Article
Microbiology
Sarah R. Beattie, Taiwo Esan, Robert Zarnowski, Emily Eix, Jeniel E. Nett, David R. Andes, Timothy Hagen, Damian J. Krysan
Summary: New antifungal therapies are needed for various fungal infections, including biofilms and drug-resistant strains. A novel keto-alkyl-pyridinium scaffold has been identified with broad spectrum activity against medically important fungi. This class of molecules shows potential for non-systemic applications.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Rabina Kumpakha, Donna M. Gordon
Summary: In this study, the researchers demonstrated the efficacy of occidiofungin against biofilm development of Candida albicans and Candida tropicalis, including inhibiting cell dispersal. The results suggest that occidiofungin has strong antibiofilm activity and potential as a therapeutic for Candida infections.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Milena Radunovic, Milena Barac, Jovana Kuzmanovic Pficer, Dusan Pavlica, Aleksandar Jovanovic, Ana Pucar, Sanja Petrovic
Summary: The aim of this study was to compare the antifungal susceptibility of Candida isolated from the tongue and subgingival biofilm. The results showed that both tongue and subgingival isolates were susceptible to amphotericin B. Tongue isolates were more susceptible to fluconazole, while subgingival isolates showed lower susceptibility to itraconazole. The study also found a correlation between the susceptibility of C. albicans to antifungals and oral hygiene and moderate periodontal destruction.
Article
Biochemistry & Molecular Biology
Georgiana Negru, Laure Kamus, Elena Bicu, Sergiu Shova, Boualem Sendid, Faustine Dubar, Alina Ghinet
Summary: The reaction between benzylidenemalononitriles and phenylhydrazines in refluxing ethanol did not lead to pyrazole derivatives, but instead produced hydrazones, whose structure was confirmed by X-ray analysis. The newly synthesized hydrazones showed promising antifungal activity against Candida spp., with five compounds demonstrating selective antifungal activity with MIC99 values ranging from 16 to 32 μg/mL.
Article
Microbiology
Katura Metzner, Matthew J. O'Meara, Benjamin Halligan, Jesse W. Wotring, Jonathan Z. Sexton, Teresa R. O'Meara
Summary: Fungal pathogens like Candida albicans can cause devastating human disease, but there is high resistance to antifungal therapies. Targeting virulence factors is a new approach to antimicrobial development, and we identified NSC 697923 as a compound that blocks the hyphal transition in C. albicans by targeting eIF3.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Henry W. Nabeta, Joseph C. Kouokam, Amanda B. Lasnik, Joshua L. Fuqua, Kenneth E. Palmer
Summary: This study demonstrates the novel antifungal activity of Q-Griffithsin (Q-GRFT) against various Candida strains by binding to alpha-mannan in the cell wall, disrupting cell wall integrity, and inducing ROS formation leading to cell death. Q-GRFT also inhibits the growth of other Candida species and shows potential as a drug candidate for the prevention and treatment of fungal infections.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Lynn Miesel, Melanie T. Cushion, Alan Ashbaugh, Santiago R. Lopez, Voon Ong
Summary: Rezafungin, a novel echinocandin, has shown efficacy against Candida, Aspergillus, and Pneumocystis in prophylactic studies. By reducing fungal burden and preventing infection, it has the potential to be a single-agent prophylaxis against invasive fungal diseases caused by these pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Jie Tu, Na Liu, Yahui Huang, Wanzhen Yang, Chunquan Sheng
Summary: Candida auris is a major global threat to human health due to its strong drug resistance. This review provides a comprehensive overview of current strategies, drug candidates, and lead compounds for the treatment of C. auris. The resistance profiles and mechanisms are summarized, and the structures and activities of clinical candidates, drug combinations, antifungal chemosensitizers, repositioned drugs, new targets, and new types of compounds are discussed in detail. The review also offers perspectives for guiding future research in this field.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biotechnology & Applied Microbiology
Payal Gupta, Hrishikesh Gupta, Krishna Mohan Poluri
Summary: The research evaluated the antifungal activity of geraniol against Candida glabrata biofilm, discovering multiple mechanisms including biofilm eradication, cellular pathway interference, and induction of apoptosis. These findings strengthen the candidacy of geraniol as a novel antifungal therapeutic.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Infectious Diseases
Anna Esposito, Antonella Migliaccio, Vita Dora Iula, Raffaele Zarrilli, Annalisa Guaragna, Eliana De Gregorio
Summary: The glucocorticoid PYED-1 showed weak antifungal activity against five major Candida species but exhibited good anti-biofilm activity. It also inhibited germ tube and hyphae formation of C. albicans and reduced adhesion of C. albicans to abiotic surfaces by up to 30%.
