bone, GTKO pig bone had reduced heterologous immunogenicity, tightly integrated with the defect, and showed better osseointegration with an appropriate rate of resorption. Additionally, GTKO pig bone promoted new bone formation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sukanya Mishra, Manoj Kumar, Lora Mishra, Swagatika Panda, Saurav Panda, Natalia Lewkowicz, Barbara Lapinska
Summary: This study aimed to evaluate cancellous bone using fractal analysis in patients with different clinical presentations of periodontitis, and to provide additional criteria for staging periodontitis. The results showed that fractal dimension can be used as a quantitative method for detecting cancellous bone changes in different stages of periodontitis, aiding in the diagnosis of periodontitis.
Article
Chemistry, Multidisciplinary
Zhihai Fan, Hongxiang Liu, Zhaozhao Ding, Liying Xiao, Qiang Lu, David L. Kaplan
Summary: This study successfully mimicked the complex anisotropic structures of different tissues in vitro using a composite materials strategy. Cryogels containing two types of silk nanofibers were prepared, and these bioactive cryogels showed the ability to promote bone regeneration and modulate inflammation, angiogenesis and osteogenesis responses in vivo, suggesting a promising strategy for tissue regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Maximilian Rummler, Fani Ziouti, Alice L. Bouchard, Andreas Brandl, Georg N. Duda, Bjarne Bogen, Andreas Beilhack, Maureen E. Lynch, Franziska Jundt, Bettina M. Willie
Summary: This study found that mechanical loading can enhance bone mass, prevent osteolytic destruction, and inhibit the growth and dissemination of multiple myeloma cells in mice. These findings suggest that physical stimuli may serve as an anabolic treatment for osteolytic bone destruction in patients with multiple myeloma.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Physical
Bin Wu, Le Yuan, Mao Liu, Miaoning Tang, Di Jiang, Yang Yi, Songyun Ma, Bin Yan, Yi Lu
Summary: Orthodontic treatment can affect the remodeling of cancellous bone in alveolar bone and its bone mineral density. This study quantified the effect of bone mineral density on the viscoelastic behavior of alveolar bone and assessed orthodontic forces at different bone mineral densities.
Article
Chemistry, Multidisciplinary
Zhichao Ma, Bin Huang, Fangzhou Lu, Hongwei Zhao, Luquan Ren
Summary: The energy absorption and toughening effect of cartilage are important for protecting bone from damage, and the presence of the cartilage layer can significantly enhance the strength and ductility of the bone structure.
Article
Immunology
Alison G. Abraham, Jing Sun, Anjali Sharma, Michael T. Yin, J. Keenan Brown, Shadpour Demehri, Joshua Garza, Jayesh G. Shah, Frank J. Palella, Lawrence Kingsley, Beth D. Jamieson, Keri N. Althoff, Todd T. Brown
Summary: In men who have sex with men (MSM), HIV status did not have a significant impact on hip bone structure, although cortical thickness was lower than expected overall. However, in women, those with HIV had significantly lower cortical thickness, integral bone mineral density, and trabecular bone mineral density across all quadrants compared to those without HIV.
