Article
Public, Environmental & Occupational Health
J. Jung, S. M. Moon, D. Y. Kim, S-h. Kim, W. J. Lee, S. T. Heo, J. Y. Park, S. Bae, M. J. Lee, B. Kim, S. Y. Park, H. W. Jeong, Y. Kim, Y. G. Kwak, K-h. Song, K-h. Park, S. H. Park, Y. K. Kim, E. S. Kim, H. B. Kim
Summary: This qualitative assessment of antibiotic use in asymptomatic bacteriuria (ABU) and urinary tract infection (UTI) revealed that antibiotics were often prescribed inappropriately and the duration of antibiotics was unnecessarily prolonged.
JOURNAL OF HOSPITAL INFECTION
(2023)
Review
Geriatrics & Gerontology
Damir Krinitski, Rafal Kasina, Stefan Kloeppel, Eric Lenouvel
Summary: This study supports the association between delirium and urinary tract infection in older adults, but insufficient evidence was found for the association between delirium and asymptomatic bacteriuria in this age group. The limitations of the study include the moderate quality of included studies and a lack of available research on the association between delirium and asymptomatic bacteriuria. Future research should focus on using high-quality approaches to define delirium and UTI, and consider asymptomatic bacteriuria in their investigations.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Infectious Diseases
Gebremdhin Yenehun Worku, Yerega Belete Alamneh, Woldaregay Erku Abegaz
Summary: The study found that factors such as duration of diabetes, previous history of UTIs, and symptomatic UTIs were important in increasing the prevalence of UTIs among diabetes patients. Gram-negative bacterial isolates showed high sensitivity to nitrofurantoin and meropenem, but resistance to ampicillin, doxycycline, and cefuroxime. Gram-positive bacteria exhibited high levels of resistance to penicillin. High resistance to certain antibiotics among both types of bacteria was observed in the study, indicating the importance of considering local bacterial profiles and antimicrobial responses when prescribing antibiotics for UTI treatment.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Michaela Tutone, Truls E. Bjerklund Johansen, Tommaso Cai, Shazad Mushtaq, David M. Livermore
Summary: Urinary tract infections (UTIs) are common worldwide, especially among women. A study investigated the susceptibility of current urinary isolates to fosfomycin and other antibiotics, and found that Escherichia coli was the most common uropathogen isolated and highly susceptible to fosfomycin, nitrofurantoin, and mecillinam.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Medicine, General & Internal
Jens Strohaeker, Victoria Aschke, Alfred Koenigsrainer, Silvio Nadalin, Robert Bachmann
Summary: Urinary tract infections are associated with worse graft functions, highlighting the importance of prevention and treatment accompanied by antibiotic stewardship teams.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Lalitha Maniam, Kumutha Malar Vellasamy, Teng Aik Ong, Cindy Shuan Ju Teh, Kartini Abdul Jabar, Vanitha Mariappan, Vallikkannu Narayanan, Jamuna Vadivelu, Vinod Pallath
Summary: This study aimed to investigate the distribution of virulence determinants and antimicrobial resistance among different phylogroups of UPEC isolated from various clinical categories of cUTI and ASB E. coli isolates. The findings showed that the virulence factors and antibiotic resistance of UPEC isolates varied in different cUTI categories, and specific genotypic characteristics of UPEC were associated with severe UTI.
Article
Infectious Diseases
Julien Coussement, Nassim Kamar, Marie Matignon, Laurent Weekers, Anne Scemla, Magali Giral, Judith Racape, Eric Alamartine, Laurent Mesnard, Mireille Kianda, Lidia Ghisdal, Concetta Catalano, Emine N. Broeders, Olivier Denis, Karl M. Wissing, Marc Hazzan, Daniel Abramowicz
Summary: Screening and treating ASB in kidney transplant recipients does not reduce the occurrence of symptomatic UTI, but instead increases antibiotic use and the emergence of resistant organisms.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Chayanan Santithanmakorn, Jakapat Vanichanan, Natavudh Townamchai, Kamonwan Jutivorakool, Salin Wattanatorn, Methee Sutherasan, Julin Opanuruk, Stephen J. Kerr, Kearkiat Praditpornsilpa, Yingyos Avihingsanon, Suwasin Udomkarnjananun
Summary: This study aimed to investigate the risks and consequences of UTI in kidney transplant recipients with post-transplantation cotrimoxazole prophylaxis. The results showed that female sex, higher body mass index, human leukocyte antigen mismatch, and high panel reactive antibody were risk factors for UTI. Recipients with recurrent UTI had worse allograft function and lower patient survival in the first post-transplant month. Higher degree of immunosuppression was associated with recurrent UTI and drug-resistant organisms.
