Review
Nutrition & Dietetics
Stefano Maric, Tanja Restin, Julian Louis Muff, Simone Mafalda Camargo, Laura Chiara Guglielmetti, Stefan Gerhard Holland-Cunz, Pascal Crenn, Raphael Nicolas Vuille-dit-Bille
Summary: L-Citrulline, an important amino acid released from enterocytes, plays a crucial role in monitoring intestinal integrity and diagnosing rheumatoid diseases. It may also predict poor outcomes in cancer patients. Supplementation with L-Citrulline can slightly improve muscle strength or protein balance.
Article
Multidisciplinary Sciences
Santosh K. Panda, Do-Hyun Kim, Pritesh Desai, Patrick F. Rodrigues, Raki Sudan, Susan Gilfillan, Marina Cella, Steven J. Van Dyken, Marco Colonna
Summary: ILC2 cells selectively express the Slc7a8 gene, which plays a crucial role in maintaining cellular fitness and activation. Lack of Slc7a8 leads to reduced amino acid availability, affecting energy metabolism and signaling pathway activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Gregory Gauthier-Coles, Angelika Broer, Malcolm Donald McLeod, Amee J. George, Ross D. Hannan, Stefan Broer
Summary: SNAT2 is an important amino acid transporter involved in amino acid accumulation, cellular osmolarity, and cell growth. A potent inhibitor of SNAT2 has been identified through high-throughput screening, with selectivity against other transporters. Combined with a glucose transport inhibitor, this compound can halt the proliferative growth of cancer cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiali Wang, Yang Dong, Christof Grewer
Summary: Through comprehensive electrophysiological analysis, similarities and differences between ASCT1 and ASCT2 subtypes were identified, as well as novel functional properties. The sequential Na+/substrate binding mechanism appears to be conserved between the two subtypes. ASCT1 has a higher apparent affinity for Na+ and a larger dependence on [Na+] for substrate affinity compared to ASCT2. ASCT1 and ASCT2 also show different substrate selectivities and both exhibit rapid capacitive charge movements upon application and removal of amino acid.
Article
Food Science & Technology
Yueqin Fan, Zhendong Lei, Jiasheng Huang, Dan Su, Dejiang Ni, Yuqiong Chen
Summary: This study investigated the effect and mechanism of theaflavins (TFs) on fluoride (F-) uptake and transport in the Caco-2 cell model. The results showed that TFs significantly decreased F- transport in Caco-2 cells and influenced F- retention. The interaction between TFs and F- was analyzed, and transcriptome analysis identified key genes related to cell permeability.
Article
Multidisciplinary Sciences
Toshihiko Kobayashi, Dat Nguyen-Tien, Yuriko Sorimachi, Yuki Sugiura, Takehiro Suzuki, Hitomi Karyu, Shiho Shimabukuro-Demoto, Tatsuki Uemura, Tadashi Okamura, Tomohiko Taguchi, Kohjiro Ueki, Norihiro Kato, Nobuhito Goda, Naoshi Dohmae, Keiyo Takubo, Makoto Suematsu, Noriko Toyama-Sorimachi
Summary: The amino acid and oligopeptide transporter SLC15A4 plays a critical role in regulating inflammatory responses and cytokine production in immune cells. Loss of SLC15A4 leads to metabolic imbalances, impacting glutamine metabolism and the tricarboxylic acid cycle. Additionally, SLC15A4 is essential for AMPK activation and maintaining respiratory homeostasis in macrophages.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Dan Wang, Xuebin Wan, Xiaoli Du, Zhuxia Zhong, Jian Peng, Qi Xiong, Jin Chai, Siwen Jiang
Summary: The study reveals that leucine can increase the expressions of SLC38A9 and SLC36A1, leading to mTORC1 activation, and SLC38A9 interacts with SLC36A1 to enhance each other's expression levels and locations on the lysosomal surface. Interacting proteins of SLC38A9 in C2C12 cells are involved in amino acid sensing mechanism, mTORC1 signaling pathway, and protein synthesis, providing a resource for future investigations of skeletal muscle mass.
