Article
Neurosciences
Mario Gil, Ney Alliey-Rodriguez, Juan Carlos Lopez-Alvarenga, Vincent Diego, Ciro A. Gaona, Ledys Mata, Rosa Pirela, Carlos A. Chavez, Gabriel A. de Erausquin, Jesus D. Melgarejo, Gladys E. Maestre
Summary: Neuropsychiatric symptoms such as disturbed sleep, anxiety, and depression were found to be common in Hispanics with cognitive impairment and dementia. These symptoms were significantly associated with cognitive impairment and dementia, with the addition of NPI items improving the discrimination of severe cognitive impairment and dementia in primary care settings.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Psychology, Clinical
Nikias Siafarikas, Dag Alnaes, Jennifer Monereo-Sanchez, Martina J. Lund, Geir Selbaek, Maria Stylianou-Korsnes, Karin Persson, Maria Lage Barca, Ina Selseth Almdahl, Tormod Fladby, Dag Aarsland, Ole A. Andreassen, Lars T. Westlye
Summary: This study explored the associations between neuropsychiatric symptoms (NPS) and brain morphology in patients with mild cognitive impairment (MCI) and Alzheimer's disease with dementia (AD dementia). Several NPS factors related to brain morphology were identified, contributing to a better understanding of the NPS brain mechanisms in MCI and AD dementia patients. The findings suggest different mechanisms of NPS in MCI and AD dementia samples, indicating potential implications for diagnosis and treatment.
INTERNATIONAL PSYCHOGERIATRICS
(2021)
Article
Geriatrics & Gerontology
Masaki Shinohara, Kana Matsuda, Yuichiro Ii, Ken-ichi Tabei, Naoko Nakamura, Yoshinori Hirata, Hidehiro Ishikawa, Hirofumi Matsuyama, Keita Matsuura, Masayuki Maeda, Hidekazu Tomimoto, Akihiro Shindo
Summary: This study investigated the relationship between behavioral and psychological symptoms (BPS) and cerebral small vessel disease (SVD) in patients with mild cognitive impairment (MCI) or mild dementia. The results showed that patients with BPS had worse clinical dementia ratings, reduced psychomotor speed, higher modified CAA-SVD scores, and larger numbers of cerebral microbleeds (CMBs). Therefore, preventing these brain lesions may help mitigate the risk of BPS.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Psychology, Clinical
Paul C. Donaghy, Joanna Ciafone, Rory Durcan, Calum A. Hamilton, Sally Barker, Jim Lloyd, Michael Firbank, Louise M. Allan, John T. O'Brien, John-Paul Taylor, Alan J. Thomas
Summary: MCI-LB is characterized by more neuropsychiatric symptoms compared to MCI-AD. The presence of two or more neuropsychiatric supportive symptoms as defined by MCI-LB diagnostic criteria is highly specific and moderately sensitive for a diagnosis of MCI-LB. The cognitive profile of MCI-LB differs from MCI-AD.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Clinical Neurology
Maria Clara Zanon Zotin, Lukas Sveikata, Anand Viswanathan, Pinar Yilmaz
Summary: Recent developments in the field of small vessel disease (SVD)-related vascular cognitive impairment have highlighted the importance of standardized diagnosis, aggressive management of cardiovascular risk factors, and the need for disease-modifying treatments. Advances in imaging techniques provide valuable tools for early diagnosis and monitoring of cognitive decline.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Clinical Neurology
Paul C. C. Donaghy, Calum Hamilton, Rory Durcan, Sarah Lawley, Sally Barker, Joanna Ciafone, Nicola Barnett, Kirsty Olsen, Michael Firbank, Gemma Roberts, Jim Lloyd, Louise M. M. Allan, Ranjan Saha, Ian G. G. McKeith, John T. T. O'Brien, John-Paul Taylor, Alan J. J. Thomas
Summary: Through the investigation of patients with mild cognitive impairment with Lewy bodies (MCI-LB), it was found that MCI-LB patients have more symptoms, and a 10-point symptom scale can effectively differentiate MCI-LB and MCI-AD. These findings are important for clinicians to diagnose and treat MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Natalia Roberto, Maria J. Portella, Marta Marquie, Montserrat Alegret, Isabel Hernandez, Ana Mauleon, Maitee Rosende-Roca, Carla Abdelnour, Ester Esteban de Antonio, Silvia Gil, Juan P. Tartari, Liliana Vargas, Ana Espinosa, Gemma Ortega, Alba Perez-Cordon, Angela Sanabria, Adelina Orellana, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Emilio Alarcon-Martin, Agustin Ruiz, Lluis Tarraga, Merce Boada, Sergi Valero
Summary: Neuropsychiatric symptoms (NPS) have been identified as risk factors for conversion to Alzheimer's disease (AD) and other dementia types in patients with Mild Cognitive Impairment (MCI). Four NPS profiles emerged based on prominent symptoms in MCI patients, with Irritability and Apathy being predictors of dementia conversion. The findings suggest that NPS can be used as early diagnosis facilitators and to identify different illness trajectories in MCI progression.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Wietse A. Wiels, Mandy M. J. Wittens, Dieter Zeeuws, Chris Baeken, Sebastiaan Engelborghs