Article
Nanoscience & Nanotechnology
Sebastian Schaefer, Thi Thu Phuong Pham, Sascha Brunke, Bernhard Hube, Kenward Jung, Megan Denise Lenardon, Cyrille Boyer
Summary: Research has been conducted on the effect of degree of polymerization and hydrophobic functionalities on the antifungal activity of synthetic polyacrylamides. Short copolymers with a calculated log P of around 1.5 have shown optimal activity against major human fungal pathogens, with limited toxicity to mammalian host cells. Selected copolymers have shown potential as novel antifungal compounds, outperforming commercial antifungal drugs.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Infectious Diseases
Clarice Elvira Saggin Sabadin, Soraia Lima Lopes, Olga Fischmamm Gompertz, Gilglecia Novaes Pereira Santana, Analy Salles de Azevedo Melo, Lilian Rigo, Daniel Archimedes Da Matta, Dulce Aparecida Barbosa
Summary: This study investigated oral colonization of Candida species and their susceptibility to antifungals in liver transplant patients. Results showed stable yeast species colonization in some patients over 6 months, but substitution in others. The study highlights the importance of monitoring antifungal resistant strains.
Article
Dermatology
Jiacheng Dong, Guanzhao Liang, Hailin Zheng, Siyue Kan, Nana Song, Meijie Zhang, Weida Liu
Summary: Ravuconazole showed good activity against C. auris and vaginal Candida isolates, suggesting it could be used as an effective treatment for drug-resistant candidiasis.
Article
Microbiology
Antonio Serrano, Miguel A. Basante-Bedoya, Martine Bassilana, Robert A. Arkowitz
Summary: Ergosterol, an essential component of the fungal plasma membrane, plays a critical role in the cell cycle of Candida albicans. The dynamics of ergosterol and its response to drug treatment were investigated using the D4H reporter. The study showed that highly polarized ergosterol is not necessary for budding or filamentous growth in this opportunistic pathogen.
Article
Microbiology
Jiadi Shen, Ming Ma, Wei Duan, Yun Huang, Banruo Shi, Qiaochu Wu, Xin Wei
Summary: This study aimed to investigate the effects of an activator and an inhibitor of autophagy on the susceptibility of C. albicans biofilms to antifungal agents and the related mechanisms. It was found that the autophagic activity of C. albicans biofilms was closely related to their susceptibility to antifungal agents.
Letter
Infectious Diseases
Jan Hendrik Grothe, Oliver A. Comely, Jon Salmanton-Garcia
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2023)
Article
Infectious Diseases
Jannik Stemler, Jon Salmanton-Garcia, Ben Weise, Christina Toebben, Carolin Joisten, Julian Fleig, Oliver A. Cornely
Summary: A prevalence investigation using rapid antigen testing found a more than twofold higher prevalence of SARS-CoV-2 infection compared to governmental reports in Germany. Out of 419 valid test results, 7 (1.67%) were positive, and three positive individuals were not included in the governmental statistics as they did not have a PCR test.
Review
Infectious Diseases
Molly Murton, Emma Drane, James Jarrett, Oliver A. Cornely, Alex Soriano
Summary: This study conducted a systematic literature review to summarize economic evaluations, and cost and resource use evidence related to remdesivir during the COVID-19 pandemic. The results showed an increase in the prescription rate of remdesivir and a decrease in bed occupancy with its use. The cost estimates for remdesivir varied widely, and most economic evaluations considered it cost-effective.
