期刊
CLINICAL NUTRITION
卷 32, 期 3, 页码 452-459出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2012.10.002
关键词
Gastrointestinal mucositis; Long-chain fatty acids; Nutrient absorption; Liver fatty acid appearance; Chemotherapy; Citrulline
资金
- Fonds NutsOhra (The Netherlands)
Background & aims: Patients with chemotherapy-induced gastrointestinal mucositis suffer from weight loss and possibly malabsorption. Since long-chain fatty acids serve important functions in the body, we aimed to determine the intestinal capacity of fat absorption in rats with and without methotrexate-induced mucositis. Methods: Four days after intravenous injection with methotrexate (60 mg/kg) or saline, rats received saturated ([U-C-13]palmitic acid) and unsaturated ([U-C-13]linoleic acid) fatty acids dissolved in oil, either as a single bolus by oral gavage or by continuous intraduodenal infusion. We determined plasma and liver label concentrations at specific time points. Results: We confirmed methotrexate-induced mucositis by villus atrophy using microscopy. Methotrexate treatment severely reduced the appearance of [U-C-13]palmitic- and [U-C-13]linoleic acid in plasma and liver, compared to controls, either when administered as a bolus or continuously (all at least -63%, P < 0.05). Liver [U-C-13]palmitic acid appearance was higher than [U-C-13]linoleic acid appearance, either when administered as a bolus (2.8-fold, P < 0.01) or continuously (5.7-fold, P < 0.01). Conclusions: The intestinal capacity to absorb long-chain fatty acids is severely reduced in rats with methotrexate-induced mucositis. Continuous administration does not overcome this impairment. The liver takes up and/or retains mainly saturated fatty acids during mucositis. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据