Article
Biochemistry & Molecular Biology
Frantisek Barta, Alena Dedikova, Michaela Bebova, Sarka Duskova, Jaroslav Mraz, Heinz H. Schmeiser, Volker M. Arlt, Petr Hodek, Marie Stiborova
Summary: The exposure to AAI/AAII mixture may enhance AA-DNA adduct formation in rat livers and kidneys, partially due to inhibition of AAI detoxification and induction of NQO1. Additionally, AAII may act as an inhibitor of AAI detoxification, leading to increased AAI residues in liver and kidney tissues and enhanced AAI DNA adduct formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Liping Ma, Zhuowei Shen, Haihong Hu, Hui Zhou, Lushan Yu, Huidi Jiang, Su Zeng
Summary: The study demonstrated that co-administration with rhein significantly increased the plasma exposure of AAI and AAIa while decreasing their renal accumulation in rats. RP extract reduced the renal accumulation of AAI and AAIa, but had no significant effect on their plasma exposure levels in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Hongjian Ji, Jingyin Hu, Guozhe Zhang, Jianxiang Song, Xiaohua Zhou, Dean Guo
Summary: This study conducted a scientometric analysis of global research literature on Aristolochic acid nephropathy (AAN), indicating the significant research topic in nephrology with a focus on the mechanisms of AA-induced nephropathy.
Article
Endocrinology & Metabolism
Dong-Yuan Chang, Meng-Rui Li, Xiao-Juan Yu, Su-Xia Wang, Min Chen, Ming-Hui Zhao
Summary: In this study, it was found that compared to proteinuric DN patients, nonproteinuric DN patients had lower frequency of diabetic retinopathy (DR) and better renal outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Physiology
Aleix Navarro Garrido, Young Chul Kim, Yuji Oe, Haiyan Zhang, Maria Crespo-Masip, Helen A. Goodluck, Sadhana Kanoo, Paul W. Sanders, Stefan Broer, Volker Vallon
Summary: B0AT1 plays an important role in the retention of renal glucose and albumin, but may have adverse effects on kidney response following aristolochic acid-induced kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Biology
Chu-Kuang Chou, Yu-Shen Huang, Pei-Yu Lin, Kazuhiro Imai, Shih-Ming Chen, Jen-Ai Lee
Summary: This study revealed that Panax ginseng extract and ginsenoside saponin can significantly reduce renal injuries induced by aristolochic acid, with Rg(1) showing the best renoprotective effect among all GS-treated groups. The mechanism and renoprotective effects of Rg(1) were found to be associated with the expression of mitochondrial proteins, particularly ACO2, Usmg5, and COX5a.
Article
Oncology
Fan Lin, Yunqi Liu, Lili Tang, Xiaohui Xu, Xueli Zhang, Yifan Song, Bicheng Chen, Yeping Ren, Xiangdong Yang
Summary: The study demonstrated that rapamycin protects against aristolochic acid-induced nephropathy by activating the mTOR-autophagy axis. This finding provides evidence for rapamycin as a promising pharmacological target for the treatment of aristolochic acid nephropathy.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Medicine, General & Internal
Thomas Baudoux, Ines Jadot, Anne-Emilie Decleves, Marie-Helene Antoine, Jean-Marie Colet, Olivia Botton, Eric De Prez, Agnieszka Pozdzik, Cecile Husson, Nathalie Caron, Joelle L. Nortier
Summary: This review discusses the pathogenesis of aristolochic acid nephropathy (AAN) and its mechanisms of kidney damage. By reproducing human AAN in rodent models, the researchers have discovered the process of transition from acute kidney injury (AKI) to chronic kidney disease (CKD) and identified key factors involved in this transition. These findings are important for a better understanding of the complex AKI-to-CKD transition.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Gordana Kocic, Mihajlo Gajic, Katarina Tomovic, Jovan Hadzi-Djokic, Marko Anderluh, Andrija Smelcerovic
Summary: Aristolochic acid nephropathy is a progressive disease leading to end-stage renal disease and malignancies. New insights are provided on the energy crisis induced by aristolochic acid and the potential links with known mechanisms.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qian Zhang, Piao Luo, Jiayun Chen, Chuanbin Yang, Fei Xia, Junzhe Zhang, Huan Tang, Dandan Liu, Liwei Gu, Qiaoli Shi, Xueling He, Tong Yang, Jigang Wang
Summary: This study reveals the targeting molecular mechanisms of AA-induced nephrotoxicity. Key enzymes involved in metabolic processes and mitochondrial respiration were found to be directly bound by AA, disrupting metabolic biosynthesis processes and impairing mitochondrial functions. This ultimately leads to renal cell apoptosis and the development of aristolochic acid nephropathy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Urology & Nephrology
Shasha Zhang, Chaofan Li, Jing Huang, Yan Zhou, Caifeng Gao, Mengyao Sun, Rong Wang, Bing Chen
Summary: This study investigated the clinical manifestations, pathological features, pathogenesis, treatment, and prognosis of anti-glomerular basement membrane (anti-GBM) disease with membranous nephropathy (MN). It was found that the occurrence of acute kidney disease is lower in patients with anti-GBM disease and MN compared to anti-GBM glomerulonephritis (GN) patients. Furthermore, the proportion of glomerular crescents is lower and the renal function prognosis is better in patients with both anti-GBM disease and MN compared to classical anti-GBM GN.
