期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 20, 期 9, 页码 839-853出版社
ELSEVIER SCI LTD
DOI: 10.1111/1469-0691.12678
关键词
beta-Lactamase; Carba NP; carbapenemase; detection; Enterobacteriaceae; MALDI-TOFMS
资金
- Ministry of Health of the Czech Republic [NT11032-6/ 2010]
- Charles University Research Fund [P36]
- Charles University - Education for Competitiveness Operational Programme (ECOP) [CZ.1.07/2.3.00/30.0022]
- ESF
- government budget of the Czech Republic
Carbapenemase-producing bacteria have now spread all over the world. Infections caused by those bacteria are difficult to treat. Therefore, there is an urgent need for accurate and fast detection of carbapenemases in diagnostic laboratories. In this review, we summarize screening methods for suspected isolates, direct assays for confirmation of carbapenemase activity (e.g. the Carba NP test and matrix-assisted laser desorption ionization time-of-flight mass spectrometry carbapenem hydrolysis assay), inhibitor-based methods for carbapenemase classification, and molecular-genetic techniques for precise identification of carbapenemase genes. We also propose a workflow for carbapenemase identification in diagnostic laboratories.
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