Article
Multidisciplinary Sciences
Vonne van Polanen
Summary: The study found that the planning and execution of reach-to-grasp movements do not reliably affect the perception of object size. Even when adjusting the size during grasping, it does not bias the perception of object size or alter discrimination performance.
Review
Psychology, Multidisciplinary
Sonia Betti, Umberto Castiello, Chiara Begliomini
Summary: This review investigates how reach-to-grasp movements are influenced by multisensory information, emphasizing the importance of multisensory elements in shaping prehensile behavior and providing some considerations for future research developments.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
Liansheng Chang, Shahid Hussain Soomro, Hongfeng Zhang, Hui Fu
Summary: Ankfy1 protein plays a critical role in the development and maintenance of Purkinje cells in the cerebellum. Its absence leads to loss of most Purkinje cells in the cerebellum, resulting in impaired motor function.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Madhur Mangalam, Mathew Yarossi, Mariusz P. Furmanek, Eugene Tunik
Summary: The study found that while there were differences in the coordination of reaching-to-grasp movements in virtual and physical environments, there was still a unified control policy governing the initiation of closure in both environments.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Review
Environmental Sciences
Manar Ibdali, Marios Hadjivassiliou, Richard A. Grunewald, Priya D. Shanmugarajah
Summary: Cerebellar degeneration is prevalent in patients with epilepsy, with factors such as temporal lobe epilepsy, poor seizure control, and phenytoin treatment being consistent predictors. Additionally, whole brain and hippocampal atrophy are also identified in patients with epilepsy. Further prospective studies are needed to confirm the predictors and establish pathogenic mechanisms leading to cerebellar insult.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Luke Shaw, Kuan Hong Wang, Jude Mitchell
Summary: Primates have developed sophisticated reaching behaviors for interacting with dynamic objects during foraging. Previous research focused on constrained reaching paradigms, but a recent study in marmoset monkeys showed the predictive aspects of visually guided reaching in a more natural setting. To explore this further, the researchers developed an unrestrained reach-to-grasp task involving live crickets. By using high-speed cameras and machine vision algorithms, they found that reaching for dynamic targets can occur with very short visuo-motor delays, with predictions of future location compensating for these delays. These findings suggest the importance of visual prediction in facilitating online movement adjustments for dynamic prey.
Article
Neurosciences
Sharif I. Kronemer, Mitchell B. Slapik, Jessica R. Pietrowski, Michael J. Margron, Owen P. Morgan, Catherine C. Bakker, Liana S. Rosenthal, Chiadi U. Onyike, Cherie L. Marvel
Summary: Neuropsychiatric symptoms are common in patients with cerebellar ataxia, with 95% experiencing at least one symptom. The most prevalent symptoms include anxiety, depression, nighttime behaviors, irritability, and agitation. Discrepancies in symptom recognition between patients and informants highlight the importance of monitoring psychiatric health in CA patients.
Article
Clinical Neurology
Akihiko Kudo, Hiroaki Yaguchi, Keiko Tanaka, Akio Kimura, Ichiro Yabe
Summary: A retrospective study was conducted in a Japanese hospital to investigate the clinical features of autoimmune cerebellar ataxia (ACA) and differentiate it from neurodegenerative CA. Among the 243 CA patients enrolled, 13 were diagnosed with ACA. ACA showed less cerebellar atrophy compared to CA but had a higher frequency of CSF pleocytosis. Further studies are needed to identify additional clinical features and accurate diagnostic biomarkers for ACA.
JOURNAL OF NEUROLOGY
(2023)
Article
Oncology
Zeynep Ozozen Ayas, Gulgun Uncu
Summary: This article presents a rare case of a patient with paraneoplastic cerebellar degeneration (PCD) and papillary thyroid carcinoma (PTC), highlighting the importance for clinicians to be alert to this rare comorbidity.
Article
Neurosciences
Ewa Niechwiej-Szwedo, Susana Wu, Mina Nouredanesh, James Tung, Lisa W. Christian
Summary: Eye-hand coordination is crucial for performing daily activities accurately, and studies have shown that eye and hand movements are planned in parallel. Efficiency of eye-hand coupling improves during adolescence and is associated with visual acuity, stereoacuity, and accommodative facility in children.