Article
Microbiology
Cheng-Yen Kao, Yen-Zheng Zhang, Deng-Chi Yang, Pek Kee Chen, Ching-Hao Teng, Wei-Hung Lin, Ming-Cheng Wang
Summary: This study investigated the characteristics of host and bacteria in recurrent urinary tract infections (RUTI) caused by genetically identical or different Escherichia coli strains. The results showed that E. coli strains in RUTI were more virulent and important for the development of RUTI in patients who were younger, without anatomical/functional defects or immune dysfunction. Prior antibiotic therapy, especially fluoroquinolones, could induce subsequent antimicrobial resistance in genetically highly-related E. coli RUTI.
Review
Infectious Diseases
Yveline Ansaldi, Begona Martinez de Tejada Weber
Summary: Urinary tract infections (UTIs) during pregnancy can have significant consequences for both the mother and the baby. Treating asymptomatic bacteriuria (ASB) can reduce the risk of low birth weight and preterm birth. Further research is needed to understand the complications of ASB and to explore preventive measures.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Urology & Nephrology
Shohei Ishida, Yoshihisa Matsukawa, Takuma Yuba, Yushi Naito, Kazuna Matsuo, Tsuyoshi Majima, Momokazu Gotoh
Summary: The study investigated the prevalence of asymptomatic bacteriuria (ASB) in middle-aged and older men with non-neurogenic lower urinary tract symptoms (LUTS) and identified urodynamic factors related to the presence of ASB. The results showed that ASB was found in over 20% of these patients and was associated with decreased bladder contractility and decreased bladder voiding efficiency (BVE). BVE showed high sensitivity and specificity in predicting the presence of ASB.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Microbiology
Rikke Fleron Leihof, Karen Leth Nielsen, Niels Frimodt-Moller
Summary: The study found a significantly higher prevalence of asymptomatic bacteriuria (ABU) in elderly residents of nursing homes, and these patients had more antibiotic-resistant Escherichia coli. The prevalence of virulence genes in E. coli isolates from ABU and urinary tract infection (UTI) patients was similar, and no specific clustering was observed in whole-genome sequencing of ABU isolates compared to UTI isolates.
Article
Microbiology
Ciara Kenneally, Craig P. Murphy, Roy D. Sleator, Eamonn P. Culligan
Summary: The discovery of the urobiome has challenged the previous understanding of urine sterility and its association with urinary disorders. The imbalance of microbial communities in the urobiome can contribute to infection and disease. As the effectiveness of traditional antimicrobial treatments decreases, there is growing interest in microbiome-based therapies as non-antibiotic alternatives. However, the urobiome remains underexplored.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Microbiology
David Melnick, Angela K. Talley, Vipul K. Gupta, Ian A. Critchley, Paul B. Eckburg, Kamal A. Hamed, Nivedita Bhatt, Gary Moore, Daren Austin, Christopher M. Rubino, Sujata M. Bhavnani, Paul G. Ambrose
Summary: The clinical relevance of bacteriuria after antibiotic treatment of complicated urinary tract infections is controversial. This study evaluated the impact of urine pharmacokinetics on the timing of recurrent bacteriuria in a clinical trial comparing oral tebipenem pivoxil hydrobromide and intravenous ertapenem. The prolonged urinary clearance and dwell time of ertapenem were associated with a temporal difference in the repopulation of bladder urine with bacteria following treatment, potentially confounding efficacy assessment.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Medicine, General & Internal
Katarzyna Werbel, Dorota Jankowska, Anna Wasilewska, Katarzyna Taranta-Janusz
Summary: The study analyzed the increasing resistance of bacteria in children with UTI over the years, identified parameters related to antibiotic sensitivity using the CART method, and provided guidance for antibiotic therapy to inhibit increasing antibiotic resistance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Dermatology
E. M. M. Oyen, K. I. Maijer, S. A. S. van derBent, J. M. Prins, S. Janssen, S. Kuipers, H. J. C. De Vries
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Immunology
Colette Smit, Anders Boyd, Bart J. A. Rijnders, Thijs J. W. van de Laar, Eliane M. Leyten, Wouter F. Bierman, Kees Brinkman, Mark A. A. Claassen, Jan den Hollander, Anne Boerekamps, Astrid M. Newsum, Janke Schinkel, Maria Prins, Joop E. Arends, Eline L. M. Op de Coul, Marc van der Valk, Peter Reiss
Summary: The incidence of HCV infections in individuals with HIV in the Netherlands has decreased since 2015, with a significant rate of reinfection observed mainly in men who have sex with men, highlighting the need for additional preventive measures.
