Review
Clinical Neurology
Danielle Golub, Jonathan Hyde, Siddhant Dogra, Joseph Nicholson, Katherine A. Kirkwood, Paulomi Gohel, Stephen Loftus, Theodore H. Schwartz
Summary: The study compared the efficacy of 5-ALA and IMRI in optimizing EOR in HGG, finding both to be superior to conventional neuronavigation. However, no clear difference in effectiveness was found between IMRI and 5-ALA.
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Anant Naik, Emily J. Smith, Ariana Barreau, Mark Nyaeme, Samuel W. Cramer, Daniel Najafali, David T. Krist, Paul M. Arnold, Wael Hassaneen
Summary: A network meta-analysis comparing 5-ALA, IMRI, and FS as intraoperative navigation methods for high-grade glioma resection showed that IMRI, FS, and 5-ALA all led to higher rates of gross total resection and improved overall survival and progression-free survival.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Oncology
Abel Ferres, Alberto Di Somma, Alejandra Mosteiro, Thomaz Eduardo Topczewski, Pedro Roldan, Leire Pedrosa, Dioulde Diao, Estela Pineda, Angels Sierra, Joaquim Ensenat, Jose Juan Gonzalez-Sanchez
Summary: In this study, an inadvertent effect of 5-ALA-mediated photodynamic therapy has been detected in vivo. This finding opens up possibilities for further research on this promising therapeutic tool.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marek Mazurek, Dariusz Szczepanek, Anna Orzylowska, Radoslaw Rola
Summary: This article summarizes the current knowledge on the differences in the level of emitted fluorescence in glial tumors. It discusses how the level of fluorescence may depend on the histological type and genetic profile of the tumor, as well as the activity and expression of enzymes involved in the intracellular metabolism of fluorescent dyes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Tiffany A. Eatz, Daniel G. Eichberg, Victor M. Lu, Long Di, Ricardo J. Komotar, Michael E. Ivan
Summary: 5-aminolevulinic acid (5-ALA) has been shown to enhance the outcomes of high-grade glioma (HGG) surgery, including extent of resection and patient survival. However, its impact on postoperative neurological function remains inconclusive.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Kazuhide Shimizu, Kaoru Tamura, Shoko Hara, Motoki Inaji, Yoji Tanaka, Daisuke Kobayashi, Takashi Sugawara, Hiroaki Wakimoto, Tadashi Nariai, Kenji Ishii, Ichiro Sakuma, Taketoshi Maehara
Summary: This study aimed to investigate the correlation between preoperative MET-PET signals and intraoperative 5-ALA-induced fluorescence in malignant brain tumor surgery. The results showed that strong tumor fluorescence correlated with high MET-PET uptake and cellular proliferation, providing valuable tumor biology information for surgery in situations where MET-PET is not accessible.
Article
Oncology
Katharina Lutz, Levin Haeni, Cedric Kissling, Andreas Raabe, Philippe Schucht, Kathleen Seidel
Summary: There is evidence supporting the correlation between the extent of resection of low-grade glioma and patients' outcomes. The preservation of function is important in brain tumor surgery. This study focuses on analyzing the impact of tumor resection within the face motor cortex (M1) on neurological deficits, with findings suggesting that such resection may be safe and associated with only transient impairment.
Article
Clinical Neurology
Asfand Baig Mirza, Jose Pedro Lavrador, Loannis Christodoulides, Timothy Martyn Boardman, Amisha Vastani, Qusai Al Banna, Irena C. F. Norman, Christopher Murphy, Sharmila Devi, Francesco Vergani, Richard Gullan, Ranjeev Bhangoo, Keyoumars Ashkan, Razna Ahmed, Anastasios Giamouriadis
Summary: This study investigated the use of 5-aminolevulinic acid (5-ALA) in assisting the resection of grade III gliomas. The results showed that 5-ALA did not have significant benefits in grade III tumors, except for a subgroup of patients who achieved gross total resection (GTR). Additionally, worse postoperative outcomes and 6-month performance status were observed in the 5-ALA group, mainly due to poorer outcomes in the subtotal resection subgroup.
