期刊
CLINICAL NEUROPHYSIOLOGY
卷 120, 期 4, 页码 834-839出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2009.02.001
关键词
TMS; Motor cortex; GABA; I-waves; Dystonia
Objective: A loss of inhibition in central motor circuits resulting in abnormal motor control is the hypothesised cause of dystonia. So far, changes in inhibitory function of cerebral cortex in dystonia, have been revealed only indirectly by recording muscle responses evoked by transcranial magnetic stimulation (TMS) of the brain. The aim of present study was to evaluate more directly cerebral cortex changes in dystonia. We had the almost unique opportunity to record directly motor cortex output after brain stimulation, in a dystonic patient who had epidural electrodes implanted in the upper cervical cord. Methods: We evaluated descending activity evoked by single and paired pulse TMS together with the inhibitory effects produced by afferent stimuli on TMS evoked activity, and compared the results with those obtained in thirteen subjects with no central nervous system abnormality who also had cervical spinal electrodes. Results: The intrinsic inhibitory activity produced by paired TMS of the motor cortex, and the inhibitory effects produced by afferent inputs, were suppressed in the patient with dystonia. Conclusions: These findings provide a direct evidence of the abnormality in motor cortex inhibitory systems in dystonia. Significance: The abnormality in cortical inhibitory system might have a role in the pathophysiology of dystonia. (C) 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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