期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 14, 期 -, 页码 175-180出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1469-0691.2007.01868.x
关键词
ertapenem; extented-spectrum beta-lactamases; imipenem; meropenem; panipenem
Among the many different structurally distinct classes of beta-lactams, the carbapenem class is regarded as that which is most potent and which has the widest spectrum of antimicrobial activity. Rapidly bactericidal, and demonstrating time-dependent killing, carbapenernes have a spectrum of antimicrobial activity that includes Gram-positive and Gram-negative aerobic and anaerobic pathogens. Their in-vitro activity includes extended-spectrum P-lactamase (ESBL)-producing pathogens and carbapenems are currently considered to be the treatment of choice for serious infections due to ESBL-producing organisms. However, isolates acquiring resistance under treatment have been reported. Imipenem, meropenern and ertapenem are licensed in the European Community and panipenem and biapenem are also available in Japan and South Korea. Other carbapenernes are under development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据