Article
Immunology
Joanna Waldock, Carol D. Weiss, Wei Wang, Min Z. Levine, Stacie N. Jefferson, Sammy Ho, Katja Hoschler, Brandon Z. Londt, Elisa Masat, Louise Carolan, Stephany Sanchez-Ovando, Annette Fox, Shinji Watanabe, Miki Akimoto, Aya Sato, Noriko Kishida, Amelia Buys, Lorens Maake, Cardia Fourie, Catherine Caillet, Sandrine Raynaud, Richard J. Webby, Jennifer DeBeauchamp, Rebecca J. Cox, Sarah L. Lartey, Claudia M. Trombetta, Serena Marchi, Emanuele Montomoli, Ivan Sanz-Munoz, Jose Maria Eiros, Javier Sanchez-Martinez, Danny Duijsings, Othmar G. Engelhardt
Summary: This article presents the importance of External Quality Assessment (EQA) schemes and a feasibility study on conducting an EQA scheme for influenza serology testing. The study analyzed data from 16 laboratories and found good laboratory performance for HAI and higher intra-assay variation for MN assays. The results showed that using a human sera pool as a standard can significantly reduce inter-laboratory variation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Satoshi Kamidani, Shikha Garg, Melissa A. Rolfes, Angela P. Campbell, Charisse N. Cummings, Julia C. Haston, Kyle P. Openo, Emily Fawcett, Shua J. Chai, Rachel Herlihy, Kimberly Yousey-Hindes, Maya L. Monroe, Sue Kim, Ruth Lynfield, Chad Smelser, Alison Muse, Christina B. Felsen, Laurie Billing, Ann Thomas, H. Keipp Talbot, William Schaffner, Ilene Risk, Evan J. Anderson
Summary: This study provides important population-based data on influenza-associated hospitalizations in US children. It highlights the higher rates of hospitalization and death among younger children, but also emphasizes the increased risk of severe outcomes among older children.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Business, Finance
Di Gong, Tao Jiang, Liping Lu
Summary: This paper empirically analyzes the impact of pandemic on the contracting of bank loans. Using data on syndicated loans during the season of H1N1 Swine Flu, we find that more flu is associated with higher loan spreads and smaller loan size. The adverse impact of pandemic was alleviated by the approval of vaccines.
FINANCE RESEARCH LETTERS
(2021)
Article
Clinical Neurology
Xiling Wang, Fulong Xiao, Yiping Wang, Xiaowei Deng, Zhiyuan Chen, Xiaosong Dong, Wei Wang, Chenyang Li, Zhifei Xu, Huijuan Wu, Huan Yu, Changjun Su, Zan Wang, Xiangdong Tang, Yunhui Lv, Yun Li, Shuchen Sun, Junying Huang, Lijuan Hao, Xuan Wei, Liying Deng, Yu-Shu Huang, Jihui Zhang, Yun-Kwok Wing, Jun Zhang, Emmanuel Mignot, Fang Han, Hongjie Yu
Summary: The incidence of narcolepsy increased during the 2009 H1N1 pandemic, possibly due to the circulation of the A(H1N1) pdm09 virus. This observation should be considered for future influenza pandemic preparedness plans.
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Petra Mooij, Daniella Mortier, Aafke Aartse, Alexandre B. Murad, Ricardo Correia, Antonio Roldao, Paula M. Alves, Zahra Fagrouch, Dirk Eggink, Norbert Stockhofe, Othmar G. Engelhardt, Ernst J. Verschoor, Marit J. van Gils, Willy M. Bogers, Manuel J. T. Carrondo, Edmond J. Remarque, Gerrit Koopman
Summary: Influenza-naive cynomolgus macaques were immunized with virus-like particles (VLPs) displaying different hemagglutinin (HA) antigens from seasonal H1N1 strains. Subsequent infection with pandemic H1N1 (H1N1pdm09) resulted in increased immune response against intermediate antigenic variants but not against all H1N1 vaccine strains.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Behavioral Sciences
Daiva Radzisauskiene, Monika Vitkauskaite, Karolina Zvinyte, Ruta Mameniskiene
Summary: The study described a case series of influenza A-associated neurological complications, with a low incidence rate of influenza-associated neurological complications in hospitalized patients in 2019 at 1.9%. The findings suggest that during influenza epidemics, patients with unexplained neurological symptoms resembling aseptic and septic meningitis/encephalitis should be tested for influenza virus.