Editorial Material
Gastroenterology & Hepatology
Heike E. F. Becker, John Penders, Daisy M. A. E. Jonkers
Article
Genetics & Heredity
Alaric W. D'Souza, Manish Boolchandani, Sanket Patel, Gianluca Galazzo, Jarne M. van Hattem, Maris S. Arcilla, Damian C. Melles, Menno D. de Jong, Constance Schultsz, Gautam Dantas, John Penders
Summary: The study found that international travel significantly increased the abundance and diversity of antimicrobial resistance (AMR) genes in the travelers' gut resistome, leading to the acquisition of various resistant genes. The shaping of the gut resistome by travel was closely associated with geographical destinations, with individuals returning from the same destination country more likely to have similar resistome features.
Article
Immunology
Lisa Vork, John Penders, Jonna Jalanka, Svetlana Bojic, Sander M. J. van Kuijk, Anne Salonen, Willem M. de Vos, Mirjana Rajilic-Stojanovic, Zsa Zsa R. M. Weerts, Ad A. M. Masclee, Marta Pozuelo, Chaysavanh Manichanh, Daisy M. A. E. Jonkers
Summary: This study found an association between stool consistency and fecal microbiota, but no effect of day-to-day fluctuations in stool consistency within seven days. This highlights the importance of considering stool consistency in gut microbiota research and confirms the validity of single fecal sampling to represent an individual's microbiota at a given time point.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Heike E. F. Becker, Casper Jamin, Liene Bervoets, Annemarie Boleij, Pan Xu, Marie J. Pierik, Frank R. M. Stassen, Paul H. M. Savelkoul, John Penders, Daisy M. A. E. Jonkers
Summary: The study found a higher prevalence of B. fragilis during exacerbations of Crohn's disease, with B. fragilis being more common in CD patients with intestinal strictures. Additionally, secretomes of bft-positive strains increased intestinal epithelial barrier function, although Bft was ruled out as the likely causative factor.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Armand M. A. Linkens, Niels van Best, Petra M. Niessen, Nicole E. G. Wijckmans, Erica E. C. de Goei, Jean L. J. M. Scheijen, Martien C. J. M. van Dongen, Christel C. J. A. W. van Gool, Willem M. de Vos, Alfons J. H. M. Houben, Coen D. A. Stehouwer, Simone J. M. P. Eussen, John Penders, Casper G. Schalkwijk
Summary: The study found that a 4-week diet low or high in AGEs has limited impact on the gut microbial composition of abdominally obese humans, with only Anaerostipes spp. showing a relative abundance difference. The habitual intake of dicarbonyls was not associated with microbial richness or general community structure, but the intake of 3-deoxyglucosone was linked to several genera abundances. Further investigation into the effects of dietary dicarbonyls on gut microbiota composition is warranted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Lars M. M. Vliex, Giang N. Le, Marina Fassarella, Dorien Reijnders, Gijs H. Goossens, Erwin G. Zoetendal, John Penders, Ellen E. Blaak
Summary: This study found that the effect of vancomycin treatment on tissue-specific insulin sensitivity and gut microbiota composition varied among individuals, depending on the presence of the vancomycin resistance gene vanB in their baseline gut microbiota.
