Quality of life in patients with focal dystonia

Objectives: The aims of this study were to identify the clinical and demographic factors influencing health-related quality of life (HR-QoL) and to compare HR-QoL measures between various types of focal dystonia (cervical dystonia, blepharospasm, and writer's cramp). Methods: We examined 157 consecutive patients with adult-onset primary focal dystonia, and HR-QoL was assessed by using the SF-36 questionnaire. Univariate and multivariate regression analyses were performed. Results: Patients with writer's cramp scored better in all SF-36 domains, except role functioning physical while these differences were statistically significant for physical functioning (PF) (p = 0.020), bodily (RP), pain (BP) (p = 0.001), and general health (GH) (p = 0.004). Patients with writer's cramp and blepharospasm scored significantly better for BP (p=0.001) than patients with cervical dystonia. We found that each of the eight dimensions of SF-36 proved to be significantly correlated to the Hamilton depression rating scale score in patients with torticollis and blepharospsm, while vitality (VT), social functioning (SF), and mental health (MH) scales showed statistically significant correlations in patients with hand dystonia. Similar relationships were observed between anxiety and SF-36 domains. Conclusion: Depression and anxiety are the most important predictors of poorer HR-QoL in patients with all three types of focal dystonia. (c) 2008 Elsevier B.V. All rights reserved.