期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 29, 页码 8449-8453出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201502430
关键词
antioxidants; DNA damage; glutathione peroxidase; reactive oxygen species; selenium
资金
- Department of Science and Technology (DST)
- Department of Biotechnology (DBT), New Delhi
- CSIR
- DST-INSPIRE
Novel isoselenazoles with high glutathione peroxidase (GPx) and peroxiredoxin (Prx) activities provide remarkable cytoprotection to human cells, mainly by exhibiting antioxidant activities in the presence of cellular thiols. The cytotoxicity of the isoselenazoles is found to be significantly lower than that of ebselen, which is being clinically evaluated by several groups for the treatment of reperfusion injuries and stroke, hearing loss, and bipolar disorder. The compounds reported in this paper have the potential to be used as therapeutic agents for disorders mediated by reactive oxygen species.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据