Review
Medicine, Research & Experimental
Carlos Henrique Alves, Karolayne Larissa Russi, Natalia Conceicao Rocha, Fabio Bastos, Michelle Darrieux, Thais Manzano Parisotto, Raquel Girardello
Summary: In recent decades, there have been significant advances in ortho-aesthetic-functional rehabilitation with the introduction of implantology. However, there is still a percentage of failures in implantology surgeries, mainly due to infections caused by bacterial proliferation, fungi presence, and biofilm formation, leading to peri-implantitis. Various studies have been conducted to explore the interaction between the host-oral microbiome and the development of peri-implantitis. Peri-implantitis is associated with a diversity of bacterial species, with Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia being identified in higher proportions of peri-implantitis samples. In addition, the injury of peri-implant tissue triggers an inflammatory response mediated by the activation of innate immune cells, such as macrophages, dendritic cells, mast cells, and neutrophils. Activation of the host immune system may disrupt the balance of oral microbiota, leading to dysbiosis and the production of various substances that contribute to implant loss.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ettore Amerio, Gonzalo Blasi, Cristina Valles, Vanessa Blanc, Gerard Alvarez, Alexandre Arredondo, Jose Nart, Alberto Monje
Summary: This study aimed to investigate the impact of smoking on peri-implant bleeding, bone loss, and microbiota. The results showed an inverse correlation between smoking and bleeding, and a positive correlation with gingival inflammation, probing pocket depth, and gender. Moreover, smoking led to changes in the peri-implant microbiota.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2022)
Review
Immunology
Jagjit Singh Dhaliwal, Nurul Adhwa Abd Rahman, Long Chiau Ming, Sachinjeet Kaur Sodhi Dhaliwal, Joe Knights, Rubens Ferreira Albuquerque Junior
Summary: This systematic review focuses on decontamination methods of microbial biofilm on titanium implant surfaces used in dentistry. The review summarized 17 different groups of decontamination methods from 116 studies, with most methods proven effective in preventing biofilm formation and decontaminating established biofilm on dental implants.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Microbiology
Virginie Gazil, Octave Nadile Bandiaky, Emmanuelle Renard, Katia Idiri, Xavier Struillou, Assem Soueidan
Summary: The success rates of dental implants at 5 and 10 years are nearly 90%. The prevalence of peri-implant diseases, such as peri-implantitis and peri-implant mucositis, is significant. Recent studies using new generation sequencing methods have compared the microbiota of healthy and diseased periodontal and peri-implant sites, revealing distinct differences in diversity and composition. Understanding the characteristics of the peri-implant microbiota can optimize therapeutic strategies for peri-implant diseases.
Article
Biotechnology & Applied Microbiology
Caroline Dini, Raphael Cavalcante Costa, Martinna Bertolini, Jamil Awad Shibli, Magda Feres, Marlise Inez Klein, Erica Dorigatti de Avila, Joao Gabriel Silva Souza, Valentim Adelino Ricardo Barao
Summary: This study successfully developed a clinically relevant oral polymicrobial biofilm model that mimics the microbial composition of implant-related infections. The results showed that the biofilm developed from patients' biofilm inoculum had a microbial composition more similar to the clinical subgingival biofilm of patients with peri-implantitis.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
J. Martinez-Amargant, B. de Tapia, A. Pascual, J. Takamoli, C. Esquinas, J. Nart, C. Valles
Summary: This study aimed to determine the association between tobacco and peri-implant diseases and investigate patient- and implant-related variables associated with peri-implant diseases. Data from 117 patients treated with implant-supported restorations were analyzed, and the study found that smoke intensity was associated with an increased risk of peri-implant diseases.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lorenzo Marini, Cristiano Tomasi, Rodolfo Gianserra, Filippo Graziani, Luca Landi, Mauro Merli, Luigi Nibali, Mario Roccuzzo, Nicola M. Sforza, Maurizio S. Tonetti, Federico Deli, Piero Papi, Bianca Di Murro, Mariana A. Rojas, Andrea Pilloni