Article
Gastroenterology & Hepatology
D. J. M. Barnett, M. F. Endika, C. E. Klostermann, F. Gu, C. Thijs, A. Nauta, H. A. Schols, H. Smidt, I. C. W. Arts, J. Penders
Summary: The infant gut microbiota is influenced by antibiotic exposures and prebiotic oligosaccharides found in breast milk. This study analyzed the stool microbiota of 1023 one-month-old infants and found that breastfeeding and antibiotic exposure both decrease gut microbial diversity, but have different effects on microbiota composition. Other factors such as C-section, homebirth, siblings, and exposure to animals also impact microbiota composition. Understanding these factors can help protect and promote a healthy infant gut microbiota.
Review
Biochemistry & Molecular Biology
Robert van Vorstenbosch, Hao Ran Cheng, Daisy Jonkers, John Penders, Erik Schoon, Ad Masclee, Frederik-Jan van Schooten, Agnieszka Smolinska, Zlatan Mujagic
Summary: Colorectal cancer (CRC) is associated with changes in volatile metabolic profiles, making it possible for non-invasive detection. However, the origin of these volatile organic compounds (VOCs) and their relation to gut microbiome are still not fully understood. This systematic review provides a comprehensive overview of the current understanding on this topic. The analysis of seventy-one included studies revealed dysregulations in various matrices, such as feces, urine, breath, blood, tissue, and saliva, with short-chain fatty acids, amino acids, proteolytic fermentation products, and products related to tricarboxylic acid cycle and Warburg metabolism being the most frequently reported.
Article
Microbiology
Evy Maas, John Penders, Koen Venema
Summary: Most research on the human microbiome has focused on bacteria, with less attention given to fungi and their role in human health, particularly their modulation through diet. This study used a validated in vitro model of the colon to investigate the gut fungal community and its response to different dietary interventions. The results showed that the mycobiome had lower diversity and greater variability compared to the bacterial community, and that diet could influence its composition and diversity.
Article
Microbiology
Evy Maas, John Penders, Koen Venema
Summary: This study investigated the relationships between fungi and bacteria using a complex computer-controlled in vitro model of the colon. The results showed that cross-kingdom interactions exist between fungi and bacteria, and they can influence each other. These findings are important for understanding the role of the microbial community in the human gut.
Article
Microbiology
Evy Maas, John Penders, Koen Venema
Summary: Most studies on the human gut microbiota focus on bacteria, but recent research indicates that intestinal fungi are also important for maintaining health. This study analyzed the mycobiome of healthy individuals and its interaction with the bacterial component of the microbiome. The results showed a lower diversity of fungi compared to bacteria, with significant inter-individual variation. Positive correlations were observed between certain fungi and bacteria, including those associated with alleviating inflammatory bowel disease. Further research is needed to investigate the importance of these correlations and distinguish between gut colonizers and transient species.
Article
Cultural Studies
Alena Kamenshchikova, Petra F. G. Wolffs, Christian J. P. A. Hoebe, John Penders, Klasien Horstman
Summary: Complex phenomena, such as antimicrobial resistance (AMR), are often explained in biomedical sciences using analogies and metaphors. These metaphors play a crucial role in knowledge production and can shape scientific models of thought. Some metaphors, like 'AMR is an apocalypse' or 'antibiotics are weapons', are recognized immediately, but others, such as 'bacterial reservoirs' and 'bacterial colonies', are presented as literal and descriptive. However, these terms still carry historical links and can perpetuate thinking about bacteria as foreign actors.
SCIENCE AS CULTURE
(2023)
Article
Microbiology
Danyta I. Tedjo, Jennifer A. Wilbrink, Jos Boekhorst, Harro M. Timmerman, Simon W. Nienhuijs, Arnold Stronkhorst, Paul H. M. Savelkoul, Ad A. M. Masclee, John Penders, Daisy M. A. E. Jonkers
Summary: This study investigated the changes in fecal microbiota composition in obese individuals before and after sleeve gastrectomy (SG) and found a significant shift in microbiota composition after the surgery, but not towards a leaner profile. There were no correlations found between inflammatory markers, intestinal permeability, and changes in microbial profile.
