Article
Microbiology
Alvaro de Obeso Fernandez del Valle, Christian Quintus Scheckhuber, David Armando Chavaro-Perez, Erandi Ortega-Barragan, Sutherland K. Maciver
Summary: Some members of Acanthamoeba are facultative pathogens that can infect the cornea, causing Acanthamoeba keratitis. During encystation, there is an upregulation of glutathione S-transferase (GST) genes, which play a role in maintaining redox balance. Inhibiting GST with ethacrynic acid decreases cell viability by 70%. Targeting GST and associated processes could be a potential treatment strategy to reduce relapses of Acanthamoeba infection.
Article
Genetics & Heredity
Parnian Kheirkhah Rahimabad, A. Daniel Jones, Hongmei Zhang, Su Chen, Yu Jiang, Susan Ewart, John W. Holloway, Hasan Arshad, Shakiba Eslamimehr, Robert Bruce, Wilfried Karmaus
Summary: This study aimed to investigate whether polymorphisms in GST genes influence the effect of MSP on offspring DNAm. The results showed that in males, GST gene polymorphisms modified the associations between hydroxycotinine and DNAm, as well as between norcotinine and DNAm. In females, GST gene polymorphisms also modified the associations between hydroxycotinine and DNAm, as well as between norcotinine and DNAm. This study highlights the role of genetic polymorphism in GST genes in the susceptibility of DNAm to MSP.
Review
Medicine, General & Internal
Yi Zhu, Jian-Hua Yang, Jun-Ping Hu, Ming Qiao
Summary: This study revealed that the GSTM1 null, GSTT1 null and GSTP1-Val genotypes might be related to increased NAFLD susceptibility.
Article
Biochemistry & Molecular Biology
Warin Rangubpit, Eukote Suwan, Danai Sangthong, Kannika Wongpanit, Roger W. Stich, Prapasiri Pongprayoon, Sathaporn Jittapalapong
Summary: In this study, molecular dynamics simulations were conducted to investigate the binding of GTX and GSH to RmGST. It was found that GSH binds tighter and sits rigidly inside the G-site, while GTX occupies both active sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xingang Li, Yuanting Pang, Yiwang Zhong, Zhandong Cai, Qibin Ma, Ke Wen, Hai Nian
Summary: In this study, a tau-like glutathione transferase family gene named GmGSTU23 was identified in soybean, which showed a concentration-time-specific expression pattern in response to salt stress. Transgenic lines with GmGSTU23 displayed enhanced salt tolerance, root length, and fresh weight compared to the wild type. Changes in glutathione pools and associated enzyme activity were observed, indicating that GmGSTU23 enhances the activity of glutathione transferase to scavenge reactive oxygen species and glutathione, thereby conferring enhanced tolerance to salt stress in plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Katarzyna Grussy, Magdalena Laska, Wiktoria Moczurad, Magdalena Krol-Kulikowska, Milena Sciskalska
Summary: Glutathione S-transferases play a crucial role in the pathophysiology of cancer and cardiovascular diseases. Genetic polymorphisms in the genes encoding these enzymes have been associated with the development of these diseases, but results vary across different ethnic groups. The development of these diseases is influenced by both genetic changes and environmental factors, increasing the chance of developing the diseases when combined.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Environmental Sciences
Ahmed A. A. Aioub, Ahmed S. S. Hashem, Ahmed H. H. El-Sappah, Amged El-Harairy, Amira A. A. Abdel-Hady, Laila A. A. Al-Shuraym, Samy Sayed, Qiulan Huang, Sarah I. Z. Abdel-Wahab
Summary: This study identified and characterized GST genes in the fall armyworm S. frugiperda and evaluated the toxicity of emamectin benzoate (EBZ) and chlorantraniliprole (CHP) on the larvae. A total of 31 GST genes were identified, and SfGSTe10 and SfGSTe13 showed the highest expression after EBZ and CHP treatments. Molecular docking analysis revealed high binding affinity between EBZ and CHP with SfGSTe10 and SfGSTe13. These findings provide important insights into the detoxification processes of S. frugiperda regarding EBZ and CHP.
