Article
Neurosciences
Alexandre Caux-Dedeystere, Etienne Allart, Pierre Morel, Alexandre Kreisler, Philippe Derambure, Herve Devanne
Summary: In patients with writer's cramp (WC), alterations in GABAergic inhibitory mechanisms result in longer duration of LICI and delayed LCD, affecting the activity of primary motor cortex inhibitory and excitatory circuits controlling hand muscles. This study highlights the impact of these changes on involuntary muscle contractions while writing and the potential therapeutic targets for WC.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Olivia Samotus, Robert Chen, Mandar Jog
Summary: The study investigated the relationship between BoNT-A treatment, tremor amplitude, and modulation of intracortical excitability in early, tremor-dominant PD patients using pp-TMS. Findings suggest that tremor severity in early PD may be related to impaired intracortical inhibition and defective sensorimotor integration.
Article
Biochemistry & Molecular Biology
Kevin Pacheco-Barrios, Danielle Carolina Pimenta, Anne Victorio Pessotto, Felipe Fregni
Summary: The clinical correlates of transcranial magnetic stimulation (TMS) measures, such as resting motor threshold (MT), motor-evoked potential (MEP), short intracortical inhibition (SICI), and intracortical facilitation (ICF), in fibromyalgia syndrome (FMS) patients were investigated. It was found that SICI was associated with sleepiness, comorbidities, disease duration, and anxiety, while ICF showed a positive correlation with pain levels and a negative correlation with body mass index (BMI). These findings suggest that SICI and ICF metrics may serve as potential phenotyping biomarkers in FMS.
Review
Psychiatry
Parmis Fatih, M. Utku Kucuker, Jennifer L. Vande Voort, Deniz Doruk Camsari, Faranak Farzan, Paul E. Croarkin
Summary: Based on 113 articles, it is suggested that LICI may serve as a biomarker of GABA(B) functioning, but more rigorous research is required. The existing LICI literature shows methodological heterogeneity and inconsistencies in findings, which are also non-specific to diseases. Future studies should address these weaknesses and focus on high-quality test-retest reliability.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Behavioral Sciences
Halil Can Alaydin, Bulent Cengiz
Summary: The study investigates the impact of the Rubber Hand Illusion (RHI) on motor cortex excitability, revealing increased Short-Latency Afferent Inhibition (SAI) during illusion. Short-Interval Intracortical Inhibition (SICI) is significantly reduced at 2.5 and 3 ms intervals during the illusion, indicating modulation of motor cortex excitability through altered sensory processing and sensorimotor integration.
Article
Clinical Neurology
Martin Syvertsen Mykland, Martin Uglem, Jan Petter Neverdahl, Lise Rystad Oie, Tore Wergeland Meisingset, David W. Dodick, Erling Tronvik, Morten Engstrom, Trond Sand, Petter Moe Omland
Summary: This study investigates the mechanisms of insufficient sleep in migraine by using transcranial magnetic stimulation. It is found that sleep restriction reduces GABAergic cortical inhibition during the interictal period in individuals with migraine, particularly in non-sleep related migraine and migraine with aura. The sleep restriction effect is associated with hypersensitivity symptoms such as photophobia, while the overall silent period is associated with premonitory dopaminergic symptoms such as yawning. These findings suggest that sleep related mechanisms may affect the pathophysiology of migraine and differentiate between migraine subgroups.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Huimin Sun, Caiting Gan, Lina Wang, Min Ji, Xingyue Cao, Yongsheng Yuan, Heng Zhang, Aidi Shan, Mengxi Gao, Kezhong Zhang
Summary: This study aimed to reveal the mechanisms of OFF-period FOG and levodopa-unresponsive FOG in PD. The study found that motor cortex disinhibition, represented by decreased SICI, is related to FOG in PD. Additionally, pharmacological treatment and high-frequency repetitive TMS can improve gait in FOG patients.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Nathan Pavey, Parvathi Menon, Mehdi A. J. van den Bos, Matthew C. Kiernan, Steve Vucic
Summary: A complex interaction of inhibitory and facilitatory interneuronal processes may underlie the development of cortical excitability. The study utilized threshold tracking transcranial magnetic stimulation to assess cortical excitability with different coil orientations. Significant effects of coil orientation were observed on short interval intracortical inhibition (SICI) and facilitation (SICF). The results suggest that distinct interneuronal processes are recruited with variable cortical orientation and thresholds.