Article
Plant Sciences
Matusorn Wongon, Nanteetip Limpeanchob
Summary: Oxyresveratrol and Puag Haad can inhibit glucose transporter 2 and sodium-dependent glucose transporter 1, potentially reducing postprandial hyperglycemic peaks in diabetics.
Article
Pharmacology & Pharmacy
Qi Tao, Zhe Qin, Xi-Wang Liu, Zhen-Dong Zhang, Shi-Hong Li, Li-Xia Bai, Jian-Yong Li, Ya-Jun Yang
Summary: This study investigated the uptake and transport mechanisms of aspirin eugenol ester (AEE) in Caco-2 cells. The results showed that the intestinal absorption of AEE was related to passive transport. The uptake and transport of AEE were concentration-dependent, and temperature significantly affected their uptake and transport. These findings are important for understanding the absorption and transport mechanisms of chemosynthetic drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Parasitology
Matthew Pinch, Theodore Muka, Yashoda Kandel, Mahesh Lamsal, Nathan Martinez, Marialuisa Teixeira, Dmitri Y. Boudko, Immo A. Hansen
Summary: This study identified a putative interacting protein GCN1 for the mosquito's CAT1 protein, which is important for egg development. The results suggest that GCN1 is part of the nutrient sensor mechanism in mosquitoes.
PARASITES & VECTORS
(2022)
Article
Oncology
Souad R. R. Sennoune, Gunadharini Dharmalingam Nandagopal, Sabarish Ramachandran, Marilyn Mathew, Sathish Sivaprakasam, Valeria Jaramillo-Martinez, Yangzom D. D. Bhutia, Vadivel Ganapathy
Summary: Niclosamide, a drug used to treat tapeworm infection, has anticancer effects by interfering with signaling pathways and causing intracellular acidification. It blocks macropinocytosis mediated by the amino acid transporter SLC38A5 and inhibits the activity of the peptide transporter. These mechanisms contribute to nutrient starvation in cancer cells. This study reveals novel mechanisms for the anticancer efficacy of Niclosamide.
Article
Agriculture, Multidisciplinary
Min Wu, Cong Wang, Leqin Ke, Dewen Chen, Yumei Qin, Jianzhong Han
Summary: This study found that the intracellular accumulation of copper derived from copper ion and copper complex is mediated by distinct copper transport pathways, indicating that copper speciation may affect copper absorption and toxicity.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Plant Sciences
Lin Feng, Yongchao Yu, Shijia Lin, Tianyuan Yang, Qi Chen, Linlin Liu, Jun Sun, Pengcheng Zheng, Zhaoliang Zhang, Xiaochun Wan
Summary: Theanine, an important component in tea, is stored in the root of tea plants during winter and transported to the new shoots in spring. The protein CsCAT2 has been identified as an H+-dependent theanine transporter localized in the tonoplast, which is highly expressed in the root during theanine storage and negatively modulates theanine transport from root to shoot.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Nutrition & Dietetics
Prasanthi Jegatheesan, Christel Vicente, Perrine Marquet de Rouge, Nathalie Neveux, Radji Ramassamy, Salimata Magassa, Christian Aussel, Agathe Raynaud-Simon, Luc Cynober, Jean-Pascal De Bandt
Summary: The combination of citrulline and lactoserum has shown significant effects on plasma and muscle amino acid levels in aged rats, leading to the activation of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, which may promote protein synthesis and muscle anabolism.
Article
Radiology, Nuclear Medicine & Medical Imaging
Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, William Ewan Hume, Hisashi Doi, Yasuyoshi Watanabe
Summary: F-18-FIMP, a promising PET probe, has affinity not only for LAT1 but also for ATB(0,+). This study provides insights into the whole-body distribution and tumor accumulation mechanisms of F-18-FIMP.
Article
Mathematical & Computational Biology
Lilith Faucheux, Matthieu Resche-Rigon, Emmanuel Curis, Vassili Soumelis, Sylvie Chevret
Summary: A consensus-based clustering algorithm was developed taking into account left-censored data using modified multiple imputation method and estimating the number of clusters for each imputed dataset. Simulation study and real-world application showed that this method performs well in terms of clustering performance, potentially revealing novel patient clusters.
