Article
Medicine, General & Internal
Michael J. Econs, Daryl J. Selen, Rene Balza, Omar Zurkiya, Henry M. Kronenberg, Yin P. Hung
Summary: A 29-year-old woman presented with recurrent fractures and hypophosphatemia, and the cause is yet to be determined.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Urology & Nephrology
Brendan Wallace, John A. Chmiel, Kait F. Al, Jennifer Bjazevic, Jeremy P. Burton, Harvey A. Goldberg, Hassan Razvi
Summary: The pathogenesis of infectious kidney stones is not well understood. Bacteria and urinary modulators play a complex role in stone formation. This study investigated the impact of bacterial cell-free extracts on crystal production and identified various urinary modulators that influence the process.
JOURNAL OF ENDOUROLOGY
(2023)
Article
Gastroenterology & Hepatology
Michael Simonov, Erica A. Abel, Melissa Skanderson, Amir Masoud, Ronald G. Hauser, Cynthia A. Brandt, Francis P. Wilson, Loren Laine
Summary: In a large cohort study of veterans, PPI use was found to be associated with a dose-dependent increase in risk of kidney stones. H2RA use also had an association with risk of kidney stones, suggesting that acid suppression might be an involved mechanism. However, the effect size was small and should not alter prescribing practices for most patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Api Chewcharat, Charat Thongprayoon, Lisa E. Vaughan, Ramila A. Mehta, Phillip J. Schulte, Helen M. O'Connor, John C. Lieske, Eric N. Taylor, Andrew D. Rule
Summary: This study found that lower intake of calcium, potassium, caffeine, phytate, and fluids were associated with a higher risk of incident symptomatic kidney stone formation. Among incident stone formers, lower dietary calcium and potassium intake were predictive of symptomatic kidney stone recurrence. Increasing dietary intake of calcium and potassium may help prevent recurrent symptomatic kidney stones.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Urology & Nephrology
Daniel Rodriguez, Ekaterina Gurevich, Soroush Mohammadi Jouabadi, Eva Maria Pastor Arroyo, Alexander Ritter, Sandrine Estoppey Younes, Carsten A. Wagner, Pedro Henrique Imenez Silva, Harald Seeger, Nilufar Mohebbi
Summary: This study investigated the association between serum sclerostin levels and recurrent kidney stone formation. The findings suggest that sclerostin levels are increased in recurrent kidney stone formers, particularly in women. There was an association between serum sclerostin and the status as a recurrent kidney stone former, independent of hypercalciuria. However, further studies are needed to understand the underlying mechanisms.
CLINICAL KIDNEY JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Cody McCoy, John M. Miller, Tanyanan Tanawuttiwat
Summary: A woman in her mid-40s presented to the emergency department after a fall with head trauma. During day 15 of admission, the patient had 3 episodes of torsade de pointes while taking 50 mg of oral metoprolol succinate daily. What would you do next?
Article
Environmental Sciences
Mahmoud Abdel-Gawad, Bedeir Ali-El-Dein, Emad Elsobky, Sanjeev Mehta, Naimet Alsaigh, Thomas Knoll, Mustafa Kura, Guido Kamphuis, Sameh Alhayek, Khaled Alkohlany, Noor Buchholz, Manoj Monga
Summary: In the process of urinary stone formation, a variety of heavy metals and trace elements have been identified. The types and concentrations of these elements vary between different countries. Conventional stone analysis techniques cannot identify stone micro-elements or the concentrations of heavy metals and trace elements, requiring specific tools like ICP-OES. Further research on the microelemental structure of urinary stones could lead to new strategies for prevention and recurrence of stone formation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Crystallography
Claudia Conti, Lea Cutard, Alessandra Botteon, Luigi Brambilla, Nicoletta Marinoni, Marco Realini, Maria Catrambone, Elena Possenti, Chiara Colombo
Summary: This study aimed to investigate crystals formed through the interaction of an inorganic conservation treatment with carbonatic stones using micro-Raman Spectroscopy. The results showed that Raman Spectroscopy is an effective method for identifying poorly crystalline calcium phosphates and distinguishing between different complex calcium phosphate mixtures in stones.
Article
Chemistry, Analytical
Iris H. Valido, Victor Fuentes-Cebrian, Roberto Boada, Oriol Vallcorba, Montserrat Resina-Gallego, Manuel Valiente, Montserrat Lopez-Mesas
Summary: Nephrolithiasis is a multifactorial disease that results in the formation of stones in the kidneys. The most common type of stones are calcium oxalate hydrate stones, which are associated with hypercalciuria and hyperoxaluria. By analyzing the composition and crystalline structures of calcium oxalate stones, distinctions can be made between dihydrated and monohydrated phases, improving diagnosis accuracy for patients.
