Article
Biochemistry & Molecular Biology
Claudia Siverino, Shorouk Fahmy-Garcia, Didem Mumcuoglu, Heike Oberwinkler, Markus Muehlemann, Thomas Mueller, Eric Farrell, Gerjo J. V. M. van Osch, Joachim Nickel
Summary: This study proposes an alternative strategy for the treatment of large bone defects by covalently immobilizing an engineered BMP2 variant to biocompatible scaffolds. The results demonstrate the translational potential of this innovative technique in inducing bone tissue formation, improving safety for patients, and reducing costs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Ji Won Baek, Ki Su Kim, Ho Park, Nak Gyu Park, Beom-Su Kim
Summary: In this study, we improved the osteoinductive activity of marine-plankton-derived whitlockite (MP-WH) granules by incorporating bone morphogenetic protein2 (BMP2). The results showed that hMSCs seeded on MP-WH/BMP2 granules exhibited better biocompatibility, proliferation, and adhesion compared to MP-WH. Furthermore, the incorporation of BMP2 significantly upregulated the expression of bone-specific markers, indicating enhanced osteogenic effects.
BIOENGINEERING-BASEL
(2022)
Article
Engineering, Biomedical
Claudia Siverino, Shorouk Fahmy-Garcia, Viktoria Niklaus, Nicole Kops, Laura Dolcini, Massimiliano Maraglino Misciagna, Yanto Ridwan, Eric Farrell, Gerjo J. V. M. van Osch, Joachim Nickel
Summary: Bone Morphogenetic proteins (BMPs) like BMP2 and BMP7 have shown great potential in the treatment of severe bone defects. However, BMP9, although having the highest osteogenic potential in vitro, does not show superior bone forming capacity compared to BMP2 or BMP7 in vivo.
BIOACTIVE MATERIALS
(2023)
Review
Engineering, Biomedical
Marc Bohner, Yassine Maazouz, Maria-Pau Ginebra, Pamela Habibovic, Jonathan G. Schoenecker, Howard Seeherman, Jeroen J. J. P. van den Beucken, Frank Witte
Summary: This study aims to evaluate the hypothesis that sustained local ionic homeostatic imbalance (SLIHI) created by mineral formation during tissue calcification modulates inflammation to trigger heterotopic ossification (HO), and to provide insights for the design of cell-free, drug-free osteoinductive bone graft substitutes.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Wytrwal, Malgorzata Sekula-Stryjewska, Agata Pomorska, Ewa Oclon, Ewa Zuba-Surma, Szczepan Zapotoczny, Krzysztof Szczubialka
Summary: This study investigated the covalent binding of recombinant human bone morphogenetic protein-2 and -7 in stem cells and its effects on cell adhesion, migration, and osteogenesis. The presence of both proteins enhanced cell adhesion but limited cell motility, while the presence of single proteins promoted cell migration activity. Additionally, the coexistence of the proteins significantly increased early osteogenic marker expression.
Article
Nanoscience & Nanotechnology
Yanbo Jiang, Ming Gong, Donghui Chen, Jiaojie Li, Hailun Zhou, Yongfeng Lin, Li Tang
Summary: This study investigated the biomechanical behaviors of maxillary sinus elevation with bone grafts of various heights and widths using finite element analysis. Results show that a bone graft height of 6 mm is the most appropriate for all types of maxillary sinus elevation.
Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Review
Biotechnology & Applied Microbiology
Sung-Woon On, Sang-Yoon Park, Sang-Min Yi, In-Young Park, Soo-Hwan Byun, Byoung-Eun Yang
Summary: This review presents the current status of recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillofacial surgery, including its clinical application, efficacy, safety, and limitations. Studies have shown that rhBMP-2 has potential in reducing donor site complications and increasing bone height, but it may not be as effective as autogenous bone grafts. In the treatment of medication-related osteonecrosis of the jaw, rhBMP-2 has promising results but requires further investigation for long-term safety. In maxillofacial trauma, it is limited to large defect restoration. Safety concerns include postoperative edema and the theoretical risk of carcinogenesis. Limitations include the lack of an ideal carrier, high cost, and optimal dosing regimen.
