Article
Urology & Nephrology
Stefanie W. Benoit, Thelma Kathman, Jay Patel, Melinda Stegman, Cristina Cobb, Jonathan Hoehn, Prasad Devarajan, Edward J. Nehus
Summary: This study assessed the impact of IFCC calibration on cystatin C values and GFR estimations, finding a significant increase in cystatin C values and altered performance of GFR estimating equations following incorporation of the IFCC standard. The recommendation is for clinical laboratories and providers to update the equation used for cystatin C-based estimation of GFR after adopting the IFCC reference standard.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Medicine, General & Internal
Mads Hornum, Morten Baltzer Houlind, Esben Iversen, Esteban Porrini, Sergio Luis-Lima, Peter Oturai, Martin Iversen, Pia Bredahl, Jorn Carlsen, Christian Holdflood Moller, Mads Jonsson Andersen, Bo Feldt-Rasmussen, Michael Perch
Summary: Patients undergoing lung transplantation (LTx) experience a rapid decline in glomerular filtration rate (GFR) in the acute postoperative period. This study compared different equations for estimating GFR in LTx patients and found that equations based on plasma creatinine underestimated GFR decline, while equations based on plasma cystatin C overestimated GFR decline after LTx. The 2021 CKD-EPI combination equation had the most accurate estimation of GFR in both pre-LTx and post-LTx periods. Therefore, caution should be exercised when interpreting renal function based on GFR estimation equations in the acute postoperative period following LTx.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Cynthia Delgado, Mukta Baweja, Deidra C. Crews, Nwamaka D. Eneanya, Crystal A. Gadegbeku, Lesley A. Inker, Mallika L. Mendu, W. Greg Miller, Marva M. Moxey-Mims, Glenda V. Roberts, Wendy L. St. Peter, Curtis Warfield, Neil R. Powe
Summary: The National Kidney Foundation and the American Society of Nephrology have made recommendations regarding the consideration of race in GFR estimation. They suggest implementing the CKD-EPI creatinine equation without the race variable in all US laboratories and promoting the use of cystatin C for more accurate estimation. They also encourage research on new filtration markers and interventions to eliminate racial disparities. The unified approach should be adopted nationwide.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Review
Medical Laboratory Technology
Reuben Roy, John Macdonald, Paul Dark, Philip Kalra, Darren Green
Summary: Recent events have highlighted the flaws in creatinine-based estimating equations for glomerular filtration. The behavior of creatinine itself, especially in acute and critical illness, contributes to these issues. There are important implications for patient treatment decisions, including drug therapies and imaging modalities. While Cystatin C has shown some success as an alternative biomarker, limitations and costs hinder its widespread use. This review explores the historical and recent evidence for glomerular filtration estimation, including options for direct measurement.
CLINICAL BIOCHEMISTRY
(2023)
Article
Immunology
Robin Chazot, Elisabeth Botelho-Nevers, Christophe Mariat, Anne Fresard, Etienne Cavalier, Frederic Lucht, Pierre Delanaye, Nicolas Maillard, Amandine Gagneux-Brunon
Summary: In individuals with HIV infection, cystatin C and urine albumin to creatinine ratio are associated with all-cause mortality and/or cardiovascular events independently of baseline mGFR. Biomarkers were not predictive of changes in glomerular filtration rate over time.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Geriatrics & Gerontology
Hye-Yeon Kim, Sun-Seog Kweon, Young-Hoon Lee, So-Yeon Ryu, Hae-Sung Nam, Min-Ho Shin, Kyeong-Soo Park, Seong-Woo Choi
Summary: The study found independent associations between estimated glomerular filtration rate (eGFR) and albumin to creatinine ratio (ACR) with all-cause and cardiovascular mortality in Korean adults aged >= 50 years. When comparing eGFR performance, eGFR(cys) showed superior predictive accuracy for all-cause mortality compared to eGFR(MDRD) and eGFR(CKD-EPI).
