Article
Medicine, General & Internal
Vandana Bhushan, Susan Lester, Liz Briggs, Raif Hijjawi, E. Michael Shanahan, Eliza Pontifex, Jem Ninan, Catherine Hill, Fin Cai, Jennifer Walker, Fiona Goldblatt, Mihir D. Wechalekar
Summary: Similar retention rates of the second and third compared to the first b/tsDMARD in RA, PsA, and AS support a differential b/tsDMARDs use strategy based on patient presentation. The risk of b/tsDMARD failure was halved in PsA patients, and covariates were not associated with the risk of bDMARD failure. The most common reason for switching was treatment failure.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
Luis Fernando Perez-Garcia, Esther Roder, Robbert J. Goekoop, Johanna M. W. Hazes, Marc R. Kok, Hieronymus T. W. Smeele, Ilja Tchetverikov, Annette H. M. Van der Helm-van Mil, Jos H. van der Kaap, Petra Kok, Bouwe P. Krijthe, Radboud J. E. M. Dolhain
Summary: This study is the first to demonstrate that inflammatory arthritis can impact male fertility. Men diagnosed with IA before and during the peak reproductive years have lower fertility rates, higher rates of childlessness, and more fertility problems.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Soo Min Ahn, Young Bin Joo, Yun Jin Kim, So -Young Bang, Hye-Soon Lee
Summary: This study analyzed the effects of biologic agents on pregnancy outcomes using a nationwide population-based database. The results suggest that biologic agent use may be associated with several adverse pregnancy outcomes, especially in patients who use biologics during pregnancy.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Rheumatology
Christina Charles-Schoeman, Ernest Choy, Iain B. McInnes, Eduardo Mysler, Peter Nash, Kunihiro Yamaoka, Ralph Lippe, Nasser Khan, Anna K. Shmagel, Hannah Palac, Jessica Suboticki, Jeffrey R. Curtis
Summary: This study provides an integrated analysis of major adverse cardiovascular events (MACEs) and venous thromboembolism (VTE) events in rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) patients treated with upadacitinib. The results show that the rates of MACEs and VTE events with upadacitinib are similar to those reported for conventional synthetic and biologic disease-modifying drugs, and comparable to adalimumab and methotrexate.
Review
Rheumatology
Charlotte Krieckaert, Borja Hernandez-Breijo, Johanna Elin Gehin, Guillaume le Meledo, Alejandro Balsa, Meghna Jani, Denis Mulleman, Victoria Navarro-Compan, Gertjan Wolbink, John Isaac, Astrid van Tubergen
Summary: The objective of this review is to collect and summarize evidence on therapeutic drug monitoring of biopharmaceuticals in inflammatory rheumatic and musculoskeletal diseases. The review found that there is evidence to support the use of TDM in some clinical scenarios, but not enough to support routine implementation.
Article
Rheumatology
Walter Reinisch, Wayne Hellstrom, Radboud J. E. M. Dolhain, Suresh Sikka, Rene Westhovens, Rajiv Mehta, Timothy Ritter, Ursula Seidler, Oleksandr Golovchenko, Vladimir Simanenkov, Olena Garmish, Slawomir Jeka, Radka Moravcova, Vijay Rajendran, Franck-Olivier Le Brun, Sarah Arterburn, Timothy R. Watkins, Robin Besuyen, Dirk Vanderschueren
Summary: The phase 2 MANTA and MANTA-RAy studies aimed to determine the impact of the oral Janus kinase 1 inhibitor filgotinib on semen parameters and sex hormones in men with inflammatory diseases. Results showed that once daily filgotinib 200 mg for 13 weeks had no measurable impact on semen parameters or sex hormones.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Chia-Jung Tsai, Yu-Chih Lin, Chung-Yu Chen, Chih-Hsing Hung, Yi-Ching Lin
Summary: This retrospective study analyzed the impact of biologics and non-biologics treatment on the development of hematologic malignancies in patients with AS, psoriasis, and PsA. The results showed that biologics significantly increased the risk of hematologic malignancies, specifically non-Hodgkin's lymphoma. Different treatment patterns, types of biologics, cumulative defined daily doses, comorbidities, and comedications did not have a significant effect on hematologic malignancy development.