HUMAN MOVEMENT SCIENCE
(2021)
Article
Medicine, General & Internal
Sungeun Hwang, Chang-Hyun Park, Regina Eun-Young Kim, Hyeon Jin Kim, Yun Seo Choi, Sol-Ah Kim, Jeong Hyun Yoo, Ki Wha Chung, Byung-Ok Choi, Hyang Woon Lee
Summary: Structural changes were observed in cerebellar white matter in CMT patients with NEFL mutations, while abnormal diffusion tensor imaging findings were found in specific cerebellar regions associated with NEFL and GJB1 mutations. The presence of cerebellar ataxia was linked to cerebellar white matter abnormalities in the NEFL subgroup, highlighting the importance of neuroimaging in detecting these abnormalities in CMT patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Romina Romaniello, Ludovica Pasca, Elena Panzeri, Fulvio D'Abrusco, Lorena Travaglini, Valentina Serpieri, Sabrina Signorini, Chiara Aiello, Enrico Bertini, Maria Teresa Bassi, Enza Maria Valente, Ginevra Zanni, Renato Borgatti, Filippo Arrigoni
Summary: Pathogenic variants in the ITPR1 gene are associated with autosomal dominant spinocerebellar ataxia. Superior vermian and hemispheric cerebellar atrophy on MRI can be a distinguishing feature of ITPR1-related disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Jennifer Faber, Tamara Schaprian, Koyak Berkan, Kathrin Reetz, Marcondes Cavalcante Franca, Thiago Junqueira Ribeiro Rezende, Jiang Hong, Weihua Liao, Bart Warrenburg, Judith Gaalen, Alexandra Durr, Fanny Mochel, Paola Giunti, Hector Garcia-Moreno, Ludger Schoels, Holger Hengel, Matthis Synofzik, Benjamin Bender, Gulin Oz, James Joers, Jereon J. Vries, Jun-Suk Kang, Dagmar Timmann-Braun, Heike Jacobi, Jon Infante, Richard Joules, Sandro Romanzetti, Jorn Diedrichsen, Matthias Schmid, Robin Wolz, Thomas Klockgether
Summary: The study aimed to quantify regional brain volumes and cervical spinal cord areas in spinocerebellar ataxia type 3 patients using MRI, revealing that tissue loss in the brain and spinal cord starts before ataxia onset in early-stage patients. Pontine volume is identified as a potential imaging biomarker candidate for intervention trials aiming to slow the progression of the disease.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Scott Barbuto, Sheng-Han Kuo, Lauren Winterbottom, Seonjoo Lee, Yaakov Stern, Michael O'Dell, Joel Stein
Summary: A trial comparing home aerobic to balance training in cerebellar ataxia found that home aerobic training had a significant improvement in ataxia symptoms compared to balance training.
Article
Neurosciences
Mange Liu, Haitao Ren, Yicheng Zhu, Siyuan Fan, Lin Bai, Jing Wang, Liying Cui, Hongzhi Guan
Summary: This study reported a large series of autoimmune cerebellar ataxia (ACA) cases in China and analyzed their clinical features, treatment, and outcome. The study found heterogeneity in the clinical features of ACA and emphasized the importance of neuronal antibody testing in its diagnosis. Paraneoplastic cerebellar degeneration (PCD) and primary autoimmune cerebellar ataxia (PACA) were identified as the dominant ACA subtypes, with PCD having a poorer prognosis.
Letter
Cardiac & Cardiovascular Systems
Elke R. Gizewski, Hannes Deutschmann, Michael Knoflach, Lukas Mayer-Suess, Thomas Gattringer
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Neurosciences
Noora Tuovinen, Nursen Yalcin-Siedentopf, Anna-Sophia Welte, Christian M. Siedentopf, Ruth Steiger, Elke R. Gizewski, Alex Hofer
Summary: The study investigated the relationship between personality traits, behavioral measures, and metabolite ratios, finding gender differences in metabolite correlates and personality traits.
Article
Biochemistry & Molecular Biology
Stephanie Mangesius, Lukas Haider, Lukas Lenhart, Ruth Steiger, Ferran Prados Carrasco, Christoph Scherfler, Elke R. Gizewski
Summary: Brain volumetric software is widely used in clinical practice, but the agreement across different software applications is limited. This study found moderate to low agreement among different applications in categorizing hippocampal volumes. Despite the quantitative differences, the volumetric measures derived from different software still differed significantly from the mean value.