Article
Orthopedics
Taha Ozer, Vusala Guliyeva, Alper Aktas, Emre Baris, Mert Ocak
Summary: In this study, the impact of local risedronate administered with autogenous bone grafts on the healing of defects in rabbit skulls was investigated. Results showed that the new bone area was significantly higher in the risedronate group than in the control group at 8 weeks. Risedronate enhanced the osteoconductive properties of autogenous bone grafts and created better-quality bone.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Dan Zhang, Ying Su, Peng Sun, Xingzhi Liu, Lin Zhang, Xuwei Ling, Yuhui Fan, Kang Wu, Qin Shi, Jisheng Liu
Summary: The GelMA-T/BMSCs scaffold showed good biocompatibility and promoted chondrogenic differentiation, indicating its potential for repairing nasal septum cartilage defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xiaofan Chen, Haicheng Wang, Yuning Wang, Ying Shi, Zuolin Wang
Summary: This study investigated and compared the effects of combining deproteinized bovine bone mineral (DBBM) with autologous cortical (CorBC) or cancellous bone chips (CanBC) as bone grafts on guided bone regeneration (GBR) both in vivo and in vitro. The results showed that the combination of DBBM and CanBC had a more favorable osteogenic effect compared to DBBM and CorBC, as demonstrated by various evaluation methods.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Orthopedics
Marysol Luna, Jason D. Guss, Laura S. Vasquez-Bolanos, Adrian J. Alepuz, Sophie Dornevil, Jasmin Strong, Denise Alabi, Qiaojuan Shi, Tania Pannellini, Miguel Otero, Ilana L. Brito, Marjolein C. H. van der Meulen, Steven R. Goldring, Christopher J. Hernandez
Summary: Obesity may not influence cartilage loss after a single mechanical insult without surgery/fracture, suggesting that damage to surrounding tissues or repeated mechanical insult is necessary for obesity to affect cartilage degeneration.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Orthopedics
Mengying Wang, Samantha G. Lessard, Purva Singh, Tania Pannellini, Tony Chen, Brennan J. Rourke, Luvana Chowdhury, Vinicius Craveiro, Peter K. Sculco, Marjolein C. H. van der Meulen, Miguel Otero
Summary: The study showed that fibrosis primarily occurred in the synovium, capsule, and IFP in a load-induced OA mouse model, accompanied by increased macrophage presence and a significant increase in T cells.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Orthopedics
Joseph H. Choi, Zhiwei Wang, Frederick P. Ross, Marjolein C. H. van der Meulen, Mathias P. G. Bostrom
Summary: The study found that OPG does not enhance osseointegration and may have detrimental effects, particularly at high doses.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Endocrinology & Metabolism
Alexander Vesprey, Eun Sung Suh, Didem Goz Ayturk, Xu Yang, Miracle Rogers, Branden Sosa, Yingzhen Niu, Ivo Kalajzic, Lionel B. Ivashkiv, Mathias P. G. Bostrom, Ugur M. Ayturk
Summary: This study identified specific bone marrow stromal cell populations essential for bone formation around metal implants. P alpha S cells are mobilized after surgery to repair bone tissue and participate in implant osseointegration.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Orthopedics
Ashley E. Levack, Kathleen Turajane, Xu Yang, Andy O. Miller, Alberto Carli, Mathias P. Bostrom, David S. Wellman
Summary: This study revealed significant differences in thermal stability and elution among antibiotics used for treating infections, with amikacin showing activity similar to tobramycin, and meropenem demonstrating favorable elution kinetics and thermal stability in the initial 7-day period.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Endocrinology & Metabolism
Sophia N. Ziemian, Olufunmilayo O. Ayobami, Amanda M. Rooney, Natalie H. Kelly, Derek T. Holyoak, F. Patrick Ross, Marjolein C. H. van der Meulen
Summary: The study found that the loss of estrogen receptor-alpha in bone cells resulted in reduced subchondral bone mass, exacerbating load-induced OA pathology. Changes in bone specific to estrogen loss may contribute to the increased incidence of OA in post-menopausal women.
Article
Endocrinology & Metabolism
Amanda M. Rooney, Olufunmilayo O. Ayobami, Natalie H. Kelly, John C. Schimenti, F. Patrick Ross, Marjolein C. H. van der Meulen
Summary: Estrogen receptor-alpha (ER alpha) plays a crucial role in skeletal maintenance and adaptation to mechanical loading, with its effects depending on sex and age. Deletion of ER alpha in mature osteoblasts leads to reduced bone mass and increased mechanoadaptation in adult female mice, while the effects in male mice are minimal.
