Article
Urology & Nephrology
Peimei Zou, Hang Li, Jianfang Cai, Zhenjie Chen, Chao Li, Xuewang Li
Summary: Prophylactic use of statins can effectively reduce the occurrence of VTE in patients with PMN, and the benefits are similar across different potency of statins.
Article
Pharmacology & Pharmacy
Yanhong Guo, Liuwei Wang, Yulin Wang, Xiaodan Li, Zihan Zhai, Lu Yu, Yan Liang, Peipei Liu, Lin Tang
Summary: Rituximab therapy may be an effective and safe treatment for reducing proteinuria and maintaining stable renal function in patients with membranous nephropathy and kidney insufficiency.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Elham Ahmadian, Seyed Mahdi Hosseiniyan Khatibi, Sepideh Zununi Vahed, Mohammadreza Ardalan
Summary: Rituximab has become the first-line therapeutic agent for non-severe cases of primary membranous nephropathy to achieve remission of proteinuria. However, approximately 20-40% of patients do not respond to rituximab treatment, leading to the need for new biologic agents such as second-generation anti-CD20 antibodies, plasma cell depleting agents, and proteasome inhibition.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Lijin Duo, Lei Chen, Yongdi Zuo, Jiulin Guo, Manrong He, Hongsen Zhao, Yingxi Kang, Wanxin Tang
Summary: A nomogram was established to predict remission probability in patients with IMN, assisting clinicians in treatment decisions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Urology & Nephrology
Aishwarya Ravindran, Marta Casal Moura, Fernando C. Fervenza, Samih H. Nasr, Mariam P. Alexander, Mary E. Fidler, Loren P. Herrera Hernandez, Pingchuan Zhang, Joseph P. Grande, Lynn D. Cornell, Lou Ann Gross, Vivian Negron, Grace E. Jenson, Benjamin J. Madden, M. Cristine Charlesworth, Sanjeev Sethi
Summary: In membranous lupus nephritis, EXT1/EXT2-positive patients have more favorable kidney biopsy findings with less chronicity, while EXT1/EXT2-negative patients are more likely to progress to ESKD. This suggests that the presence of EXT1/EXT2 is associated with better renal outcomes.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Endocrinology & Metabolism
Maya E. Lee, Yashira M. Ortega-Sustache, Sunita K. Agarwal, Aisha Tepede, James Welch, Adel Mandl, Rashika Bansal, Amit Tirosh, Paolo Piaggi, Craig Cochran, William F. Simonds, Lee S. Weinstein, Jenny E. Blau
Summary: MEN1 patients have an increased risk of venous thromboembolism (VTE), with a prevalence rate of 12.9% and an age-sex adjusted incidence rate of 9.11 per 1000 patient-years. The majority of patients who had a VTE were diagnosed with pancreatic NETs. Further studies are needed to confirm the increased prevalence of VTE in MEN1.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Wang Shujun, Zhang Huijie, Bai Xia, Wang Hongjian
Summary: Cerebral venous sinus thrombosis is a rare complication of inflammatory bowel disease, and early diagnosis along with prompt treatment is crucial for better prognosis. Anemia, low albumin, and elevated d-dimer are independent predictors of CVST in IBD patients.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Maxime Teisseyre, Marion Cremoni, Sonia Boyer-Suavet, Thomas Crepin, Sylvia Benzaken, Kevin Zorzi, Vincent Esnault, Vesna Brglez, Barbara Seitz-Polski
Summary: In patients with primary membranous nephropathy (pMN), residual rituximab levels at month-3 are identified as a novel early predictor of treatment remission at month-6 and month-12. Low serum albumin and high anti-PLA2R1 titers are associated with reduced likelihood of remission. High baseline proteinuria and undetectable rituximab levels at month-3 are independent risk factors for treatment failure at month-6, while high baseline weight and undetectable rituximab levels at month-3 are independent risk factors for treatment failure at month-12. Serum albumin at baseline is a predictive factor for rituximab levels at month-3.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Xuxiang Hui, Qiuhua Zhang, Jiayu Li, Yuan Qin, Xiumei Zhou, Xueqin Zhao, Yan Xu, Biao Huang
Summary: A new highly sensitive method for the detection of 11-dehydro-TXB2 in serum was successfully established in this study. This marker has great potential in evaluating the risk of thromboembolic events in patients with membranous nephropathy and is expected to be applied to other thromboembolic-related diseases.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Ai-bo Qin, Zi-shan Lin, Su-xia Wang, Hui Wang, Zhao Cui, Fu-de Zhou, Ming-hui Zhao
Summary: This study compared the clinicopathological and ultrastructural features of patients with mercury-associated membranous nephropathy (M-MN) and idiopathic membranous nephropathy (I-MN). The results showed that M-MN patients were younger, achieved complete remission more quickly, and had a lower relapse rate compared to I-MN patients. M-MN patients also exhibited less severe foot process effacement and a higher rate of mesangial electron-dense deposits.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Hematology
Lara N. Roberts, Annakan Navaratnam, Roopen Arya, Tim W. R. Briggs, William K. Gray
Summary: The aim of this study was to examine the incidence of venous thromboembolism (VTE) in patients hospitalized with COVID-19 in England. The study found that VTE was a common complication in hospitalized patients and was associated with longer hospital stays and higher mortality rates.
