Article
Nutrition & Dietetics
Yuqian Li, Xiaotian Liu, Runqi Tu, Jian Hou, Guihua Zhuang
Summary: This study aims to evaluate the causal association between SOCS3 methylation and abdominal obesity. Through a case-control study on Chinese subjects, it was found that SOCS3 methylation levels were inversely associated with abdominal obesity, and the causal relationship was confirmed using Mendelian randomization.
Article
Biotechnology & Applied Microbiology
Woo-Jung Park, Sang-Hoon Han, Dong-Hwi Kim, Young-Jo Song, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, In-Soo Choi
Summary: The study found that TLR3 and RIG-I expression levels significantly increased after CIV infection, and blocking their signals with siRNA could lower IFN-beta expression and potentially suppress CIV replication by affecting MX1 production.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ara Jo, Jina Won, Chan Hee Gil, Su Keun Kim, Kang-Mu Lee, Sang Sun Yoon, Hyun Jik Kim
Summary: Our recent study reveals the mechanism in which human nasal commensal Staphylococcus epidermidis enhances antiviral immune response in the nasal mucosa. The bacterium promotes a balance of protease-protease inhibitor, preventing influenza virus replication in the nasal mucosa and lungs. This manipulation of cellular environment through Serpine1 induction by S. epidermidis disturbs the spread of the virus to the lungs.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Veterinary Sciences
Wen-Jie Wu, Xiao-Ping Lv, Xiao-Yan Wang, Xue-Li Gao, Chao -Nan Liu, Chen -Hui Zhao, Xian-Zhe Gu, Shi-Min Zheng
Summary: Birds infected by Reticuloendotheliosis virus (REV) are susceptible to other microorganisms due to immunosuppression caused by REV-induced damage to immune organs. The TLR-3/IFN-beta pathway is disturbed by REV, impacting the levels of NF-kappa B p65 and IRF-7 at both transcriptional and translational levels.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Medicine, Research & Experimental
Yi-wen Lv, Yang Du, Sheng-suo Ma, Yu-cong Shi, Hua-chong Xu, Li Deng, Xiao-yin Chen
Summary: This study aimed to evaluate the protective effects of Proanthocyanidins (PAs) against Influenza A virus (IAV)-induced acute lung injury (ALI) and its potential mechanisms. The results demonstrated that PAs attenuated ALI induced by IAV through the TGF-beta 1/Smad2/3 signaling pathway and significantly reduced inflammation and ferroptosis. Therefore, PAs may be a promising therapeutic candidate for ALI.
Article
Biochemistry & Molecular Biology
Gulsah Koc, Tansu Doran, Meliha Melin Uygur, Deniz Kirac
Summary: Gene polymorphisms of IL-6 (rs1800795 and rs1800796) are associated with obesity risk and may serve as indicators for obesity risk assessment. The SOCS3 (rs4969170) polymorphism is not significantly associated with obesity.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Multidisciplinary Sciences
Kaori Cho, Takashi Ushiki, Hajime Ishiguro, Suguru Tamura, Masaya Araki, Tatsuya Suwabe, Takayuki Katagiri, Mari Watanabe, Yoko Fujimoto, Riuko Ohashi, Yoichi Ajioka, Ippei Shimizu, Shujiro Okuda, Masayoshi Masuko, Yoshimi Nakagawa, Hideyo Hirai, Warren S. Alexander, Hitoshi Shimano, Hirohito Sone
Summary: SOCS3 protein plays a critical role in regulating obesity and diabetes, but the mechanism of action and the relationship with gut microbiota remain to be clarified.
Article
Immunology
Shih-Wei Wu, Chung-Kan Peng, Shu-Yu Wu, Yu Wang, Sung-Sen Yang, Shih-En Tang, Kun-Lun Huang
Summary: Obesity protects lungs from ventilator-induced lung injury (VILI) by upregulating SOCS3, suppressing the inflammatory pathway, and enhancing AFC related to WNK4. However, WNK4 activation mainly comes from NF kappa B downstreaming, rather than SOCS3 upregulation. JAK2-STAT3/NF kappa B signaling dominates the pathogenesis of VILI, and further investigation is needed to understand the interaction between SOCS3 and WNK4 in modulating VILI in obesity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Seungil Kim, Sohyeon Lee, Tae-Young Kim, Su-Hyun Lee, Sang-Uk Seo, Mi-Na Kweon
Summary: The MI29 strain activates host defense immunity through the gut-lung axis, enhancing resistance to influenza virus infection.
