Article
Agriculture, Dairy & Animal Science
Hiep Thi Dao, Nishchal K. Sharma, Emma J. Bradbury, Robert A. Swick
Summary: Supplementing broilers with arginine and citrulline may improve performance under warm temperature conditions. Feeding broilers with normal protein diets is necessary to maintain growth performance.
Article
Agriculture, Dairy & Animal Science
Hiep Thi Dao, Jonathon W. Clay, Nishchal K. Sharma, Emma J. Bradbury, Robert A. Swick
Summary: Feeding reduced protein diets may affect microbial fermentation in the ceca of broilers, and this study investigated the effects of specific amino acid supplementation in reduced protein diets on cecal fermentation products under different temperature and necrotic enteritis challenge conditions. The results showed that feeding an Arg-deficient reduced protein diet increased plasma ammonia levels, while supplementation of Arg or Cit reduced plasma ammonia levels.
Article
Agriculture, Dairy & Animal Science
Hiep Thi Dao, Nishchal K. Sharma, Emma J. Bradbury, Robert A. Swick
Summary: The study examined the effects of reduced protein diet, arginine deficiency, and the addition of arginine substitutes on Hy-Line Brown laying hens. It was found that while an arginine deficient diet decreased performance, the addition of guanidinoacetic acid or citrulline allowed birds to perform similarly or better than with added arginine.
Review
Nutrition & Dietetics
Stefano Maric, Tanja Restin, Julian Louis Muff, Simone Mafalda Camargo, Laura Chiara Guglielmetti, Stefan Gerhard Holland-Cunz, Pascal Crenn, Raphael Nicolas Vuille-dit-Bille
Summary: L-Citrulline, an important amino acid released from enterocytes, plays a crucial role in monitoring intestinal integrity and diagnosing rheumatoid diseases. It may also predict poor outcomes in cancer patients. Supplementation with L-Citrulline can slightly improve muscle strength or protein balance.
Article
Immunology
Melanie C. McKell, Rebecca R. Crowther, Stephanie M. Schmidt, Michelle C. Robillard, Rachel Cantrell, Maria A. Lehn, Edith M. Janssen, Joseph E. Qualls
Summary: Macrophages rely on L-arginine for anti-Mtb defense, not only for NO production but also for regulating metabolism and other host defense mechanisms. Inhibition of glycolysis or mTOR reduces macrophage control of Mtb, as well as macrophage number and viability in the presence of L-arginine. L-arginine is essential for macrophage function in combating intracellular pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Physiology
Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi
Summary: Citrulline is more favorable for nitric oxide production compared to arginine due to its higher absorption and reabsorption rates, and cells prefer to use citrulline instead of arginine to increase NO output.
Article
Nutrition & Dietetics
Jerome Filippi, Amandine Rubio, Virgine Lasserre, Jean Maccario, Stephanie Walrand, Nathalie Neveux, Servane Le Plenier, Xavier Hebuterne, Luc Cynober, Christophe Moinard
Summary: The study found that citrulline supplementation promotes body weight gain, preserves muscle trophicity, and enhances intestinal adaptation in a dose-dependent manner in a model of resected rats.
Article
Chemistry, Multidisciplinary
Saehyun Choi, McCauley O. Meyer, Philip C. Bevilacqua, Christine D. Keating
Summary: Research has found significant differences in interactions between RNA and adjacent phases of decapeptide-based multiphase model membraneless organelles. Single- and double-stranded RNAs preferentially accumulate in different phases within the same droplet. This discovery is important for understanding and designing functional artificial membraneless organelles.
Review
Nutrition & Dietetics
Shiqi Liu, Hengxu Liu, Li Yang, Kun Wang, Nuo Chen, Tingran Zhang, Jiong Luo
Summary: This study discusses the special needs of chronic stroke patients in rehabilitation exercise and nutrition supplement, evaluates the physiological mechanism of nutrition intervention to promote training adaptation, and compares the effects of various nutrition supplement strategies on stroke rehabilitation.
Article
Endocrinology & Metabolism
Mahmoud A. Mohammad, Inka C. Didelija, Barbara Stoll, Trung C. Nguyen, Juan C. Marini
Summary: ADI-PEG20 administration rapidly depletes circulating arginine while maintaining tissue concentrations, without affecting blood pressure or protein metabolism, demonstrating high citrulline turnover and regeneration of arginine through the citrulline recycling pathway.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Bilgehan Ozcan, Britanny Blachot-Minassian, Stephanie Paradis, Lucile Maziere, Marie Chambion-Diaz, Sophie Bouyon, Jean-Louis Pepin, Vincent Pialoux, Claire Arnaud, Christophe Moinard, Elise Belaidi
Summary: Intermittent hypoxia, a hallmark of obstructive sleep apnea, triggers oxidative stress and contributes to cardiovascular consequences. Citrulline supplementation has shown protective effects on the cardiovascular system. This study demonstrates that citrulline significantly reduces blood pressure and infarct size under intermittent hypoxia, indicating its potential as a pharmacological strategy for high-risk OSA patients.
Review
Nutrition & Dietetics
Hun-Young Park, Sung-Woo Kim, Jisoo Seo, Yanghoon P. P. Jung, Hyunji Kim, Ah-Jin Kim, Sonwoo Kim, Kiwon Lim
Summary: The global market for nutritional supplements is rapidly growing, and there is considerable research interest in the effects of Arg, Cit, and CitMal supplements on cardiovascular health and exercise performance. Previous studies have shown that Cit supplements have a positive impact on nitric oxide synthesis and athletic performance, while the effects of Arg supplements are inconclusive. Further research is needed to determine the impact of CitMal supplements on muscle endurance performance. Future studies should also explore the effects of these supplements on different populations and dosage, timing, and long-term effects.
Article
Multidisciplinary Sciences
Magdalena Mierzchala-Pasierb, Malgorzata Lipinska-Gediga, Mariusz G. Fleszar, Lukasz Lewandowski, Pawel Serek, Sylwia Placzkowska, Malgorzata Krzystek-Korpacka
Summary: The study compared patterns of urine and serum amino acids in sepsis, septic shock, and survival, identifying significant differences in concentrations of specific amino acids at different stages. This suggests that urine and serum amino acids could potentially be used to assess and diagnose sepsis or septic shock in patients.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Stefano Maric, Pascal Fluchter, Laura Chiara Guglielmetti, Ralph Fabian Staerkle, Tom Sasse, Tanja Restin, Christoph Schneider, Stefan Gerhard Holland-Cunz, Pascal Crenn, Raphael Nicolas Vuille-dit-Bille
Summary: This study revealed a correlation between small intestinal basolateral LAT4 expression and plasma citrulline concentration for the first time, indicating LAT4's important role in mediating citrulline efflux from enterocytes. Additionally, urine arginine was found to correlate with plasma citrulline, suggesting it as a potential additional marker for small intestine enterocyte mass. Furthermore, the expression of basolateral LAT4 along the human small intestine was demonstrated for the first time.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Ye Zhao, Qin Jiang, Xuefei Zhang, Xiaoxiao Zhu, Xia Dong, Linyuan Shen, Shunhua Zhang, Lili Niu, Lei Chen, Ming Zhang, Jun Jiang, Daiwen Chen, Li Zhu
Summary: l-Arginine has been shown to reduce muscle injury by regulating the SIRT1-Akt-Nrf2 and SIRT1-FOXO3a-mitochondria apoptosis signaling pathways as a potential nutraceutical.