Article
Oncology
Martha Nowosielski, Georg Goebel, Sarah Iglseder, Ruth Steiger, Lukas Ritter, Daniel Stampfl, Johanna Heugenhauser, Johannes Kerschbaumer, Elke R. Gizewski, Christian F. Freyschlag, Guenther Stockhammer, Christoph Scherfler
Summary: In this retrospective study, a quantitative textural analysis of apparent diffusion coefficient (ADC) images derived from diffusion weighted MRI (DW-MRI) of single brain metastases (BM) patients from different primary tumors was performed to test whether these imaging parameters may improve established clinical risk models. The results showed that textural analysis of ADC maps in patients with single brain metastases improved established clinical risk models, which may aid in understanding the pathogenesis of BM and selecting patients for new treatment options.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Neuroimaging
Hanna Styczen, Volker Maus, Lukas Goertz, Martin Koehrmann, Christoph Kleinschnitz, Sebastian Fischer, Markus Moehlenbruch, Iris Muehlen, Bernd Kallmuenzer, Franziska Dorn, Asadeh Lakghomi, Matthias Gawlitza, Daniel Kaiser, Joachim Klisch, Donald Lobsien, Stefan Rohde, Gisa Ellrichmann, Daniel Behme, Maximilian Thormann, Fabian Flottmann, Laurens Winkelmeier, Elke R. Gizewski, Lukas Mayer-Suess, Tobias Boeckh-Behrens, Isabelle Riederer, Randolf Klingebiel, Bjoern Berger, Martin Schlunz-Hendann, Dominik Grieb, Ali Khanafer, Richard du Mesnil de Rochemont, Christophe Arendt, Jens Altenbernd, Jan-Ulrich Schlump, Adrian Ringelstein, Vivian Jean Marcel Sanio, Christian Loehr, Agnes Maria Dahlke, Carolin Brockmann, Sebastian Reder, Ulrich Sure, Yan Li, Ruben Muehl-Benninghaus, Thomas Rodt, Kai Kallenberg, Alexandru Durutya, Mohamed Elsharkawy, Paul Stracke, Mathias Gerhard Schumann, Alexander Bock, Omid Nikoubashman, Martin Wiesmann, Hans Henkes, Pascal J. Mosimann, Rene Chapot, Michael Forsting, Cornelius Deuschl
Summary: There is limited data on the frequency and outcome of mechanical thrombectomy (MT) for large vessel occlusion (LVO) in COVID-19 patients. Our multicenter study found that most cases of LVO treated with MT in COVID-19 patients were due to cardioembolic events. While successful reperfusion was achieved in the majority of cases, there was a significant rate of procedure-related complications and poor clinical outcomes, with a high mortality rate.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vincent Beliveau, Christoph Birkl, Ambra Stefani, Elke R. Gizewski, Christoph Scherfler
Summary: The purpose of this study was to accurately predict susceptibility from homodyne-filtered phase images using convolutional neural networks. The results showed that the U-Net model provided more accurate voxel-wise predictions of susceptibility, while the HFP-QSMGAN model had stronger correlations with TGV-QSM in terms of regional estimates of susceptibility.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Clinical Neurology
Andrea Quattrone, Maria G. Bianco, Angelo Antonini, David E. Vaillancourt, Klaus Seppi, Roberto Ceravolo, Antonio P. Strafella, Gioacchino Tedeschi, Alessandro Tessitore, Roberto Cilia, Maurizio Morelli, Salvatore Nigro, Basilio Vescio, Pier Paolo Arcuri, Rosa De Micco, Mario Cirillo, Luca Weis, Eleonora Fiorenzato, Roberta Biundo, Roxana G. Burciu, Florian Krismer, Nikolaus R. McFarland, Christoph Mueller, Elke R. Gizewski, Mirco Cosottini, Eleonora Del Prete, Sonia Mazzucchi, Aldo Quattrone
Summary: This study developed an automated Magnetic Resonance Parkinsonism Index 2.0 (MRPI 2.0) algorithm to differentiate progressive supranuclear palsy-parkinsonism (PSP-P) from Parkinson's disease (PD) and validated its diagnostic performance in two large independent cohorts. The automated MRPI 2.0 showed excellent performance in distinguishing PSP-P from PD and control subjects in both cohorts, suggesting its generalizability. The use of the automated MRPI 2.0 algorithm could standardize measures in patients with PSP-P across centers and have a positive impact on multicenter studies and clinical trials.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Stephanie Alice Treichl, Wing Mann Ho, Ruth Steiger, Astrid Ellen Grams, Andreas Rietzler, Markus Luger, Elke Ruth Gizewski, Claudius Thome, Ondra Petr
Summary: This pilot study evaluated the feasibility and diagnostic potential of early 31P-MRS in patients with aneurysmal subarachnoid hemorrhage (aSAH). The results showed that 31P-MRS can detect significant changes in cerebral energy metabolism in different cerebrovascular territories, providing valuable information for understanding early brain injury.
FRONTIERS IN NEUROLOGY
(2022)
Review
Oncology
Malik Galijasevic, Ruth Steiger, Stephanie Mangesius, Julian Mangesius, Johannes Kerschbaumer, Christian Franz Freyschlag, Nadja Gruber, Tanja Janjic, Elke Ruth Gizewski, Astrid Ellen Grams
Summary: This review provides an insight into the use of magnetic resonance spectroscopy (MRS) in the diagnosis and follow-up of gliomas. It covers both proton and phosphorous MRS techniques in clinical and scientific practice, including preoperative grade prediction and post-treatment follow-up. The review also discusses the current research utility and possible future strategies of proton and phosphorous MRS in glioma research.
