Article
Clinical Neurology
Gulcin Benbir Senel, Esra Kochan Kizilkilic, Derya Karadeniz
Summary: The study revealed that Restless Sleep Disorder (RSD) had a significant prevalence among children with NREM parasomnias, leading to poorer sleep quality and increased arousal reactions.
Review
Medicine, General & Internal
Carlotta Mutti, Irene Pollara, Anna Abramo, Margherita Soglia, Clara Rapina, Carmela Mastrillo, Francesca Alessandrini, Ivana Rosenzweig, Francesco Rausa, Silvia Pizzarotti, Marcello luigi Salvatelli, Giulia Balella, Liborio Parrino
Summary: Obstructive sleep apnea (OSA) is a worldwide disorder that deeply affects the sleeping brain. In recent years, efforts have been made to find new measures to assess the real impact and severity of OSA, which has been traditionally trivialized by the simplistic apnea/hypopnea index. This review focuses on the role of cyclic alternating pattern (CAP) in linking the breathing disorder with sleep pathophysiology, emphasizing that sleep structure can provide valuable information to stratify OSA severity and predict its dangerous consequences.
Article
Multidisciplinary Sciences
Simon Hartmann, Raffaele Ferri, Oliviero Bruni, Mathias Baumert
Summary: This study investigates the causal relationships between cortical and cardiovascular activities during sleep, revealing a stronger influence of delta activity and more pronounced changes in autonomic activity during rapid, high-amplitude EEG activation phases. This has implications for understanding the level of decoupling in sleep disorders.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2021)
Article
Clinical Neurology
Silvia Miano, Anna Castelnovo, Oliviero Bruni, Mauro Manconi
Summary: The analysis focused on the sleep microstructure in children with ADHD, revealing different patterns associated with sleep disorders such as obstructive sleep apnea. Children with obstructive sleep apnea showed a significantly higher rate of cyclic alternating pattern, while those without epileptic abnormalities or sleep apnea had lower rates. This study suggests the possibility of differentiating primary forms of ADHD based on NREM instability and its associations with sleep apnea and epileptic activity.
JOURNAL OF SLEEP RESEARCH
(2022)
Review
Clinical Neurology
Wei-Chih Yeh, Huan-Jan Lin, Ying-Sheng Li, Ching-Fang Chien, Meng-Ni Wu, Li-Min Liou, Cheng-Fang Hsieh, Chung-Yao Hsu
Summary: Patients with epilepsy experience sleep instability, particularly during non-rapid eye movement (NREM) sleep. Medications may decrease this instability but do not alter the microstates of sleep.
Article
Behavioral Sciences
Maurizio Gorgoni, Andrea Galbiati
Summary: Isolated Rapid Eye Movement Sleep (REM) behaviour disorder (iRBD) can serve as a prodromal sign of neurodegenerative disorders. Research on NREM sleep electroencephalography (EEG) in iRBD is increasing gradually. Studies mainly focus on alterations in sleep spindles and cyclic alternating pattern, with varying results on slow wave activity.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Cell Biology
Chiara Cirelli, Giulio Tononi
Summary: Sleep is necessary for renormalizing synaptic weights after learning, which is a smart process of synaptic down-selection, explaining the beneficial effects of sleep on cognition. While some molecular mechanisms have been identified, others are still being investigated to understand how most synapses are weakened during sleep while some are protected.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Yi Zhou, Hui Li, Yanlu Jia, Jun Wu, Jinshuai Yang, Chunling Liu
Summary: This study analyzed the microstructural features of sleep in patients with vestibular migraine and migraine, and hypothesized the pathophysiological mechanism between vestibular migraine and sleep disorders. The results showed that patients with vestibular migraine had poor sleep quality, thalamic-cortical hyperfunction, and an active arousal system.
Article
Clinical Neurology
Valentina Gnoni, Panagis Drakatos, Sean Higgins, Iain Duncan, Danielle Wasserman, Renata Kabiljo, Carlotta Mutti, Peter Halasz, Peter J. Goadsby, Guy D. Leschziner, Ivana Rosenzweig
Summary: Obstructive sleep apnea is associated with various health issues and studies have shown different patterns of cyclic alternating pattern subtypes in relation to severity of the condition.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Chemistry, Analytical
Jiajia Cui, Zhipei Huang, Jiankang Wu
Summary: The cyclic alternating pattern is a periodic electroencephalogram activity that occurs during sleep and is correlated with sleep-related pathologies. In this study, the feasibility of using cardiopulmonary features to automatically detect the cyclic alternating pattern and diagnose sleep-related pathologies is explored. By analyzing and comparing the cardiopulmonary characteristics of different groups, an automatic recognition scheme is proposed. The scheme combines statistical models and machine learning algorithms to achieve high recognition rates for sleep-wake classification and disease diagnosis.
