Article
Endocrinology & Metabolism
Victoria Persky, Chibuzor Abasilim, Konstantina Tsintsifas, Tessa Day, Robert M. Sargis, Martha L. Daviglus, Jianwen Cai, Sally Freels, Terry Unterman, Noel Chavez, Robert Kaplan, Carmen R. Isasi, Amber Pirzada, Michelle L. Meyer, Gregory A. Talavera, Bharat Thyagarajan, Brandilyn A. Peters, Jessica M. Madrigal, Arielle Grieco, Mary E. Turyk
Summary: This study examined the associations between endogenous sex hormones and diabetes progression. It found an inverse association between testosterone levels in men and conversion from prediabetes to diabetes, and an inverse association between SHBG levels in women and various glycemic measures as well as prediabetes to diabetes conversion.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Agronomy
Wenkai Duan, Lingyao Peng, Jingyong Jiang, Hui Zhang, Guotong Tong
Summary: This study analyzed the differential genes and metabolites in strawberry plants infected with powdery mildew using transcriptomic and metabolomic methods. The results showed that genes involved in plant-pathogen interactions, carbon metabolism, and photosynthesis were upregulated in infected plants. Additionally, the differential metabolites mainly consisted of amino acids, phenols, flavonoids, carbohydrates, and acids. The study provides a reference for developing disease-resistant strawberry plants.
Article
Immunology
Victoria Peer, Khitam Muhsen, Moshe Betser, Manfred S. Green
Summary: Pregnant women have lower immune response to pertussis vaccination compared to non-pregnant women, possibly due to higher levels of hormones during pregnancy. Sex hormones during pregnancy, such as progesterone and estrogen, are negatively associated with anti-pertussis toxin antibody levels.
Review
Dermatology
Matheus de Castro Costa, Milena Moraes de Carvalho, Felipe Fornias Sperandio, Noe Vital Ribeiro Junior, Joao Adolfo Costa Hanemann, Suzane Cristina Pigossi, Marina Lara de Carli
Summary: A review of cases of oral PCM in women found that Brazilian White women between 40 and 50 years who were housewives or rural workers were most affected. Some cases showed systemic changes at the time of PCM diagnosis, such as HIV infection, pregnancy, and depression. Most patients were treated with sulfamethoxazole + trimethoprim or itraconazole.
Article
Microbiology
Tereza Graciano Nascimento de Brito, Mariane Taborda, Bruna Provenci, Andre Nathan Costa, Gil Benard
Summary: Clinical observations have shown that women may have a protective effect against paracoccidioidomycosis, but the mechanism behind this protection remains unclear. While experiments in murine models have produced conflicting results, studies comparing disease severity between men and women are lacking. Data from skin test surveys suggest similar infection rates but lower disease prevalence in women, highlighting a paradox that warrants further investigation.
Article
Multidisciplinary Sciences
Marcelo R. A. de Figueiredo, Anita Kuepper, Jenna M. Malone, Tijana Petrovic, Ana Beatriz T. B. de Figueiredo, Grace Campagnola, Olve B. Peersen, Kasavajhala V. S. K. Prasad, Eric L. Patterson, Anireddy S. N. Reddy, Martin F. Kubes, Richard Napier, Franck E. Dayan, Christopher Preston, Todd A. Gaines
Summary: A 27-nucleotide deletion removing nine amino acids in the degron tail of the auxin coreceptor Aux/IAA2 (SoIAA2) is associated with 2,4-D resistance in a Sisymbrium orientale weed population. The deletion reduces binding to TIR1 and increases dissociation rates, resulting in resistance to synthetic auxin herbicides.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Xin Wang, Ning Ding, Sioban D. Harlow, John F. Randolph, Bhramar Mukherjee, Ellen B. Gold, Sung Kyun Park
Summary: Exposure to heavy metals may affect sex hormone levels in women. This study analyzed the association between urinary metal concentrations and serum levels of estradiol (E-2), follicle-stimulating hormone (FSH), testosterone, and sex hormone-binding globulin (SHBG) in a multi-ethnic group of women aged 45-56 years. The results showed that higher urinary metal concentrations were linked to lower E-2 levels for mercury and lead, higher FSH levels for lead, and higher SHBG levels for cadmium. However, no significant association was found between metals and testosterone levels.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Tao Feng, Zhao-Yang Zhang, Peng Gao, Zhi-Ming Feng, Shi-Min Zuo, Shou-Qiang Ouyang