BRAIN AND BEHAVIOR
(2021)
Article
Obstetrics & Gynecology
Nicola Vousden, Marian Knight
Summary: Influenza during pregnancy is associated with an increased risk of hospital admission, and there is variability in policies and uptake of immunization globally. Immunization is cost-effective and safe in preventing influenza in pregnant women and their infants.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Immunology
Anu Haveri, Niina Ikonen, Carita Savolainen-Kopra, Ilkka Julkunen
Summary: The study found that sequential vaccination with two different H5N1 vaccines can induce long-lasting high level cross-subtype immunity, supporting a prime-boost vaccination strategy in vaccination plans.
Article
Infectious Diseases
Irene Cassaniti, Elena Percivalle, Antonella Sarasini, Giuseppe Cambie, Edoardo Vecchio Nepita, Roberta Maserati, Alessandro Ferrari, Alfonso Corcione, Raffaella Di Martino, Alice Bonetti, Annapia Di Napoli, Guglielmo Ferrari, Fausto Baldanti
Summary: This study aimed to determine the seroprevalence of SARS-CoV-2 in blood donors in a specific region in Lombardy, evaluate the agreement between different serological assays, and assess the persistence of neutralizing antibodies. The study found a prevalence of 19.7% for SARS-CoV-2 IgG in blood donors, with a correlation between IgG quantification and neutralizing antibody titres. These findings underscore the importance of monitoring neutralizing antibodies in assessing the duration of immunity to SARS-CoV-2.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Jose Alberto Choreno-Parra, Luis Armando Jimenez-Alvarez, Alfredo Cruz-Lagunas, Tatiana Sofia Rodriguez-Reyna, Gustavo Ramirez-Martinez, Montserrat Sandoval-Vega, Diana Lizzeth Hernandez-Garcia, Eduardo M. Choreno-Parra, Yalbi I. Balderas-Martinez, Mariana Esther Martinez-Sanchez, Eduardo Marquez-Garcia, Edda Sciutto, Jose Moreno-Rodriguez, Jose Omar Barreto-Rodriguez, Hazel Vazquez-Rojas, Gustavo Ivan Centeno-Saenz, Nestor Alvarado-Pena, Citlaltepetl Salinas-Lara, Carlos Sanchez-Garibay, David Galeana-Cadena, Gabriela Hernandez, Criselda Mendoza-Milla, Andrea Dominguez, Julio Granados, Lula Mena-Hernandez, Luis Angel Perez-Buenfil, Guillermo Dominguez-Cheritt, Carlos Cabello-Gutierrez, Cesar Luna-Rivero, Jorge Salas-Hernandez, Patricio Santillan-Doherty, Justino Regalado, Angelica Hernandez-Martinez, Lorena Orozco, Federico Avila-Moreno, Ethel A. Garcia-Latorre, Carmen M. Hernandez-Cardenas, Shabaana A. Khader, Albert Zlotnik, Joaquin Zuniga
Summary: By comparing patients with COVID-19 and pandemic influenza A(H1N1), it was found that influenza patients had more severe respiratory symptoms, while COVID-19 patients more often experienced dry cough and gastrointestinal symptoms. The immune responses also differed between the two diseases, with pandemic influenza A(H1N1) characterized by higher levels of certain cytokines and COVID-19 displaying a distinct immune profile with increased Th1 and Th2 cytokine levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Zhaomin Feng, Wenfei Zhu, Lei Yang, Jia Liu, Lijuan Zhou, Dayan Wang, Yuelong Shu
Summary: Eurasian avian-like H1N1 swine influenza viruses in China have shown a genotypic diversity with 11 genotypes, among which genotypes 3 and 5 are predominant in pig population. These viruses continuously reassort with other co-circulated influenza viruses and show different genetic characteristics.