Summary: The study suggests that as cognitive impairment progresses, neuropsychiatric symptoms such as apathy, agitation, aggression, and activity disturbances increase, while affective symptoms like anxiety and depressive symptoms remain relatively stable. The research findings also indicate that there are no significant differences in neuropsychiatric symptoms between pure AD and AD with a significant vascular component.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Fennie Choy Chin Wong, Chathuri Yatawara, Audrey Low, Heidi Foo, Benjamin Yi Xin Wong, Levinia Lim, Brian Wang, Dilip Kumar, Kok Pin Ng, Nagaendran Kandiah
Summary: The investigation revealed that hippocampal subfield atrophy worsened with increasing severity of small vessel disease. Positive SVD-HSA was characterized by significant atrophy in specific subfields, with greater atrophy seen in moderate to severe SVD compared to mild SVD. Atrophy in these subfields of SVD-HSA was significantly associated with poor episodic memory and frontal executive function.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Geriatrics & Gerontology
Laura Vernuccio, Davide Sara, Florenza Inzerillo, Giuseppina Catanese, Angela Catania, Miriam Vesco, Federica Cacioppo, Ligia J. Dominguez, Nicola Veronese, Mario Barbagallo
Summary: This study investigated the impact of the COVID-19 quarantine on older people with dementia/MCI in Palermo, Sicily. Results showed a significant decline in functional and cognitive status, as well as increased neuropsychiatric symptoms and caregiver stress during the quarantine period. The decline was more pronounced in individuals with milder dementia, and higher baseline instrumental activities of daily living were associated with lower worsening in neuropsychiatric symptoms and caregiver stress.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Woori Moon, Ji Won Han, Jong Bin Bae, Seung Wan Suh, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim
Summary: This study investigated the disease burden of various dementias and mild cognitive impairment in a representative South Korean population, predicting a significant increase in disability-adjusted life-years and years lived with disability due to these conditions by 2065.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Clinical Neurology
Maryam Ghahremani, Meng Wang, Hung-Yu Chen, Henrik Zetterberg, Eric Smith, Zahinoor Ismail
Summary: This study investigated the association between mild behavioral impairment (MBI) and plasma p-tau181 levels, cognitive function changes, and the risk of developing Alzheimer's disease (AD). The findings showed that compared to individuals with no behavioral symptoms, those with MBI had higher levels of p-tau181, which was associated with declined memory and executive function, and an increased risk of developing AD.
Review
Clinical Neurology
Olivia K. L. Hamilton, Ellen V. Backhouse, Esther Janssen, Angela C. C. Jochems, Caragh Maher, Tuula E. Ritakari, Anna J. Stevenson, Lihua Xia, Ian J. Deary, Joanna M. Wardlaw
Summary: This paper proposes an update on the characterization of cognitive impairments associated with sporadic cerebral small vessel disease (SVD) and suggests the use of comprehensive cognitive assessments and the measurement of educational level in clinics and research settings. The study indicates that SVD affects all major domains of cognitive ability and low levels of education could be a modifiable risk factor for SVD-related cognitive impairment.
ALZHEIMERS & DEMENTIA
(2021)
Article
Cardiac & Cardiovascular Systems
Russell P. Sawyer, Bradford B. Worrall, Virginia J. Howard, Michael G. Crowe, George Howard, Hyacinth I. Hyacinth
Summary: This study aims to examine the racial disparity in the prevalence and trajectory of vascular cognitive impairment and dementia in non-Hispanic White and non-Hispanic Black participants. It will focus on the role of cerebral small vessel disease and genetic risk factors for Alzheimer's disease and related dementias.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Geriatrics & Gerontology
Bruna Seixas-Lima, Malcolm E. Binns, Sandra Black, Corinne Fischer, Morris Freedman, Sanjeev Kumar, Durjoy Lahiri, Carlos Tyler Roncero, Stephen F. Strother, David Tang-Wai, Maria Carmela Tartaglia, Howard Chertkow, TDRA Clinical Res Database Grp
Summary: This retrospective case-control study investigated the rate of occurrence of neuropsychiatric symptoms (NPS) in subjects with Alzheimer's disease and related dementias (ADRD) and their relationship with age, sex and cognitive performance. The results showed that younger individuals and females were more likely to have NPS, and anxiety, depression, agitation, and apathy were associated with a higher overall rate of NPS. Additionally, individuals under 65 years of age with NPS had worse cognitive scores, indicating a more aggressive neurodegenerative disease.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)