期刊
CLINICAL NUTRITION
卷 37, 期 5, 页码 1485-1491出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2017.08.029
关键词
Depression; Anxiety; Diet; Inflammation; Dietary inflammatory index
资金
- Irish Health Research Board [HRC/2007/13]
- United States National Institute of Diabetes and Digestive and Kidney Diseases [R44DK103377]
Background & aims: The relationship between diet, inflammation and mental health is of increasing interest. However, limited data regarding the role of dietary inflammatory potential in this context exist. Therefore the aim of this work was to examine associations between the inflammatory potential of habitual diet and mental health outcomes in a cross-sectional sample of 2047 adults (50.8% female). Methods: Diet was assessed using a self-completed food frequency questionnaire from which dietary inflammatory index (DII (R)) scores were determined. Depressive symptoms, anxiety and well-being were assessed using the CES-D, HADS-A and WHO-5 screening tools. Results: Logistic regression analyses revealed that higher energy-adjusted DII (E-DII (R)) scores, reflecting a more pro-inflammatory diet, were associated with increased risk of depressive symptoms (odds ratios (OR) 1.70, 95% confidence intervals (CI) 1.23-2.35, p = 0.001) and anxiety (OR 1.60, 95% CI 1.15-2.24, p = 0.006) and lower likelihood of well-being (OR 0.62, 95% Cl 0.46-0.83, p = 0.001), comparing highest to lowest tertile of E-DII. In gender-stratified analyses associations were noted in women only. Women with the highest E-DII scores were at elevated risk of depressive symptoms (OR 2.29, 95% CI 1.49-3.51, p < 0.001) and anxiety (OR 2.00, 95% CI 1.30-3.06, p = 0.002), while likelihood of reporting good wellbeing was lower (OR 0.55, 95% CI 0.36-0.79, p = 0.002), relative to those with the lowest E-DII scores. Conclusions: These findings, which suggest that a pro-inflammatory diet is associated with adverse mental health, may be of clinical and public health significance regarding the development of novel nutritional psychiatry approaches to promote good mental health. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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