Article
Immunology
Tobias Weinberger, Julius Steffen, Andreas Osterman, Tonina T. Mueller, Maximilian Muenchhoff, Paul R. Wratil, Alexander Graf, Stefan Krebs, Caroline Quartucci, Patricia M. Spaeth, Beatrice Grabein, Kristina Adorjan, Helmut Blum, Oliver T. Keppler, Matthias Klein
Summary: During the first wave of the pandemic in southern Germany, frontline healthcare workers faced an increased risk of SARS-CoV-2 infection, highlighting the need for stringent infection control measures to protect all patient-facing staff.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Management
Emilio Gutierrez, Adrian Rubli
Summary: This study examines the impact of hospital congestion on in-hospital mortality using data from a large public hospital system in Mexico, leveraged the shock in hospitalizations induced by the 2009 H1N1 pandemic, and found that congestion led to an increase in non-ARI in-hospital mortality. The effects were nonlinear in the size of the local outbreak, and supply-side policies such as improving patient assignment and strategically increasing hospital capacity could mitigate some of the negative impacts.
MANAGEMENT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Clare Smith, David Odd, Rachel Harwood, Joseph Ward, Mike Linney, Matthew Clark, Dougal Hargreaves, Shamez N. Ladhani, Elizabeth Draper, Peter J. Davis, Simon E. Kenny, Elizabeth Whittaker, Karen Luyt, Russell Viner, Lorna K. Fraser
Summary: A clinical review of all pediatric deaths in England from March 2020 to February 2021 attributes 25 deaths to SARS-CoV-2 infection and identifies risk factors to guide interventions. These results are important for guiding decisions on shielding and vaccinating children, with factors like age, ethnicity, and comorbidities potentially influencing mortality rates related to SARS-CoV-2.
Article
Microbiology
Francis Simo-Fouda, Laurence Thirion, Antoine Nougairede, Lea Luciani, Jean-Selim Driouich, Paul Remi Petit, Pascal Delaunay, Remi N. Charrel
Summary: In the South-East of France, Bufavirus (BuV) circulates with a relatively high rate in stool samples, especially in men, adults, and patients from nephrology and infectious disease departments. In contrast, human parvovirus 4 (PARV4) was rarely detected in stool samples in this area.
Article
Microbiology
Marie Pouquet, Dorine Decarreaux, Pol Prevot-Monsacre, Corentin Herve, Andreas Werner, Brigitte Grosgogeat, Helene Blanche, Pascaline Rabiega, Julien Laupie, Fabienne Kochert, Nathalie Abraham, Jean-Marc Sebaoun, Xavier de Lamballerie, Remi Charrel, Cecile Souty, Ibrahima Camara, Jeanne Pergeline, Harold Noel, Caroline Guerrisi, Sylvie van der Werf, Fabrice Carrat, Thomas Hanslik, Thierry Blanchon, Alessandra Falchi
Summary: This study focuses on the seroprevalence of IgG antibodies against SARS-CoV-2 in primary health care workers and their household contacts in metropolitan France, achieved through vaccination and/or natural protection. It will be conducted in two phases using ELISA and virus neutralization tests to estimate seroprevalence.
