期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 18, 期 9, 页码 E369-E372出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1469-0691.2012.03969.x
关键词
Antimicrobial resistance; carbapenemase; molecular epidemiology; nosocomial transmission; Pseudomonas aeruginosa
Clin Microbiol Infect 2012; 18: E369E372 Abstract Recently, the first outbreak of clonally related VIM-2 metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa in a Dutch tertiary-care centre was described. Subsequently, a nationwide surveillance study was performed in 2010-2011, which identified the presence of VIM-2 MBL-producing P. aeruginosa in 11 different hospitals. Genotyping by multiple-locus variable-number tandem-repeat analysis (MLVA) showed that the majority of the 82 MBL-producing isolates found belonged to a single MLVA type (n = 70, 85%), identified as ST111 by multilocus sequence typing (MLST). As MBL-producing isolates cause serious infections that are difficult to treat, the presence of clonally related isolates in various hospitals throughout the Netherlands is of nationwide concern.
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