期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 16, 期 10, 页码 1576-1578出版社
ELSEVIER SCI LTD
DOI: 10.1111/j.1469-0691.2010.03212.x
关键词
H1N1; immunocompromised; influenza A; oseltamivir; resistance
Although neuraminidase inhibitors are active against most 2009-2010 pandemic influenza A (H1N1) swine-origin strains, sporadic cases of oseltamivir resistance have been described. Since April 2009, 54 cases of oseltamivir-resistant H1N1 swine-origin have been reported in the USA (http://www.cdc.gov/flu/weekly/; accessed 1 February 2010). Approximately 1.4% of tested isolates are oseltamivir resistant. We report a patient with an underlying hematological malignancy who was hospitalized with influenza A (H1N1) swine-origin and whose strain developed oseltamivir resistance during therapy.
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