Editorial Material
Urology & Nephrology
Borja Quiroga, Javier Diez
Summary: The progressive reduction in estimated glomerular filtration rate (eGFR) resulting in chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease (CVD). Creatinine plus cystatin C-based eGFR and cystatin C-based eGFR can better assess the risk of adverse cardiovascular outcomes. It is suggested to use cystatin C and/or creatinine plus cystatin C-based eGFR for routine clinical practice in cardiorenal patients to accurately stratify cardiovascular risk and evaluate the kidney and cardiovascular protective effects of SGLT2 inhibitors.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Endocrinology & Metabolism
Baiyu Feng, Yu Lu, Lin Ye, Lijun Yin, Yingjun Zhou, Anqun Chen
Summary: This study used Mendelian randomization analysis to determine the causal relationship between cystatin C and diabetic nephropathy. The study found that cystatin C is an independent risk factor for diabetic nephropathy in patients with diabetes, regardless of BMI and SBP.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medical Laboratory Technology
Etienne Cavalier, Konstantinos Makris, Oytun Portakal, Ana Nikler, Pradip Datta, Tomas Zima, Pierre Delanaye, EFLM Task Grp CKD
Summary: Chronic kidney disease (CKD) is the third leading cause of death worldwide. European Federation of Laboratory Medicine (EFLM) conducted a survey in 2022 to evaluate CKD testing practices and offer recommendations for improving test standardization.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Medicine, General & Internal
Vera H. Koch
Summary: Obesity is a chronic disease with a rapidly increasing global prevalence of overweight and obesity. It can affect kidney function, leading to more deaths worldwide than underweight. Creatinine may not be the ideal marker for GFR measurement in obese individuals.
FRONTIERS IN MEDICINE
(2021)
Article
Transplantation
Edouard L. Fu, Andrew S. Levey, Josef Coresh, Morgan E. Grams, Anne-Laure Faucon, Carl-Gustaf Elinder, Friedo W. Dekker, Pierre Delanaye, Lesley A. Inker, Juan-Jesus Carrero
Summary: This study evaluated the performance of various equations to estimate glomerular filtration rate in a Swedish cohort. The eGFRcr-cys equations performed the best, showing minimal variation among equations. They also performed well in patients with liver disease, cancer, and heart failure.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Luis C. O. Goncalves, Anibal M. Magalhaes-Neto, Adriana Bassini, Eduardo Seixas Prado, Renan Muniz-Santos, Marcio V. A. Verli, Lukas Jurisica, Jaqueline S. S. Lopes, Igor Jurisica, Claudia M. B. Andrade, L. C. Cameron
Summary: This study used a high-intensity functional training method, CCombat, to induce metabolic stress and evaluated its effects on hydration and kidney function. The results showed an increase in blood myoglobin, d-dimer levels, albuminemia, creatininemia, and cystatin C levels, as well as an increase in albuminuria, suggesting the potential use of microalbuminuria as a biomarker for evaluating hydration status changes during intensive exercise.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Shoshana H. Ballew, Linda Zhou, Aditya Surapaneni, Morgan E. Grams, B. Gwen Windham, Elizabeth Selvin, Josef Coresh, Shiyuan Miao, Lesley A. Inker, Andrew S. Levey
Summary: This study describes a novel creatinine muscle index (CMI) based on serum creatinine and cystatin C, which is associated with frailty and mortality in older adults. Lower CMI is linked to increased frailty and mortality, suggesting that creatinine filtration may serve as an index of muscle mass in clinical practice, particularly at low levels.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Neurosciences
Xin-Rui Wu, Kai-Min Wu, Yue-Ting Deng, Shu-Yi Huang, Liu Yang, Qiang Dong, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: This study found impaired kidney function to be a critical risk factor for dementia, with the use of cystatin C strengthening the relationship between CKD and dementia. It highlights the significant value of preserving kidney function to reduce the risk of dementia and suggests considering cystatin C measurement as part of clinical practice in evaluating dementia risk.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Nutrition & Dietetics
Cristina Valle-Hita, Andres Diaz-Lopez, Nerea Becerra-Tomas, Estefania Toledo, Isabel Cornejo-Pareja, Itziar Abete, Antoni Sureda, Maira Bes-Rastrollo, J. Alfredo Martinez, Francisco J. Tinahones, Josep A. Tur, Tany E. Garciduenas-Fimbres, Francisco Paris-Palleja, Albert Goday, Nuria Goni-Ruiz, Jordi Salas-Salvado, Nancy Babio
Summary: The consumption of ultra-processed food (UPF) is associated with a decline in kidney function, particularly among older adults. Therefore, reducing the intake of UPF is important for maintaining kidney function.
