Article
Clinical Neurology
Fengjun Zhu, Hanwen Wang, Lin Li, Anatol Bragin, Dezhi Cao, Yuan Cheng
Summary: This study tested the feasibility and reliability of intracranial electrophysiological recordings in a pig model of acute status epilepticus. The results showed that the model successfully induced status epilepticus and the high-frequency oscillations (HFOs) rate was a sensitive and reliable measurement. This model is of great significance for studying the mechanisms of epileptogenesis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Engineering, Biomedical
Carolina Migliorelli, Sergio Romero, Alejandro Bachiller, Javier Aparicio, Joan F. Alonso, Miguel A. Mananas, Victoria San Antonio-Arce
Summary: This study introduces a novel modeling approach to differentiate pathological and physiological ripples in the ripple band, improving the delineation of the epileptogenic zone (EZ). Individual models are found to be more appropriate than a traditional whole-population approach, with significant differences in pathological ripple rates inside and outside the seizure onset zone. This individual Gaussian mixture model (GMM) approach enhances ripple classification and helps in investigating the interaction of epileptogenic and propagation networks.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Clinical Neurology
Jonas Christian Bruder, Kathrin Wagner, Daniel Lachner-Piza, Kerstin Alexandra Klotz, Andreas Schulze-Bonhage, Julia Jacobs
Summary: This study aimed to investigate the relationship between mesial-temporal spindle-ripples and memory performance. The study found that all ripple rates were significantly higher in seizure onset zone channels. Patients with pre-surgical verbal memory impairment had significantly higher overall ripple rates in the left mesial-temporal channels. There was a highly significant negative correlation between pre-surgical verbal memory performance and left mesial-temporal spike-associated ripples and overall ripples.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Victor Karpychev, Alexandra Balatskaya, Nikita Utyashev, Nikita Pedyash, Andrey Zuev, Olga Dragoy, Tommaso Fedele
Summary: High-frequency oscillations (HFO) are a valuable biomarker for identifying epileptogenic tissue. This study validated the predictive power of HFO rates and examined their morphological features. The findings support the use of HFO in epilepsy surgery and contribute to the understanding of HFO morphology.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Vasileios Kokkinos, Helweh Hussein, Birgit Frauscher, Mirela Simon, Alexandra Urban, Alan Bush, Anto I. Bagic, R. Mark Richardson
Summary: The study evaluated whether hippocampal spindles and barques are markers of epileptogenicity in epilepsy patients. The results show that both spindles and barques are normal entities in the hippocampal intracranial electroencephalogram and do not indicate epileptogenic properties. Understanding this is crucial for the correct interpretation of epilepsy surgery evaluations and the selection of appropriate surgical treatments.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jan Cimbalnik, Jaromir Dolezal, Cagdas Topcu, Michal Lech, Victoria S. Marks, Boney Joseph, Martin Dobias, Jamie Van Gompel, Gregory Worrell, Michal Kucewicz
Summary: This study recorded intracranial EEG and pupillometric signals to investigate brain activity and behavioral performance of epilepsy patients during memory tasks. Each dataset includes electrode channel localization and behavioral event labels.
Article
Medicine, General & Internal
Jiajie Mo, Jianguo Zhang, Wenhan Hu, Lin Sang, Xiaoqiu Shao, Chao Zhang, Kai Zhang
Summary: This study investigated the metabolic and electrophysiological characteristics of temporal lobe LEAT epileptic network using PET and SEEG techniques. Patients with temporal lobe LEAT showed a more widespread epileptic network compared to controls, with significant differences in metabolic patterns.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Laura Mirandola, Daniela Ballotta, Francesca Talami, Giada Giovannini, Giacomo Pavesi, Anna Elisabetta Vaudano, Stefano Meletti
Summary: In drug-resistant temporal lobe epilepsy (TLE) patients, interictal epileptiform discharges (IED) were found to impact distant extra-temporal areas, particularly the motor/premotor cortex. Individual analysis revealed involvement of at least one Intrinsic Connectivity Network (ICN) in each patient's spike-related fMRI map.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Yujiang Wang, Gabrielle M. Schroeder, Jonathan J. Horsley, Mariella Panagiotopoulou, Fahmida A. Chowdhury, Beate Diehl, John S. Duncan, Andrew W. McEvoy, Anna Miserocchi, Jane de Tisi, Peter N. Taylor
Summary: Comparing patient data to a normative map has shown promise in identifying abnormalities on interictal intracranial electroencephalogram (iEEG) for localization of epileptogenic tissue and outcome prediction. However, the temporal stability of these findings has not been established.
Article
Medicine, General & Internal
Kai-Feng Shen, Xiao-Lin Yang, Guo-Long Liu, Gang Zhu, Zhong-Ke Wang, Xian-Jun Shi, Ting-Ting Wang, Zhi-Feng Wu, Sheng-Qing Lv, Shi-Yong Liu, Hui Yang, Chun-Qing Zhang
Summary: The study revealed that ClC-mediated current was increased in the hippocampal neurons of chronic TLE mice. Application of chloride channel blockers NPPB and DIDS reduced the current and increased inhibitory synaptic transmission in TLE mice. These drugs also decreased seizure frequency and the average power of ictal high-frequency oscillations in TLE mice.