Summary: The purpose of this study was to evaluate the reliability and accuracy of assigning case definitions to dental implants according to the 2018 classification. The study found that the reliability and accuracy of the case definitions were mostly moderate.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Karin Apaza-Bedoya, Maria Elisa Galarraga-Vinueza, Bruna Barbosa Correa, Frank Schwarz, Marco Aurelio Bianchini, Cesar Augusto Magalhaes Benfatti
Summary: This study assessed the prevalence and risk indicators of peri-implant diseases, and associated specific clinical characteristics with these diseases. In the medium term, peri-implant diseases were correlated with factors inherent to the patient's conditions, presurgical treatment plan, and hygiene maintenance care.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yitian Shi, Zian Tong, Yu Zhang, Misi Si, Fuming He
Summary: The microbiome distribution in peri-implant mucositis and peri-implantitis sites was found to be similar, with significant differences at the genus and phylum levels. Microbial dysbiosis was significantly associated with an increase in marginal bone loss.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Andrea Roccuzzo, Jean-Claude Imber, Giovanni Edoardo Salvi, Mario Roccuzzo
Summary: Peri-implantitis is a common disease characterized by inflammation in the tissues around dental implants, leading to bone loss. Nonideal conditions in implant therapy, such as poor planning and insufficient periodontal therapy, may contribute to its progression. There is a good level of evidence for certain factors, while more research is needed to identify others and their long-term impact on peri-implantitis.
PERIODONTOLOGY 2000
(2023)
Article
Dentistry, Oral Surgery & Medicine
Himabindu Dukka, Muhammad H. A. Saleh, Andrea Ravida, Henry Greenwell, Hom-Lay Wang
Summary: Bleeding on probing (BOP) is an indispensable diagnostic tool for evaluating periodontal disease, but its role in peri-implant disease is more complex. The confusion in interpretation is due to differences in how BOP originates and is used in implants. A comprehensive bleeding index and other parameters should be used together for diagnosing peri-implant diseases accurately.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Anmar Kensara, Hanae Saito, Emmanuel F. Mongodin, Radi Masri
Summary: This study characterized the microbiome composition in the peri-implant pocket of peri-implantitis and peri-implant control sulcus using 16S rRNA gene sequencing. The results showed that the peri-implant control sulcus harbored predominantly Gram-positive bacteria, while the peri-implant pockets of implants with peri-implantitis predominantly harbored Gram-negative bacteria.
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
S. Barootchi, L. Tavelli, J. Majzoub, H. L. Chan, H. L. Wang, O. D. Kripfgans
Summary: The study demonstrates that ultrasound color flow can serve as a valuable tool in evaluating the degree of clinical inflammation at implant sites and is directly correlated with clinical diagnoses.
JOURNAL OF DENTAL RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Teresa Chanting Sun, Chun-Jung Chen, German O. Gallucci
Summary: The review article aims to summarize the current evidence on the potential risk factors and preventive strategies for peri-implant diseases. The associated risk factors can be categorized into patient-specific factors, implant-specific factors, and long-term factors. Early intervention and a comprehensive maintenance program for assessing potential risk factors are the best strategies for preventing peri-implant diseases.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Review
Infectious Diseases
Betul Rahman, Anirudh Balakrishna Acharya, Ruqaiyyah Siddiqui, Elise Verron, Zahi Badran
Summary: Peri-implant diseases are inflammatory infections caused by oral bacteria. Mechanical debridement is the standard management approach, and photodynamic therapy is gaining attention as an adjunctive treatment.