Article
Infectious Diseases
Maria Ortuno, Clara Munoz, Tatiana Spitzova, Petra Sumova, Maria Asuncion Iborra, Pedro Perez-Cutillas, Nazli Ayhan, Remi N. Charrel, Petr Volf, Eduardo Berriatua
Summary: In a study conducted in Murcia Region, southeast Spain, the prevalence of antibodies against Phlebotomus perniciosus sandfly salivary gland homogenate (SGH) and recombinant protein rSP03B was found to be 69% and 88%, respectively. The prevalence of Toscana virus (TOSV), Sandfly Fever Sicilian virus (SFSV), and Leishmania infections were 26%, 0%, and 1%, respectively. The study also questioned the diagnostic value of rSP03B as a marker for these infections in humans.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Virology
Nazli Ayhan, Aissam Hachid, Laurence Thirion, Kamel Eddine Benallal, Laura Pezzi, Fayez Ahmed Khardine, Chahrazed Benbetka, Sihem Benbetka, Zoubir Harrat, Remi Charrel
Summary: Sindbis virus (SINV), a zoonotic alphavirus, has been identified as a cause of human diseases in Africa, Europe, Asia, and Australia. In this study, SINV was detected and isolated from mosquitoes in Algeria, and genetic analysis revealed its similarity to a strain found in Kenya.
Article
Virology
Dorine Decarreaux, Marie Pouquet, Cecile Souty, Ana-Maria Vilcu, Pol Prevot-Monsacre, Toscane Fourie, Paola Mariela Saba Villarroel, Stephane Priet, Helene Blanche, Jean-Marc Sebaoun, Jean-Francois Deleuze, Clement Turbelin, Andreas Werner, Fabienne Kochert, Brigitte Grosgogeat, Pascaline Rabiega, Julien Laupie, Nathalie Abraham, Caroline Guerrisi, Harold Noel, Sylvie van der Werf, Fabrice Carrat, Thomas Hanslik, Remi Charrel, Xavier de Lamballerie, Thierry Blanchon, Alessandra Falchi
Summary: This study aimed to investigate the immune response and neutralizing activity against SARS-CoV-2 among primary health care workers (PHCW) in France and assess the association between neutralizing activity and various factors, including the COVID-19 vaccination scheme. The study found that individuals with previous SARS-CoV-2 infection were more likely to have neutralizing antibodies, regardless of vaccination status. Among those vaccinated with two doses, the time since vaccination was associated with the detection of neutralizing antibodies.
Article
Virology
Khalil Dachraoui, Ifhem Chelbi, Mourad Ben Said, Raja Ben Osman, Saifedine Cherni, Remi Charrel, Elyes Zhioua
Summary: The study investigated the transmission dynamics of Punique virus (PUNV) in Tunisia and found that Phlebotomus perniciosus is the main vector of PUNV. The research provided evidence of intensive circulation of PUNV in sandflies and hosts, reaching a peak during the autumn season.
Article
Virology
Celia Sentis, Genevieve Billaud, Antonin Bal, Emilie Frobert, Maude Bouscambert, Gregory Destras, Laurence Josset, Bruno Lina, Florence Morfin, Alexandre Gaymard
Summary: This study found that the RT-PCR Ct values of Omicron cases were significantly higher than Delta cases when sampled within 5 days of symptom onset, indicating that the spread of the Omicron variant is indeed related to higher viral loads.
Article
Virology
Antonin Bal, Gregory Destras, Marina Sabatier, Maxime Pichon, Hadrien Regue, Guy Oriol, Yves Gillet, Bruno Lina, Karen Brengel-Pesce, Laurence Josset, Florence Morfin
Summary: This study analyzed respiratory samples from children with acute respiratory infections of unknown etiology and found a high prevalence of Torque teno mini virus (TTMV) in these samples, as well as in samples with respiratory syncytial virus (RSV) or influenza infection. Larger studies are needed to explore the role of TTMV in childhood respiratory diseases.
