Review
Biochemistry & Molecular Biology
Babak Pakbin, Wolfram M. Bruck, John W. A. Rossen
Summary: Escherichia coli are versatile microorganisms found in the normal intestinal microbiota of humans and animals. They can become emerging human pathogens by acquiring genes encoding virulence factors. Nine enteric E. coli pathotypes have been characterized, utilizing various virulence factors to cause intestinal and extraintestinal diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Dennis J. Woerde, Krystle L. Reagan, Barbara A. Byrne, Bart C. Weimer, Steven E. Epstein, Cory Schlesener, Bihua C. Huang, Jane E. Sykes
Summary: This study examined ESBL-producing bacterial infections in dogs and cats presenting to a veterinary teaching hospital from 2011-2021. Escherichia coli was the most commonly identified bacterial species, with urinary tract infection being the most common clinical presentation. Multi-drug resistance was present in 90% of ESBL-producing bacterial infections. Based on susceptibility patterns, antimicrobials such as piperacillin-tazobactam, amikacin, and cefoxitin may be alternative antibiotics to the current recommended regimen. Whole genome sequencing of bacteria revealed bla(CTX-M-15) as the most common ESBL gene.
VETERINARY SCIENCES
(2023)
Review
Microbiology
Valerio M. Sora, Gabriele Meroni, Piera A. Martino, Alessio Soggiu, Luigi Bonizzi, Alfonso Zecconi
Summary: The One Health approach highlights the importance of antimicrobial resistance in both public health and food animal production, with specific focus on the ExPEC strains of E. coli which may transfer resistance genes to other pathogenic bacteria, posing a serious threat to public health globally.
Article
Immunology
Danchun Chen, Benyu Tang, Ying Li, Kelu Zheng, Xiaojing Li, Wenxiong Chen, Fei Gao, Yuanyuan Gao, Kaili Shi
Summary: This study collected information from 252 children with bacterial meningitis infected with Streptococcus agalactiae, Streptococcus pneumoniae, or Escherichia coli. The results showed distinct trends and age distribution for each pathogen. The antimicrobial resistance patterns for each pathogen were reviewed, providing guidance for drug use. Furthermore, blood white blood cell count was found to be a protective factor, while glucose levels in cerebrospinal fluid were a risk factor for hospitalization length.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Sulaiman F. Aljasir, Dennis J. D'Amico
Summary: This study demonstrates the potential of Hafnia alvei B16 to attenuate Salmonella virulence and protect against pathogen invasion of intestinal epithelial cells, thereby enhancing food safety.
Article
Infectious Diseases
Yijun Ding, Jinjing Zhang, Kaihu Yao, Wei Gao, Yajuan Wang
Summary: This study assessed the antimicrobial resistance and molecular characteristics of E. coli ST1193 isolates causing neonatal bloodstream infections and meningitis in China, revealing that ST1193 isolates were often multidrug-resistant. Further multicenter studies are needed to control the spread of this emerging fluoroquinolone-resistant clone.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Microbiology
Luca Bedetti, Francesca Miselli, Chiara Minotti, Giuseppe Latorre, Sabrina Loprieno, Alessandra Foglianese, Nicola Laforgia, Barbara Perrone, Matilde Ciccia, Maria Grazia Capretti, Chiara Giugno, Vittoria Rizzo, Daniele Merazzi, Silvia Fanaro, Lucia Taurino, Rita Maria Pulvirenti, Silvia Orlandini, Cinzia Auriti, Cristina Haass, Laura Ligi, Giulia Vellani, Chryssoula Tzialla, Cristina Tuoni, Daniele Santori, Mariachiara China, Lorenza Baroni, Silvia Nider, Federica Visintini, Lidia Decembrino, Giangiacomo Nicolini, Roberta Creti, Elena Pellacani, Arianna Dondi, Marcello Lanari, Belinda Benenati, Giacomo Biasucci, Lucia Gambini, Licia Lugli, Alberto Berardi
Summary: This study evaluated the rates of lumbar puncture in infants with culture-proven sepsis. The results showed that lumbar puncture was infrequently performed after antibiotic initiation, leading to a reduced ability to identify the pathogen in cerebrospinal fluid culture. Polymerase chain reaction increased the probability of positive results compared to microbiological culture.