Article
Dentistry, Oral Surgery & Medicine
V. Moraschini, I. C. C. Kischinhevsky, S. C. Sartoretto, J. A. Shibli, A. T. Dias, R. Sacco, J. Yates, M. D. Calasans-Maia
Summary: This network meta-analysis compared the clinical effects of different biomaterials for peri-implant soft tissue phenotype modification. The results showed that autologous tissue grafts had the best effects in increasing the width and thickness of keratinized mucosa.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Caroline Dini, Marta Maria Alves Pereira, Joao Gabriel Silva Souza, Jamil A. Shibli, Erica Dorigatti Avila, Valentim Adelino R. Barao
Summary: Industry support does not appear to have a significant association with positive outcomes in implant dentistry RCTs. However, industry trends do show a correlation with geographic origins, number of institutions, and specific research topics.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2022)
Article
Cell & Tissue Engineering
Camila Pinheiro Furquim, Rose Yakushijin Kumagai, Willy Bustillos-Torrez, Jonathan Meza-Mauricio, Caio Junji Tanaka, Veronica Santana, Belen Retamal-Valdes, Jamil Awad Shibli
Summary: This review presents the state of the art in whole tooth regeneration based on in vivo studies, demonstrating the feasibility of regenerating a complete tooth in animals.
TISSUE ENGINEERING PART C-METHODS
(2022)
Article
Cell & Tissue Engineering
Jamil Awad Shibli, Bruna Egumi Nagay, Lina J. Suarez, Celeste Urdaniga Hung, Martinna Bertolini, Valentim A. R. Barao, Joao Gabriel S. Souza
Summary: The review summarizes the latest studies and clinical trials related to bone tissue regeneration using osteogenic cells, biomaterials, and scaffolds. It highlights the importance of scaffolds in transporting cells and supporting the mineralization process, as well as the evaluation of their properties on bone regeneration. The review also emphasizes the key factors and mechanisms involved in bone homeostasis and the differentiation of osteoblast lineage.
TISSUE ENGINEERING PART C-METHODS
(2022)
Article
Chemistry, Physical
Leonardo P. Faverani, William P. P. Silva, Cecilia Alves de Sousa, Gileade Freitas, Ana Paula F. Bassi, Jamil A. Shibli, Valentim A. R. Barao, Adalberto L. Rosa, Cortino Sukotjo, Wirley G. Assuncao
Summary: Chemical and topographical surface modifications on dental implants can enhance bone integration. This study investigated the cellular response of undifferentiated mesenchymal stem cells on different surfaces. Results showed better cell growth and viability on the bioactive coating surface and sandblasting followed by acid-etching surface. Gene expression and mineralized matrix formation were also improved on the bioactive coating surface. Therefore, these findings are important for future clinical investigations.
Article
Immunology
Debora Pallos, Vanessa Sousa, Magda Feres, Belen Retamal-Valdes, Tsute Chen, Mike Curtis, Richardson Mondego Boaventura, Marcia Hiromi Tanaka, Gustavo Vargas da Silva Salomao, Louise Zanella, Tania Regina Tozetto-Mendoza, Gabriela Schwab, Lucas Augusto Moyses Franco, Ester Cerdeira Sabino, Paulo Henrique Braz-Silva, Jamil Awad Shibli
Summary: Differences in salivary microbiome composition were observed between patients with healthy peri-implant sites and those with peri-implantitis. Bleeding on probing may affect the diversity of the salivary microbiome.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Microbiology
Luciene Cristina Figueiredo, Nathalia Freitas Figueiredo, Daniele Ferreira da Cruz, Gustavo Titonele Baccelli, Gabriela Espinoza Sarachini, Manuela Rocha Bueno, Magda Feres, Bruno Bueno-Silva
Summary: The oral cavity contains various microorganisms that can cause diseases like periodontitis. Traditional periodontal treatment focuses on mechanical control of biofilm, but chemical control can also be useful. Natural products such as propolis, aloe vera, green tea, cranberry, calendula, myrrha, and salvia have shown potential as oral hygiene products due to their antimicrobial and anti-inflammatory properties.