NEUROSCIENCE LETTERS
(2023)
Article
Clinical Neurology
Emily Swinkin, Karlo J. Lizarraga, Musleh Algarni, Luis Garcia Dominguez, Julianne K. Baarbe, James Saravanamuttu, Robert Chen, Elizabeth Slow, Anthony E. Lang, Richard A. Wennberg
Summary: Celiac disease is associated with motor cortex hyperexcitability and cortical myoclonus. Neurophysiological characteristics in patients with celiac-associated cortical myoclonus include lateralized low-amplitude, electropositive beta-frequency polyspike activity over the central head region. Studies suggest that the oscillatory electroencephalography activity may be a distinct marker of celiac-related cortical myoclonus and is consistent with celiac-related motor cortex hyperexcitability, which may not necessarily result from cerebellar disinhibition.
MOVEMENT DISORDERS
(2021)
Article
Behavioral Sciences
Nitish Kamble, Amitabh Bhattacharya, Shantala Hegde, N. Vidya, Mohit Gothwal, Ravi Yadav, Pramod Kumar Pal
Summary: This study used transcranial magnetic stimulation (TMS) to assess cortical excitability changes in Parkinson's disease patients with different levels of cognitive impairment. The results showed that as the disease progressed, there was an increase in intracortical inhibition and a decrease in intracortical facilitation, suggesting abnormalities in glutaminergic and cholinergic transmission.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Clinical Neurology
Viviana Versace, Paola Ortelli, Sabrina Dezi, Davide Ferrazzoli, Alessia Alibardi, Ilenia Bonini, Michael Engl, Roberto Maestri, Martina Assogna, Valentina Ajello, Elke Pucks-Faes, Leopold Saltuari, Luca Sebastianelli, Markus Kofler, Giacomo Koch
Summary: The objective of this study was to test the effects of co-ultramicronized palmitoylethanolamide/luteolin (PEA-LUT) on cortical activity in patients experiencing cognitive dysfunction and fatigue after COVID-19. The results showed that treatment with PEA-LUT improved long-interval intracortical inhibition (LICI) and cortical plasticity in these patients.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Leo Tomasevic, Hartwig Roman Siebner, Axel Thielscher, Fiore Manganelli, Giuseppe Pontillo, Raffaele Dubbioso
Summary: The study reveals a strong functional relationship between high-frequency responses in the human sensorimotor cortex (HFO and SICF). It also establishes a correlation between the degree of regional cortical myelination and the expression of high-frequency responses, providing insights into their generators.
Review
Biochemistry & Molecular Biology
Bruno Benedetti, Annika Weidenhammer, Maximilian Reisinger, Sebastien Couillard-Despres
Summary: Evidence suggests that cortical disinhibition can be either beneficial or detrimental in a context-dependent manner. Careful examination of clinical data and research using SCI animal models can help to better understand this mechanism and improve treatment outcomes through targeted pharmacological and rehabilitative interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neuroimaging
Stephanie M. Hare, Xiaoming Du, Bhim M. Adhikari, Shuo Chen, Chen Mo, Ann Summerfelt, Mark D. Kvarta, Laura Garcia, Peter Kochunov, L. Elliot Hong
Summary: Short interval intracortical inhibition (SICI) is a biomarker for altered motor inhibition in schizophrenia. The study found that higher SICI ratios in patients were associated with lower regional homogeneity in the right insula, and reduced connectivity between the right insula and hubs of the corticospinal pathway. Mediation analysis supported a model in which the direct effect of local insular connectivity strength on SICI is mediated by interhemispheric connectivity between the insula and left sensorimotor cortex.
