Editorial Material
Hematology
Jorg P. Halter
Summary: The study by Cutler et al. shows promising results in treating patients with inadequately controlled chronic graft-versus-host disease (cGVHD) using the ROCK2 inhibitor belumosudil.
Article
Dermatology
Hanjae Lee, Kyu Han Kim
Summary: Pediatric periorificial dermatitis is a papulopustular eruption around the facial orifices in children, and treatment with topical calcineurin inhibitors and metronidazole can be effective. Studies have shown that most Korean patients have a good response to this treatment approach.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Margret J. Einarsdottir, Maria Bankvall, Jairo Robledo-Sierra, Per-Olof Rodstrom, Ragnhildur Bergthorsdottir, Penelope Trimpou, Bengt Hasseus, Oskar Ragnarsson
Summary: The study aimed to investigate the prevalence of glucocorticoid-induced adrenal insufficiency in patients with oral lichen planus treated with topical clobetasol propionate. The results showed that approximately 20% of patients receiving intermittent topical glucocorticoid treatment for oral lichen planus had glucocorticoid-induced adrenal insufficiency.
Article
Dermatology
S. Utz, V. G. A. Suter, S. Cazzaniga, L. Borradori, L. Feldmeyer
Summary: Topical tacrolimus is an effective therapy for oral lichen planus, especially for patients who are unresponsive to potent topical corticosteroids. Adjusting the treatment frequency based on signs of clinical activity and subjective impairment is important, with regular follow-up essential for early detection of potential squamous cell carcinoma.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Monica Pentenero, Samuele Sutera, Giovanni Lodi, Jose Bagan, Camile S. Farah
Summary: This report investigates the attitudes and practices of Oral Medicine Practitioners (OMPs) in the diagnosis, risk stratification, and treatment of oral leukoplakia (OL). Lack of consensus in the management of OL was observed, indicating a need for treatment guidelines to reduce variability among practitioners.
Review
Dentistry, Oral Surgery & Medicine
Jasper Vonk, Jaron Gerard de Wit, Floris Jan Voskuil, Max Johannes Hendrikus Witjes
Summary: Early diagnosis and aggressive surgical excision are crucial for optimal treatment outcomes in oral squamous cell carcinomas. However, current diagnostic tools and intraoperative assessment methods are limited, leading to late-stage detection of oral cancer.
Article
Oncology
Tejus Satish, Shaheer Khan, Matt Levin, Richard Carvajal, Angela J. Yoon
Summary: In this case, a patient with oral mucosal melanoma recurred despite multiple resections and adjuvant temozolomide, but achieved complete histopathologic remission with the combination of topical imiquimod and pembrolizumab, demonstrating the potential efficacy of this combined treatment for oral melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Nanoscience & Nanotechnology
Hongyu Liu, Yisheng Huang, Mingshu Huang, Zhijie Huang, Qin Wang, Ling Qing, Li Li, Shuaimei Xu, Bo Jia
Summary: Oral cancer is a common and low survival rate cancer. Exosomes have great potential as biomarkers, drug delivery vehicles, and therapeutic targets for the early diagnosis and treatment of oral cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Clinical Neurology
Raymond Price, Don Smith, Gary Franklin, Gary Gronseth, Michael Pignone, William S. David, Carmel Armon, Bruce A. Perkins, Vera Bril, Alexander Rae-Grant, John Halperin, Nicole Licking, Mary Dolan O'Brien, Scott R. Wessels, Leslie C. MacGregor, Kenneth Fink, Lawrence B. Harkless, Lindsay Colbert, Brian C. Callaghan
Summary: The updated guideline on the treatment of painful diabetic neuropathy focused on topical and oral medications and medical class effects. Clinicians should assess diabetes patients for PDN and consider concurrent mood and sleep disorders. They should offer medication from different effective classes when patients do not respond well to initial treatment.
Review
Gastroenterology & Hepatology
Brigida Barberio, Jonathan P. Segal, M. Nabil Quraishi, Christopher J. Black, Edoardo Savarino, Alexander C. Ford
Summary: Topical mesalazine and combined oral and topical mesalazine are the most effective in inducing remission for ulcerative colitis. High-dose oral mesalazine has more evidence for inducing remission and is significantly more effective than lower doses.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Hematology
Hildegard T. Greinix
Summary: This study utilized metabolomics to measure metabolites in different samples and found that plasma α-ketoglutaric acid was consistently elevated before and at the onset of chronic graft-versus-host disease (cGVHD) in pediatric and adolescent patients.
Review
Infectious Diseases
Matthew Dallo, Kavina Patel, Adelaide A. Hebert
Summary: Topical antibiotics are effective in managing various indications in dermatology, such as acne vulgaris, wound infections, secondarily infected dermatitis, and impetigo. Dermatologists need to be familiar with the different types of topical antibiotics, their indications, mechanisms of action, adverse events, and spectra of activity. Antibiotic resistance should also be taken into consideration when prescribing these medications.
Review
Chemistry, Medicinal
Marion Voute, Veronique Morel, Gisele Pickering
Summary: Topical lidocaine is a safe and effective option for pain management, with proven efficacy in various pain conditions. It can be used alone or in conjunction with systemic drugs and non-pharmacological approaches for optimized pain management and multimodal analgesia.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Magdalena Lukaszewska-Kuska, Zuzanna Slebioda, Barbara Dorocka-Bobkowska
Summary: This systematic review compared the efficacy of dexamethasone with other treatments in oral lichen planus (OLP) and found that dexamethasone was more advantageous in some cases compared to photodynamic therapy and low-level laser therapy. However, due to limited study numbers, there is insufficient evidence to support the selection of treatment for OLP.
Article
Engineering, Biomedical
Mayuka Nakajima, Eden E. L. Tanner, Nao Nakajima, Kelly N. Ibsen, Samir Mitragotri
Summary: IDEA is a deep eutectic antimicrobial ion gel that exhibits deep tissue penetration and antimicrobial activity against P. gingivalis, showing promising topical treatment against periodontitis.