BIOMETRICAL JOURNAL
(2021)
Article
Rheumatology
Anne-Priscille Trouvin, Chouki Chenaf, Marie Riquelme, Emmanuel Curis, Ioannis Nicolis, Rose-Marie Javier, Pascale Vergne-Salle, Francoise Laroche, Sophie Pouplin, Nicolas Authier, Serge Perrot
Summary: The study examined opioid prescribing patterns by rheumatologists in France in 2015. Rheumatologists mainly prescribed morphine, less oxycodone and fentanyl, and generally followed national recommendations for short-term, low-dose opioid prescriptions for non-cancer pain.
Article
Clinical Neurology
Sebastien Bergeret, Mathieu Queneau, Mathieu Rodallec, Emmanuel Curis, Julien Dumurgier, Jacques Hugon, Claire Paquet, Karim Farid, Jean-Claude Baron
Summary: The study retrospectively examined [F-18]FDG-PET/CT scans of patients with probable CAA and those with no lCMBs meeting AD criteria. The results showed a significantly lower O/PC ratio in CAA patients compared to AD patients, suggesting that [F-18]FDG-PET may be helpful in differentiating between the two conditions.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Senade Atsou, Fiona Furlan, Jerome Duchemin, Syrine Ellouze, Elise Sourdeau, Amelie Launois, Valerie Roussel-Robert, Natalie Stieltjes, Sophie Combe, Michaela Fontenay, Emmanuel Curis, Georges Jourdi
Summary: Eftrenonacog-alfa, a recombinant factor IX-Fc fusion protein, was assessed for its pharmacodynamic characteristics in severe hemophilia B patients. Thrombin generation assay (TGA) was found to be a valuable tool for evaluating hemostasis balance in treated patients.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Hematology
Geoffrey Foulon-Pinto, Georges Jourdi, Julien Perrin, Johan Abdoul, Guillaume Paris, Isabelle Gouin-Thibault, Emmanuel Curis, Thomas Lecompte, Virginie Siguret
Summary: ST Genesia system showed reliable measurement of TG parameters in both in vitro and ex vivo xaban plasma samples, with the use of reference plasma improving standardization and inter-laboratory comparisons. The system demonstrated good agreement with the CAT method, despite some observed biases in peak height and endogenous thrombin potential values.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Article
Biology
D. Grillault Laroche, E. Curis, F. Bellivier, C. Nepost, G. Gross, B. Etain, C. Marie-Claire
Summary: This study found that childhood maltreatment, especially physical abuse, may influence the circadian rhythm system by affecting the expression levels of PPARGC1A. Other subtypes of childhood maltreatment and sleep quality did not have a significant impact on the network of circadian gene expression. This result supports the hypothesis of the influence of childhood maltreatment exposure on circadian systems and emphasizes the importance of PPARGC1A in these processes.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Letter
Medical Laboratory Technology
Mikael Laredo, Emmanuel Curis, Elisabeth Masson-Fron, Sebastian Voicu, Bruno Megarbane
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Neurosciences
Camille Taccola, Pascal Barneoud, Sylvaine Cartot-Cotton, Delphine Valente, Nathalie Schussler, Bruno Saubamea, Stephanie Chasseigneaux, Veronique Cochois, Virginie Mignon, Emmanuel Curis, Murielle Lochus, Sophie Nicolic, Agnes Dodacki, Salvatore Cisternino, Xavier Decleves, Fanchon Bourasset
Summary: The inducible p25 overexpression mouse model showed no significant alterations in brain vascular surface area and BBB physical integrity, but a 14% decrease in cerebrovascular volume in 6 weeks ON mice, possibly due to a 27% increase in collagen IV in brain capillaries. Additionally, a 17% reduction in D-glucose brain uptake was observed in 6 weeks ON p25 mice, indicating impaired BBB transport function.