Article
Biology
Jiaxin You, Yu Ma, Yuanyuan Wang
Summary: This paper proposes an automated method to detect CAP using a Transformer-based U-Net framework, achieving improved performance by extracting local information and providing global dependencies.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Clinical Neurology
Elisabetta Verrillo, Martino Pavone, Oliviero Bruni, Raffaele Ferri, Maria Beatrice Chiarini Testa, Claudio Cherchi, Adele D'Amico, Renato Cutrera
Summary: The aim of this study is to assess the effects of Nusinersen on sleep architecture and microstructure in patients with spinal muscular atrophy. The results showed that Nusinersen significantly reduced sleep latency and improved sleep efficiency, but had no significant effect on sleep microstructure.
Article
Chemistry, Analytical
Won-Ho Jun, Hyung-Ju Kim, Youn-Sik Hong
Summary: Sleep plays a significant role in an individual's life and is an indicator of health. Both the duration and quality of sleep are important for maintaining good health. Sleep patterns are influenced by genetic factors and it is necessary to analyze if individual sleep patterns ensure sufficient sleep.
Article
Clinical Neurology
Gulcin Benbir Senel, Aysun Tunali, Derya Karadeniz, Lourdes M. DelRosso
Summary: This study investigated the frequency and characteristics of restless sleep disorder (RSD) among children with epileptic and non-epileptic nocturnal attacks. The results showed that children with sleep-related epilepsy had significantly higher levels of RSD compared to other groups. The prevalence of restless sleep disorder was higher in children with sleep-related epilepsy and it was associated with an increased cyclic alternating pattern.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
B. L. M. Ramos, A. M. B. Umemura, O. Bruni, J. F. de Souza, J. V. N. B. Menezes
Summary: This study evaluated the prevalence of sleep disorders in Brazilian preschool children and found a high prevalence rate. It also found significant associations between parental report of dental pain and discomfort and sleep disorders in these children.
EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY
(2023)
Article
Clinical Neurology
Oliviero Bruni
Summary: The purpose of this review is to provide updated information on the diagnosis and treatment of excessive daytime sleepiness (EDS) in children and adolescents to pediatric neurologists. EDS is an emerging problem for the health system due to changes in societal habits. The evaluation of EDS is often lacking in the current literature. EDS is commonly reported as a side effect of other sleep disorders or as a consequence of poor sleep habits. It can manifest with symptoms such as hyperactivity and inattention in children. The diagnosis should include subjective and objective measures to avoid misdiagnosis. Particularly, early and correct treatment is crucial for the psychosocial development of children and adolescents with narcolepsy and other forms of EDS.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2023)
Article
Clinical Neurology
Lourdes M. DelRosso, Jodi Mindell, Oliviero Bruni, Maria P. Mogavero, Raffaele Ferri
Summary: Sleep disturbances are common in infants, and sleep-related movement disorders can contribute to sleep disruption. This study found that preterm infants had higher periodic limb movement index and lower ferritin levels compared to infants with Down syndrome, Prader-Willi syndrome, or without diagnosis. Hemoglobin and ferritin were negatively correlated with periodic limb movement index, and iron deficiency is associated with increased leg movements during sleep in infants.
JOURNAL OF SLEEP RESEARCH
(2023)
Letter
Clinical Neurology
Raffaele Ferri, Simon J. G. Lewis, Valerie Cochen De Cock, Naoko Tachibana, Clete A. Kushida, Carlos H. Schenck
Article
Clinical Neurology
Maria Grazia Melegari, Raffaele Ferri, Martina Giallonardo, Renato Donfrancesco, Oliviero Bruni
Summary: This study aimed to explore how changes in sleep patterns and sleep problems during the Covid-19 lockdown period affected the mood-behavioral functioning of children with ADHD. The results showed that sleep problems had a negative impact on the internalizing and externalizing behaviors of children with ADHD, but the effects varied depending on the specific sleep problems.
Article
Clinical Neurology
Giuliano De Meo, Melania Martucci, Maria Ausilia Musumeci, Miriam Aric, Martina Forlani, Lourdes M. DelRosso, Raffaele Ferri, Oliviero Bruni
Summary: Restless sleep disorder (RSD) is a separate condition characterized by frequent large muscle movements (LMM) per hour of sleep. This study compared the scoring of LMM using video-PSG (vPSG) and PSG criteria in children with RSD. Results showed that PSG criteria detected more LMM than vPSG, indicating higher sensitivity. These findings suggest that PSG criteria should be considered for inclusion in the current sleep scoring manual.
