Article
Oncology
Nishita M. S. Baldewpersad Tewarie, Maaike van Ham, Michel Wouters, Roy Kruitwagen, Willemien van Driel
Summary: This study investigated the adherence to surgical staging guidelines and the regional variation of surgical staging in patients with early-stage ovarian carcinoma in the Netherlands. The results showed lower than expected guideline adherence and identified reasons for incomplete surgical staging, such as perioperative findings. Regional variation in surgical staging was also observed.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Review
Oncology
Anthony W. Kim, Michael T. Jaklitsch
Summary: The history of Thoracic Surgical Oncology is built upon strong foundational contributions from the past. Current surgical approaches and techniques, along with newer systemic therapies, have been developed through iterative modifications to previous successes. Progress challenges traditional thinking and reexamines classic topics with a contemporary perspective. Cumulatively, the past and present efforts in clinical and scientific research point towards a promising future in the field of Thoracic Surgical Oncology.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Elizabeth Josephine Olecki, Paddy Ssentongo, Joseph Dao, William G. Wong, Kelly A. Stahl, Richard Ofosu-Akromah, Foster Amponsah-Manu, Colette Pameijer
Summary: This study investigates the surgical burden of malignant disease in the Eastern Region of Ghana and finds a high prevalence of malignancy in the surgical population. It also highlights that over 13% of breast cancer patients admitted for surgery did not undergo a surgical procedure.
Article
Endocrinology & Metabolism
Nan Liang, Han Zhang, Chengqiu Sui, Rui Du, Canxiao Li, Jingting Li, Gianlorenzo Dionigi, Daqi Zhang, Hui Sun
Summary: This study investigated the recurrence of differentiated thyroid cancer (DTC) and found that the true recurrence rate has been increasing. Additionally, second surgeries for DTC have become more standardized, leading to a decrease in complications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Cara E. Morin, Maddy Artunduaga, Gary R. Schooler, Rachel C. Brennan, Geetika Khanna
Summary: This article discusses the characteristics and imaging findings of the three most common pediatric solid tumors of the abdomen, as well as their corresponding staging systems. The crucial role of imaging in the staging process and its value in post-treatment evaluation and surveillance are emphasized.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Surgery
Saneya Pandrowala, Shraddha Patkar, Deepa Nair, Amita Maheshwari, C. S. Pramesh, Ajay Puri
Summary: This study examined the occurrence of gender discrimination in a surgical oncology department in India and found that approximately 28% of female trainees and 26.6% of female faculty members perceived gender discrimination. Additionally, around 13% of trainees and 12% of faculty mentioned that gender discrimination affected their professional performance or mental well-being.
FRONTIERS IN SURGERY
(2022)
Review
Medicine, General & Internal
Ting Chen, Huaping Wei, Weigang Yue, Yan Su, Xiaoyan Fu
Summary: This study aims to evaluate the efficacy and safety of ERAS in patients with lung cancer. A systematic review will be conducted by searching eight databases and conducting a meta-analysis. The results of this study will be published in a peer-reviewed journal.
Article
Oncology
Lauren M. Theiss, Adam T. Lucy, Shelby L. Bergstresser, Daniel Chu, Gregory D. Kennedy, Robert Hollis, Kelly M. Kenzik
Summary: Patient, societal, and hospital factors impact whether patients receive guideline-adherent colon cancer care. Interventions are needed to improve access to timely and guideline-adherent cancer care as a possible mechanism to combat surgical disparities.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Arun Chockalingam, Menelaos Konstantinidis, Brandon Koo, John Timothy Moon, Andrew Tran, Sahar Nourouzpour, Emily Lawson, Kathleen Fox, Peiman Habibollahi, Bruno Odisio, Mohammed Loya, Ali Bassir, Nariman Nezami
Summary: This study aims to compare the efficacy and clinical outcomes of surgical, ablative, and second-line external beam therapies in the treatment of non-small cell lung cancer. Through a meta-analysis of randomized controlled trials and cohort studies, we will analyze primary outcomes including survival, recurrence rates, and toxicity, and assess the risk of bias in the included studies.
Article
Oncology
Steinar Solberg, Yngvar Nilssen, Odd Terje Brustugun, Per Magnus Haram, Aslaug Helland, Bjorn Moller, Trond-Eirik Strand, Sissel Gyrid Freim Wahl, Lars Fjellbirkeland
Summary: This study investigated the concordance between clinical and pathology staging of lung cancer patients and found a disappointingly low precision and concordance. There were significant differences in tumor diameter and staging categories reported, with some patients being upstaged or downstaged. These results highlight the need for improvement in lung cancer staging.