Editorial Material
Microbiology
Martinna Bertolini, Raphael Cavalcante Costa, Valentim Adelino Ricardo Barao, Cristina Cunha Villar, Belen Retamal-Valdes, Magda Feres, Joao Gabriel Silva Souza
Article
Medicine, General & Internal
Marcio de Carvalho Formiga, Helio Doyle Pereira da Silva, Bruna Ghiraldini, Rafael Shinoske Siroma, Lavinia Cosmina Ardelean, Adriano Piattelli, Jamil Awad Shibli
Summary: Primary stability is crucial for the success of dental implants. Osseodensification (OD) is a new bone site preparation method that increases bone-to-implant contact and primary stability. This study compared the effects of OD on cylindrical and conical implants with conventional instrumentation. The results showed that OD improved implant stability quotient (ISQ), insertion torque (IT), and removal torque (RT) for both types of implants.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Caio Junji Tanaka, Jose Augusto Rodrigues, Joao Marcos Spessoto Pingueiro, Tatiane Tiemi Macedo, Magda Feres, Jamil Awad Shibli, Bruno Bueno-Silva
Summary: Bioactive materials with fluoride release and antimicrobial potential are widely used in dentistry. However, the antimicrobial activity of bioactive surface pre-reacted glass (S-PRG) coatings on periodontopathogenic biofilms has been insufficiently studied. This study investigated the antibacterial activity of S-PRG fillers on a multi-species subgingival biofilm. The results showed that the bioactive coating containing S-PRG modified the composition of the subgingival biofilm in vitro and reduced the bacterial activity by 25.7%.
Article
Infectious Diseases
Stella de Noronha Campos Mendes, Camila Machado Esteves, Juliana Alethusa Velloso Mendes, Magda Feres, Nathalia Figueiredo, Tamires Szeremeske de Miranda, Jamil Awad Shibli, Luciene Cristina Figueiredo
Summary: The study evaluated the effects of scaling and root planing combined with antimicrobial chemical control on different oral cavity sites. The use of antibiotics and chlorhexidine mouth rinse significantly reduced the proportion of red complex species. In conclusion, antimicrobial chemical control showed a beneficial effect on the composition of oral microbiota.
Review
Engineering, Biomedical
Suelen Cristina Sartoretto, Jamil Awad Shibli, Kayvon Javid, Khalila Cotrim, Antonio Canabarro, Rafael Seabra Louro, Adam Lowenstein, Carlos Fernando Mourao, Vittorio Moraschini
Summary: Implant therapy is a commonly used method for rehabilitating edentulous patients, and its indications are increasing due to its clinical success and convenience. This literature review compares the long-term survival rates and treatment outcomes of endodontically or periodontally treated teeth with dental implants. The evidence suggests that the decision between keeping a tooth or replacing it with an implant should consider the condition of the tooth, systemic disorders, and patient preference. However, failures and complications are common, so efforts should be made to save maintainable teeth before resorting to dental implants.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Magda Feres, Rodrigo Martins, Joao Gabriel S. Souza, Martinna Bertolini, Valentim A. R. Barao, Jamil A. Shibli
Summary: This review aimed to evaluate the efficacy of antibiotics in treating peri-implantitis. The results showed that the use of systemic metronidazole combined with ultrasonic debridement can effectively improve the outcomes of nonsurgical treatment. However, further research is needed to assess the clinical and microbiological effects of different antibiotic protocols.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Vittorio Moraschini, Richard J. Miron, Carlos Fernando de Almeida Barros Mourao, Rafael Seabra Louro, Anton Sculean, Luiz Afonso Morgenstern da Fonseca, Monica Diuana Calasans Maia, Jamil Awad Shibli
Summary: This systematic review evaluated the antimicrobial potential of different types of platelet-rich fibrin (PRF) used in regenerative treatments. The findings showed that all types of PRF had significant antimicrobial action, with greater efficacy against bacteria compared to fungi. Future studies analyzing the clinical effect of PRF are important.
PERIODONTOLOGY 2000
(2023)