期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 28, 页码 8259-8262出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201502626
关键词
amination; cross-coupling; ligand design; palladium; synthetic methods
资金
- National Institutes of Health [GM58160]
- National Science Foundation Graduate Research Fellowship
In Pd-catalyzed CN cross-coupling reactions, -branched secondary amines are difficult coupling partners and the desired products are often produced in low yields. In order to provide a robust method for accessing N-aryl -branched tertiary amines, new catalysts have been designed to suppress undesired side reactions often encountered when these amine nucleophiles are used. These advances enabled the arylation of a wide array of sterically encumbered amines, highlighting the importance of rational ligand design in facilitating challenging Pd-catalyzed cross-coupling reactions.
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