Article
Clinical Neurology
Tim A. Guth, Lukas Kunz, Armin Brandt, Matthias Duempelmann, Kerstin A. Klotz, Peter C. Reinacher, Andreas Schulze-Bonhage, Julia Jacobs, Jan Schoenberger
Summary: The study shows that HFO-IEDs and non-HFO-IEDs have different single-unit correlates. Single-unit firing rates are higher in HFO-IEDs compared to non-HFO-IEDs, with a pronounced pre-peak increase in firing in HFO-IEDs. Moreover, most cells exhibit higher rates during HFO-IEDs, suggesting a distinct subset of neurons prefer this IED subtype.
Article
Biotechnology & Applied Microbiology
Mu Shen, Lin Zhang, Yi Gong, Lei Li, Xianzeng Liu
Summary: Skewness-based functional connectivity (SFC) is proposed as an effective method for epileptic tissue localization and surgical outcome evaluation. SFC measures the amplitude distribution asymmetry between high-frequency oscillations and baseline activity, constructs a functional network based on rank correlation, and extracts connectivity strength. Significant differences (p<0.001) in connectivity strength between epileptic and non-epileptic tissue were found, and the performance of SFC was superior to low-frequency bands. The AUC for pooled and individual epileptic tissue localization was 0.66 and 0.63, respectively, and the AUC for surgical outcome classification was 0.75.
BIOENGINEERING-BASEL
(2023)
Article
Multidisciplinary Sciences
Somin Lee, Julia Henry, Andrew K. Tryba, Yasar Esengul, Peter Warnke, Shasha Wu, Wim van Drongelen
Summary: Infraslow activity (ISA) has become an interesting biomarker for characterizing seizures. However, studying low frequency activity in clinical seizure recordings has been challenging due to technical limitations. This study presents a digital inverse filter that can recover attenuated low frequency activity in intracranial recordings and demonstrates its application in identifying and assessing the seizure onset zone.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Petr Nejedly, Vaclav Kremen, Kamila Lepkova, Filip Mivalt, Vladimir Sladky, Tereza Pridalova, Filip Plesinger, Pavel Jurak, Martin Pail, Milan Brazdil, Petr Klimes, Gregory Worrell
Summary: Manual review, annotation, and categorization of EEG data is time-consuming and biased, requiring experts. We propose a semi-supervised machine learning technique using deep learning methods and minimal gold-standard labels. The method achieved acceptable results in EEG classification and was able to generalize to new patients for detecting epileptic discharges.
SCIENTIFIC REPORTS
(2023)
Review
Behavioral Sciences
Thato Mary Mokhothu, Kazumasa Zen Tanaka
Summary: Temporal Lobe Epilepsy (TLE) is characterized by focal brain hyperexcitability, leading to abnormal neuronal discharge and seizures. The hippocampus, known for its high excitability, is often the focus of TLE and is associated with high-frequency oscillations (HFOs) as a marker. However, distinguishing pathological HFOs from non-pathological ones and understanding their role in disease development remain challenging in research.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Anesthesiology
E. Li
Summary: Surgical patients with peri-operative or recent SARS-CoV-2 infection are at increased risk of postoperative venous thromboembolism compared to those without a history of SARS-CoV-2. However, the optimal prophylaxis and treatment for venous thromboembolism in this patient population remains unknown. Venous thromboembolism is independently associated with 30-day mortality.
Letter
Behavioral Sciences
Naoto Kuroda, Nozomi Akatsu, Keisuke Hatano, Naoki Ikegaya, Kazuto Katsuse, Satoshi Kodama, Yutaro Takayama, Ayataka Fujimoto
EPILEPSY & BEHAVIOR
(2022)
Letter
Behavioral Sciences
Izumi Kuramochi, Naoto Kuroda, Naoto Nagino, Daichi Sone, Mao Fujioka, Ayataka Fujimoto
EPILEPSY & BEHAVIOR
(2022)
Article
Neurosciences
Kyoichi Tomoto, Toshiki Nozaki, Chikanori Inenaga, Ayataka Fujimoto
Summary: The exoscope is a new optical device that provides high-quality magnification and illumination, improving visibility during surgeries. In this report, the authors share their initial experience of using the exoscope for corpus callosotomy, highlighting its effectiveness and lack of complications.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Neurosciences
Masataka Hayashi, Ayataka Fujimoto, Hideo Enoki, Keiko Niimi, Chikanori Inenaga, Keishiro Sato, Kazunari Homma, Tomoya Arakawa, Tohru Okanishi
Summary: This study suggests that fornix injury, rather than anterior corpus callosum injury, might be the major cause of Korsakoff's amnesia in patients with subcallosal artery infarction.