Article
Ecology
Ayush Pathak, Daniel C. Angst, Ricardo Leon-Sampedro, Alex R. Hall
Summary: Some bacterial resistance mechanisms can degrade antibiotics, potentially protecting neighboring susceptible cells. However, the effects of such mechanisms on bacterial communities of more than two species are not well understood. By conducting experiments on multispecies communities, we found that resistance in one species reduced antibiotic inhibition of other species, but the extent of benefit varied among species.
Article
Food Science & Technology
Peili Wang, Jiaxiang Zhang, Yanfei Chen, Haoran Zhong, Heng Wang, Jianji Li, Guoqiang Zhu, Pengpeng Xia, Luying Cui, Jun Li, Junsheng Dong, Qingqing Gao, Xia Meng
Summary: The study confirmed that clbG is essential for the synthesis of genotoxin colibactin in APEC XM strain, and its deletion reduced the likelihood of APEC meningitis in mice.
Article
Biotechnology & Applied Microbiology
Xi Lu, Dingyan Wu, Xin Zhao, Mingxin Zhang, Ke Ren, Ningning Zhou, Yanni Zhao, Weisheng Qian
Summary: Enterotoxigenic Escherichia coli (ETEC), a diarrheal pathogen, can utilize ethanolamine (EA) as a nitrogen source, which enhances its virulence phenotype and causes damage to host intestinal cells. The concentration of EA in the intestine also impacts the metabolic profile and pathogenicity of ETEC.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jorge Soria-Bustos, Zeus Saldana-Ahuactzi, Partha Samadder, Jorge A. Yanez-Santos, Ygnacio Martinez Laguna, Maria L. Cedillo-Ramirez, Jorge A. Giron
Summary: This study investigates the relationship between flagella expression and the type III secretion system (T3SS) in enteropathogenic Escherichia coli (EPEC). The results suggest that the assembly of an intact T3SS is required for flagella production, and certain regulator genes play a role in activating or inhibiting flagella expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Timothy Kudinha, Fanrong Kong
Summary: The prevalence of ST131, especially among ciprofloxacin resistant isolates, increased from fecal to clinical samples in women, men, and children. ST131 isolates showed higher virulence potential compared to non-ST131 isolates, particularly in urinary samples. There was a strong association between ST131 prevalence and fluoroquinolone resistance, with FQ resistant ST131 isolates harboring more virulence genes.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Infectious Diseases
Samina Ievy, M. Nazmul Hoque, Md Saiful Islam, Md Abdus Sobur, Fatimah Muhammad Ballah, M. Shaminur Rahman, Md Bahanur Rahman, Jayedul Hassan, Mohammad Ferdousur Rahman Khan, M. D. Tanvir Rahman
Summary: This study sequenced the whole genome of APEC MTR_BAU02 strain isolated from layer birds and identified widespread antimicrobial resistance genes and virulence factor genes, similar to those found in human isolates, highlighting the growing threat of antimicrobial resistance in both poultry and humans.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Agriculture, Dairy & Animal Science
Toshiyuki Murase, Hiroichi Ozaki
Summary: This study showed that the prevalence of phylogroup F was higher in colibacillosis-related isolates compared to healthy chicken-related isolates, while phylogroups A and B1 were more commonly found in the latter. APEC strains with virulence-associated genes were more prevalent in colibacillosis-related isolates, indicating that phylogroup F can predict colibacillosis in E. coli strains.