OPERATIVE NEUROSURGERY
(2022)
Review
Clinical Neurology
Emily J. Smith, Kavita Gohil, Charee M. Thompson, Anant Naik, Wael Hassaneen
Summary: This meta-analysis demonstrates that fluorescein-guided surgery improves GTR rates of HGGs compared to non-fluorescence guided surgery, while showing similar GTR rates compared to reported 5-ALA-guided resection rates.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Sadahiro Kaneko, Eric Suero Molina, Peter Sporns, Stephanie Schipmann, David Black, Walter Stummer
Summary: This study investigates the real-time kinetics of protoporphyrin IX (PpIX) in low-grade glioma (LGG) using hyperspectral fluorescence-based measurements and identifies factors that predict fluorescence. The results show that fluorescence in LGG peaks between 7 and 8 hours after 5-ALA application, and it is related to 18F-FET PET uptake and Ki-67/MIB-1.
JOURNAL OF NEUROSURGERY
(2022)
Review
Oncology
Harshal A. Shah, Sandra Leskinen, Hamza Khilji, Vinayak Narayan, Netanel Ben-Shalom, Randy S. D'Amico
Summary: The current studies on 5-ALA fluorescence in brain metastases are limited and do not confirm its efficacy in improving the extent of resection or post-operative survival. Fluorescence varies greatly across and within tumor types.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Clinical Neurology
Johannes Herta, Anna Cho, Thomas Roetzer-Pejrimovsky, Romana Hoeftberger, Wolfgang Marik, Gernot Kronreif, Tanja Peilnsteiner, Karl Roessler, Stefan Wolfsberger
Summary: The potential of 5-aminolevulinic acid (5-ALA) and Raman spectroscopy (RS) in detecting tumor-infiltrated brain in glioblastoma patients was assessed and compared. The study found that RS has higher sensitivity and 5-ALA has higher specificity in detecting tumor-infiltrated brain. Combining the two methods can increase the accuracy of tumor detection by about 10%.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Eric Suero Molina, Sonke J. Hellwig, Anna Walke, Astrid Jeibmann, Herbert Stepp, Walter Stummer
Summary: This study introduces a triple-LED headlight/loupe device for fluorescence-guided resections and compares it to the BLUE400 system. The new device provides slightly higher fluorescence intensities compared to BLUE400, while having similar spectra and illumination intensities.
JOURNAL OF NEUROSURGERY
(2022)
Article
Plant Sciences
Hamed M. El-Shora, Gehan F. Massoud, Ghada A. El-Sherbeny, Salma Saleh Alrdahe, Doaa B. Darwish
Summary: Lead stress negatively impacts the physiological parameters of Salvia plants, but ALA application can effectively improve germination and protein content while reducing oxidative damage. This suggests that ALA at a certain concentration level can protect plants from heavy metal stress, recommending its application for alleviating lead stress.
Article
Clinical Neurology
Michael Muether, Mohammed Jaber, Timothy D. Johnson, Daniel A. Orringer, Walter Stummer
Summary: Using a logistic regression model, the study found a strong correlation between enhancement on preoperative MRI and the likelihood of visible fluorescence during surgery in patients with intermediate-grade glioma. The research provides a robust method for predicting 5-ALA-induced fluorescence in patients with grade II and grade III gliomas with high accuracy.