Article
Immunology
Dongqing Wang, Changwei Wu, Sipei Chen, Yi Li, Li Wang, Yong Zhang, Guisen Li
Summary: This study investigated the distribution of complement in the urine of IgA nephropathy (IgAN) patients using LC-MS/MS and analyzed its correlation with clinical and pathological characteristics. The results showed that urinary complement in IgAN patients was significantly correlated with renal function, proteinuria, and renal tissue damage. This could provide potential biomarkers for monitoring IgAN and insights for therapeutic choices targeting the complement system in IgAN patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xiaoyan Wang, Ping Jia, Ting Ren, Zhouping Zou, Sujuan Xu, Yunlu Zhang, Yiqin Shi, Siyu Bao, Yingxiang Li, Yi Fang, Xiaoqiang Ding
Summary: This study reveals the involvement of miR-382 in macrophage activation during AA-induced kidney fibrosis. Knockout of miR-382 inhibits M2-like macrophage activation and kidney interstitial fibrosis, while overexpression of miR-382 promotes kidney injury. The findings highlight the important role of miR-382 in regulating kidney fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takeo Ishii, Tomohiro Kumagae, Hiromichi Wakui, Shingo Urate, Shohei Tanaka, Eriko Abe, Toru Suzuki, Takahiro Yamaji, Sho Kinguchi, Ryu Kobayashi, Kotaro Haruhara, Takashi Nakamura, Shuzo Kobayashi, Kouichi Tamura
Summary: The study found that the activity of xanthine oxidoreductase (XOR) was continuously increased in renal tissue in a mouse model of nephropathy induced by aristolochic acid, contributing to the progression of tubulo-interstitial disorders.
Review
Medicine, Research & Experimental
Qichao Hu, Yuan Chen, Xinyu Deng, Yubing Li, Xiao Ma, Jinhao Zeng, Yanling Zhao
Summary: Diabetic nephropathy is a severe complication of diabetes, but no effective therapeutic methods other than ACEIs and ARBs have been applied due to its complex pathological mechanisms. Recent studies have shown that emerging therapeutics such as novel target-based pharmacotherapy, cell therapies, and dietary regulation are leading to new hopes for DN management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Transplantation
Hongling Di, Jiahui Zhang, Erzhi Gao, Chunxia Zheng, Xianghua Huang, Qing Wang, Xiaomin Yu, Zhihong Liu
Summary: This study investigated the effects of COL4A5 gene mutations on the clinical manifestations and response to therapy in XLAS patients. The results revealed a strong relationship between transcript type and renal outcome, and the response to RAAS blockers varied among different genotypes. These findings contribute to the assessment of prognosis in AS patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Cell & Tissue Engineering
Gang Wang, Erzhi Gao, Hangdi Wu, Li Zhang, Yuqing Zhu, Jin Zhang, Zhihong Liu
Summary: Alport syndrome is a genetic chronic kidney disease with three modes of inheritance. This study reprogrammed patient's blood cells with a novel COL4A4 mutation into induced pluripotent stem cells, providing a cell model for studying the disease's pathogenesis and drug screening.