CLINICAL NUTRITION
(2023)
Article
Urology & Nephrology
Steven Habbous, Jennifer Arnold, Mehmet A. Begen, Neil Boudville, Matthew Cooper, Christine Dipchand, Stephanie N. Dixon, Liane S. Feldman, Dariusz Gozdzik, Martin Karpinski, Scott Klarenbach, Greg A. Knoll, Ngan N. Lam, Krista L. Lentine, Charmaine Lok, Eric McArtur, Susan Mckenzie, Matthew Miller, Mauricio Monroy-Cuadros, Chris Nguan, G. V. Ramesh Prasad, Sebastian Przech, Sisira Sarma, Dorry L. Segev, Leroy Storsley, Amit X. Garg
AMERICAN JOURNAL OF KIDNEY DISEASES
(2018)
Article
Health Care Sciences & Services
Nicholas A. Fergusson, Tim Ramsay, Michael Chasse, Shane W. English, Greg A. Knoll
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2018)
Article
Transplantation
Michelle C. Lamarche, Wilma M. Hopman, Jocelyn S. Garland, Christine A. White, Rachel M. Holden
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2019)
Article
Multidisciplinary Sciences
Christopher McCudden, Ayub Akbari, Christine A. White, Mohan Biyani, Swapnil Hiremath, Pierre Antoine Brown, Navdeep Tangri, Scott Brimble, Greg Knoll, Peter G. Blake, Manish M. Sood
Review
Hematology
Hilalion Ahn, Jason Tay, Beverley Shea, Brian Hutton, Risa Shorr, Greg A. Knoll, Donald William Cameron, Juthaporn Cowan
Article
Urology & Nephrology
Debarati Chakraborty, Ayub Akbari, Greg A. Knoll, Jennifer A. Flemming, Catherine Lowe, Shareef Akbari, Christine A. White
Article
Medical Laboratory Technology
Christine A. White, Celine M. Allen, Ayub Akbari, Christine P. Collier, David C. Holland, Andrew G. Day, Greg A. Knoll
CLINICA CHIMICA ACTA
(2019)
Review
Immunology
Francois Gaillard, Christophe Legendre, Christine A. White
Review
Urology & Nephrology
Pierre Delanaye, Kitty J. Jager, Arend Bokenkamp, Anders Christensson, Laurence Dubourg, Bjorn Odvar Eriksen, Francois Gaillard, Giovanni Gambaro, Markus van der Giet, Richard J. Glassock, Olafur S. Indridason, Marco van Londen, Christophe Mariat, Toralf Melsom, Olivier Moranne, Gunnar Nordin, Runolfur Palsson, Hans Pottel, Andrew D. Rule, Elke Schaeffner, Maarten W. Taal, Christine White, Anders Grubb, Jan A. J. G. van den Brand
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Urology & Nephrology
Shareef Akbari, Greg Knoll, Christine A. White, Teerath Kumar, Todd Fairhead, Ayub Akbari
KIDNEY INTERNATIONAL REPORTS
(2019)
Review
Medicine, General & Internal
Sriram Sriperumbuduri, Robert Dent, Janine Malcolm, Swapnil Hiremath, Ran Klein, Christine A. White, Pierre Antoine Brown, Ayub Akbari
SYSTEMATIC REVIEWS
(2019)
Article
Urology & Nephrology
Christine A. White, Joanne E. Kappel, Adeera Levin, Sarah M. Moran, Sanjay Pandeya, Susan J. Thanabalasingam
CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE
(2020)
Review
Urology & Nephrology
Edward G. Clark, Swapnil Hiremath, Steven D. Soroka, Ron Wald, Matthew A. Weir
CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE
(2020)
Article
Urology & Nephrology
Michael Copland, Juliya Hemmett, Jennifer M. MacRae, Brendan McCormick, Michael McCormick, Elena Qirjazi, Rajinder S. Singh, Deborah Zimmerman
CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE
(2020)
Review
Medicine, General & Internal
Swapnil Hiremath, Jeanne Francoise Kayibanda, Benjamin J. W. Chow, Dean Fergusson, Greg A. Knoll, Wael Shabana, Brianna Lahey, Olivia McBride, Alexandra Davis, Ayub Akbari
SYSTEMATIC REVIEWS
(2018)