Summary: MicroRNAs (miRNAs) are small RNA molecules in eukaryotes that play important roles in plant development and defense against stresses. Osa-miR444b.2 was found to be induced after infection with the fungal pathogen Rhizoctonia solani in rice. Overexpression of Osa-miR444b.2 compromised resistance to R. solani, while knocking out this miRNA improved resistance. Knocking out Osa-miR444b.2 also affected agronomic traits in rice. RNA-seq analysis revealed that Osa-miR444b.2 regulated resistance to rice sheath blight by influencing the expression of hormone signaling pathway genes and transcription factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Brandilyn A. Peters, David B. Hanna, Yi Wang, Kathleen M. Weber, Elizabeth Topper, Allison A. Appleton, Anjali Sharma, Howard N. Hodis, Nanette Santoro, Chantal Guillemette, Patrick Caron, Rob Knight, Robert D. Burk, Robert C. Kaplan, Qibin Qi
Summary: The study found that there is an interplay between sex hormones and the gut microbiome, which may impact cardiovascular risk. Serum sex hormones are associated with gut microbiome diversity and composition, and the gut microbiome may play a role in estrogen-related cardiovascular protection.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Pahriya Ashrap, Emily S. Barrett, Deborah J. Watkins, Amber L. Cathey, Carmen M. Velez-Vega, Zaira Rosario, Jose F. Cordero, Akram Alshawabkeh, John D. Meeker
Summary: Metal(loid)s may act as endocrine disruptors by altering prenatal hormone levels, with potential effects depending on specific windows of exposure during pregnancy. Essential metal(loid)s such as manganese and cobalt may also contribute to adverse maternal and fetal outcomes. Future studies are needed to further investigate these associations, as the study of metal(loid)s as endocrine disruptors is still in its early stages of epidemiological research.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Eva Cecilie Bonefeld-Jorgensen, Sophie Amalie H. Boesen, Maria Wielsoe, Tine Brink Henriksen, Bodil Hammer Bech, Thorhallur Ingi Halldorson, Manhai Long
Summary: This study examines the possible associations between maternal Persistent Organic Pollutants (POP) exposure, maternal hormone levels, and fetal growth indices (FGI). Lipophilic POP exposure was inversely associated with androgen and estrogen levels, but not strongly associated with thyroid hormones. Higher levels of perfluorinated-alkyl-acid (PFAA) were associated with higher thyroid and androgen levels. The thyroid-peroxidase-antibody (TPO-Ab) and estradiol levels were associated with birth weight and length in sons, but inversely associated with birth weight and length in daughters.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Martin Rutegard, John Moshtaghi-Svensson, Caroline E. Weibull, Ulrika Ottander, Caroline Nordenvall, Malin Sund
Summary: Anastomotic leakage rates are lower in women exposed to hormone replacement therapy before surgery for colorectal cancer, especially in rectal cancer cases.
COLORECTAL DISEASE
(2022)
Article
Environmental Sciences
Catheryne Chiang, Diana C. Pacyga, Rita S. Strakovsky, Rebecca L. Smith, Tamarra James-Todd, Paige L. Williams, Russ Hauser, Daryl D. Meling, Zhong Li, Jodi A. Flaws
Summary: This study found that there are positive associations between phthalate exposure and hormone levels in midlife women, especially affecting reproductive hormones, but the specific mechanisms are still unclear. Exposure to phthalates may have adverse effects on ovarian function, leading to changes in hormone levels, particularly estrogen, progesterone, and others.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Behavioral Sciences
Hongying Han, Xiaowei Xia, Huirong Zheng, Zhiyong Zhong, Chongbang Zhao, Xianglan Wang, Ximei Zhi
Summary: This study found that the high susceptibility of perimenopausal women to depression may be associated with lower educational level, more severe perimenopausal symptoms, and altered metacognition.