STEM CELL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Qi Wang, Yang Zhang, Bolei Zhang, Yao Fu, Xiaozhi Zhao, Jing Zhang, Ke Zuo, Yuexian Xing, Song Jiang, Zhaohui Qin, Erguang Li, Hongqian Guo, Zhihong Liu, Jingping Yang
Summary: Papillary renal cell carcinoma (pRCC) is a highly heterogeneous cancer with varying patient survival. Recent studies have found that pRCC can originate from proximal tubule (PT) cells as well as kidney collecting duct principal cells. Different cell-of-origin for pRCC result in distinct molecular characteristics and clinical behaviors. Metabolic reprogramming may play a role in the progression of pRCC. Determining the cell-of-origin and monitoring origin-dependent metabolism could potentially aid in early diagnosis and treatment of pRCC.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Jicheng Lv, Muh Geot Wong, Michelle A. Hladunewich, Vivekanand Jha, Lai Seong Hooi, Helen Monaghan, Minghui Zhao, Sean Barbour, Meg J. Jardine, Heather N. Reich, Daniel Cattran, Richard Glassock, Adeera Levin, David C. Wheeler, Mark Woodward, Laurent Billot, Sandrine Stepien, Kris Rogers, Tak Mao Chan, Zhi-Hong Liu, David W. Johnson, Alan Cass, John Feehally, Jurgen Floege, Giuseppe Remuzzi, Yangfeng Wu, Rajiv Agarwal, Hong Zhang, Vlado Perkovic
Summary: This international multicenter randomized clinical trial found that oral methylprednisolone significantly reduced the risk of kidney function decline, kidney failure, or death due to kidney disease in patients with IgA nephropathy at high risk of progression. However, it also increased the incidence of serious adverse events.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Chemistry, Multidisciplinary
Tushuai Li, Li Chen, Xiao Fu, Zhihong Liu, Shenglong Zhu, Yongquan Chen, Jie Zhang
Summary: This study presents the synthesis of a safe and universal nanoparticle Fe SANP, which acts as a catalase-like nanozyme and generates hydroxyl radicals to enhance cancer cell elimination. The nanoparticles exhibit pH-induced degradable properties for specific drug release in the tumor microenvironment, with negligible systematic toxicity.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Wen Zheng, Jia Guo, Xiaoqing Lu, Yingjin Qiao, Dongwei Liu, Shaokang Pan, Lulu Liang, Chang Liu, Hongchao Zhu, Zhihong Liu, Zhangsuo Liu
Summary: The study identified cAMP-response element binding protein (CREB) as a key regulator of long non-coding RNA DLX6-AS1 in diabetic nephropathy (DN). CREB targeted DLX6-AS1 and aggravated renal inflammation, leading to podocyte injury. Inhibition of CREB reduced DLX6-AS1 levels and attenuated renal damage, suggesting that CREB may be a potential therapeutic target for the treatment of DN.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Transplantation
William G. Herrington, Christoph Wanner, Jennifer B. Green, Sibylle J. Hauske, Parminder Judge, Kaitlin J. Mayne, Sarah Y. A. Ng, Emily Sammons, Doreen Zhu, Natalie Staplin, David Preiss, Will Stevens, Karl Wallendszus, Rejive Dayanandan, Carol Knott, Michael Hill, Jonathan Emberson, Susanne Brenner, Vladimir Cejka, Alfred K. Cheung, Zhihong Liu, Jing Li, Peiling Chen, Laiseong Hooi, Wen Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Cherney, Roberto Pontremoli, Aldo Pietro Maggioni, Shinya Goto, Aiko Tomita, Rajat Deo, Katherine Tuttle, Jens Eilbracht, Stefan Hantel, Mark Hopley, Martin J. Landray, Colin Baigent, Richard Haynes
Summary: The EMPA-KIDNEY trial aims to evaluate the effects of empagliflozin on the risk of kidney disease progression or cardiovascular death in patients with chronic kidney disease. The trial includes a widely generalizable population of CKD patients and uses a streamlined design with minimal data collection. Results are anticipated in 2022.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Cell Biology
Hui Wang, Daoyuan Lv, Song Jiang, Qing Hou, Lei Zhang, Shen Li, Xiaodong Zhu, Xiaodong Xu, Jianqiang Wen, Caihong Zeng, Mingchao Zhang, Fan Yang, Zhaohong Chen, Chunxia Zheng, Jing Li, Ke Zen, Zhihong Liu, Limin Li
Summary: The study reveals the critical role of pyroptosis in podocyte damage mediated by complement activation in membranous nephropathy. It also uncovers mitochondrial dysfunction as an important mechanism underlying pyroptosis. These findings provide new insight and potential therapeutic targets for the treatment of membranous nephropathy.