Article
Rheumatology
Anton Jonatan Landgren, Mats Dehlin, Lennart Jacobsson, Ulrika Bergsten, Eva Klingberg
Summary: The study aimed to compare traditional cardiovascular risk factors among patients with different rheumatic diseases, and found that hypertension was the most common comorbidity, with patients with gout having the highest prevalence of traditional CVRFs. Significant differences in occurrence of CVRFs by sex were also observed among patients with PsA, RA and AS.
Article
Endocrinology & Metabolism
Xinlin Nie, Zhaoliang Liu, Dongheng Xie, Yang Sun
Summary: This study provides genetic evidence for causal associations between rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis with eye diseases, and identifies an increased risk of juvenile idiopathic arthritis associated with disorders of sclera, cornea, iris, and ciliary body.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Rheumatology
Celeste J. T. van der Togt, Bart van den Bemt, Daniel Aletaha, Rieke Alten, Katerina Chatzidionysiou, James Galloway, John Isaac, Denis Mulleman, P. Verschueren, Arnold G. Vulto, Paco M. J. Welsing, Lise Verhoef, Alfons A. den Broeder
Summary: The objective of this study was to develop evidence-based points to consider for cost-effective use of biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in the treatment of inflammatory rheumatic diseases.
Review
Rheumatology
Ana De Vicente Delmas, Lara Sanchez-Bilbao, Vanesa Calvo-Rio, David Martinez-Lopez, Alba Herrero-Morant, Eva Galindez-Agirregoikoa, Inigo Gonzalez-Mazon, Nuria Barroso-Garcia, Natalia Palmou-Fontana, Miguel A. Gonzalez-Gay, Jose L. Hernandez, Ricardo Blanco
Summary: This study aimed to assess the frequency and clinical features of uveitis in psoriatic arthritis (PsA) patients, as well as its association with disease activity, functional disability, and biological treatment. The prevalence of uveitis in PsA patients was about 5%, and it was associated with a worse quality of life and greater functional disability. The incidence rate of uveitis varied depending on the type of biological treatment used.
Article
Immunology
Milena Iwaszko, Joanna Wielinska, Jerzy Swierkot, Katarzyna Kolossa, Renata Sokolik, Bartosz Bugaj, Monika Chaszczewska-Markowska, Slawomir Jeka, Katarzyna Bogunia-Kubik
Summary: The IL-33 gene polymorphisms are closely associated with clinical parameters, disease activity, and response to TNF inhibitor treatment in patients with RA and AS, with the rs16924159 AA genotype potentially linked to higher disease activity and poor treatment response.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Rheumatology
Juergen Braun, Dietmar Krause, Uta Kiltz
Summary: This editorial discusses the impact evaluation of a nurse-led program for patient self-assessment and self-management in axial spondyloarthritis, presented in a prospective, multicenter, randomized, controlled trial (COMEDSPA) conducted by Anna Molto et al.
Article
Medicine, General & Internal
Boglarka Soos, Miklos Fagyas, Agnes Horvath, Edit Vegh, Anita Pusztai, Monika Czokolyova, Alexandra Csongradi, Attila Hamar, Zsofia Petho, Nora Bodnar, Gyoergy Kerekes, Katalin Hodosi, Eva Szekanecz, Szilvia Szamosi, Sandor Szanto, Gabriella Szucs, Zoltan Papp, Zoltan Szekanecz
Summary: The study revealed that anti-TNF therapy may increase ACE and ACE2 levels in the sera of RA and AS patients, and these levels are associated with disease duration, markers of inflammation, and vascular pathophysiology. The changes in ACE and ACE2 are influenced by treatment and other factors such as RF or FMD.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Xenofon Baraliakos, Effie Pournara, Laure Gossec, Philip J. Mease, Roisin White, Eamonn O'Brien, Barbara Schulz, Helena Marzo-Ortega, Laura C. Coates
Summary: This study investigated patient characteristics predictive of response to secukinumab in patients with psoriatic arthritis with axial manifestations. Nail dystrophy was identified as a predictor of response to secukinumab in these patients.