BIOENGINEERING-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Hyun Seok, Hee-Youl Kim, Dong-Cheol Kang, Jung-Ho Park, Jong Hoon Park
Summary: The study compared the bone regeneration ability of bone scaffolds using particle and block bones with rhBMP-2, showing that rhBMP-2 with block bones resulted in significantly higher bone volume but also led to the formation of adipose tissue and void spaces.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Simina Angela Lacrimioara Iusan, Carmen Costache, Ondine Patricia Lucaciu, Bianca-Nausica Petrescu, Ioana Codruta Mirica, Dan-Alexandru Toc, Silviu Albu
Summary: This review article aims to synthesize existing information in the specialized literature regarding the correlations between peri-implant diseases and maxillary sinusitis. The included studies reported a positive correlation between maxillary sinusitis and peri-implant infectious diseases, as well as other pathologies such as abscesses and foreign body reactions. Therefore, preventing infectious peri-implant diseases is crucial to avoid these complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ronald E. Jung, Marionna N. Kovacs, Daniel S. Thoma, Christoph H. F. Hammerle
Summary: The long-term outcomes of implants placed in conjunction with guided bone regeneration (GBR) with or without recombinant human bone morphogenetic protein-2 (rhBMP-2) were assessed. The study showed that after at least 17 years, the implant survival rate was 100% and the clinical and radiographic results were excellent.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Engineering, Biomedical
Jonathan Dorogin, Henry B. B. Hochstatter, Samantha O. O. Shepherd, Justin E. E. Svendsen, Morrhyssey A. A. Benz, Andrew C. C. Powers, Karly M. M. Fear, Jakob M. M. Townsend, James S. S. Prell, Parisa Hosseinzadeh, Marian H. H. Hettiaratchi
Summary: By using yeast surface display, unique BMP-2-specific affibodies were identified to modulate the release and activity of BMP-2, offering a promising approach for controlling BMP-2 delivery in clinical applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Won-Bae Park, Gazelle Jean Crasto, Philip Kang
Summary: This case report introduces a novel approach for successful lateral maxillary sinus augmentation in the unrepairable perforation area of the Schneiderian membrane. By performing bone grafting on the sinus floor and utilizing the open lateral window technique, the risk of bone graft particles blocking the sinus ostium was minimized.
APPLIED SCIENCES-BASEL
(2022)
Article
Engineering, Biomedical
Sihan Lin, Shi Yin, Junfeng Shi, Guangzheng Yang, Xutao Wen, Wenjie Zhang, Mingliang Zhou, Xinquan Jiang
Summary: In this study, the dose of bone morphogenetic protein-2 (BMP-2) was reduced and its safety and efficacy were improved through the regulation of magnesium ion (Mg2+). Magnesium ion enhanced cellular bioenergetic levels and the osteoinductivity of BMP-2. A co-delivery system, fabricated using microfluidic and 3D printing technologies, was able to rapidly and robustly induce bone regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Clinical Neurology
Mohammed A. Munim, Elyse Berlinberg, Vincent P. Federico, Michael T. Nolte, Michael Prabhu, Hanna Pawlowski, Karan S. Patel, Matthew W. Colman
Summary: This study used retrospective cohort analysis to investigate the utilization of rhBMP-2 in spinal tumor surgery and its association with postoperative complications, revisions, and carcinogenicity. The results showed that patients who underwent fusion with rhBMP-2 had significantly increased rates of surgical site and systemic infections. However, there were no significant differences in survival, implant removal, revision rates, or new cancer diagnoses.
GLOBAL SPINE JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Kyeong-Won Paeng, Jae-Kook Cha, Daniel S. Thoma, Ronald E. Jung, Ui-Won Jung, Goran Benic
Summary: The aim of this study was to investigate the additional effects of collagen membrane and synthetic bone substitute on lateral bone augmentation of chronic peri-implant defect. The results suggest that the use of collagen membrane and/or synthetic bone substitute did not provide additional benefits for lateral bone augmentation.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Hye-Min Chung, Jin-Young Park, Kyung-A Ko, Chang-Sung Kim, Seong-Ho Choi, Jung-Seok Lee
Summary: The aim of this study was to compare the supra-alveolar gingival dimension (GD) and the clinical pocket probing depth (PD) using data from an intraoral scanner (IOS) and cone-beam computed tomography (CBCT) and identify the clinical features affecting PD. The results showed a positive correlation between GD and PD, and this correlation was stronger for untreated sites, sites with bleeding on probing (BOP), and sites with a larger PD.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sung-Bae Lee, Bo-Ah Lee, Seong-Ho Choi, Young-Taek Kim
Summary: This study aimed to determine the long-term outcomes after peri-implantitis treatment and the factors affecting these outcomes. The study found that full compliance to recall visits, not smoking, placement of fewer implants, and less bone loss at baseline significantly influenced the treatment outcome.