NEUROIMAGE-CLINICAL
(2021)
Article
Psychology, Multidisciplinary
Ashlee M. Hendy, Justin W. Andrushko, Paul A. Della Gatta, Wei-Peng Teo
Summary: Transcranial magnetic stimulation studies have shown that there is increased cortical facilitation and reduced inhibition in the brain after aerobic exercise, which may contribute to adaptive plasticity and motor learning. One potential mechanism behind these benefits is the increase in brain-derived neurotropic factor (BDNF) observed following exercise. This study aimed to investigate changes in motor cortex excitability and inhibition, as well as circulating BDNF levels, after high-intensity interval training (HIIT) on a stationary bicycle. The findings suggest that acute high-intensity exercise can induce cortical neuroplasticity, leading to enhanced motor learning.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Takahiro Shimizu, Ritsuko Hanajima, Yuichiro Shirota, Ryosuke Tsutsumi, Nobuyuki Tanaka, Yasuo Terao, Masashi Hamada, Yoshikazu Ugawa
Article
Clinical Neurology
Satoshi Kodama, Shin-ichi Tokushige, Yusuke Sugiyama, Kazuya Sato, Juuri Otsuka, Yuichiro Shirota, Masashi Hamada, Atsushi Iwata, Tatsushi Toda, Shoji Tsuji, Yasuo Terao
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2020)
Review
Neurosciences
Anna Sadnicka, Masashi Hamada
EXPERIMENTAL BRAIN RESEARCH
(2020)
Article
Neurosciences
Hideyuki Matsumoto, Yoshikazu Ugawa
EXPERIMENTAL BRAIN RESEARCH
(2020)
Article
Clinical Neurology
Shin-ichi Tokushige, Shunichi Matsuda, Satomi Inomata-Terada, Masashi Hamada, Yoshikazu Ugawa, Shoji Tsuji, Yasuo Terao
Summary: The study found that saccade amplitudes and directions are determined approximately 100-150 ms after target presentation. Patients with Parkinson's disease and spinocerebellar degeneration had lower frequencies of premature saccades compared to normal subjects.
CLINICAL NEUROPHYSIOLOGY
(2021)
Letter
Clinical Neurology
Mitsuhiro Kainaga, Yuichiro Shirota, Satoshi Kodama, Tatsushi Toda, Masashi Hamada
MOVEMENT DISORDERS
(2021)
Article
Medicine, General & Internal
Toshiyuki Kakumoto, Satoshi Kobayashi, Hayato Yuuki, Mitsuhiro Kainaga, Yuichiro Shirota, Masashi Hamada, Meiko Hashimoto Maeda, Akatsuki Kubota, Mizuho Kawai, Masaaki Saito, Hiroyuki Ishiura, Tatsushi Toda
Summary: This case report highlights a Japanese patient with post-COVID-19 GBS, characterized by muscle weakness, sensory deficits, and autonomic dysfunction. Treatment including intubation, IV immunoglobulin therapy, and rehabilitation improved the patient's condition.
Article
Multidisciplinary Sciences
Akira Yamashita, Takenobu Murakami, Noriaki Hattori, Ichiro Miyai, Yoshikazu Ugawa
Summary: The study demonstrated that PCMS with supramaximal PNS intensity increased CMEP amplitude, and its facilitatory effect was greater than those of weaker PNS intensities for PCMS. Sham TMS with supramaximal PNS showed no changes in CMEP after intervention. The PNS intensity influences the magnitude of synaptic plasticity induction between CSTs and SMs at the spinal level, with supramaximal intensity being the most effective for inducing long-term potentiation-like effects.