Article
Infectious Diseases
Renato Pascale, Alice Toschi, Abdullah Tarik Aslan, Giulia Massaro, Angelo Maccaro, Davide Fabbricatore, Andrea Dell'Aquila, Marco Ripa, Mehmet Emirhan Isik, Yesim Uygun Kazmaz, Saverio Iacopino, Marta Camici, Francesco Perna, Karolina Akinosoglou, Arta Karruli, Matthaios Papadimitriou-Olivgeris, Bircan Kayaaslan, Yesim Aybar Bilir, Emin Evren Ozcan, Oguzhan Ekrem Turan, Muhammed Cihan Isik, Maria Teresa Perez-Rodriguez, Belen Loeches Yague, Alejandro Martin Quiros, Mesut Yilmaz, Sabine Petersdorf, Tom De Potter, Emanuele Durante-Mangoni, Murat Akova, Antonio Curnis, Dino Gibertoni, Igor Diemberger, Luigia Scudeller, Pierluigi Viale, Maddalena Giannella
Summary: This study investigated the risk factors and clinical characteristics of Gram-negative bacteria CIED infections. It found that obesity, a high number of comorbidities, and right subclavian vein implantation site were associated with an increased risk of GNB-CIED infection. Prompt therapeutic intervention guided by FDG PET/CT is suggested for patients with GNB-CIED infection due to the poorer outcome observed in this group.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
Katharine E. Stott, Melanie Moyo, Ajisa Ahmadu, Cheusisime Kajanga, Ebbie Gondwe, Wezzie Chimang'anga, Madalitso Chasweka, Tshepo B. Leeme, Mooketsi Molefi, Awilly Chofle, Gabriella Bidwell, John Changalucha, Jenny Unsworth, Ana Jimenez-Valverde, David S. Lawrence, Henry C. Mwandumba, David G. Lalloo, Thomas S. Harrison, Joseph N. Jarvis, William Hope, Anne-Grete Martson
Summary: This study describes the population PK of AmBisome and highlights the variability therein. It also emphasizes the importance of thorough PK/PD analysis in the development of novel antifungals and highlights the challenges associated with post hoc PK/PD analysis.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Taha Koray Sahin, Enes Erul, Melek Seren Aksun, Meliha Cagla Sonmezer, Serhat Unal, Murat Akova
Summary: This study surveyed 283 physicians in Turkey about their knowledge, attitude, concerns, and vaccine acceptance for monkeypox. The results showed that 32.5% of the physicians had a good level of knowledge and 31.4% planned to have the monkeypox vaccine. Female physicians and older individuals were more likely to be knowledgeable about monkeypox. Physicians from internal medicine divisions, those who learned about monkeypox during medical school or residency, and those previously exposed to COVID-19 had a higher knowledge score of monkeypox. Physicians with a good knowledge score were more worried about monkeypox compared to COVID-19.
Article
Microbiology
Alex Howard, William Hope
Summary: Pharmacokinetic-pharmacodynamic (PK-PD) analysis is crucial for the development of antifungal drugs in clinical use. This review focuses on the progress made in disease model design, outcome selection and translational modelling in antifungal PK-PD studies over the past 30 years. The review also discusses the application of PK-PD parameters in current clinical practice and their relevance to existing and novel antifungal agents.
Article
Microbiology
Verena Harpf, Guenter Rambach, Nadia Parth, Magdalena Neurauter, Verena Fleischer, Michaela Lackner, Cornelia Lass-Floerl, Reinhard Wuerzner, Cornelia Speth
Summary: Mucormycetes, a heterogeneous group of fungi, induce a life-threatening disease called mucormycosis. Immune deficiencies represent a major risk factor; hence, we wanted to illuminate the role of complement and platelets in the defense against mucormycetes. In vitro experiments showed significant differences in complement deposition between mucormycetes.
Article
Infectious Diseases
Maria-Ioanna Beredaki, Maiken C. Arendrup, David Andes, Joseph Meletiadis
Summary: By developing a novel in vitro dialysis-diffusion PK/PD model, the pharmacodynamics of micafungin against Candida albicans were studied. The study supports the EUCAST breakpoints but questions the appropriateness of the current CLSI breakpoint.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Alessandro Busca, Jon Salmanton-Garcia, Francesco Marchesi, Francesca Farina, Guldane Cengiz Seval, Jaap Van Doesum, Nick C. De Jonge, Nathan C. Bahr, Johan Maertens, Joseph S. Meletiadis, Nicola S. Fracchiolla, Barbora Weinbergerova, Luisa Verga, Zdenek Racil, Moraima Jimenez, Andreas Glenthoj, Ola Blennow, Alina Daniela Tanase, Martin Schoenlein, Lucia Prezioso, Nina F. Khanna, Rafael F. Duarte, Pavel Zak, Marcio Nucci, Marina Machado, Austin Kulasekararaj, Ildefonso Espigado, Elizabeth De Kort, Jose-Maria Ribera-Santa Susana, Monia Marchetti, Gabriele Magliano, Iker Falces-Romero, Osman Ilhan, Emanuele Ammatuna, Sofia Zompi, Panagiotis Tsirigotis, Anastasia Antoniadou, Giovanni Paolo Maria Zambrotta, Anna Nordlander, Linda Katharina Karlsson, Michaela Hanakova, Giulia Dragonetti, Alba Cabirta, Caroline Berg Venemyr, Stefanie Graefe, Jens Van Praet, Athanasios Tragiannidis, Verena Petzer, Alberto Lopez-Garcia, Federico Itri, Ana Groh, Eleni Gavriilaki, Michelina Dargenio, Laman A. Rahimli, Oliver A. Cornely, Livio Pagano
Summary: This multicenter retrospective study analyzed the outcome and risk factors for mortality in 326 adult HSCT patients who developed COVID-19. The results showed that age, comorbidities, active hematologic disease, timing from transplant, and severity of the infection were associated with a higher risk of mortality. The overall mortality rate was 21%, with COVID-19 being the main or secondary cause of death in 16% of the patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Jannik Stemler, Christina Toebben, Cornelia Lass-Floerl, Joerg Steinmann, Katharina Ackermann, Peter-Michael Rath, Michaela Simon, Oliver Andreas Cornely, Philipp Koehler
Summary: The review provides an overview of the management of invasive aspergillosis caused by non-fumigatus Aspergillus species. It discusses diagnostic and therapeutic differences and similarities compared to A. fumigatus for species such as A. flavus, A. terreus, A. niger, and A. nidulans. These species exhibit varying resistance to antifungal drugs and have different clinical manifestations.