CELL DEATH & DISEASE
(2022)
Article
Public, Environmental & Occupational Health
Ping Li, Mingjia Yang, Dong Hang, Yongyue Wei, Hongling Di, Hongbing Shen, Zhihong Liu
Summary: Current smoking, high TG, and high SBP were the top three risk factors contributing to CKD burden in China. Increased BMI, DBP, plasma glucose, and decreased HDL-C were also associated with the increase in CKD burden.
JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiuwen Zhai, Chunyou Mao, Qingya Shen, Shaokun Zang, Dan-Dan Shen, Huibing Zhang, Zhaohong Chen, Gang Wang, Changming Zhang, Yan Zhang, Zhihong Liu
Summary: In this study, the cryo-electron microscopy structures of PTH- and ABL-bound PTH1R-Gs complexes were reported, revealing the molecular basis of ligand duration. The results provide insights into the mechanistic understanding of ligand-mediated prolonged or transient signaling.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Na Zhang, Jie Zhang, Zhihong Liu, Tushuai Li
Summary: This study utilized ChIP-seq data to analyze the gene transcription regulation network of ASCL1 in GBM and identified EGFR, SPTAN1, and CTNN1B as potential downstream genes in GBM development.
FRONTIERS IN GENETICS
(2022)
Article
Computer Science, Interdisciplinary Applications
Yang Nan, Peng Tang, Guyue Zhang, Caihong Zeng, Zhihong Liu, Zhifan Gao, Heye Zhang, Guang Yang
Summary: This paper introduces a novel unsupervised learning method for accurate tissue segmentation by integrating a deep mixture model with a constrained indicator. The proposed method achieves better performance and improved stability compared to other existing unsupervised segmentation approaches, with similar performance to the fully supervised U-Net.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Medicine, General & Internal
William G. Herrington, Natalie Staplin, Christoph Wanner, Jennifer B. Green, Sibylle J. Hauske, Jonathan R. Emberson, David Preiss, Parminder Judge, Kaitlin J. Mayne, Sarah Y. A. Ng, Emily Sammons, Doreen Zhu, Michael Hill, Will Stevens, Karl Wallendszus, Susanne Brenner, Alfred K. Cheung, Zhi-Hong Liu, Jing Li, Lai Seong Hooi, Wen Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Cherney, Aldo P. Maggioni, Roberto Pontremoli, Rajat Deo, Shinya Goto, Xavier Rossello, Katherine R. Tuttle, Dominik Steubl, Michaela Petrini, Dan Massey, Jens Eilbracht, Martina Brueckmann, Martin J. Landray, Colin Baigent, Richard Haynes
Summary: Empagliflozin therapy reduces the risk of disease progression or cardiovascular death in patients with chronic kidney disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yujie Zhu, Mingchao Zhang, Weiran Wang, Shuang Qu, Minghui Liu, Weiwei Rong, Wenwen Yang, Hongwei Liang, Caihong Zeng, Xiaodong Zhu, Limin Li, Zhihong Liu, Ke Zen
Summary: Reduction of renal tubular cell PNPT1 causes renal tubular translation arrest and atrophy, which leads to tubular injury. Increasing PNPT1 expression can alleviate tubular injury.
NATURE COMMUNICATIONS
(2023)
Article
Urology & Nephrology
Daisuke Koya, Stefan D. Anker, Luis M. Ruilope, Peter Rossing, Zhihong Liu, Byung Wan Lee, Chien-Te Lee, Charlie Scott, Peter Kolkhof, Robert Lawatscheck, Lili Wang, Amer Joseph, Bertram Pitt
Summary: This study found that finerenone significantly improved cardiorenal outcomes in Asian patients, with similar benefits seen in non-Asian patients as well. The safety profile of finerenone was consistent across subgroups.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)