Review
Neurosciences
Danny Adrian Spampinato, Jaime Ibanez, Lorenzo Rocchi, John Rothwell
Summary: Transcranial magnetic stimulation (TMS) is a non-invasive technique used to study the human brain. One outcome measure of TMS is the motor-evoked potential (MEP), which estimates changes in corticospinal excitability. This article summarizes the neural pathways and circuits contributing to MEP generation, discusses factors to consider when interpreting MEP amplitude in motor processing and neurological conditions, and explores how emerging technologies can enhance understanding of neural substrates influencing MEPs.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Neurosciences
Michal Demjan, Laura Saisanen, Jusa Reijonen, Saara Rissanen, Sara Maattaa, Petro Julkunen
Summary: Transcranial magnetic stimulation (TMS) can be used to induce motor evoked potentials (MEPs). This study aimed to characterize the individual near-threshold recruitment of MEPs and determine the proper suprathreshold stimulation intensity (SI). The study found that individual near-threshold characteristics significantly influenced MEP production at suprathreshold SIs and emphasized the importance of selecting the appropriate SI for TMS applications.
Article
Neurosciences
Katarina Hosel, Francois Tremblay
Summary: This study investigates the lasting facilitation of corticospinal excitability induced by 30 Hz/6 Hz iTBS. Most participants showed MEP facilitation post iTBS, and recruitment of early I-waves appears to predict this facilitation effect.
Article
Clinical Neurology
Kathrin Machetanz, Lasse Wiesinger, Maria Teresa Leao, Marina Liebsch, Leonidas Trakolis, Sophie Wang, Alireza Gharabaghi, Marcos Tatagiba, Georgios Naros
Summary: Conventional time-series parameters may not be reliable descriptors of motor-evoked potentials (MEPs) in brain tumor patients, and frequency domain analysis is suggested instead. The time-frequency representation of MEPs provides additional information about the status of the cortico-spinal motor system and its relation to motor performance.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Brice Cleland, Sonia Pradhan, Sangeetha Madhavan
Summary: This study found that performing brief cognitive, voluntary breathing, and stretching tasks before transcranial magnetic stimulation (TMS) can reduce the variability of motor evoked potentials (MEPs) with no effect on MEP amplitude.
Article
Clinical Neurology
Kathrin Machetanz, Alberto L. Gallotti, Maria Teresa Leao Tatagiba, Marina Liebsch, Leonidas Trakolis, Sophie Wang, Marcos Tatagiba, Alireza Gharabaghi, Georgios Naros
Summary: The study found no significant differences in time series characteristics between brain tumor patients and healthy subjects after transcranial magnetic stimulation mapping. However, in frequency analysis, patients showed a reduction in event-related spectral perturbation (ERSP) at higher frequencies (>100 Hz) and an increase in inter-peak MEP latencies.
FRONTIERS IN NEUROLOGY
(2021)
Review
Neurosciences
Mirja Osnabruegge, Carolina Kanig, Florian Schwitzgebel, Karsten Litschel, Wolfgang Seiberl, Wolfgang Mack, Martin Schecklmann, Stefan Schoisswohl
Summary: This article systematically reviews and evaluates the reliability of motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) as a neurophysiological marker of cortical excitability in clinical and scientific practice, and proposes best-practice recommendations for reliable measurements of MEPs.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Takayuki Toki, Noriaki Fujita, Tomohiro Ichikawa, Noriki Ochi, Isao Yokota, Hideki Sudo, Yuji Morimoto
Summary: Using STS-INP during adolescent scoliosis surgery allows for accurate measurement of TcMEP amplitude without the influence of various intraoperative factors and without complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Behavioral Sciences
Arran T. T. Reader, Sara Coppi, Victoria S. S. Trifonova, H. Henrik Ehrsson
Summary: In this study, the researchers attempted to replicate the reduction in MEP amplitude associated with the rubber hand illusion (RHI) and identify the components of the illusion that might explain these changes. Despite participants reporting the presence of the illusion and shifts in perceived real hand position towards the fake limb, no reduction in MEP amplitude was observed.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Georgios Naros, Kathrin Machetanz, Maria Teresa Leao, Sophie Wang, Marcos Tatagiba, Alireza Gharabaghi
Summary: This study investigated the impact of glial brain tumors on the functional corticospinal integrity and found that conventional MEP features were unreliable in reflecting this impact. Frequency-domain MEP features, on the other hand, provided a better assessment of motor impairment.
HUMAN BRAIN MAPPING
(2022)
Article
Engineering, Biomedical
Marco Antonio Cavalcanti Garcia, Jordania Lindolfo-Almas, Renan Hiroshi Matsuda, Vitoria Labiapari Pinto, Anaelli Aparecida Nogueira-Campos, Victor Hugo Souza
Summary: This study aimed to evaluate the effect of three different sEMG electrode montages on the MEP amplitude. The results showed that different electrode montages can provide contrasting MEP amplitudes, highlighting the need for standard recommendations on electrode placement for MEP recordings.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Engineering, Biomedical
Robert Guggenberger, Bettina Hanna Trunk, Sine Canbolat, Lukas Ziegler, Alireza Gharabaghi
Summary: This study evaluated the reliability and validity of ipsilateral motor-evoked potentials (iMEP) induced by transcranial magnetic stimulation in healthy adults. The results showed significant variations in iMEP estimation between different algorithms, and template-based approaches may be more valid. This is important for the selection and development of analysis algorithms for magnetically induced potentials.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
Sanne Lotte Journee, Henricus Louis Journee, Hanneke Irene Berends, Steven Michael Reed, Wilhelmina Bergmann, Cornelis Marinus de Bruijn, Catherine John Ghislaine Delesalle
Summary: This study provides normative data for trapezius motor evoked potentials (MEP) in horses using transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS). The study also distinguishes between direct and indirect conduction routes using neurophysiological models. The results are important for clinical diagnosis.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Mariagiovanna Cantone, Giuseppe Lanza, Francesco Fisicaro, Rita Bella, Raffaele Ferri, Giovanni Pennisi, Gunnar Waterstraat, Manuela Pennisi
Summary: This study provides a set of age- and height-adjusted reference values for motor evoked potential (MEP) latency, central motor conduction time (CMCT), and peripheral motor conduction time (PMCT). The study also highlights the influence of sex on MEP latency and motor conduction time. These reference values are important for clinical studies and evaluation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Jessica M. Ross, Recep A. Ozdemir, Shu Jing Lian, Peter J. Fried, Eva M. Schmitt, Sharon K. Inouye, Alvaro Pascual-Leone, Mouhsin M. Shafi
Summary: This study aims to separate the auditory evoked potential (AEP) from transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) using independent component analysis (ICA) and evaluate the effectiveness of this procedure. The results show that removing AEP significantly reduces the global and local mean field power of TEPs and decreases the similarity between TEPs of different subjects and stimulation conditions. The residual TEPs have unique characteristics that are different from AEPs and may provide insights into TMS-evoked potentials and other modulated oscillatory dynamics.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)