Article
Clinical Neurology
Tohru Okanishi, Yuji Fujii, Satoru Sakuma, Hideaki Shiraishi, Hirotaka Motoi, Kotaro Yazaki, Hideo Enoki, Ayataka Fujimoto
Summary: This study aimed to evaluate the efficacy of lacosamide monotherapy for the treatment of childhood epilepsy with centrotemporal spikes (CECTS). The results showed that lacosamide effectively controlled seizures with fewer adverse effects.
BRAIN & DEVELOPMENT
(2022)
Article
Neurosciences
Ayataka Fujimoto, Hideo Enoki, Keisuke Hatano, Keishiro Sato, Tohru Okanishi
Summary: This study aimed to identify factors associated with ceasing anti-seizure medication (ASM) for patients with drug-resistant epilepsy secondary to brain cavernous angioma (BCA) who underwent BCA removal surgery. The study found that age at surgery correlated significantly with the group that did not require ASM, while history of epilepsy did not show any correlation.
Article
Clinical Neurology
Yuto Arai, Tohru Okanishi, Masayoshi Oguri, Sotaro Kanai, Ayataka Fujimoto, Yoshihiro Maegaki
Summary: We present a case of a nine-year-old girl who developed cerebellar mutism syndrome after surgery and showed improvement in language, dysmetria, and gait ataxia during a 20-month follow-up. Electroencephalogram analyses revealed transient changes in the power spectra of different frequency bands and continuous improvements in connectivity. These findings indicate the plasticity and remodeling of brain function after cerebellar mutism syndrome. Power and connectivity analyses for EEG might provide insights into the underlying pathophysiology of this syndrome.
BRAIN & DEVELOPMENT
(2022)
Article
Clinical Neurology
Kento Ohta, Tohru Okanishi, Sotaro Kanai, Yuko Nakamura, Ayataka Fujimoto, Yoshihiro Maegaki
Summary: CBZ overdose can cause various types of seizures, and stimulus-induced focal seizures may indicate a favorable prognosis for CBZ overdose.
BRAIN & DEVELOPMENT
(2022)
Editorial Material
Clinical Neurology
Kento Ohta, Tohru Okanishi, Sotaro Kanai, Tetsuya Okazaki, Ayataka Fujimoto, Yoshihiro Maegaki
EPILEPTIC DISORDERS
(2022)
Article
Medicine, General & Internal
Ayataka Fujimoto, Hideo Enoki, Keisuke Hatano, Keishiro Sato, Tohru Okanishi
Summary: This study compares the non-inferiority of new anti-seizure medications (ASMs) in replacing valproic acid (VPA) for idiopathic generalized epilepsy (IGE), and finds that the use of new ASMs can result in better seizure control for patients on monotherapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Keisuke Hatano, Ayataka Fujimoto, Keishiro Sato, Takamichi Yamamoto, Hideo Enoki
Summary: In patients with juvenile myoclonic epilepsy (JME), performing hyperventilation (HV) during electroencephalogram (EEG) may increase interictal epileptiform discharges (IEDs) and facilitate the accurate diagnosis of epilepsy.
Editorial Material
Neurosciences
Ayataka Fujimoto, Tohru Okanishi
Article
Neurosciences
Keisuke Hatano, Ayataka Fujimoto, Keishiro Sato, Takamichi Yamamoto, Hiroshi Sakuma, Hideo Enoki
Summary: The main causes of anti-NMDAR encephalitis are ovarian teratoma and HSV encephalitis. This case report describes a rare case of suspected anti-NMDAR encephalitis caused by CC. The patient experienced various unexplained symptoms that gradually developed over a 2-month period, which were promptly improved after immunotherapy.
Article
Neurosciences
Atsushi Fujita, Mitsuhiro Kato, Hidenori Sugano, Yasushi Iimura, Hiroharu Suzuki, Jun Tohyama, Masafumi Fukuda, Yosuke Ito, Shimpei Baba, Tohru Okanishi, Hideo Enoki, Ayataka Fujimoto, Akiyo Yamamoto, Kentaro Kawamura, Shinsuke Kato, Ryoko Honda, Tomonori Ono, Hideaki Shiraishi, Kiyoshi Egawa, Kentaro Shirai, Shinji Yamamoto, Itaru Hayakawa, Hisashi Kawawaki, Ken Saida, Naomi Tsuchida, Yuri Uchiyama, Kohei Hamanaka, Satoko Miyatake, Takeshi Mizuguchi, Mitsuko Nakashima, Hirotomo Saitsu, Noriko Miyake, Akiyoshi Kakita, Naomichi Matsumoto
Summary: In this study, genetic analysis was performed on epileptogenic brain malformed lesions from 64 patients with focal cortical dysplasia, hemimegalencephy, brain tumors, or hippocampal sclerosis. The results showed that somatic variants of diverse genes were detected in these patients, with MTOR and MAP2K1 being involved in focal cortical dysplasia type IIB and MAP2K1 and PTPN11 in focal cortical dysplasia type I. The study demonstrated that these brain malformed lesions, except for focal cortical dysplasia type II, were eventually linked to the mTOR pathway.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)
