Article
Nutrition & Dietetics
Jing Chen, Ruiguo You, Yao Lv, Huimin Liu, Guoqing Yang
Summary: CLA increases the expression of A-FABP through PPAR alpha signaling pathway and regulates the expression of genes and enzymes related to IMF deposition, thus increasing IMF content.
FRONTIERS IN NUTRITION
(2022)
Article
Fisheries
Xiang-Yu Wu, Li Nie, Xin-Jiang Lu, Chen-Jie Fei, Jiong Chen
Summary: In this study, the role of PPAR gamma in immune regulation in teleost fish was investigated. Results showed that the expression of LcPPAR gamma changed during infection and DHA treatment, and was associated with the expression of immune-related genes.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Zhao Gao, Xinrui Xu, Yang Li, Kehan Sun, Manfang Yang, Qingyue Zhang, Shuqi Wang, Yiyi Lin, Lixia Lou, Aiming Wu, Weijing Liu, Bo Nie
Summary: Atherosclerosis is the main pathological cause of acute cardiovascular and cerebrovascular diseases, involving inflammation and immune responses. PPARγ and regulatory T cells (Tregs) play crucial roles in inhibiting atherosclerotic inflammation by regulating inflammatory factors and immune responses. Their activation can help reduce inflammation and exert anti-atherosclerotic effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters
Summary: Long-term ligand activation of PPARa in mice causes hepatocarcinogenesis, while hepatocarcinogenesis is diminished in Ppara-null and PPARA-humanized mice. Lipidomic analyses showed elevated levels of hepatic linoleic acid and overall fatty liver in Ppara-null and PPARA-humanized mice. The accumulation of linoleic acid and loss of CD4+ T cells suggest a new role for PPARa in age-associated hepatocarcinogenesis.
Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In our literature review of 27 relevant studies published between 2000 and 2023, it was found that PPAR alpha and PPAR beta/delta isoforms were upregulated in endometrial cancer cells, while PPAR gamma levels were significantly lower. Interestingly, PPAR agonists were found to be potent anti-cancer therapeutic alternatives. Overall, PPARs seem to play a significant role in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Gang Huang, Wei Jiang, Weiyong Xie, Wei Lu, Weimin Zhu, Zhenhan Deng
Summary: PPARs regulate cartilage homeostasis and reduce inflammation in OA, deficiency of PPARs may accelerate OA progression. PPAR agonists can inhibit catabolic and inflammatory factors synthesis, reducing cartilage lesions development in OA.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Cell Biology
In Soo Kim, Prashanta Silwal, Eun-Kyeong Jo
Summary: This review discusses the roles of peroxisome proliferator-activated receptors (PPARs) alpha, beta, and gamma in transcriptional regulation, energy metabolism, inflammation regulation, cellular development, and differentiation. PPAR signaling pathways play important roles in the development of viral, bacterial, and parasitic infectious diseases. The review also explores the potential therapeutic uses of PPAR agonists/antagonists in infectious disease treatment.
Article
Reproductive Biology
Karol Mierzejewski, Aleksandra Kurzynska, Zuzanna Kunicka, Anna Klepacka, Monika Golubska, Iwona Bogacka
Summary: This study investigated the effect of PPARγ agonists on the expression of inflammatory mediators in the porcine endometrium, showing that they can decrease pro-inflammatory markers and increase anti-inflammatory mediators.
Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Iason Psilopatis, Kleio Vrettou, Eleni Nousiopoulou, Kostas Palamaris, Stamatios Theocharis
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, causing severe menstrual irregularities, skin conditions, and insulin resistance-associated health problems. Peroxisome proliferator-activated receptors (PPARs) have been investigated for their role in PCOS, but studies have reached contradictory conclusions about PPAR expression in PCOS. However, natural agents have shown promise as alternative treatments for PCOS. Overall, PPARs appear to play a significant role in PCOS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yiyi Ma, Minglu Wang, Shuaishuai Guo, Tong Li, Xiaodong Liu, Limei Zhao
Summary: Valproic acid (VPA) is widely used in the treatment of epilepsy, but its potential hepatotoxicity is a major concern. This study aimed to investigate the biomarkers and mechanisms of VPA-induced liver injury in epileptic children. Metabolomic analysis revealed that VPA disrupts fatty acid beta-oxidation (beta-FAO) and leads to the accumulation of serum long-chain acylcarnitines (LCACs). Additionally, the study found that fenofibrate (Feno) can improve beta-FAO and protect against VPA-induced hepatotoxicity by activating PPAR alpha.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Riham M. Mansour, Nesrine S. El Sayed, Maha A. E. Ahmed, Ayman E. El-Sahar
Summary: This study aimed to explore the neuroprotective effect of telmisartan in 3-nitropropionic acid-induced neurotoxicity. The results showed that telmisartan improved motor and cognitive functioning, reduced neuronal inflammation and apoptosis, and promoted mitochondrial biogenesis through PPAR gamma activation.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Elena Valeria Fuior, Evangelia Zvintzou, Theodosios Filippatos, Katerina Giannatou, Victoria Mparnia, Maya Simionescu, Anca Violeta Gafencu, Kyriakos E. Kypreos
Summary: Peroxisome proliferator-activated receptors (PPARs) are ligand-binding transcription factors that regulate energetic metabolism, immune responses, and cell proliferation and differentiation. PPAR alpha receptors play a crucial role in modulating plasma lipid and lipoprotein metabolism, with pluripotent effects on atherogenic and antiatherogenic lipoproteins. Clinical evidence supports the use of PPAR alpha agonists in the treatment of hypertriglyceridemia and/or low high-density lipoprotein cholesterol levels.
Review
Cell Biology
Yaqin Zhao, Huabing Tan, Xiaoyu Zhang, Jing Zhu
Summary: This article summarizes the role of PPARs in the occurrence and development of HCC, as well as their value in the diagnosis, treatment, and prognosis of HCC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Gary R. Lichtenstein, Edward V. Loft, Kim L. Isaacs, Miguel D. Regueiro, Lauren B. Gerson, Bruce E. Sands
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2018)
Article
Gastroenterology & Hepatology
Hans Herfarth, Edward L. Barnes, John F. Valentine, John Hanson, Peter D. R. Higgins, Kim L. Isaacs, Susan Jackson, Mark T. Osterman, Kristen Anton, Anastasia Ivanova, Millie D. Long, Christopher Martin, Robert S. Sandler, Bincy Abraham, Raymond K. Cross, Gerald Dryden, Monika Fischer, William Harlan, Campbell Levy, Robert McCabe, Steven Polyak, Sumona Saha, Emmanuelle Williams, Vijay Yajnik, Jose Serrano, Bruce E. Sands, James D. Lewis
Article
Gastroenterology & Hepatology
Siobhan S. Proksell, Julia B. Greer, Brian K. Theisen, Peter L. Davis, Joel R. Rosh, David J. Keljo, Alka Goyal, Samir A. Shah, Myron H. Brand, Hans H. Herfarth, Raymond K. Cross, Corey A. Siegel, Walter A. Koltun, Kim L. Isaacs, Miguel D. Regueiro
INFLAMMATORY BOWEL DISEASES
(2018)
Letter
Medicine, General & Internal
Hans Herfarth, Millie D. Long, Kim L. Isaacs
Article
Gastroenterology & Hepatology
Eric J. Mao, Sarah Sheibani, Christopher Martin, Richard S. Bloomfeld, Kim Isaacs, Sumona Saha, Uma Mahadevan
INFLAMMATORY BOWEL DISEASES
(2019)
Letter
Gastroenterology & Hepatology
Gary R. Lichtenstein, Edward V. Loftus, Kim L. Isaacs, Miguel D. Regueiro, Bruce E. Sands
