期刊
CLINICAL NEUROPHYSIOLOGY
卷 122, 期 8, 页码 1595-1601出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2011.01.010
关键词
Rigidity; Parkinson's disease; Contralateral activation; Dopaminergic medication
资金
- National Institutes of Health [R15-HD061022, R15-HD061022-S1]
Objective: Quantify the enhancement of parkinsonian rigidity associated with a contralateral activation maneuver. Methods: Twelve subjects with PD and eight controls participated in the study protocol. Subjects' tested hand was displaced by a servo-motor throughout wrist flexion and extension motions of 60 degrees without and with a concurrent gripping activation in the contralateral hand, referred to as Passive and Active conditions, respectively. Subjects with PD were tested in both OFF-MED and ON-MED states. Rigidity was quantified by integrating torque with position during both flexion and extension (torque resistance). ANOVA was performed to assess the effect of contralateral activation on rigidity. Results: PD patients had significantly (0.038) enhanced torque resistance in OFF-MED compared to healthy controls and ON-MED. In the Active condition, differences in torque resistance were magnified (p = 0.002). Medication substantially reduced differences in torque resistance between controls and PD patients in the Passive and Active conditions. Conclusions: A contralateral activation maneuver substantially increases rigidity in patients with PD, specifically the OFF-MED state. Rigidity is reduced with the application of dopaminergic medication, even with the presence of a contralateral activation maneuver. Significance: These data support the use of a contralateral activation maneuver as a tool in the diagnosis of PD. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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