BRAIN AND BEHAVIOR
(2023)
Article
Physiology
Kayoko Kamemoto, Mizuki Yamada, Tomoka Matsuda, Hazuki Ogata, Akira Ishikawa, Moe Kanno, Masashi Miyashita, Mikako Sakamaki-Sunaga
Summary: This study compared the effects of acute exercise on appetite-regulating hormones in different phases of the menstrual cycle in physically active women. The results showed that exercise increased ovarian hormones, but did not have a significant impact on appetite-regulating hormones, subjective appetite, or energy intake.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Shraddha Tiwari, Sonia K. Shishodia, Jata Shankar
Article
Biochemical Research Methods
Sonia Kumari Shishodia, Jata Shankar
CURRENT PROTEOMICS
(2020)
Article
Biochemical Research Methods
Sonia K. Shishodia, Jata Shankar
JOURNAL OF PROTEOMICS
(2020)
Article
Chemistry, Multidisciplinary
Shanu Hoda, Lovely Gupta, Jata Shankar, Alok Kumar Gupta, Pooja Vijayaraghavan
Review
Plant Sciences
Manali Gangwar, Jata Shankar
FRONTIERS IN PLANT SCIENCE
(2020)
Article
Environmental Sciences
Komal Agrawal, Jata Shankar, Raj Kumar, Pradeep Verma
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
(2020)
Article
Biotechnology & Applied Microbiology
Komal Agrawal, Jata Shankar, Pradeep Verma
Review
Nutrition & Dietetics
Jata Shankar
Summary: The mycobiota in the human gut is not only associated with healthy homeostasis, but it can also be influenced by factors such as diet habits and alcohol consumption, leading to changes in composition that may affect the immune system or overall health.
FRONTIERS IN NUTRITION
(2021)
Article
Immunology
Pooja Sen, Lovely Gupta, Mukund Vijay, Maansi Vermani Sarin, Jata Shankar, Saif Hameed, Pooja Vijayaraghavan
Summary: The present study investigated the antibiofilm activity of eugenol against azole-resistant A. fumigatus isolates. The results showed that eugenol exhibited antibiofilm activity and significantly decreased the expression of efflux pump and biofilm-related genes in azole-resistant isolates.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tulika Srivastava, Divya Tyagi, Siraj Fatima, Malur Thirumalesh Vishnu Sathyan, Ritu Raj, Aniket Sharma, Minal Chaturvedi, Meetali Sinha, Sonia Kumari Shishodia, Dinesh Kumar, Sandeep K. Sharma, Jata Shankar, Aruna Satish, Smriti Priya
Summary: Small molecules have shown promise as therapeutic molecules for metabolic and neurological disorders. In this study, the natural small molecule Shikonin was found to inhibit protein aggregation and protect against neurodegenerative diseases in Caenorhabditis elegans. Shikonin significantly reduced the aggregation of a-synuclein, improved locomotor activity, and prevented neuronal degeneration. These findings highlight the potential of natural small molecules in the treatment of protein aggregation and neurodegenerative diseases.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Chhavi Thakur, Amanjot Singh Malhotra, Jata Shankar
Summary: In this study, the interaction between gallic acid and polyketide synthase A (PksA) in aflatoxin-producing Aspergilli was investigated using molecular docking and molecular dynamics simulations. The results showed that gallic acid has the potential to inhibit the biosynthesis of aflatoxin.
CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY
(2023)
Article
Biology
Jata Shankar
Summary: This study investigated the germination process of Aspergillus niger conidia using protein analysis and identified key proteins involved in biochemical pathways. The findings contribute to comparative proteomics and understanding of pathogenic fungi.
Article
Integrative & Complementary Medicine
Shanu Hoda, Maansi Vermani, Rajesh K. Joshi, Jata Shankar, Pooja Vijayaraghavan
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2020)
Article
Mycology
Sonia K. Shishodia, Shraddha Tiwari, Shanu Hoda, Pooja Vijayaraghavan, Jata Shankar
MYCOLOGY-AN INTERNATIONAL JOURNAL ON FUNGAL BIOLOGY
(2020)
Article
Mycology
Sonia Kumari Shishodia, Shraddha Tiwari, Jata Shankar
MYCOLOGY-AN INTERNATIONAL JOURNAL ON FUNGAL BIOLOGY
(2019)