Article
Public, Environmental & Occupational Health
Christos Argyropoulos, Janina Leckler, Jon Salmanton-Garcia, Marinos Constantinou, Alexandra Alexandrou, Sophia Themistocleous, Evgenia Noula, George Shiamakkides, Andria Nearchou, Fiona A. Stewart, Kerstin Albus, Markela Koniordou, Ioannis Kopsidas, Orly Spivak, Margot Hellemans, Greet Hendrickx, Ruth Joanna Davis, Anna Maria Azzini, Paula Valle Simon, Antonio Javier Carcas-Sansuan, Helena Hervius Askling, Sirkka Vene, Jana Baranda Prellezo, Elena alvarez-Barco, Alan J. Macken, Romina Di Marzo, Catarina Luis, Ole F. Olesen, Jesus A. Frias Iniesta, Imre Barta, Krisztina Toth, Murat Akova, Marc M. J. Bonten, Miriam Cohen-Kandli, Rebecca Jane Cox, Lenka Souckova, Petr Husa, Ligita Jancoriene, Odile Launay, Jens Lundgren, Patrick Mallon, Charis Armeftis, Laura Marques, Pontus Naucler, Jordi Ochando, Evelina Tacconelli, Pierre van Damme, Theoklis Zaoutis, Sanne Hofstraat, Patricia Bruijning-Verhagen, Markus Zeitlinger, Oliver A. Cornely, Zoi Dorothea Pana
Summary: This study aims to develop a toolkit that provides trustworthy information and promotes positive attitudes towards vaccine trials, with a focus on inclusiveness and equity. The produced materials, including brochures, videos, and puzzles, inform the public about the benefits and risks of trial participation and aim to build confidence in the COVID-19 vaccines.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Infectious Diseases
Julia Jeck, Florian Jakobs, Melina S. Kurte, Oliver A. Cornely, Florian Kron
Summary: This study conducts a cost-of-illness analysis of Candida infections, finding that the treatment of candidiasis is costly and reducing ICU length of stay can lead to significant cost savings.
JAC-ANTIMICROBIAL RESISTANCE
(2023)
Article
Public, Environmental & Occupational Health
Sibylle C. Mellinghoff, Caroline Bruns, Markus Albertsmeier, Juliane Ankert, Louis Bernard, Sofia Budin, Camille Bataille, Annika Y. Classen, Florian B. Cornely, Elodie Couve-Deacon, Maria Fernandez Ferrer, Jesus Fortun, Alicia Galar, Eva Grill, Thomas Guimard, Juergen A. Hampl, Sebastian Wingen-Heimann, Juan P. Horcajada, Felix Koehler, Carolin Koll, Joan Mollar, Patricia Munoz, Mathias W. Pletz, Jule Rutz, Jon Salmanton-Garcia, Harald Seifert, Ferdinand Serracino-Inglott, Alex Soriano, Jannik Stemler, Janne J. Vehreschild, Tim O. Vilz, Jan-Hendrik Naendrup, Oliver A. Cornely, Blasius J. Liss
Summary: This study retrospectively investigated the incidence and risk factors of S. aureus SSI in various surgical disciplines in Europe, and found a low infection rate. The study provides a method for utilizing big data in epidemiological research.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Veterinary Sciences
Sophie Amalie Blirup-Plum, Henrik Elvang Jensen, Soren Saxmose Nielsen, Karen Pankoke, Mette Sif Hansen, Ken Steen Pedersen, Esben Ostergaard Eriksen, Jens Peter Nielsen, John Elmerdahl Olsen, Egle Kudirkiene, Lars Erik Larsen, Nicole Bakkegard Goecke, Kristiane Barington
Summary: This study investigated the associations between pathological manifestations and pathogens in pigs with and without post-weaning diarrhoea (PWD). The results showed that most of the pigs had gastric lesions, but gastric ulcers were less common in PWD pigs compared to pigs without PWD. Abnormal content in the colon was associated with PWD. No apparent associations were found between lesions and the various pathogens or a combination of these.
ACTA VETERINARIA SCANDINAVICA
(2023)