Article
Multidisciplinary Sciences
Tarani Kanta Barman, Victor C. Huber, Jesse L. Bonin, Danielle Califano, Sharon L. Salmon, Andrew N. J. McKenzie, Dennis W. Metzger
Summary: This study reveals the interplay between host interferon (IFN)-gamma and viral PB1-F2 virulence protein in regulating the functions of innate lymphoid cells (ILCs) and T cells during influenza virus infection. In the absence of IFN-gamma, lung ILC2s initiate a robust IL-5 response, leading to improved tissue integrity and increased survival. However, the presence of functional PB1-F2 suppresses ILC2 responses and induces a dominant IL-13 CD8 T cell response. This study also demonstrates the importance of IFN-gamma in host resistance against lethal doses of the influenza virus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Benjamin Hamid, Josephine Schlosser-Brandenburg, Lalita Bechtold, Friederike Ebner, Sebastian Rausch, Susanne Hartmann
Summary: This study examined the early immune response initiation after exposure to Toxoplasma gondii in pigs, revealing that porcine CD3-NKp46+ cells serve as important IL-12 producers following TLR ligation, while IL-18 likely plays a prominent role in early immune response initiation in pigs after T. gondii infection.
Article
Biochemistry & Molecular Biology
Joao A. B. Pedroso, Ivson B. da Silva, Thais T. Zampieri, Leonardo T. Totola, Thiago S. Moreira, Ana P. T. Taniguti, Gabriela P. Diniz, Maria Luiza M. Barreto-Chaves, Jose Donato
Summary: Increasing leptin sensitivity can have therapeutic effects against obesity, but it may also lead to cardiovascular and glucose metabolism issues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Yidi Guo, Xiaohang Yu, Ning Su, Ning Shi, Shu Zhang, Le Zhang, Li Yang, Lili Zhao, Zhenhong Guan, Maolin Zhang, Ming Duan
Summary: Influenza A virus (IAV) is a major pathogen causing annually recurring epidemics. This study found that circRNA_0082633 expression is increased during IAV infection and overexpression of circRNA_0082633 suppresses viral proliferation. Activation of the JAK-STAT signaling pathway is involved in the regulation of circRNA_0082633. This research provides new insights into the pathogenesis of IAV infection and suggests an important role for circRNA_0082633.
VETERINARY MICROBIOLOGY
(2022)
Article
Immunology
Bo Liu, LinLin Bao, Li Wang, Fengdi Li, Mingjie Wen, Hui Li, Wei Deng, Xulong Zhang, Bin Cao
Summary: The study showed that neutralization of IFN-gamma alleviated acute lung injury in BALB/c mice infected with severe influenza A (H1N1)pdm09 virus, reducing lung microvascular leak and cellular infiltrate, and improving survival rate.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Cell Biology
Taylor Schmit, Kai Guo, Jitendra Kumar Tripathi, Zhihan Wang, Brett McGregor, Mitch Klomp, Ganesh Ambigapathy, Ramkumar Mathur, Junguk Hur, Michael Pichichero, Jay Kolls, M. Nadeem Khan
Summary: This study identifies IFN-gamma-regulated CCR2(+) monocytes as the main driver of lung damage during IAV infection. IFN-gamma regulates the recruitment and inflammatory phenotype of CCR2(+) monocytes. CD8+ T cells are the main source of IFN-gamma in the infected lungs.
Article
Chemistry, Applied
Jonathan Cortes, Ernesto Sanchez-Mendoza, Alejandro Zamilpa, Manases Gonzalez-Cortazar, Maribel Herrera-Ruiz, Julio Cesar Almanza-Perez, Eli Teran-Cabanillas, Renaud Conde, Lenin Dominguez-Ramirez, Elizur Montiel Arcos, Jesus Enrique Jimenez-Ferrer
Summary: This paper describes the pharmacological activity and chemistry of a new saponin isolated from Agave marmorata Roezl, which displayed immunomodulating activity and inhibition of NO production and NF-kappa B expression.
NATURAL PRODUCT RESEARCH
(2022)
Article
Ophthalmology
Fatima Sofia Magana-Guerrero, Diana Hinojosa Trujillo, Beatriz Buentello-Volante, Jose Eduardo Aguayo-Flores, Edgar Alonso Melgoza-Gonzalez, Jesus Hernandez, Maria C. Jimenez-Martinez, Sonia Mayra Perez-Tapia, Yonathan Garfias
Summary: During the COVID-19 pandemic, healthcare workers are at a high risk of being infected with SARS-CoV-2, especially those in ophthalmology departments. A study conducted in Mexico City found that 32% of HCWs at an Ophthalmological Reference Centre tested RT-PCR positive, with 20% presenting IgG antibodies against SARS-CoV-2. Despite the high infection rate, most HCWs showed mild symptoms, and a significant portion of RT-PCR positive participants did not show IgG antibodies.