Article
Biochemistry & Molecular Biology
Qing-Lin Ye, Da-Ming Wang, Xin Wang, Zhi-Qiang Zhang, Qi-Xing Tian, Shi-Yao Feng, Zhi-Hui Zhang, De-Xin Yu, De-Mao Ding, Dong-Dong Xie
Summary: The study found that the levels of Sirt1 expression are closely related to CaOx kidney stone formation, with downregulation of Sirt1 leading to increased cell injury and crystal deposition. Increasing Sirt1 expression in vitro or administering resveratrol in vivo can alleviate cell damage and reduce crystal deposition.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Urology & Nephrology
Xiaopeng Zheng, Wei Zhu, Guohua Zeng
Summary: The purpose of this paper is to assist patients with calcium oxalate stones in accessing prevention and treatment options through dietary management. Typical cases from our hospital and other hospitals were selected for case review, and a literature review was conducted through PubMed search to provide comprehensive analysis and suggestions.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Genetics & Heredity
Yuqi Xia, Xiangjun Zhou, Zehua Ye, Weimin Yu, Jinzhuo Ning, Yuan Ruan, Run Yuan, Fangyou Lin, Peng Ye, Di Zheng, Ting Rao, Fan Cheng
Summary: This study identified potential ceRNAs and immune cell infiltration involvement in kidney stone pathogenesis, providing novel therapeutic targets for kidney stones. The ceRNA network includes specific molecules like NEAT1, PVT1, hsa-miR-23b-3p, hsa-miR-429, hsa-miR-139-5p, CCL7, and ROBO2, while immune cells like macrophages and mast cells play a role in the process.
FRONTIERS IN GENETICS
(2021)
Review
Endocrinology & Metabolism
Ramy M. Hanna, Rebecca S. Ahdoot, Kamyar Kalantar-Zadeh, Lena Ghobry, Ira Kurtz
Summary: Calcium is an essential ion involved in various physiological processes, and the kidney plays a crucial role in maintaining whole-body calcium balance. Dysregulation of calcium handling can lead to several diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Critical Care Medicine
Sana Ghalib, Amit Chopra, John P. Fantauzzi, John P. Nabagiez, Anupama Tiwari
Summary: The 19-year-old female patient has been experiencing recurrent fevers and productive coughs for the past 2 years, requiring antibiotic therapy. Other than being a nonsmoker with no history of immunodeficiency, she does not have any other significant medical conditions.
Article
Biology
Ihsan Ullah, Khadijah Murtaza, Hafiza Ammara, Misbah, Munir Ahmad Bhinder, Amjad Riaz, Wasim Shehzad, Muhammad Yasir Zahoor
Summary: This study found that CLDN14 gene mutations are associated with hearing loss and renal stone formation. Specific genotypes are significantly correlated with kidney stones, and a novel haplotype is associated with an increased risk of kidney stone formation.
OPEN LIFE SCIENCES
(2022)
Letter
Pharmacology & Pharmacy
Valery Lavergne, Marc Ghannoum, Sophie Gosselin, David Goldfarb, Thomas D. Nolin, Paul I. Dargan, Darren M. Roberts
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Urology & Nephrology
James C. Williams, Giovanni Gambaro, Allen Rodgers, John Asplin, Olivier Bonny, Antonia Costa-Bauza, Pietro Manuel Ferraro, Giovanni Fogazzi, Daniel G. Fuster, David S. Goldfarb, Felix Grases, Ita P. Heilberg, Dik Kok, Emmanuel Letavernier, Giuseppe Lippi, Martino Marangella, Antonio Nouvenne, Michele Petrarulo, Roswitha Siener, Hans-Goran Tiselius, Olivier Traxer, Alberto Trinchieri, Emanuele Croppi, William G. Robertson
Summary: The Consensus Group concluded that analyses of urine and stones are essential for the diagnosis and treatment of urinary stone diseases, with 24-hour urine being the most useful collection type. Patient education is important for proper urine sample collection. Proper analysis of stones is also crucial for patient diagnosis and management.
