Article
Clinical Neurology
Roderick P. P. W. M. Maas, Sven Killaars, Bart P. C. van de Warrenburg, Dennis J. L. G. Schutter
Summary: The CCAS-S is effective in identifying cognitive deficits in SCA3 patients, showing a high discriminative ability and correlating with disease severity measures.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Heike Jacobi, Jennifer Faber, Dagmar Timmann, Thomas Klockgether
Summary: Besides its well-established role in motor control, there is now strong evidence that the cerebellum plays a crucial role in a wide range of cognitive and affective functions. Clinical and neuropsychological studies, along with evidence from anatomical studies and advanced neuroimaging, have provided significant insights into the specific features and clinical relevance of cerebellar involvement in normal cognition and mood.
JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Gilles Naeije, Jorg B. Schulz, Louise A. Corben
Summary: This study aimed to investigate the cognitive profile of individuals with Friedreich ataxia (FRDA) and examine the correlations between clinical, genetic, and imaging characteristics and neuropsychological impairments. The meta-analysis of 18 studies revealed that individuals with FRDA demonstrated significantly lower performance in multiple cognitive domains compared to control participants. The study also identified significant associations between neuropsychological test results and disease severity, as well as links between reduced cognitive performance and changes in cerebellar structure.
Article
Clinical Neurology
Anissa Abderrakib, Noemie Ligot, Gilles Naeije
Summary: This study assessed the prevalence of CCAS after acute cerebellar vascular lesions and found that almost all patients had a definite CCAS. The study also found that CCAS can be efficiently evaluated using the CCAS-S in acute stroke settings.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Elizabeth Alejandra de la Cruz Cordoba, Juan Antonio Gonzalez Medrano, Patricia Herrera Mora, Gilberto Gomez-Garza, Maria Edith Gonzalez-Serrano, Marco Antonio Yamazaki-Nakashimada, Carmen Alicia Correa-Ramirez
Summary: Ataxia-telangiectasia (A-T) is a disease caused by mutations in the ATM gene, characterized by ataxia, mucocutaneous telangiectasia, immunodeficiency, and malignancy. Patients with A-T also experience neurocognitive and emotional disorders, showing features of cerebellar cognitive affective syndrome (CCAS). This study investigated the neurocognitive and emotional state of 9 pediatric patients with A-T and found impaired executive functioning, visual-motor integration and abilities, language problems, emotional disorders, and ataxia.
Article
Neurosciences
Stephanie Suzanne de Oliveira Scott, Jose Luiz Pedroso, Victor Vitalino Elias, Paulo Ribeiro Nobrega, Emmanuelle Silva Tavares Sobreira, Marcela Patricia de Almeida, Maria Thereza Drumond Gama, Breno Kazuo Massuyama, Orlando Graziani Povoas Barsottini, Norberto Anizio Ferreira Frota, Pedro Braga-Neto
Summary: This study translated and culturally adapted the CCAS scale to Brazilian Portuguese and validated it in a Brazilian population. The translated and adapted scale demonstrated good internal consistency and reliability, making it a potential reliable tool for screening cognitive symptoms in patients with cerebellar disease.
Article
Biology
Zegni Triki, Maria Granell-Ruiz, Stephanie Fong, Mirjam Amcoff, Niclas Kolm
Summary: Understanding how variation in brain morphology affects cognitive abilities is crucial for understanding individual differences in cognition and cognitive evolution. However, there is limited experimental data available that quantifies both cognitive abilities and brain morphology in the same individuals. In this study, female guppies were tested in two tasks to evaluate their learning abilities and cognitive flexibility, and brain regions were measured to estimate their size. The results showed that different brain regions have distinct functional correlations with cognitive tasks, with telencephalon size emerging as an important neural correlate of cognitive flexibility.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Ruben S. van der Giessen, Djaina Satoer, Peter J. Koudstaal
Summary: This study demonstrates that cerebellar lesions are associated with mild but long-term cognitive impairment in multiple neurocognitive functions. Semantic and phonemic fluency are most affected in patients with cerebellar stroke. Additionally, cognitive deficits after cerebellar stroke are more prominent in women than men.
