期刊
CLINICAL NEUROPHYSIOLOGY
卷 125, 期 8, 页码 1626-1638出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2013.12.118
关键词
Attention-deficit/hyperactivity disorder; Electroencephalography; Eyes-closed resting-state; Support vector machine; Linear regression; Development
资金
- University Research Priority Program Integrative Human Physiology
Objective: Objective biomarkers for attention-deficit/hyperactivity disorder (ADHD) could improve diagnostics or treatment monitoring of this psychiatric disorder. The resting electroencephalogram (EEG) provides non-invasive spectral markers of brain function and development. Their accuracy as ADHD markers is increasingly questioned but may improve with pattern classification. Methods: This study provides an integrated analysis of ADHD and developmental effects in children and adults using regression analysis and support vector machine classification of spectral resting (eyes-closed) EEG biomarkers in order to clarify their diagnostic value. Results: ADHD effects on EEG strongly depend on age and frequency. We observed typical non-linear developmental decreases in delta and theta power for both ADHD and control groups. However, for ADHD adults we found a slowing in alpha frequency combined with a higher power in alpha-1 (8-10 Hz) and beta (13-30 Hz). Support vector machine classification of ADHD adults versus controls yielded a notable cross validated sensitivity of 67% and specificity of 83% using power and central frequency from all frequency bands. ADHD children were not classified convincingly with these markers. Conclusions: Resting state electrophysiology is altered in ADHD, and these electrophysiological impairments persist into adulthood. Significance: Spectral biomarkers may have both diagnostic and prognostic value. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved
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