Article
Obstetrics & Gynecology
Olivier Serres-Cousine, Fiene Marie Kuijper, Emmanuel Curis, Diana Atashroo
Summary: In this study, clinical symptoms improved in 91.2% of female patients of childbearing age after uterine artery embolization, with no major complications. One year post-surgery, there was a significant reduction in myoma volume and a high pregnancy and live birth rate, with a focus on uterine anatomy restoration and ovarian protection for obstetrical success.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Editorial Material
Obstetrics & Gynecology
Olivier Serres-Cousine, Fiene Marie Kuijper, Emmanuel Curis, Diana Atashroo
Summary: Uterine fibroids are the most common tumors of the reproductive tract and can cause symptoms in women of reproductive age, affecting fertility, pregnancy, and childbirth.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2022)
Article
Substance Abuse
El-Hadi Zerdazi, Emmanuel Curis, Emily Karsinti, Romain Icick, Maeva Fortias, Philippe Batel, Olivier Cottencin, Cyrille Orizet, Aurelia Gay, Philippe Coeuru, Alice Deschenau, Philippe Lack, Delphine Moisan, Anne-Laure Pelissier-Alicot, Arnaud Plat, Jean-Baptiste Trabut, Isabelle Kousignian, Luana Boumendil, Eric Vicaut, Nathalie Prince, Jean-Louis Laplanche, Frank Bellivier, Jean-Pierre Lepine, Cynthia Marie-Claire, Georges Brousse, Florence Vorspan, Vanessa Bloch
Summary: This study finds that the occurrence and severity of cocaine-induced transient hallucinations (CIH) are two distinct phenotypes in cocaine users. Cocaine dependence, number of dependence criteria, and frequency of use during the worst period of misuse are significantly associated with the occurrence and severity of CIH.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Clinical Neurology
Luisa Alessandra Atehortua Martinez, Emmanuel Curis, Nawel Mekdad, Claire Larrieu, Cindie Courtin, Laurent Jourdren, Corinne Blugeon, Jean-Louis Laplanche, Bruno Megarbane, Cynthia Marie-Claire, Nadia Benturquia
Summary: The study investigated the variability in the expression of the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm and identified differentially expressed genes in the nucleus accumbens (NAc) between rats that did or did not express cocaine-induced place preference. The findings provide insights into the mechanisms underlying interindividual variability in response to cocaine's rewarding effects, with immediate early genes showing differential expression in CPPE rats.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Hematology
Geoffrey Foulon-Pinto, Carmelo Lafuente-Lafuente, Georges Jourdi, Julien Le Guen, Fatoumata Tall, Etienne Puymirat, Maxime Delrue, Lea Riviere, Flora Ketz, Isabelle Gouin-Thibault, Francois Mullier, Pascale Gaussem, Eric Pautas, Thomas Lecompte, Emmanuel Curis, Virginie Siguret
Summary: This study investigated the pharmacokinetics, pharmacodynamics, and clinical outcomes of direct oral anticoagulants in very elderly atrial fibrillation in-patients. The results showed significant inter-individual variability in drug concentrations and thrombin generation, highlighting the need for further research on the clinical implications of these findings.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Pharmacology & Pharmacy
Lea Darnaud, Clement Delage, Youssef Daali, Anne-Priscille Trouvin, Serge Perrot, Nihel Khoudour, Nadia Merise, Laurence Labat, Bruno Etain, Frank Bellivier, Celia Lloret-Linares, Vanessa Bloch, Emmanuel Curis, Xavier Decleves
Summary: Drug-metabolizing enzymes and drug transporters play crucial roles in drug pharmacokinetics and response. The cocktail-based phenotyping approach involves administering multiple probe drugs to evaluate the activities of CYP and transporter simultaneously. This study determined the range of phenotyping indices in healthy volunteers and classified patients with therapeutic issues based on CYP and P-gp activities.
Article
Hematology
Ambre de Fautereau-Vassel, Antoine Mokhtarian, Manon Mangenot, Ombeline Krekounian, Isabelle Kousignian, Xavier Delavenne, Emmanuel Curis, Isabelle Gouin-Thibault, Virginie Siguret
Summary: This study compared three methods for measuring dabigatran plasma levels and found that both the dTT and ECA-II assays were accurate and consistent in clinical practice, particularly in emergency situations.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)