期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 17, 期 12, 页码 E24-E26出版社
ELSEVIER SCI LTD
DOI: 10.1111/j.1469-0691.2011.03669.x
关键词
Carbapenems; class D ss-lactamase; Klebsiella pneumoniae; OXA-48; ST395
资金
- INSERM [U914]
- Ministere de l'Education Nationale et de la Recherche [UPRES-EA3539]
- Universite Paris XI, France
- European Community (TEMPO-test-QC) [HEALTH-2009-241742]
- UEFISCDI [42121/2008]
A Klebsiella pneumoniae isolate with decreased susceptibility to carbapenems was isolated in April 2011 in a hospital in Amsterdam (the Netherlands) and later found to be the source of an important outbreak in a Rotterdam hospital. The strain, belonging to sequence type (ST) 395, carried the blaOXA-48 gene located onto a c 62-kb conjugative plasmid, together with the extended-spectrum beta-lactamase gene blaCTX-M-15. It was closely related or identical to other OXA-48-positive Klebsiella pneumoniae isolates belonging to the same ST type and identified in France and Morocco. This study sheds light on the European dissemination of a single OXA-48 K. pneumoniae clone.
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