BRAIN AND COGNITION
(2023)
Review
Neurosciences
Z. Cattaneo, C. Ferrari, A. Ciricugno, E. Heleven, D. J. L. G. Schutter, M. Manto, F. Van Overwalle
Summary: Research on the role of the posterior cerebellum in social and affective cognition using various brain stimulation methods has been reviewed. The functional role of the posterior cerebellum in processes such as mood regulation and social cognition may be explained by a generic prediction mechanism, and could involve different cortico-cerebellar and cerebellar limbic networks. Stimulation approaches such as paired-pulse TMS and frequency-tuned stimulation provide insights into cerebro-cerebellar circuits and potential clinical applications for improving social and affective skills associated with cerebellar abnormalities.
Review
Behavioral Sciences
Jessica A. Bernard
Summary: With the growing population of older adults, understanding brain and cognitive aging, especially the role of the cerebellum, is crucial. Integrating the cerebellum into models of cognitive aging is a significant step forward and could enhance our understanding of neurodegenerative diseases like Alzheimer's.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Niels Hansen, Katrin Radenbach, Kristin Rentzsch, Janosch Fox, Jens Wiltfang, Claudia Bartels
Summary: This study reports a case of a disease associated with Homer-3 autoantibodies, which presents as mild cognitive impairment and depressive symptoms. MRI showed cerebellar atrophy and CSF analysis revealed elevated tau181 protein, suggesting a possible autoimmune basis. Further research is needed to confirm whether impaired AMPAR signaling in the hippocampus caused by Homer-3 antibodies contributes to cognitive dysfunction.
Article
Pharmacology & Pharmacy
Sule Aydin, Zeynep Gul Yazici, Cansu Kilic, Birce Ercelen Ozozturk, Fatma Sultan Kilic
Summary: This study investigated the effects of Topiramate (TPM) on depression, anxiety, learning, memory, and neurobiological changes in rats exposed to chronic unpredictable mild stress (CUMS). The findings showed that TPM had different effects on cognition and neurobiological changes in rats under CUMS at different doses.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Raul Rodriguez-Cruces, Jessica Royer, Sara Lariviere, Dani S. Bassett, Lorenzo Caciagli, Boris C. Bernhardt
Summary: This manuscript reviews recent literature on the brain network substrates of cognitive and affective dysfunction in common epilepsy syndromes. The authors discuss prior work that has shown both shared and distinct brain network signatures of dysfunction across the epilepsy spectrum. This review improves our understanding of structure-function links and interindividual heterogeneity, and can aid in screening and monitoring of therapeutic strategies.
NETWORK NEUROSCIENCE
(2022)
Article
Clinical Neurology
Ece Gok-Dursun, Ozge Berna Gultekin-Zaim, Ersin Tan, Isin Unal-Cevik
Summary: The awareness of Cerebellar Cognitive Affective Syndrome (CCAS) is growing, characterized by impaired executive functions, linguistic skills, visuospatial cognition, and personality changes. In cases with features of cognitive and affective disorders, consideration should be given to posterior cerebellar and vermian pathologies. The CCAS Scale is an appropriate screening tool for detecting these patients and guiding evidence-based treatment.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Neurosciences
Chiara Ferrari, Andrea Ciricugno, Maria Arioli, Zaira Cattaneo
Summary: The medial sectors of the posterior cerebellum are involved in basic emotional recognition, while the lateral sectors are recruited for higher-level social inference. Moreover, the contribution of the cerebellum in these processes is limited to negative emotional stimuli.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Stephanie Vanclooster, Johan Bilsen, Lieve Peremans, Jutte Van der Werff Ten Bosch, Genevieve Laureys, Elsie Willems, Sophie Genin, Patrick Van Bogaert, Philippe Paquier, Anna Jansen
DEVELOPMENTAL NEUROREHABILITATION
(2019)
Article
Audiology & Speech-Language Pathology
Hyo Jung De Smet, Philippe Paquier, Jo Verhoeven, Peter Marien
BRAIN AND LANGUAGE
(2013)
Article
Neurosciences
Mathieu Bourguignon, Xavier De Tiege, Marc Op de Beeck, Noemie Ligot, Philippe Paquier, Patrick Van Bogaert, Serge Goldman, Riitta Hari, Veikko Jousmaki