Review
Biochemistry & Molecular Biology
Alice Innocenti, Giuliana Lentini, Serena Rapacchietta, Paola Cinnirella, Maurizio Elia, Raffaele Ferri, Oliviero Bruni
Summary: The sleep-wake cycle is regulated by a variety of neurotransmitters, which are in turn influenced by different nutrients. Good sleep quality is crucial for children's development, but an increasing number of children suffer from sleep disorders. Behavioral interventions and supplements, such as iron and antihistamines, are recommended as the first line treatment. This systematic review aims to evaluate the role of key nutrients involved in sleep-regulating pathways and their application in managing pediatric sleep disorders, providing a practical guide for clinicians.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Walter Currenti, Justyna Godos, Amer M. Alanazi, Giuseppe Lanza, Raffaele Ferri, Filippo Caraci, Giuseppe Grosso, Fabio Galvano, Sabrina Castellano
Summary: The increase in life expectancy has led to a higher prevalence of age-related neurological diseases, such as cognitive impairment, dementia, and Alzheimer's disease. This study aimed to examine the association between specific categories and subcategories of dietary fats and cognitive status in older Italian adults. The results showed that moderate consumption of certain types of saturated fatty acids and monounsaturated fatty acids was associated with a lower risk of cognitive impairment, while moderate intake of linoleic acid was associated with a higher risk of cognitive impairment.
Article
Biochemistry & Molecular Biology
Akeem Sanni, Mona Goli, Jingfu Zhao, Junyao Wang, Chloe Barsa, Samer El Hayek, Farid Talih, Bartolo Lanuzza, Firas Kobeissy, Giuseppe Plazzi, Monica Moresco, Stefania Mondello, Raffaele Ferri, Yehia Mechref
Summary: This study aimed to identify potential serum biomarkers for narcolepsy type 1 (NT1), a life-threatening disorder characterized by a sleep-wake cycle disorder. A proteomics analysis was conducted, which revealed 36 differentially expressed proteins associated with NT1. These findings provide insights into the pathophysiological effects and important biochemical pathways involved in NT1.
Article
Clinical Neurology
Katerina Bernardi, Federica Prono, Ginevra Bruni, Simonetta Panerai, Raffaele Ferri, Oliviero Bruni
Summary: This study investigated the prevalence of sleep disturbances in individuals with autism and its impact on the family. The results showed that insomnia was the most common sleep disorder in these individuals, and restless sleep was also prevalent. Parents reported that melatonin was an effective treatment, but insomnia negatively affected their children's behavior and family life.
Review
Nutrition & Dietetics
Maria P. Mogavero, Justyna Godos, Giuseppe Grosso, Filippo Caraci, Raffaele Ferri
Summary: This review focuses on the relationship between sleep-wake regulation and appetite control, emphasizing the inhibitory effect of OREXIN, a neurotransmitter, on REM sleep. It further examines the intricate relationship between OREXIN, REM sleep, and appetite regulation, shedding light on their interconnected nature in both physiological conditions and diseases. Understanding this complex relationship is crucial for unraveling the mechanisms underlying sleep-wake patterns and metabolic control, and for developing novel therapeutic approaches to sleep disorders and metabolic conditions associated with OREXIN dysregulation.
Article
Cell Biology
Emanuele G. Coci, Ornella Galesi, Thomas Morgan, Sabrina Giglio, Elsebet Ostergaard, Maurizio Elia
Summary: Neurodevelopmental syndromes caused by copy number variation are well-known in clinical settings. However, there is limited understanding of the unbalanced expression of long noncoding RNAs. This study investigates the clinical consequences of heterozygous deletion of long noncoding RNA AK127244, either isolated or combined with partial NRXN1 deletion, in individuals with nonsyndromic neurodevelopmental delay. The retrospective study analyzes a bicentric cohort of four individuals, including two siblings, with isolated heterozygous deletion in long noncoding RNA AK127244.
CYTOGENETIC AND GENOME RESEARCH
(2023)
Article
Clinical Neurology
Oliviero Bruni, Maria Breda, Emanuela Malorgio, Paolo Brambilla, Flavia Ceschin, Andrea Di Pilla, Maurizio Elia, Raffaele Ferri
Summary: This study aimed to describe the use of melatonin by Italian pediatricians in healthy children with chronic insomnia. The results showed that a high percentage of pediatricians prescribed melatonin, especially in children aged 1-2 years. The most common dosage was 1 mg/day and it was usually recommended to be taken 30 minutes before bedtime. Melatonin was often combined with sleep hygiene and was found to be effective in reducing difficulties falling asleep.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Claudio Babiloni, Claudio Del Percio, Claudia Piervincenzi, Filippo Carducci, Raffaele Ferri, Paolo Onorati, Ginevra Toma, Stefano Ferracuti, Paolo Roma, Valentina Correr, Francesco Di Campli, Antonio Aceti, Marco Salvatore, Andrea Soricelli, Elisabetta Teti, Alfredo Pennica, Loredana Sarmati, Vincenzo Vullo, Gabriella D'Ettorre, Claudio Mastroianni, Nikolaos Petsas, Patrizia Pantano, Roberto Floris, Fabrizio Stocchi, Massimo Andreoni, Giovanni Di Perri, Andrea Calcagno, Giuseppe Noce
Summary: The abnormal connectivity of parietal resting-state electroencephalographic (rsEEG) alpha waves is associated with subcortical white matter vascular lesions in HIV-positive individuals, even without neurocognitive disorders. These rsEEG markers can be used to screen HIV-positive individuals at risk of neurocognitive disorders.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)