Article
Environmental Sciences
Dorine Decarreaux, Julie Sevila, Shirley Masse, Lisandru Capai, Toscane Fourie, Paola Mariela Saba Villarroel, Abdennour Amroun, Elif Nurtop, Matthieu Vareille, Marie Pouquet, Thierry Blanchon, Xavier de Lamballerie, Remi Charrel, Alessandra Falchi
Summary: This study estimated the seroprevalence of SARS-CoV-2 infection among the staff and students of the University of Corsica during the second wave of the epidemic. The overall seroprevalence was found to be 12.8%, and factors such as residence, public transportation usage, and contact with infected individuals were associated with seropositivity. The main symptoms associated with seropositivity were acute respiratory infection and loss of smell.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Immunology
Marine Jourdain, Mehdi Benchaib, Dominique Ploin, Yves Gillet, Etienne Javouhey, Come Horvat, Mona Massoud, Marine Butin, Olivier Claris, Bruno Lina, Jean-Sebastien Casalegno
Summary: This study identifies predictors of respiratory syncytial virus (RSV) hospitalizations in infants and proposes a two-level RSV prevention intervention program based on these predictors. The study provides valuable information for targeting both mothers and infants for non-pharmaceutical and pharmaceutical interventions.
Article
Virology
Dalal Nour, Rayane Rafei, Alessandra P. Lamarca, Luiz G. P. de Almeida, Marwan Osman, Mohamad Bachar Ismail, Hassan Mallat, Atika Berry, Gwendolyne Burfin, Quentin Semanas, Laurence Josset, Hamad Hassan, Fouad Dabboussi, Bruno Lina, Philippe Colson, Ana Tereza R. Vasconcelos, Monzer Hamze
Summary: This study provides a retrospective genomic surveillance of the SARS-CoV-2 pandemic in Lebanon, revealing the dominance of four different lineages and the role of Lebanon as a dispersal center for lineage B.1.398. The district of Tripoli in Lebanon was identified as a significant source of dispersal within the country. These findings highlight the potential role of developing countries in the emergence of new variants.
Article
Infectious Diseases
Elisabetta Colosi, Giulia Bassignana, Alain Barratt, Bruno Lina, Philippe Vanhems, Julia Bielicki, Vittoria Colizza
Summary: As the Omicron variant cases increased in early 2022, schools faced significant disruptions. A study compared reactive screening, regular screening, and reactive class closure protocols in France, Baselland (Switzerland), and Italy, respectively. The findings showed that reactive screening required more testing resources but had lower control compared to weekly screening. The study suggests optimizing school protocols based on incidence levels. Evaluation: 9 out of 10.
Article
Environmental Sciences
Dorine Decarreaux, Julie Sevila, Shirley Masse, Lisandru Capai, Toscane Fourie, Paola Mariela Saba Villarroel, Abdennour Amroun, Elif Nurtop, Matthieu Vareille, Thierry Blanchon, Xavier de Lamballerie, Remi Charrel, Alessandra Falchi
Summary: This study investigated the humoral immune response to SARS-CoV-2 in a French adult population. The results showed that single infection does not provide effective protection, and vaccination significantly affects antibody levels and neutralizing activity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Virology
Khalil Dachraoui, Ifhem Chelbi, Imen Labidi, Raja Ben Osman, Aida Sayadi, Mourad Ben Said, Saifedine Cherni, Mohammed Abdo Saghir Abbas, Remi Charrel, Elyes Zhioua
Summary: This study investigated the role of dogs as reservoir hosts for Toscana virus (TOSV) and Leishmania infantum infections. Dogs exposed to sandfly bites were examined for TOSV and L. infantum infections, and the sandflies were screened for the presence of these pathogens. The results showed that dogs with zoonotic visceral leishmaniasis (ZVL) can serve as reservoirs for both TOSV and L. infantum, and can transmit TOSV to sandfly vectors in natural settings.
Article
Immunology
Carla Saade, Bruno Pozzetto, Melyssa Yaugel-Novoa, Guy Oriol, Laurence Josset, Bruno Lina, Stephane Paul, Antonin Bal, Sophie Trouillet-Assant
Summary: This study examines the humoral immune response in vaccinated patients who are simultaneously infected with Delta and Omicron BA.1 variants of SARS-CoV-2. The findings indicate that exposure to both Delta and BA.1 S proteins does not provide an additional immune advantage compared to exposure to BA.1 S protein alone.