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Gastroenterology & Hepatology
Kimberly N. Weaver, Martin Gregory, Gaurav Syal, Patrick Hoversten, Stephen Bradley Hicks, Devin Patel, George Christophi, Poonam Beniwal-Patel, Kim L. Isaacs, Laura Raffals, Parakkal Deepak, Hans H. Herfarth, Edward L. Barnes
INFLAMMATORY BOWEL DISEASES
(2019)
Letter
Gastroenterology & Hepatology
Gary R. Lichtenstein, Edward V. Loftus, Kim L. Isaacs, Miguel D. Regueiro, Bruce E. Sands
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Letter
Gastroenterology & Hepatology
Gary R. Lichtenstein, Edward V. Loftus, Kim L. Isaacs, Miguel D. Regueiro, Bruce E. Sands
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Gastroenterology & Hepatology
Joseph D. Feuerstein, Kim L. Isaacs, Yecheskel Schneider, Shazia Mehmood Siddique, Yngve Falck-Ytter, Siddharth Singh
Article
Gastroenterology & Hepatology
Takahiko Toyonaga, Erin C. Steinbach, Benjamin P. Keith, Jasmine B. Barrow, Matthew R. Schaner, Elisabeth A. Wolber, Caroline Beasley, Jennifer Huling, Yuli Wang, Nancy L. Allbritton, Nicole Chaumont, Timothy S. Sadiq, Mark J. Koruda, Animesh Jain, Millie D. Long, Edward L. Barnes, Hans H. Herfarth, Kim L. Isaacs, Jonathan J. Hansen, Michael T. Shanahan, Reza Rahbar, Terrence S. Furey, Praveen Sethupathy, Shehzad Z. Sheikh
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Genetics & Heredity
Hari K. Somineni, Sini Nagpal, Suresh Venkateswaran, David J. Cutler, David T. Okou, Talin Haritunians, Claire L. Simpson, Ferdouse Begum, Lisa W. Datta, Antonio J. Quiros, Jenifer Seminerio, Emebet Mengesha, Jonathan S. Alexander, Robert N. Baldassano, Sharon Dudley-Brown, Raymond K. Cross, Themistocles Dassopoulos, Lee A. Denson, Tanvi A. Dhere, Heba Iskandar, Gerald W. Dryden, Jason K. Hou, Sunny Z. Hussain, Jeffrey S. Hyams, Kim L. Isaacs, Howard Kader, Michael D. Kappelman, Jeffry Katz, Richard Kellermayer, John F. Kuemmerle, Mark Lazarev, Ellen Li, Peter Mannon, Dedrick E. Moulton, Rodney D. Newberry, Ashish S. Patel, Joel Pekow, Shehzad A. Saeed, John F. Valentine, Ming-Hsi Wang, Jacob L. McCauley, Maria T. Abreu, Traci Jester, Zarela Molle-Rios, Sirish Palle, Ellen J. Scherl, John Kwon, John D. Rioux, Richard H. Duerr, Mark S. Silverberg, Michael E. Zwick, Christine Stevens, Mark J. Daly, Judy H. Cho, Greg Gibson, Dermot P. B. McGovern, Steven R. Brant, Subra Kugathasan
Summary: This study explored the genetic risk differences for inflammatory bowel disease among individuals with African American and European ancestries, revealing variations in gene effect sizes and allele frequencies. While there is a significant overlap in common variant risk for inflammatory bowel disease susceptibility between individuals of African and European ancestries, there are subtle differences in polygenic risk scores.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Multidisciplinary Sciences
Takahiko Toyonaga, Kenza C. Araba, Meaghan M. Kennedy, Benjamin P. Keith, Elisabeth A. Wolber, Caroline Beasley, Erin C. Steinbach, Matthew R. Schaner, Animesh Jain, Millie D. Long, Edward L. Barnes, Hans H. Herfarth, Kim L. Isaacs, Jonathan J. Hansen, Muneera R. Kapadia, Jose Gaston Guillem, Ajay S. Gulati, Praveen Sethupathy, Terrence S. Furey, Camille Ehre, Shehzad Z. Sheikh
Summary: The study found that colonic ACE2 expression is elevated in Crohn's disease patients, which may lead to a higher risk of surgery. CD patients with high ACE2 expression are more likely to undergo surgery within 5 years, with high ACE2 levels being an independent risk factor for surgery.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Gastroenterology & Hepatology
Joseph D. Feuerstein, Kim L. Isaacs, Yecheskel Schneider, Shazia Mehmood Siddique, Yngve Falck-Ytter, Siddharth Singh
Article
Gastroenterology & Hepatology
Kimberly N. Weaver, Bharati Kochar, Jonathan J. Hansen, Kim L. Isaacs, Animesh Jain, Shehzad Z. Sheikh, Alessandro Fichera, Nicole Chaumont, Tim Sadiq, Mark Koruda, Millie D. Long, Hans H. Herfarth, Edward L. Barnes
CROHNS & COLITIS 360
(2019)