Article
Neurosciences
Luca Zanin, Giorgio Saraceno, Giulia Renisi, Liana Signorini, Luigi Battaglia, Marco Ferrara, Francesco Antonio Rasulo, Pier Paolo Panciani, Marco Maria Fontanella
Summary: This case report describes the delayed onset cell-mediated encephalitis caused by COVID-19 virus, which is the first recorded case occurring more than 40 days after the diagnosis. The patient experienced intense headache, fever, and subsequent generalized epileptic seizures before being diagnosed with brain death.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Edoardo Agosti, Simona Serioli, Kanwaljeet Garg, Alberto Pietrantoni, Pietro Luigi Poliani, Marco Maria Fontanella
Summary: This study reported a rare case of multiple vertebral metastases from anal squamous cell carcinoma (SCC) and aimed to define a treatment strategy. Through case presentation and literature review, it was found that there is currently no universally accepted treatment strategy for vertebral metastases from anal SCC. Prompt and aggressive, local and systemic, and multimodal treatment of the vertebral lesions may be crucial for improving patient outcomes.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Bawarjan Schatlo, Veit Rohde, Tammam Abboud, Insa Janssen, Patrick Melich, Bernhard Meyer, Ehab Shiban
Summary: Surgery for pyogenic Spondylodiscitis as an adjunct to antibiotic therapy is an established treatment, but the technique and extent of surgical debridement remain a matter of debate. Some advocate diskectomy in all cases, while others argue that stand-alone instrumentation is sufficient.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Clinical Neurology
Tammam Abboud, Patrick Melich, Simone Scheithauer, Veit Rohde, Bawarjan Schatlo
Summary: This study provides benchmark data for patients treated surgically for Infectious Spondylodiscitis. Surgical site infection and medical complications are the main drivers of prolonged hospital stays and cost of care.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Editorial Material
Clinical Neurology
Bawarjan Schatlo, Ehab Shiban
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Clinical Neurology
Tammam Abboud, Magdalena Krolikowska-Fluori, Patrick Melich, Veit Rohde, Bawarjan Schatlo
Summary: In patients with surgically treated pyogenic spondylodiskitis, despite low in-hospital and 1-year mortality rates, there is a long-term limitation in all domains of quality of life, especially in physical health and work ability.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Review
Biochemistry & Molecular Biology
Fulvio Tartara, Andrea Montalbetti, Emanuela Crobeddu, Daniele Armocida, Eleonora Tavazzi, Andrea Cardia, Marco Cenzato, Davide Boeris, Diego Garbossa, Fabio Cofano
Summary: This paper provides a practical review of the pathophysiological events following subarachnoid hemorrhage (SAH). The complex cascade of pathophysiological events involves various interconnected but distinct pathways. The use of heparin, with its anticoagulant effect and ability to interfere with secondary events, may be an interesting therapeutic strategy for SAH management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Alessandro Frati, Daniele Armocida, Fulvio Tartara, Fabio Cofano, Sergio Corvino, Sergio Paolini, Antonio Santoro, Diego Garbossa
Summary: This study reviewed 47 cases of posterior reversible encephalopathy syndrome (PRES) that occurred after surgery to identify the clinical features, timing of symptom onset, and treatment of this rare surgical complication. The results showed that postoperative PRES can occur in both pediatric and adult patients, with cardiovascular disease being the most common comorbidity. PRES typically occurs within the first 3 weeks after surgery, and prompt recognition and treatment can lead to complete reversal of symptoms in most cases.
Review
Medicine, General & Internal
Stefano Colonna, Andrea Bianconi, Fabio Cofano, Alessandro Prior, Giuseppe Di Perna, Giuseppe Palmieri, Gianluigi Zona, Diego Garbossa, Pietro Fiaschi
Summary: Vertebral body metastases (VBM) are a common site of bone metastasis, and the treatment management presents challenges. Radiofrequency ablation (RFA) is a potential alternative, but it may affect the biomechanics and microanatomy of the vertebral body, increasing the risk of fractures and instability. This study aims to investigate the impact of RFA on spine stability.
Review
Biochemistry & Molecular Biology
Andrea Bianconi, Giuseppe Palmieri, Gelsomina Aruta, Matteo Monticelli, Pietro Zeppa, Fulvio Tartara, Antonio Melcarne, Diego Garbossa, Fabio Cofano
Summary: Glioblastoma (GBM), the most common and aggressive central nervous system tumor, is difficult to treat due to its malignant behavior and infiltrative growth pattern. Although immunotherapeutic strategies hold promise for the fight against GBM, immune resistance and the immunosuppressive environment pose challenges. New therapeutic strategies targeting the immune system, such as immune checkpoint inhibitors and chimeric antigen receptor T cell therapy, have been explored, but significant results have not been achieved. The future direction of GBM therapy may involve a combined approach that includes multifaceted immunotherapy to directly kill tumor cells and activate the immune response.