HUMAN BRAIN MAPPING
(2013)
Article
Clinical Neurology
Robbert-Jan Van Hooff, Ann De Smedt, Sylvie De Raedt, Maarten Moens, Peter Marien, Philippe Paquier, Jacques De Keyser, Raf Brouns
Article
Rehabilitation
Stephanie Vanclooster, Katelijne Van Hoeck, Lieve Peremans, Johan Bilsen, Jutte Van Der Werff Ten Bosch, Genevieve Laureys, Philippe Paquier, Anna Jansen
Summary: This study aimed to describe the experiences of childhood brain tumor survivors (CBTS) and key figures in their environment after returning to school, using the International Classification of Functioning, Disability and Health framework. The results showed that school support and professional aftercare were essential to alleviate the child's difficulties, and factors such as teacher attitude, parental involvement, and collaboration practices further influenced the reintegration process.
DISABILITY AND REHABILITATION
(2021)
Review
Geriatrics & Gerontology
Silke Coemans, Esli Struys, Dorien Vandenborre, Ineke Wilssens, Sebastiaan Engelborghs, Philippe Paquier, Kyrana Tsapkini, Stefanie Keulen
Summary: Various tDCS approaches have been used to explore the potential of tDCS in improving language outcomes or slowing down the decline of language competences in PPA cases. While the stimulation protocols and study designs in PPA are similar to post-stroke aphasic populations, differences in pathophysiology require further investigation to establish the optimal stimulation paradigm. Despite heterogeneity in patient populations, stimulation protocols, and study design, tDCS is considered an effective tool for improving language outcomes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Silke Coemans, Stefanie Keulen, Perseverence Savieri, Kyrana Tsapkini, Sebastiaan Engelborghs, Nini Chrispeels, Dorien Vandenborre, Philippe Paquier, Ineke Wilssens, Mathieu Declerck, Esli Struys
Summary: This study conducted a multi-level meta-analysis to investigate deficits in executive functions (EFs) in Primary Progressive Aphasia (PPA) patients. The results showed that PPA patients had poorer EFs compared to age-matched cognitively healthy controls. There were no significant differences between the effect sizes of different EFs components, indicating similar impairments across all components. PPA variant and disease duration were found to be significant moderators of performance.
Review
Linguistics
Anastasia Lada, Philippe Paquier, Christina Manouilidou, Stefanie Keulen
Summary: Idioms have unique semantic dimensions and studying their comprehension in clinical populations, particularly individuals with aphasia, can shed light on the role of the brain in processing idiomatic language. However, there is inconsistency in the literature regarding the existence and effects of certain factors on idiomatic comprehension. This study aimed to explore the impact of idiom stimuli and tasks on language performance in aphasia.
JOURNAL OF NEUROLINGUISTICS
(2023)
Article
Neurosciences
Silke Coemans, Esli Struys, Kyrana Tsapkini, Philippe Paquier, Dorien Vandenborre, Stefanie Keulen
Summary: Transcranial Direct Current Stimulation (tDCS) is a potential tool for enhancing speech and language therapy in individuals with aphasia. This study investigates the effects of applying anodal cerebellar tDCS (ctDCS) combined with language therapy in a bilingual patient with chronic post-stroke aphasia. The results showed that both sham and anodal treatment improved trained picture naming in the treated language (L2), while anodal ctDCS also improved picture naming of untrained items in both L2 and the patient's first language, L1. Picture description abilities improved in both languages after anodal ctDCS, but not after sham.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Cheyenne Svaldi, Philippe Paquier, Stefanie Keulen, Henrieke van Elp, Coriene Catsman-Berrevoets, Annet Kingma, Roel Jonkers, Saskia Kohnen, Vania de Aguiar
Summary: This study aims to identify language processing deficits for four levels of language processing in cerebellar tumour survivors. The results showed inter-individual heterogeneity in spontaneous language outcomes, with impairments observed across all levels of language processing. Moreover, patients with postoperative cerebellar mutism syndrome (pCMS) had predominantly morphosyntactic and semantic impairments.