Article
Medicine, Research & Experimental
Milena Sciskalska, Halina Milnerowicz
Summary: This study evaluated the impact of SNP rs1695 in the GSTP1 gene on GST and GST-pi activity, as well as the concentrations of glutathione and malonyldialdehyde. The results confirmed the important role of GST-pi in oxidative stress.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Xin Dai, Shyamali C. C. Dharmage, Caroline J. J. Lodge
Summary: Oxidative stress is a major pathophysiological mechanism for chronic respiratory disease. GST genes play important roles in antioxidant defenses and may impact respiratory health. Future research should consider gene-gene interactions, multiple environmental exposures, and gender in these complex associations.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Pharmacology & Pharmacy
Gislaine Dionisio Ferreira, Glaucia Maria de Mendonca Fernandes, Camila Penteado, Vivian Romanholi Coria, Ana Livia da Silva Galbiatti-Dias, Anelise Russo, Marcia Maria Urbanin Castanhole-Nunes, Renato Ferreira da Silva, Rita de Cassia Martins Alves da Silva, Erika Cristina Pavarino, Mariangela Torreglosa Ruiz Cintra, Eny Maria Goloni-Bertollo
Summary: The study found that age, alcohol consumption, and polymorphic variants of GSTP1 and GSTT1 are associated with the risk of developing HCC.
Article
Biochemistry & Molecular Biology
Jianqin Zhang, Wen Ma, Fei Yin, Yoonseong Park, Kun Yan Zhu, Xueyao Zhang, Xuemei Qin, Daqi Li
Summary: This study investigated the ability of two GSTEs to metabolize insecticides in the locust. One of the GSTEs was found to be able to metabolize malathion and DDT, and participate in the detoxification of the acetylcholinesterase inhibitor malathion. These findings are important for understanding insecticide resistance mechanisms and managing insect populations in the field.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Youn Kyung Chung, Jin Ju Kim, Min A. Hong, Kyu Ri Hwang, Soo Jin Chae, Sang Ho Yoon, Young Min Choi
Summary: The study found that the combination of AhRR CG or GG and GSTT1 null genotype, or the combination of GSTM1/GSTM1 null genotype, may be associated with an increased risk of PCOS, but there was no significant association between the combination of AhRR and GSTM1.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Andrology
Jun He, Yi Mu, Miao Liu, Bang-Wei Che, Wen-Jun Zhang, Ke-Hang Chen, Kai-Fa Tang
Summary: This study examined the relationship between GST polymorphisms and fluoride-induced toxicity in idiopathic male infertility. The findings suggest that male infertility patients with GST gene mutations have higher levels of semen fluoride, oxidative stress, and lower sperm quality. The study indicates that GST polymorphisms and fluoride may be related to reproductive quality and sex hormone levels in idiopathic male infertility, and oxidative stress plays a role in its development.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Article
Agronomy
Yushi Jiang, Yuzhe Zhang, Ruijie Duan, Jiayi Fan, Peng Jiao, Hongji Sun, Shuyan Guan, Siyan Liu
Summary: ZmGST26 was found to be downregulated in maize under drought stress. Overexpression of ZmGST26 in Arabidopsis resulted in increased sensitivity to drought stress and ABA, as well as inhibited ABA-mediated stomatal closure. ZmGST26 overexpression decreased the resistance of Arabidopsis to drought stress and led to the accumulation of reactive oxygen species.
Article
Neurosciences
Bo Cheng, Xiaoliang Hong, Linfang Wang, Yuanyuan Cao, Dengli Qin, Han Zhou, Dianshuai Gao
Summary: Curzerene inhibits the progression of glioma by suppressing the expression of GSTA4 and matrix metalloproteinase 9, and inhibiting the activation of the mTOR pathway. It also induces apoptosis and reduces invasion and migration of glioma cells. In vivo studies have shown that Curzerene significantly inhibits tumor growth and prolongs survival time.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)