Review
Cell Biology
Luca Zanin, Alexandra Sachkova, Pier Paolo Panciani, Veit Rohde, Marco Maria Fontanella, Bawarjan Schatlo
Summary: Liquid biopsy research on Low-Grade gliomas (LGG) has remained less conspicuous than that on other malignant brain tumors. Reliable serum markers would be precious for diagnosis, follow-up and treatment. Micro-RNA (miRs) appears to have the highest clinical utility.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Erika Ferrari, Claudio Cornali, Alessandro Fiorindi, Edoardo Agosti, Salvatore Gallone, Elisa Rubino, Francesco Ponzio, Marco Maria Fontanella, Lucio De Maria
Summary: This study investigated the associations between specific single-nucleotide polymorphisms (SNPs) in the CYP2A6 gene and the presence and rupture of intracranial aneurysms (IAs) in Italian patients. The results showed that the frequency of aSAH was significantly higher in current smokers, regardless of the pattern of CYP2A6 SNPs. There was a correlation between IA rupture and cigarette smoking in patients with the heterozygous CYP2A6 *1B2 allele.
WORLD NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Luca Zanin, Edoardo Agosti, Florian Ebner, Lucio de Maria, Francesco Belotti, Barbara Buffoli, Rita Rezzani, Bernard Hirt, Marco Ravanelli, Tamara Ius, Marco Zeppieri, Marcos Soares Tatagiba, Marco Maria Fontanella, Francesco Doglietto
Summary: This study compared the surgical volumes and exposure areas of different surgical approaches to Meckel's cave and found that endoscopic approaches can provide adequate exposure, especially for the medial portions, while microsurgical transcranial approaches still seem to be the gold standard for optimal exposure and surgical volumes in the most lateral portion of Meckel's cave.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Neurosciences
Marta Pertichetti, Daniele Corbo, Francesco Belotti, Francesca Saviola, Roberto Gasparotti, Marco Maria Fontanella, Pier Paolo Panciani
Summary: This study systematically reviewed the scientific literature on the topic of preoperative neuropsychological tests and fMRI tasks. The results showed a strong correlation between neuropsychological and fMRI results, with language being the most commonly evaluated cognitive function. The study also suggested that selecting well-adjusted and individualized neuropsychological tasks may enable the development of personalized and more efficient protocols. Furthermore, fMRI findings may help identify plasticity phenomena to avoid unintentional damage during neurosurgery.
Review
Oncology
Raffaele De Marco, Alessandro Pesaresi, Andrea Bianconi, Michela Zotta, Desiree Deandreis, Giovanni Morana, Pietro Zeppa, Antonio Melcarne, Diego Garbossa, Fabio Cofano
Summary: A systematic review of the literature was performed to investigate the integration of amino acid PET imaging in surgical practice for gliomas. Although there is limited evidence, targeting the biologically active area can assist neurosurgeons in achieving better tumor resection and provide additional information for the management of brain gliomas.
Article
Clinical Neurology
Hyunjung Kim, Jhii-Hyun Ahn, Sung Min Ko, Jin Woo Kim
Summary: The pre-navigation balloon technique significantly reduces the occurrence of distal embolism and increases the first-pass effect (FPE) during stent retriever thrombectomy. This technique is particularly effective for patients with ICA occlusion, improving clinical outcomes.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Review
Clinical Neurology
Mehdi Khaleghi, Joshua Vignolles-Jeong, Bradley Otto, Ricardo Carrau, Daniel Prevedello
Summary: This study presented a rare case of symptomatic ectopic Rathke's cleft cyst (RCC), which was located posterior to the pituitary gland and caused extensive clival erosion. The surgical technique of wide marsupialization of the cyst using intraoperative ultrasound-assisted endoscopic endonasal transclival approach was described, and a systematic literature review of intracranial ectopic RCCs was conducted.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Oscar H. Del Brutto, Denisse A. Rumbea, Aldo F. Costa, Maitri Patel, Mark J. Sedler, Robertino M. Mera
Summary: This study found an association between cognitive impairment and mortality risk in adults of Amerindian ancestry living in rural Ecuador.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Yangjingyi Xia, Li Li, Yunze Li, Manyan Hu, Tianrui Zhang, Qinghua Feng, Wenlei Li, Yuan Zhu, Minghua Wu
Summary: This study shows that fasting blood glucose (FBG) level is significantly associated with unfavorable outcome after acute ischemic stroke (AIS) in patients. The risk of unfavorable outcome increases significantly when FBG is above 5.5 mmol/L.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)