Article
Rheumatology
Holly F. Hope, Kimme L. Hyrich, James Anderson, James Bluett, Jamie C. Sergeant, Anne Barton, Lis Cordingley, Suzanne M. M. Verstappen, Ade Adebajo, Khalid Ahmed, Atheer Al-Ansari, Roshan Amarasena, Marwan Bukhari, Margaret Callan, Easwaradhas G. Chelliah, Hector Chinoy, Annie Cooper, Bhaskar Dasgupta, Martin Davis, James Galloway, Andrew Gough, Michael Green, Nicola Gullick, Jennifer Hamilton, Waji Hassan, Samantha Hider, Kimme Hyrich, Sanjeet Kamath, Susan Knight, Suzanne Lane, Martin Lee, Sarah Levy, Lizzy Macphie, Christopher Marguerie, Tarnya Marshall, Catherine Mathews, Frank McKenna, Sophia Naz, Mark Perry, Louise Pollard, Brian Quilty, Lindsay Robertson, Dipak Roy, Paul Sanders, Vadivelu Saravanan, David Scott, Gillian Smith, Richard Smith, Deborah Symmons, Lee-Suan Teh, Nick Viner
Article
Medicine, Research & Experimental
Uta Kiltz, Petros P. Sfikakis, Karl Gaffney, Paul-Gunther Sator, Ralph von Kiedrowski, Andreas Bounas, Nicola Gullick, Curdin Conrad, Dimitris Rigopoulos, Eric Lespessailles, Marco Romanelli, Pierre-Dominique Ghislain, Jan Brandt-Juergens, Rasho Rashkov, Maher Aassi, Roberto Orsenigo, Chiara Perella, Effie Pournara, Sven Gathmann, Piotr Jagiello, Justyna Veit, Matthias Augustin
ADVANCES IN THERAPY
(2020)
Review
Multidisciplinary Sciences
Tim Blake, Nicola J. Gullick, Charles E. Hutchinson, Thomas M. Barber
Review
Rheumatology
William Tillett, Alexander Allen, Laura Tucker, David Chandler, Coziana Ciurtin, Charlotte Davis, Andrew Dick, Amy Foulkes, Nicola Gullick, Philip Helliwell, Deepak Jadon, Gareth Jones, Stuart Kyle, Vishnu Madhok, Neil McHugh, Andrew Parkinson, Tim Raine, Stefan Siebert, Catherine Smith, Laura C. Coates
Summary: This guideline aims to provide updated evidence-based recommendations for the treatment of adult patients with PsA, including the optimal selection of advanced therapies and treatment strategies, with NICE accreditation.
Article
Medicine, Research & Experimental
Ines Rombach, William Tillett, Deepak Jadon, Laura Tucker, Marion Watson, Anne Francis, Yvonne Sinomati, Lucy Eldridge, Melina Dritsaki, Susan J. Dutton, Hussein Al-Mossawi, Nicola Gullick, Ben Thompson, Laura C. Coates
Summary: The TICOPA trial confirmed the clinical benefits of a T2T strategy in PsA, but it is not commonly implemented in routine care due to feasibility and cost concerns. The study highlights the heterogeneous nature of PsA and the lack of tailored drug usage based on disease severity.
Article
Medicine, General & Internal
Muhammad Shipa, Andrew Embleton-Thirsk, Mariea Parvaz, Liliana Ribeiro Santos, Patrick Muller, Kashfia Chowdhury, David A. Isenberg, Caroline J. Dore, Caroline Gordon, Michael R. Ehrenstein
Summary: In patients with refractory systemic lupus erythematosus (SLE), the use of belimumab following rituximab significantly reduced serum IgG anti-dsDNA antibody levels and decreased the risk of severe disease flares, suggesting the potential for this combination as a therapeutic strategy.
