Plasma S100A12 Level Is Associated with Cardiovascular Disease in Hemodialysis Patients

Background and objectives S100A12 is an endogenous receptor ligand for advanced glycation end products. Cardiovascular disease remains a major cause of morbidity and mortality in patients with chronic kidney disease. In this study, we report cross-sectional data on 550 hemodialysis patients and assess the relationship between plasma S100A12 level and cardiovascular disease. Design, setting, participants, & measurements A cross-sectional study of 550 maintenance hemodialysis patients was conducted. We investigated the past history of cardiovascular disease and quantified the plasma level of S100A12 protein in all participants. Results Plasma S100A12 level was higher in hemodialysis patients with cardiovascular disease (n = 197; 33.8 +/- 28.1 ng/ml) than in those without it (n = 353; 20.2 +/- 16.1 ng/ml; P < 0.001). In multivariate logistic regression analysis, the plasma S100A12 level (odds ratio [OR], 1.28; 95% confidence interval [CI], 1.13 to 1.44; P < 0.001) was identified as an independent factor associated with the prevalence of cardiovascular disease. The other factors associated with the prevalence of cardiovascular diseases were the presence of diabetes mellitus (OR, 2.81; 95% CI, 1.79 to 4.41; P < 0.001) and high-sensitivity CRP level (OR, 1.02; 95% CI, 1.00 to 1.05; P = 0.046). Furthermore, the plasma S100A12 level (OR, 1.30; 95% CI, 1.09 to 1.54; P = 0.004) was significantly associated with cardiovascular disease even in hemodialysis patients without diabetes mellitus (n = 348). Conclusions These results suggest that the plasma S100A12 protein level is strongly associated with the prevalence of cardiovascular disease in hemodialysis patients. Clin J Am Soc Nephrol 6: 718-723, 2011. doi: 10.2215/CJN.08310910