Article
Biotechnology & Applied Microbiology
Reed Woyda, Adelumola Oladeinde, Zaid Abdo
Summary: Pathogenic Escherichia coli causes disease in humans and food-producing animals. Its pathogenesis depends on virulence factors and antimicrobial resistance genes. Contaminated and undercooked food products are highly associated with food-borne outbreaks. It is important to identify the genetic factors that contribute to the virulence and antimicrobial resistance of E. coli.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Food Science & Technology
Edson A. Rios, Jesus Santos, Isidro Garcia-Menino, Saskia C. Flament-Simon, Jorge Blanco, Maria-Luisa Garcia-Lopez, Andres Otero, Jose M. Rodriguez-Calleja
LWT-FOOD SCIENCE AND TECHNOLOGY
(2019)
Article
Immunology
David Arturo Montero, Felipe Del Canto, Juliana Velasco, Rocio Colell, Nora Lia Padola, Juan Carlos Salazar, Carla San Martin, Angel Onate, Jorge Blanco, David A. Rasko, Carmen Contreras, Jose Luis Puente, Flemming Scheutz, Eelco Franz, Roberto M. Vidal
EMERGING MICROBES & INFECTIONS
(2019)
Article
Microbiology
Saskia-Camille Flament-Simon, Marion Duprilot, Noemie Mayer, Vanesa Garcia, Maria Pilar Alonso, Jorge Blanco, Marie-Helene Nicolas-Chanoine
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Rosalia Mamani, Saskia Camille Flament-Simon, Vanesa Garcia, Azucena Mora, Maria Pilar Alonso, Cecilia Lopez, Isidro Garcia-Menino, Dafne Diaz-Jimenez, Jesus E. Blanco, Miguel Blanco, Jorge Blanco
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Isidro Garcia-Menino, Dafne Diaz-Jimenez, Vanesa Garcia, Maria de Toro, Saskia C. Flament-Simon, Jorge Blanco, Azucena Mora
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Immunology
Saskia-Camille Flament-Simon, Vanesa Garcia, Marion Duprilot, Noemie Mayer, Maria Pilar Alonso, Isidro Garcia-Menino, Jesus E. Blanco, Miguel Blanco, Marie-Helene Nicolas-Chanoine, Jorge Blanco
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Microbiology
Saskia-Camille Flament-Simon, Maria de Toro, Azucena Mora, Vanesa Garcia, Isidro Garcia-Menino, Dafne Diaz-Jimenez, Alexandra Herrera, Jorge Blanco
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Saskia-Camille Flament-Simon, Maria de Toro, Liubov Chuprikova, Miguel Blanco, Juan Moreno-Gonzalez, Margarita Salas, Jorge Blanco, Modesto Redrejo-Rodriguez
SCIENTIFIC REPORTS
(2020)
Article
Infectious Diseases
Dafne Diaz-Jimenez, Isidro Garcia-Menino, Alexandra Herrera, Vanesa Garcia, Ana Maria Lopez-Beceiro, Maria Pilar Alonso, Jorge Blanco, Azucena Mora
Article
Multidisciplinary Sciences
Andressa Ballem, Soraia Goncalves, Isidro Garcia-Menino, Saskia C. Flament-Simon, Jesus E. Blanco, Concelcao Fernandes, Maria Jose Saavedra, Carlos Pinto, Hugo Oliveira, Jorge Blanco, Goncalo Almeida, Carina Almeida
Article
Microbiology
Isidro Garcia-Menino, Vanesa Garcia, Maria Pilar Alonso, Jesus E. Blanco, Jorge Blanco, Azucena Mora
Summary: The study showed that the majority of diarrheagenic E. coli in Spanish industrial pig farms were ETEC pathotype, mostly belonging to phylogroup A and clonotype CH11-24. The isolates exhibited high rates of multidrug-resistance, with notable resistance to nalidixic acid, colistin, ticarcillin, and ampicillin. Additionally, a significant proportion of isolates were ESBL-producers, with a high prevalence of mcr-carriers among them.
VETERINARY MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Jose A. Orden, Isidro Garcia-Menino, Saskia C. Flament-Simon, Jorge Blanco, Ricardo de la Fuente, Abel Martinez-Rodrigo, Alicia Mas, Javier Carrion, Francisco Sobrino, Gustavo Dominguez-Bernal
Summary: The study found a high prevalence of antimicrobial-resistant E. coli, including pathogenic strains, in raccoons from Madrid, Spain. These raccoons may pose a risk to public health due to their potential to contaminate food and the environment with their feces.
ZOONOSES AND PUBLIC HEALTH
(2021)
Article
Microbiology
Saskia-Camille Flament-Simon, Maria de Toro, Vanesa Garcia, Jesus E. Blanco, Miguel Blanco, Maria Pilar Alonso, Ana Goicoa, Juan Diaz-Gonzalez, Marie-Helene Nicolas-Chanoine, Jorge Blanco
Article
Infectious Diseases
Saskia-Camille Flament-Simon, Marie-Helrne Nicolas-Chanoine, Vanesa Garcia, Marion Duprilot, Noemie Mayer, Maria Pilar Alonso, Isidro Garcia-Menino, Jesus E. Blanco, Miguel Blanco, Jorge Blanco
Article
Immunology
Aurelie Cointe, Andre Birgy, Patricia Mariani-Kurkdjian, Sandrine Liguori, Celine Courroux, Jorge Blanco, Sabine Delannoy, Patrick Fach, Estelle Loukiadis, Philippe Bidet, Stephane Bonacorsi
EMERGING INFECTIOUS DISEASES
(2018)