Article
Oncology
Donglai Chen, Yiming Mao, Junmiao Wen, Jian Shu, Fei Ye, Yunlang She, Qifeng Ding, Li Shi, Tao Xue, Min Fan, Yongbing Chen, Chang Chen
Summary: The study found that the number of examined lymph nodes and node stations affects staging and survival in NSCLC patients, with more nodes and stations correlating with more accurate staging and lower stage migration. An optimal cutoff of 18 lymph nodes and 6 node stations may be considered for evaluating the quality of lymph node examination in patients with stage cIII radiologically pure-solid NSCLCs.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Review
Oncology
Antonin Levy, Angela Botticella, Cecile Le Pechoux, Corinne Faivre-Finn
Summary: Small-cell lung cancer (SCLC) is a type of lung cancer with poor prognosis, thoracic radiotherapy and chemoradiotherapy are the common treatments recommended. For localized disease, concurrent chemoradiotherapy is standard, while definitive thoracic radiotherapy may be offered for metastatic patients.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Nathaniel Deboever, Kyle G. Mitchell, Hope A. Feldman, Tina Cascone, Boris Sepesi
Summary: The management strategy for non-small-cell lung cancer (NSCLC) has changed due to advancements in cancer biology and the development of novel systemic therapies. Surgical resection remains the best option for cure or disease control, with reduced morbidity due to improved techniques. Patient-centered discussions and promising therapies like immune checkpoint inhibitors have improved outcomes. The field of thoracic oncology has rapidly evolved, with the expansion of indications for surgery to include advanced and metastatic disease. Careful patient selection and timing of multi-modality therapy are crucial.
Article
Critical Care Medicine
Farhood Farjah, Nichole T. Tanner
Summary: The article highlights the importance of mediastinal lymph node staging in lung cancer patients, emphasizing the need for proper pathologic proof to avoid inappropriate treatment. It also stresses the significance of a multidisciplinary approach and dialog in lung cancer staging and treatment.
Article
Oncology
Valerio Gallotta, Soo Young Jeong, Carmine Conte, Rita Trozzi, Serena Cappuccio, Rossana Moroni, Gabriella Ferrandina, Giovanni Scambia, Tae-Joong Kim, Anna Fagotti
Summary: This study aimed to analyze the long-term oncological outcomes in eEOC patients treated with minimally invasive surgery (MIS). The results showed that MIS is a valuable therapeutic option in appropriately selected patients, although further randomized controlled trials are needed.
Article
Oncology
Karla Gough, Rebecca Jane Bergin, Allison Drosdowsky, Sanchia Aranda, Linda Mileshkin, Michael Jackson, Nicole Kinnane, David Bernshaw, Ilona Juraskova, Kate White, Mustafa Mohamed, Penelope Schofield
Summary: Before commencing curative radiotherapy, a substantial minority of women with gynaecological cancers experience general psychological distress, reduced wellbeing, and moderate-to-high health system and information needs. A model of comprehensive care incorporating assessment of unmet needs, general psychological distress, and sexual issues is recommended. Health care providers may require training to address these interrelated issues and provide relevant support services for women in need.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Amelia Hyatt, Holly Chung, Ruth Aston, Karla Gough, Meinir Krishnasamy
Summary: This study utilized the SROI methodology to evaluate the social value and return on investment of lung cancer supportive care services, and found that cost savings could be achieved through implementation of the proposed supportive care service model.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Oncology
Lavinia Tan, Ben Tran, Jeanne Tie, Ben Markman, Sumi Ananda, Niall C. Tebbutt, Michael Michael, Emma Link, Stephen Q. Wong, Sushma Chandrashekar, Jerick Guinto, David Ritchie, Rachel Koldej, Benjamin J. Solomon, Grant A. McArthur, Rodney J. Hicks, Peter Gibbs, Sarah-Jane Dawson, Jayesh Desai
Summary: BRAF V600E mutant metastatic colorectal cancer is a significant clinical problem. Combination therapy with vemurafenib and small-molecule EGFR inhibitors has shown effectiveness in pre-clinical studies, but clinical investigation is lacking.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Meinir Krishnasamy, Amelia Hyatt, Holly Chung, Karla Gough, Margaret Fitch
Summary: Cancer supportive care is a comprehensive field of multidisciplinary services aimed at helping individuals affected by cancer manage the challenges of their disease and treatment to achieve optimal health outcomes. This study aimed to examine contemporary expert views on supportive care and redefine its definition and conceptual framework to better align with current cancer care practices.