OPHTHALMIC EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Marce Inzunza-Soto, Emir Leal-Leon, Marcela Vergara-Jimenez, Samuel Lopez-Moreno, Dora Maria Cedano-Prieto, Moises Franco, Jesus Enrique Jimenez-Ferrer, Elian Yuritzi Alegria Herrera, Jonathan Cortes Alvarez, David Aleman-Hidalgo, Eli Teran-Cabanillas
Summary: This study aimed to investigate whether the iron-chelating properties of curcumin are responsible for its anti-proliferative effect in breast cancer cells and to explore the translation of this effect in in vivo models. The results showed that curcumin inhibited cell proliferation in both MCF-7 and 4T1 cell lines in an iron-dependent manner. In vivo experiments also demonstrated that curcumin significantly reduced tumor growth, while optimized curcumin supplement had the opposite effect.
CURRENT NUTRITION & FOOD SCIENCE
(2023)
Article
Immunology
Noe Juvenal Mendoza-Ramirez, Julio Garcia-Cordero, Sandra Paola Martinez-Frias, Daniela Roa-Velazquez, Rosendo Luria-Perez, Jose Bustos-Arriaga, Jesus Hernandez-Lopez, Carlos Cabello-Gutierrez, Joaquin Alejandro Zuniga-Ramos, Edgar Morales-Rios, Sonia Mayra Perez-Tapia, Martha Espinosa-Cantellano, Leticia Cedillo-Barron
Summary: This study analyzes the combination of two SARS-CoV-2 viral antigens and finds that immunization with a combination of S1 or RBD and the N protein can elicit a stronger immune response. The sera from immunized mice can recognize different variants of SARS-CoV-2. This study identifies potential antigens for the second generation of COVID-19 vaccines.
Article
Microbiology
Freddy Dehesa-Canseco, Roxana Pastrana-Unzueta, Nadia Carrillo-Guzman, Francisco Liljehult-Fuentes, Juan Diego Perez-De la Rosa, Humberto Ramirez-Mendoza, Jose Guillermo Estrada-Franco, Roberto Navarro-Lopez, Jesus Hernandez, Mario Solis-Hernandez
Summary: This study aimed to evaluate the seroprevalence of neutralizing antibodies against the ancestral strain and the Omicron BA.1 subvariant in dogs and cats in Mexico. The results showed that 14.2% of cats and 1.5% of dogs presented nAbs against the ancestral strain of SARS-CoV-2, while a lower proportion had nAbs against Omicron BA.1.
Article
Nursing
Maria Josse Navarro-Ibarra, Maria del Socorro Saucedo-Tamayo, Heliodoro Aleman-Mateo, Hector Parra-Sanchez, Paola Othon-Ontiveros, Jesus Hernandez, Graciela Caire-Juvera
Summary: This study found that body fat percentage and fat mass index were positively associated with C-reactive protein (CRP) levels in female breast cancer survivors, while appendicular skeletal lean mass index (ASMI) decreased as CRP levels increased. Interleukin 6 (IL-6) was positively associated with fat mass index. Interventions to improve body composition in breast cancer survivors should consider the role of inflammatory markers to avoid sarcopenic obesity and the risk of recurrence.
BIOLOGICAL RESEARCH FOR NURSING
(2023)
Article
Multidisciplinary Sciences
Tania Lucia Madrigal-Valencia, Manuel Saavedra-Montanez, Armando Perez-Torres, Jesus Hernandez, Joaquim Segales, Yesmin Dominguez Hernandez, Irma Eugenia Candanosa-Aranda, Alfredo Perez-Guiot, Humberto Ramirez-Mendoza
Summary: This study describes an outbreak of sheep-associated malignant catarrhal fever (SA-MCF) caused by OvHV-2 in Mexico. The virus was identified using various methods and observed in primary rabbit testis cultures. It is also the first report of OvHV-2 presence in horses and Artiodactyla buffy coats in Mexico.