Editorial Material
Urology & Nephrology
David S. Goldfarb
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2021)
Review
Urology & Nephrology
Ranjeeta Chand, Erik R. Swenson, David S. Goldfarb
Summary: Respiratory acidosis is common in patients with respiratory failure, and treatment with sodium bicarbonate remains controversial. The benefits of alkali therapy for mixed acidosis are conflicting, and there is a lack of evidence supporting the net benefit of sodium bicarbonate administration for respiratory acidosis.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2021)
Article
Urology & Nephrology
Ryan S. Hsi, Phyllis L. Yan, David S. Goldfarb, Ada Egbuji, Yajuan Si, Vahakn Shahinian, John M. Hollingsworth
Summary: This study assessed the effectiveness of an empiric approach to metabolic stone prevention. The results showed that empiric therapy guided by 24-hour urine testing, on average, is not associated with a lower hazard of a stone-related event compared to selective therapy. However, greater adherence to preventive pharmacologic therapy and older age were associated with a lower hazard of a stone-related event.
Article
Urology & Nephrology
Jeremy F. Wright, Wendy Y. Craig, F. L. Lucas, David S. Goldfarb, Jonathan B. Zuckerman, Eric N. Taylor
Summary: The prevalence of urinary stone disease (USD) in cystic fibrosis (CF) patients increases with age, with known risk factors such as severe CFTR mutations, diabetes, hypertension, and chronic macrolide therapy playing a role. Interestingly, there is a higher prevalence of USD in young women and individuals with severe CFTR mutations among CF patients.
Article
Nutrition & Dietetics
James F. Borin, John Knight, Ross P. Holmes, Shivam Joshi, David S. Goldfarb, Stacy Loeb
Summary: This study compared the concentrations of important ingredients for kidney stones and chronic kidney disease in popular brands of milk alternatives. Oat, macadamia, rice, and soy milk had similar parameters to dairy milk in terms of kidney stone risk factors, while almond and cashew milk had more potential stone risk factors. Coconut milk may be a favorable dairy substitute for patients with chronic kidney disease.
JOURNAL OF RENAL NUTRITION
(2022)
Article
Nutrition & Dietetics
David E. St-Jules, Lu Hu, Kathleen Woolf, Chan Wang, David S. Goldfarb, Stuart D. Katz, Collin Popp, Stephen K. Williams, Huilin Li, Ram Jagannathan, Olugbenga Ogedegbe, Anna Y. Kharmats, Mary Ann Sevick
Summary: This clinical trial evaluated the efficacy of technology-supported behavioral intervention strategies for managing multiple lifestyle-related health outcomes in overweight adults with type 2 diabetes and chronic kidney disease. The results showed that self-monitoring diet and physical activity achieved significant short-term weight loss, while theory-based behavioral counseling alone did not have a significant effect.
JOURNAL OF RENAL NUTRITION
(2023)
Editorial Material
Medicine, General & Internal
David S. Goldfarb
Summary: Asymptomatic kidney stones are often found during screening, and patients are concerned about the possibility of them becoming symptomatic and how to prevent them from getting bigger. However, there is currently a lack of data to support the answers to these questions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Health Care Sciences & Services
Sarah M. Azer, David S. Goldfarb
Summary: Cystinuria is a common genetic cause of recurrent kidney stones. It is characterized by increased levels of cystine in the urine, resulting in recurrent kidney stones. Managing cystinuria mainly focuses on stone prevention.
Review
Health Care Sciences & Services
Kyriaki Stamatelou, David S. Goldfarb
Summary: In the past two decades, there have been no major breakthroughs in the understanding and therapy of kidney stones, which remains a challenging disease for patients, physicians, and healthcare systems. Epidemiological studies play a crucial role in identifying global changes in the prevalence and burden of kidney stones and modifiable risk factors. The expanding knowledge of kidney stone epidemiology significantly enhances the modern management of the disease.
Correction
Urology & Nephrology
David S. Goldfarb, Frank Modersitzki, John R. Asplin, Lama Nazzal
Article
Urology & Nephrology
David S. Goldfarb, Frank Modersitzki, John R. Asplin, Lama Nazzal
Summary: Increasing urine volume, especially with water intake, is a well-accepted strategy to prevent kidney stones. Our innovative beverage, Moonstone, containing high alkali citrate, has shown promising results in increasing urine citrate and pH, and reducing calcium oxalate supersaturation in calcium stone formers.
Correction
Urology & Nephrology
David S. Goldfarb, John C. Lieske, Jaap Groothoff, Gesa Schalk, Kerry Russell, Shuli Yu, Blaz Vrhnjak
Article
Urology & Nephrology
David S. Goldfarb, John C. Lieske, Jaap Groothoff, Gesa Schalk, Kerry Russell, Shuli Yu, Blaz Vrhnjak
Summary: This study assessed the safety, pharmacokinetics, and pharmacodynamics of Nedosiran in patients with primary hyperoxaluria subtype 3. The results showed that Nedosiran was well-tolerated and had a trend towards lowering urinary oxalate excretion, providing a basis for further clinical development.