SUPPORTIVE CARE IN CANCER
(2023)
Editorial Material
Oncology
Benjamin J. Solomon, Todd M. Bauer, Tony S. K. Mok, Geoffrey Liu, Julien Mazieres, Filippo de Marinis, Yasushi Goto, Dong-Wan Kim, Yi-Long Wu, Jacek Jassem, Froylan Lopez Lopez, Ross A. Soo, Alice T. Shaw, Anna Polli, Rossella Messina, Laura Iadeluca, Francesca Toffalorio, Enriqueta Felip
Editorial Material
Oncology
Trudy C. Wu, Annalise Stube, Carol Felix, Denise Oseguera, Tahmineh Romero, Jonathan Goldman, Edward B. Garon, Jay M. Lee, John Glaspy, Aaron E. Lisberg, Chad G. Rusthoven, D. Ross Camidge, Shankar Siva, Benjamin Solomon, Alan Lee, Stephen E. Tenn, Narek Shaverdian, Michael L. Steinberg, Ann C. Raldow, Percy Lee
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Letter
Oncology
Nicolas Girard, Marina C. Garassino, Benjamin Solomon
JOURNAL OF THORACIC ONCOLOGY
(2023)
Letter
Oncology
Nicolas Girard, Marina C. Garassino, Benjamin Solomon
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Ross A. Soo, Jean-Francois Martini, Anthonie J. van der Wekken, Shunsuke Teraoka, Roberto Ferrara, Alice T. Shaw, Deborah Shepard, Anna Maria Calella, Anna Polli, Francesca Toffalorio, Pascale Tomasini, Chao-Hua Chiu, Dariusz M. Kowalski, Hye Ryun Kim, Benjamin J. Solomon
Summary: In treatment-naive patients with advanced ALK-positive NSCLC, ctDNA can be used as a biomarker to predict the efficacy of lorlatinib treatment.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Medicine, General & Internal
Adrianus Johannes de Langen, Melissa L. Johnson, Julien Mazieres, Anne -Marie C. Dingemans, Giannis Mountzios, Miklos Pless, Jurgen Wolf, Martin Schuler, Herve Lena, Ferdinandos Skoulidis, Yasuto Yoneshima, Sang-We Kim, Helena Linardou, Silvia Novello, Anthonie J. van der Wekken, Yuanbin Chen, Solange Peters, Enriqueta Felip, Benjamin J. Solomon, Suresh S. Ramalingam, Christophe Dooms, Colin R. Lindsay, Carlos Gil Ferreira, Normand Blais, Cynthia C. Obiozor, Yang Wang, Bhakti Mehta, Tracy Varrieur, Gataree Ngarmchamnanrith, Bjorn Stollenwerk, David Waterhouse, Luis Paz-Ares
Summary: This study compared the efficacy and safety of Sotorasib with standard-of-care treatment in patients with non-small-cell lung cancer (NSCLC) with the KRASG12C mutation. The results showed that compared to docetaxel, Sotorasib significantly increased progression-free survival and had a more favorable safety profile.
Review
Oncology
Grace Chazan, Benjamin J. Solomon
Summary: First-line treatment options for patients with advanced non-small cell lung cancer (NSCLC) whose tumors harbour anaplastic lymphoma kinase (ALK) gene rearrangements have evolved rapidly. Although newer generation ALK inhibitors have demonstrated superiority to crizotinib, head-to-head clinical trials comparing these inhibitors are lacking. Decisions on optimal first-line treatment must be based on analysis of relevant trials and consideration of various factors.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Oncology
Lisa Guccione, Karla Gough, Allison Drosdowsky, Timothy Price, Nick Pavlakis, David Wyld, David Ransom, Michael Michael, Penelope Schofield
Summary: This study identifies the healthcare preferences, patient experiences, and quality of life of patients with NETs at a 6-month follow-up. The research findings show that there are suboptimal experiences of care, such as low involvement in decision making and difficulties in accessing and understanding information. The study suggests that addressing these issues can improve patient care and quality of life.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Medicine, Research & Experimental
Amelia Hyatt, Ruby Lipson-Smith, Karla Gough, Phyllis Butow, Michael Jefford, Thomas F. Hack, Sandra Hale, Emiliano Zucchi, Shane White, Uldis Ozolins, Penelope Schofield
Summary: The study aimed to assess the feasibility of designing research inclusive of migrants who do not speak English. The results indicated that methods utilized in the study supported the inclusion of migrant oncology patients in research, and a future multi-site RCT efficacy assessment is feasible.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2022)
Review
Medicine, General & Internal
L. B. Cameron, N. Hitchen, E. Chandran, T. Morris, R. Manser, B. J. Solomon, V Jordan
Summary: This study evaluated the safety and efficacy of ALK inhibitors as monotherapy for advanced ALK-rearranged NSCLC. The results showed that ALK inhibitors are effective in improving progression-free survival, overall survival, and overall response rate, with minimal adverse events compared to chemotherapy. Next-generation ALK inhibitors are more effective and safe than first-generation ALK inhibitors. However, further research is needed to compare different next-generation ALK inhibitors.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Endocrinology & Metabolism
Ray Wang, Benjamin Solomon, Stephen J. Luen, Owen W. J. Prall, Christine Khoo, Anthony J. Gill, Jeremy Lewin, Nirupa Sachithanandan
Summary: Adrenocortical carcinoma is a rare disease with significant clinical heterogeneity, presenting a diagnostic challenge to clinicians. Specialist multidisciplinary team input and genomics play vital roles in diagnosis and prognosis of adrenocortical carcinoma.
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2022)