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Young Woo Song, Stefan P. Bienz, Goran Benic, Jae-Kook Cha, Christoph H. F. Haemmerle, Ui-Won Jung, Ronald E. Jung
Summary: This study aimed to compare the peri-implant soft-tissue dimensional changes between particulate and collagenated soft-block-type biphasic calcium phosphate (BCP) during guided bone regeneration. The results showed that the block group had significantly higher contour changes than the particle group during the first 6 months, but the changes were similar between the two groups after 1 year. Regardless of the type of BCP, the ridge contour significantly increased over 1 year when there was a contained defect.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hyunkyu Lee, Hye Su Min, Mingyu Jang, Geonwoo Kang, Seongdae Gong, Chisong Lee, Young Woo Song, Ui-Won Jung, Somin Lee, Hyeon Yeol Ryu, Huisuk Yang, Hyungil Jung
Summary: Lidocaine is commonly used as a local anesthetic to reduce pain. Dissolving microneedles can effectively deliver lidocaine by overcoming the oral mucosal barrier, providing local anesthesia with lower doses and without mucosal irritation.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xiang Jin, Jin-Young Park, Jung-Seok Lee, Ui-Won Jung, Seong-Ho Choi, Jae-Kook Cha
Summary: This study aimed to assess the histomorphometric characteristics of non-crosslinked and crosslinked collagen membranes. The results showed that non-crosslinked membranes were more rapidly biodegraded but fully integrated with the surrounding tissues to form dense periosteum-like connective tissue. The barrier effect of the pseudoperiosteum needs further investigation.
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jeong-Woong Kim, Bo-Ah Lee, Yu-Seon Park, Jinho Chung, Seong-Ho Choi, Young-Taek Kim
Summary: The purpose of this study was to determine the efficacy of active noise-canceling (ANC) headphones in reducing the pain and discomfort associated with dental scaling. The study found that the use of ANC headphones can reduce the discomfort caused by noise and pain.
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jae-Hong Lee, Hyun-wook An, Jae-Seung Im, Woo-Joo Kim, Dong-Won Lee, Jeong-Ho Yun
Summary: This study compared the clinical and radiographic benefits of a newly developed BCP with DBBM for reconstructing peri-implant bone defects. The results showed that the newly developed BCP had similar outcomes to DBBM in terms of clinical, radiographic, postoperative discomfort, and early wound healing.
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
(2023)
Article
Medicine, General & Internal
Kyung-A Ko, Jin-Young Park, Jung-Seok Lee, Byoung Seok Ye, Ui-Won Jung, Seong-Ho Choi, Jae-Kook Cha
Summary: This study investigated the association between changes in masticatory function and cognitive impairment. The results suggest a potential causative relationship between neglected missing teeth and the onset of dementia.
YONSEI MEDICAL JOURNAL
(2022)
Article
Engineering, Biomedical
Young-Wook Seo, Jin-Young Park, Da-Na Lee, Xiang Jin, Jae-Kook Cha, Jeong-Won Paik, Seong-Ho Choi
Summary: This study compared three-dimensionally printed biphasic calcium phosphate (BCP) block bone substitutes with different pore diameters for the regeneration of rabbit calvarial defects. The results showed that the BCP blocks remained unresorbed and new bone formation occurred within the porous structures of the blocks. After 2 weeks, histomorphometric analysis indicated that new bone formation was significantly greater in the BCP groups compared with the control group. However, there were no significant differences between the groups with different pore diameters. At 8 weeks, only the 1.0-mm group presented a significantly larger area of new bone compared with the control group. Among the BCP groups, the 1.0-mm and 1.2-mm groups exhibited significantly larger areas of new bone compared with the 0.8-mm group.
BIOMATERIALS RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hyun-Chang Lim, Kyeong-Won Paeng, Myong Ji Kim, Ronald E. Jung, Christoph H. F. Hammerle, Ui-Won Jung, Daniel S. Thoma
Summary: This study assessed the effects of hard and/or soft tissue grafting on immediate implants. The results showed that subepithelial connective tissue grafting had positive effects on periimplant mucosa height and thickness, while simultaneous soft and hard tissue augmentation might not lead to satisfactory tissue contour.
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
(2022)
Article
Psychology, Clinical
Shawna J. Lee, Kaitlin P. Ward, Joyce Y. Lee, Christina M. Rodriguez
Summary: The study found that parents' perceived social isolation and recent employment loss were associated with the risk of child maltreatment (including neglect, verbal aggression, and physical punishment), even after controlling for parental depressive symptoms, income, and sociodemographic factors. The results highlight the need for mental health support for parents and children to alleviate the strain caused by COVID-19.
JOURNAL OF FAMILY VIOLENCE
(2022)