ANNALS OF INTERNAL MEDICINE
(2021)
Review
Rheumatology
Laura Tucker, Alexander Allen, David Chandler, Coziana Ciurtin, Andrew Dick, Amy Foulkes, Nicola Gullick, Philip Helliwell, Deepak Jadon, Gareth Jones, Stuart Kyle, Vishnu Madhok, Neil McHugh, Andrew Parkinson, Tim Raine, Stefan Siebert, Catherine Smith, William Tillett, Laura C. Coates
Article
Rheumatology
Laura Tucker, Alexander Allen, David Chandler, Coziana Ciurtin, Andrew Dick, Amy Foulkes, Nicola Gullick, Philip Helliwell, Deepak Jadon, Gareth Jones, Stuart Kyle, Vishnu Madhok, Neil McHugh, Andrew Parkinson, Tim Raine, Stefan Siebert, Catherine Smith, William Tillett, Laura C. Coates
Letter
Rheumatology
Laura C. Coates, Toby Garrood, Nicola Gullick, Philip Helliwell, Toby Kent, Jonathan Marks, William Tillett, Daljit Kaur-Papadakis, Hasan Tahir, Stijn van Haaren, Iain McInnes
Article
Critical Care Medicine
Abhishek Abhishek, Rosemary J. Boyton, Nicholas Peckham, Aine McKnight, Laura C. Coates, James Bluett, Vicki Barber, Lucy Cureton, Anne Francis, Duncan Appelbe, Lucy Eldridge, Patrick Julier, Ana M. Valdes, Tim Brooks, Ines Rombach, Daniel M. Altmann, Jonathan S. Nguyen-Van-Tam, Hywel C. Williams, Jonathan A. Cook
Summary: This study evaluated the impact of a 2-week interruption of methotrexate treatment after the COVID-19 vaccine booster on antibody responses in patients with immune-mediated inflammatory diseases. The findings showed that suspending methotrexate treatment enhanced the antibody responses, suggesting the potential for increased vaccine efficacy and protection duration in susceptible groups.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Rheumatology
Uta Kiltz, Petros P. Sfikakis, Karl Gaffney, Andreas Bounas, Nicola Gullick, Eric Lespessailles, Jan Brandt-Juergens, Rasho Rashkov, Barbara Schulz, Effie Pournara, Piotr Jagiello
Summary: The study evaluated the effectiveness and safety of Secukinumab in patients with PsA and AS. The results showed sustained effectiveness and favorable safety profile in patients who continued the treatment.
RHEUMATOLOGY AND THERAPY
(2022)
Review
Rheumatology
Cristiano B. Campanholo, Ajesh B. Maharaj, Nadia Corp, Stacie Bell, Luisa Costa, Kurt de Vlam, Nicola J. Gullick, Majed Khraishi, Mitsumasa Kishimoto, Natalia Palmou-Fontana, Soumya Reddy, Raffaele Scarpa, Luis Vega, Gleison Vieira Duarte, Devy Zisman, Danielle A. van der Windt, Mehmet T. Duruoz, Alexis Ogdie
Summary: The 2021 GRAPPA treatment recommendations provide evidence-based guidance for selecting therapy based on individual disease features. Comorbidities also play a significant role in therapy selection for psoriatic arthritis (PsA), and need to be assessed prior to treatment selection.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Economics
Sean P. Gavan, Ian N. Bruce, Katherine Payne
Summary: This study aimed to estimate the value of health gain for patients with a multisystem disease using specific composite response endpoints. Data from a national register were used to compare health utility values and quality-adjusted life-years for responders and nonresponders. The study found that bespoke composite response endpoints can be used to assess treatment response for multisystem diseases and provide valuable evidence for health technology assessment, decision making, and economic evaluation.
Article
Rheumatology
Hannah Jethwa, Melanie Brooke, Andrew Parkinson, Emma Dures, Nicola J. Gullick
Summary: Patients' perspectives on virtual consultations vary widely, with some finding it effective while others do not. Common drawbacks identified by patients include lack of visual cues, inability to conduct physical examinations, and impact on communication and rapport. Patients with well-controlled symptoms and established relationships with healthcare professionals appear to be more satisfied with remote reviews.
Article
Rheumatology
Gouri M. Koduri, Nicola J. Gullick, Fiona Hayes, Shirish Dubey, Chetan Mukhtyar
Summary: Individuals with inflammatory arthritis often have multiple co-morbidities, which impact their health and daily activities. Some patients reported that co-morbidities were as significant as their arthritis, and many relied on others for assistance. Lack of education and coordination in care were common issues highlighted by participants.
RHEUMATOLOGY ADVANCES IN PRACTICE
(2021)