Article
Medicine, General & Internal
Jesus Gilberto Aramburo-Galvez, Oscar Gerardo Figueroa-Salcido, Giovanni Isai Ramirez-Torres, Eli Teran-Cabanillas, Martina Hilda Gracia-Valenzuela, Aldo Alejandro Arvizu-Flores, Cesar Antonio Sanchez-Cardenas, Jose Antonio Mora-Melgem, Luisamaria Valdez-Zavala, Feliznando Isidro Cardenas-Torres, Noe Ontiveros
Summary: This study aimed to estimate the prevalence of food allergies in a Mexican preschool population and found that a significant number of cases required emergency room visits. Proper management of food allergies and prevention of cross-contamination should be prioritized.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Food Science & Technology
Karla Garcia-Rocha, Andrea Capaceta-Osuna, Alicia Ochoa-Acosta, Roberto J. Avena-Bustillos, Ulises Osuna-Martinez, Feliznando Isidro Cardenas-Torres, Wallace H. Yokoyama, Tara H. McHugh, Elii Teran-Cabanillas
Summary: The study found that supplementation with 10% romaine lettuce powder (RLP) in a high-fat diet can lower glucose and insulin levels, prevent insulin resistance in mice, and have positive effects on liver health. The results indicate that incorporating RLP into the diet may have potential health benefits for preventing metabolic syndrome.
ACS FOOD SCIENCE & TECHNOLOGY
(2023)
Letter
Biochemistry & Molecular Biology
Jesus Hernandez, Freddy Dehesa-Canseco, Alma B. Vazquez-Lopez, Monica Resendiz-Sandoval, Graciela Caire-Juvera, Mario Solis-Hernandez, Olivia Valenzuela, Bruno Gomez-Gil, Veronica Mata-Haro
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Virology
Monica Resendiz-Sandoval, Veronica A. Vazquez-Garcia, Kenneth Contreras-Vega, Edgar A. Melgoza-Gonzalez, Veronica Mata-Haro, Luis Gimenez-Lirola, Jesus Hernandez
Summary: This study investigated the presence of PCV3 in samples collected in Mexico and found that PCV3 has been circulating in the region since 2008. The virus has a higher prevalence in pigs with clinical manifestations of diseases.
Article
Agriculture, Dairy & Animal Science
Maritza Cordero-Ortiz, Monica Resendiz-Sandoval, Freddy Dehesa-Canseco, Mario Solis-Hernandez, Jahir Perez-Sanchez, Carlos Martinez-Borges, Veronica Mata-Haro, Jesus Hernandez
Summary: Summary: This study aimed to develop a double-antigen sandwich enzyme-linked immunosorbent assay (ELISA) to detect SARS-CoV-2 antibodies in serum samples from various animal species. The results showed that this assay was able to detect antibodies against SARS-CoV-2 in serum samples from cats, dogs, guinea pigs, rats, tigers, and humans.
Article
Food Science & Technology
Marce Inzunza-Soto, Roberto J. Avena-Bustillos, Sandy Thai, Valdemar Roman, Lewis Whitehill, Christina Tam, Matthew R. Rolston, David M. Aleman-Hidalgo, Eli Teran-Cabanillas, Wallace Yokoyama, Tara H. McHugh
Summary: The use of brewery spent grain (BSG) has increased in recent years as it is rich in fiber, proteins, polyphenols, vitamins, and minerals, making it a potential source of bioactive molecules with health benefits. This study evaluated two types of BSG and found that the fines fraction had higher protein content but lower total dietary fiber. When incorporated into a high fat diet, both types of BSG resulted in decreased weight, systemic levels of leptin, and liver fat in mice. Changes in the gut microbiome were also observed. These findings suggest that BSG byproducts in diet may have potential health benefits.
ACS FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Food Science & Technology
Roberto J. Avena-Bustillos, Noah Klausner, Rebecca Milczarek, Eli Teran-Cabanillas, David M. Aleman-Hidalgo, Tara H. McHugh
Summary: The characteristics of powders from different treatments of inner heart leaves and outer leaves of Romaine lettuce from farms with different cadmium content were quantified. The results showed that heart leaves from the Valencia variety had higher levels of total soluble phenolics and antioxidant capacity. Infrared dry blanching resulted in a decrease in color and properties of the powders. The Duquesne variety grown in soil with higher cadmium content had higher levels of cadmium in the leaves. Cadmium content was higher in outer leaves compared to heart leaves. There were no differences in pesticide content between lettuce from the two harvesting fields. Edible powders from Romaine lettuce outer leaves from low-cadmium soils and controlled pesticide management may be an alternative way to reduce nitrogen leaching in agricultural soils.
ACS FOOD SCIENCE & TECHNOLOGY
(2022)