Article
Psychiatry
S. Keulen, P. Marien, K. van Dun, T. D'aes, L. de Page, L. de Vroege, P. Van Schuerbeek, H. Raeymaekers, J. De Mey, R. Bastiaanse, C. Van der Feltz-Cornelis, P. Paquier, F. Van Overwalle, J. Verhoeven
Summary: This case analysis describes a 28-year-old native Dutch-speaking lady who developed Foreign Accent Syndrome (FAS) and jargon speech after experiencing trauma. The results of neuropsychological tests, fMRI experiment and psychodiagnostic exams indicate a functional etiology for the symptoms, consistent with a DSM-5 conversion disorder.
EUROPEAN JOURNAL OF PSYCHIATRY
(2021)
Article
Psychology, Clinical
Stephanie Vanclooster, Johan Bilsen, Lieve Peremans, Jutte Van der Werff Ten Bosch, Genevieve Laureys, Elsie Willems, Sophie Genin, Patrick Van Bogaert, Philippe Paquier, Anna Jansen
JOURNAL OF HEALTH PSYCHOLOGY
(2019)
Meeting Abstract
Oncology
Sophie Genin, Stephanie Vanclooster, Eric Sariban, Patrick Van Bogaert, Philippe Paquier
Meeting Abstract
Oncology
S. Vanclooster, S. Genin, S. Hardonk, L. Peremans, J. Van der Werff Ten Bosch, J. Bilsen, P. Paquier, A. Jansen
PEDIATRIC BLOOD & CANCER
(2015)
Article
Clinical Neurology
Claudine Sculier, Anne-Sophie Tilmant, Xavier De Tiege, Sanda Giurgea, Philippe Paquier, Gabrielle Rudolf, Gaetan Lesca, Patrick Van Bogaert
EPILEPTIC DISORDERS
(2017)
Article
Clinical Neurology
Hyunjung Kim, Jhii-Hyun Ahn, Sung Min Ko, Jin Woo Kim
Summary: The pre-navigation balloon technique significantly reduces the occurrence of distal embolism and increases the first-pass effect (FPE) during stent retriever thrombectomy. This technique is particularly effective for patients with ICA occlusion, improving clinical outcomes.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Review
Clinical Neurology
Mehdi Khaleghi, Joshua Vignolles-Jeong, Bradley Otto, Ricardo Carrau, Daniel Prevedello
Summary: This study presented a rare case of symptomatic ectopic Rathke's cleft cyst (RCC), which was located posterior to the pituitary gland and caused extensive clival erosion. The surgical technique of wide marsupialization of the cyst using intraoperative ultrasound-assisted endoscopic endonasal transclival approach was described, and a systematic literature review of intracranial ectopic RCCs was conducted.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Oscar H. Del Brutto, Denisse A. Rumbea, Aldo F. Costa, Maitri Patel, Mark J. Sedler, Robertino M. Mera
Summary: This study found an association between cognitive impairment and mortality risk in adults of Amerindian ancestry living in rural Ecuador.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Yangjingyi Xia, Li Li, Yunze Li, Manyan Hu, Tianrui Zhang, Qinghua Feng, Wenlei Li, Yuan Zhu, Minghua Wu
Summary: This study shows that fasting blood glucose (FBG) level is significantly associated with unfavorable outcome after acute ischemic stroke (AIS) in patients. The risk of unfavorable outcome increases significantly when FBG is above 5.5 mmol/L.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