Article
Clinical Neurology
Satomi Inomata-Terada, Hideki Fukuda, Shin-ichi Tokushige, Shun-ichi Matsuda, Masashi Hamada, Yoshikazu Ugawa, Shoji Tsuji, Yasuo Terao
Summary: This study investigated the pathophysiology of hereditary spinocerebellar degeneration (SCA) with pure cerebellar manifestation using saccade recordings. The results showed increased saccade latency and amplitude, as well as greater variability, in SCA patients compared to normal subjects. These changes correlated with the severity of cerebellar symptoms. The study also found that the saccade velocity profile and the relationship between saccade amplitude and peak velocity were affected by disease progression. This research demonstrates the importance of saccade recording in understanding the cerebellar pathophysiology of SCA.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Makoto Honda, Takahiro Shimizu, Shotaro Moriyasu, Takenobu Murakami, Hiroshi Takigawa, Yoshikazu Ugawa, Ritsuko Hanajima
Summary: This study investigates the characteristics of motor cortical LTP-like effects in PSP patients and finds that the degree of LTP is correlated with the severity of bradykinesia.
CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Clinical Neurology
Katerina Mensikova, John C. Steele, Raymond Rosales, Carlo Colosimo, Peter Spencer, Annie Lannuzel, Yoshikazu Ugawa, Ryogen Sasaki, Santiago Gimenez-Roldan, Radoslav Matej, Lucie Tuckova, Dominik Hrabos, Kristyna Kolarikova, Radek Vodicka, Radek Vrtel, Miroslav Strnad, Petr Hlustik, Pavel Otruba, Martin Prochazka, Martin Bares, Susana Boluda, Luc Buee, Gerhard Ransmayr, Petr Kanovsky
Summary: Endemic parkinsonism refers to diseases that occur in specific locations or populations. Different clusters of endemic parkinsonism exist in different geographic regions, and their persistence or disappearance is determined by genetic or environmental factors. Studying these diseases helps to understand the mechanisms of neurodegenerative diseases and provides direction for future research.
NATURE REVIEWS NEUROLOGY
(2023)
Review
Neurosciences
Mario Manto, Mariano Serrao, Stefano Filippo Castiglia, Dagmar Timmann, Elinor Tzvi-Minker, Ming-Kai Pan, Sheng-Han Kuo, Yoshikazu Ugawa
Summary: This chapter provides an overview of the advances and emerging techniques in neurophysiological tests for cerebellar disorders. Different syndromes exhibited by cerebellar patients, as well as abnormal electrophysiological patterns and impaired motor control, are discussed. Various techniques are used to better understand and evaluate cerebellar disorders.
CLINICAL NEUROPHYSIOLOGY PRACTICE
(2023)
Article
Neurosciences
Hoon-Ming Heng, Ming-Kuei Lu, Li-Wei Chou, Nai-Hsin Meng, Hui-Chun Huang, Masashi Hamada, Chon-Haw Tsai, Jui-Cheng Chen
Article
Clinical Neurology
Takashi Matsukawa, Tomotaka Yamamoto, Akira Honda, Takashi Toya, Hiroyuki Ishiura, Jun Mitsui, Masaki Tanaka, Akihito Hao, Akihito Shinohara, Mizuki Ogura, Keisuke Kataoka, Sachiko Seo, Keiki Kumano, Masataka Hosoi, Kensuke Narukawa, Megumi Yasunaga, Hiroaki Maki, Motoshi Ichikawa, Yasuhito Nannya, Yoichi Imai, Tsuyoshi Takahashi, Yuji Takahashi, Yuki Nagasako, Kyoko Yasaka, Kagari Koshi Mano, Miho Kawabe Matsukawa, Toji Miyagawa, Masashi Hamada, Kaori Sakuishi, Toshihiro Hayashi, Atsushi Iwata, Yasuo Terao, Jun Shimizu, Jun Goto, Harushi Mori, Akira Kunimatsu, Shigeki Aoki, Shin Hayashi, Fumihiko Nakamura, Syunya Arai, Kazunari Momma, Katsuhisa Ogata, Toshikazu Yoshida, Osamu Abe, Johji Inazawa, Tatsushi Toda, Mineo Kurokawa, Shoji Tsuji
BRAIN COMMUNICATIONS
(2020)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)