Article
Computer Science, Artificial Intelligence
Nadja Gruber, Malik Galijasevic, Milovan Regodic, Astrid Ellen Grams, Christian Siedentopf, Ruth Steiger, Marlene Hammerl, Markus Haltmeier, Elke Ruth Gizewski, Tanja Janjic
Summary: Segmentation of specific brain tissue from MRI volumes is crucial for brain disease diagnosis and monitoring. This paper presents an efficient deep learning approach using CNNs and multi-view segmentation models to improve segmentation performance. The proposed method is evaluated using expert rating and standard evaluation metrics, showing its competitive accuracy and clinical applicability.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2022)
Review
Oncology
Julian Mangesius, Stephanie Mangesius, Matthias Demetz, Christian Uprimny, Gianpaolo Di Santo, Malik Galijasevic, Danijela Minasch, Elke R. Gizewski, Ute Ganswindt, Irene Virgolini, Claudius Thome, Christian F. Freyschlag, Johannes Kerschbaumer
Summary: Radiation necrosis is a common problem in neuro-oncology, and interdisciplinary collaboration is necessary for image interpretation and patient management. This article provides an institutional guideline for using current imaging tools to differentiate radiation necrosis from tumor recurrence, and discusses therapeutic possibilities and future developments.
Article
Oncology
Valentin Karl Ladenhauf, Malik Galijasevic, Johannes Kerschbaumer, Christian Franz Freyschlag, Martha Nowosielski, Anna Maria Birkl-Toeglhofer, Johannes Haybaeck, Elke Ruth Gizewski, Stephanie Mangesius, Astrid Ellen Grams
Summary: MGMT-methylated glioblastomas have lower ADC values compared to glioblastomas without MGMT methylation in peritumoral white matter. There were no differences in enhancing tumor areas. These findings could improve predictions of MGMT status in glioblastomas.
Article
Oncology
Sarah Iglseder, Anna Iglseder, Vincent Beliveau, Johanna Heugenhauser, Elke R. Gizewski, Johannes Kerschbaumer, Guenther Stockhammer, Christian Uprimny, Irene Virgolini, Jozsef Dudas, Meinhard Nevinny-Stickel, Martha Nowosielski, Christoph Scherfler
Summary: This retrospective study aimed to analyze the correlation between somatostatin receptor subtypes (SSTR 1-5) and maximum standardized uptake value (SUVmax) in meningioma patients using Gallium-68 DOTA-D-Phe1-Tyr3-octreotide Positron Emission Tomography ([68Ga]Ga-DOTATOC PET). The study also developed a radiomic model based on apparent diffusion coefficient (ADC) maps derived from diffusion weighted magnetic resonance images (DWI MRI) to reproduce SUVmax. Results showed that SSTR subtypes 2A, 2B, and 5 correlated significantly with SUVmax in meningioma patients.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Medicine, General & Internal
Martin Bendszus, Jens Fiehler, Fabien Subtil, Susanne Bonekamp, Anne Hege Aamodt, Blanca Fuentes, Elke R. Gizewski, Michael D. Hill, Antonin Krajina, Laurent Pierot, Claus Z. Simonsen, Kamil Zelenak, Rolf A. Blauenfeldt, Bastian Cheng, Angelique Denis, Hannes Deutschmann, Franziska Dorn, Fabian Flottmann, Susanne Gellissen, Johannes C. Gerber, Mayank Goyal, Jozef Haring, Christian Herweh, Silke Hopf-Jensen, Vi Tuan Hua, Maerit Jensen, Andreas Kastrup, Christiane Fee Keil, Andrej Klepanec, Egon Kurca, Ronni Mikkelsen, Markus Moehlenbruch, Stefan Mueller-Huelsbeck, Nico Muennich, Paolo Pagano, Panagiotis Papanagiotou, Gabor C. Petzold, Mirko Pham, Volker Puetz, Jan Raupach, Gernot Reimann, Peter Arthur Ringleb, Maximilian Schell, Eckhard Schlemm, Silvia Schoenenberger, Bjorn Tennoe, Christian Ulfert, Katerina Valis, Eva Vitkova, Dominik F. Vollherbst, Wolfgang Wick, Goetz Thomalla
Summary: Endovascular thrombectomy is associated with improved functional outcome and lower mortality in patients with acute ischemic stroke from large vessel occlusion using non-contrast CT as the primary imaging modality for patient selection.
Article
Pediatrics
Maria Sappler, Nina Volleritsch, Marlene Hammerl, Yasmin Pellkofer, Elke Griesmaier, Elke Ruth Gizewski, Susanne Kaser, Ursula Kiechl-Kohlendorfer, Vera Neubauer
Summary: This study found that there was no impairment of brain development in GDM-exposed preterm infants compared to matched controls, but there were differences in white matter microstructure in specific regions indicating an enhanced maturation. However, neurodevelopmental outcome did not differ between the groups.