Article
Endocrinology & Metabolism
Upneet K. Sokhi, Yunwei Xia, Branden Sosa, Kathleen Turajane, Sita N. Nishtala, Tania Pannellini, Mathias P. Bostrom, Alberto Carli, Xu Yang, Lionel B. Ivashkiv
Summary: This study characterized the immune response in orthopedic periprosthetic joint infection (PJI) using histology, flow cytometry, and gene expression analysis. The results showed that persistent S. aureus infection leads to robust activation of both innate and adaptive immunity, as well as ongoing inflammation and lymph node and bone marrow reactions. However, there are feedback mechanisms that suppress immune cell activation and inhibit T-cell proliferation and tissue infiltration. These findings provide insights into the immune response to persistent S. aureus PJI and suggest potential targets for immunotherapeutic strategies.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Genetics & Heredity
Francis H. Glorieux, Lynda F. Bonewald, Nicholas C. Harvey, Marjolein C. H. van der Meulen
Summary: Recent progress has been made in understanding the mechanisms of bone growth and development, particularly in the crosstalk between muscle and bone. However, limited knowledge exists on how these mechanisms apply or are compromised in pathological states. This review summarizes the research opinions and potential outcomes for XLH patients.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Biology
Jung-Min Kim, Yeon-Suk Yang, Jaehyoung Hong, Sachin Chaugule, Hyonho Chun, Marjolein C. H. van Der Meulen, Ren Xu, Matthew B. Greenblatt, Jae-Hyuck Shim
Summary: Emerging evidence suggests that the ERK pathway in osteoblasts controls bone formation by suppressing the mTOR pathway, promoting mitochondrial function and SGK1 phosphorylation. While ERK inhibition blocks early differentiation of osteogenic precursors, it surprisingly promotes later stages of osteoblast differentiation, leading to enhanced bone formation. This study reveals a surprising dichotomy of ERK pathway functions in osteoblasts, where ERK activation promotes early differentiation but inhibits the subsequent differentiation via mTOR-mediated regulation of mitochondrial function and SGK1.
Article
Endocrinology & Metabolism
Amanda M. Rooney, Tyler J. McNeill, F. Patrick Ross, Mathias P. G. Bostrom, Marjolein C. H. van der Meulen
Summary: Parathyroid hormone (PTH) is an effective treatment for increasing bone mass and reducing fracture risk in osteoporosis. Its effects vary depending on the site, with greater bone mass increase at the spine than the hip and no increase at the radius. The differences in local loading mode may contribute to these variations. This study found that compression loading is more anabolic than tension loading, and PTH enhances the effect of loading, particularly under compression.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Carolyn Chlebek, Jacob A. Moore, F. Patrick Ross, Marjolein C. H. van der Meulen
Summary: Osteoporosis affects over 200 million women worldwide, with one-third of them predicted to experience osteoporotic fractures in their lifetime. A study using a mouse model found that mechanical loading can stimulate bone formation, potentially identifying new pathways for oral treatment.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Cell Biology
Sheela R. Damle, Agata K. Krzyzanowska, Maximilian K. Korsun, Kyle W. Morse, Susannah Gilbert, Han Jo Kim, Oheneba Boachie-Adjei, Bernard A. Rawlins, Marjolein C. H. van der Meulen, Matthew B. Greenblatt, Chisa Hidaka, Matthew E. Cunningham
Summary: This study investigated the possibility of inducing bone formation and angiogenesis in the intervertebral discs (IVDs) by manipulating the IVD environment. The results showed that gene delivery and proteoglycanase treatment can promote bone and vascular growth in the IVD. However, proteoglycanase treatment impaired bone formation and reduced histological staining in the IVD.
Article
Endocrinology & Metabolism
Kathleen Turajane, Gang Ji, Yurii Chinenov, Max Chao, Ugur Ayturk, Vincentius J. Suhardi, Matthew B. Greenblatt, Lionel B. Ivashkiv, Mathias Pg Bostrom, Xu Yang
Summary: Transcriptomic analysis identified downregulated pathways in osseointegration of aged mice compared to young mice, involving angiogenic, Notch, and Wnt signaling. Enhanced expression of inflammatory and immune genes at the bone-implant interface in aged mice may compromise bone healing, suggesting the potential for interventions targeting these pathways.
Article
Infectious Diseases
Aleksey Dvorzhinskiy, Giorgio Perino, Robert Chojnowski, Marjolein C. H. van der Meulen, Mathias P. G. Bostrom, Xu Yang
Summary: The study found that ceramic void filler with gentamicin (CERAMENT G) reduced the rate of persistent infection and promoted new bone growth as compared to the void filler without antibiotics (CERAMENT) and an empty defect in a rat model of debrided osteomyelitis.
JOURNAL OF BONE AND JOINT INFECTION
(2021)