THROMBOSIS RESEARCH
(2022)
Article
Hematology
Aurelien Delluc, Waleed Ghanima, Michael J. Kovacs, Sudeep Shivakumar, Susan R. Kahn, Per Morten Sandset, Clive Kearon, Ranjeeta Mallick, Marc A. Rodger
Summary: This pilot trial demonstrates the feasibility of conducting a larger randomized controlled trial to determine the efficacy of adjuvant rosuvastatin for the secondary prevention of VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Immunology
Qihan Zhao, Haoran Dai, Yuehong Hu, Hanxue Jiang, Zhendong Feng, Wenbin Liu, Zhaocheng Dong, Xinyue Tang, Fanyu Hou, Hongliang Rui, Baoli Liu
Summary: This article explores the role of cytokines in primary membranous nephropathy (PMN), and clarifies whether inflammation is involved in its pathological process. It also suggests certain cytokines as potential biomarkers or therapeutic targets.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Urology & Nephrology
Sanjeev Sethi
Summary: Membranous nephropathy is a disease caused by immune complex deposition along the glomerular basement membrane, with PLA2R and THSD7A being the main antigens. New mass spectrometry techniques have led to the discovery of four novel types of MN, each with distinct clinical and pathologic features. Additional studies are needed to understand the pathophysiology, treatment response, and outcomes of these new MN subtypes.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Oncology
Shaodong Luan, Shuyuan Zhang, Litao Pan, Wenjun Hu, Haihong Cui, Xing Wei, Renyong Lin, Chundi Li, Ping Zeng, Xi Wang, Weilong Li, Zigan Xu, Yingwei Zhang, Bo Hu, Hanchao Gao
Summary: The oral microbiota in patients with membranous nephropathy (MN) differed significantly from healthy controls, and certain operational taxonomic units (OTUs) were found to be correlated with clinical factors. These findings suggest that the oral microbiota may serve as potential biomarkers for the diagnosis of MN.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Urology & Nephrology
Dhruti P. Chen, Candace D. Henderson, Jaeline Anguiano, Claudia P. Aiello, Mary M. Collie, Vanessa Moreno, Yichun Hu, Susan L. Hogan, Ronald J. Falk, CureGN
Summary: The prevalence of high-risk APOL1 variant among Black membranous nephropathy participants is comparable with the general Black population (10%-15%), yet the high-risk genotype was associated with worse eGFR decline and faster time to kidney failure compared with low-risk genotype and participants that were not Black.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Transplantation
David Massicotte-Azarniouch, Randal K. Detwiler, Yichun Hu, Ronald J. Falk, Manish K. Saha, Susan L. Hogan, Vimal K. Derebail
Summary: This study found that kidney transplant patients who received pre-transplant immunosuppression (PTI) for glomerulonephritis (GN) had a higher risk of developing malignancy. Compared with kidney transplant patients without PTI, those with GN and PTI had a significantly increased risk of malignancy.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Immunology
Sarah B. See, Xue Yang, Carole Burger, Baptiste Lamarthee, Renaud Snanoudj, Ronzon Shihab, Demetra S. Tsapepas, Poulomi Roy, Stephanie Lariviere-Beaudoin, Katia Hamelin, Aleixandra Mendoza Rojas, Nicole M. van Besouw, Amanda Bartosic, Nikita Daniel, Vasilescu E. Rodica, Sumit Mohan, David Cohen, Lloyd Ratner, Carla C. Baan, Jonathan S. Bromberg, Heloise Cardinal, Dany Anglicheau, Yifei Sun, Emmanuel Zorn
Summary: This retrospective multicenter study found that pre- and posttransplant natural immunoglobulin G antibodies (Nabs) reactive to apoptotic cells were associated with poor graft outcomes and rejection after renal transplantation.
Letter
Urology & Nephrology
S. Ali Husain, Jacob S. Stevens, Kristen L. King, Shelief Y. Robbins-Juarez, Matthew Cohen, Alexander K. Lyashchenko, Serge Cremers, Sumit Mohan
Article
Urology & Nephrology
Alberto Pinsino, Matthew R. Carey, Syed Husain, Sumit Mohan, Jai Radhakrishnan, Douglas L. Jennings, Austin S. Nguonly, Annamaria Ladanyi, Lorenzo Braghieri, Koji Takeda, Robert T. Faillace, Gabriel T. Sayer, Nir Uriel, Paolo C. Colombo, Melana Yuzefpolskaya
Summary: Discrepancies between eGFR(cysC) and eGFR(Scr) are common in patients with HFrEF and are associated with clinical outcomes, HRQoL, and frailty. The decline in kidney function associated with WHF is more marked when assessed with eGFR(cysC) than with eGFR(Scr).
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Surgery
David C. Cron, Syed A. Husain, Kristen L. King, Sumit Mohan, Joel T. Adler
Summary: The newest kidney allocation policy, KAS250, expanded geographic distribution and increased complexity of the allocation system. A study found that transplant centers received more kidney offers after KAS250, but there was no significant increase in the number of transplants performed. These findings highlight the logistical burden of broader organ sharing and suggest the need to balance equitable transplant access with operational efficiency of the allocation system in future policy changes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Jon J. Snyder, Cory R. Schaffhausen, Allyson Hart, David A. Axelrod, Dorrie Dils, Richard N. Formica, A. Osama Gaber, Heather F. Hunt, Jennifer Jones, Sumit Mohan, Rachel E. Patzer, Sean P. Pinney, Lloyd E. Ratner, Dirk Slaker, Darren Stewart, Zoe A. Stewart, Sean Van Slyck, Bertram L. Kasiske, Ryutaro Hirose, Ajay K. Israni
Summary: In July 2022, SRTR organized an innovative consensus conference involving various stakeholders in the transplantation system to determine their desired information and metrics. This included patients, living donors, caregivers, deceased donor family members, transplant professionals, organ procurement organization professionals, payers, and regulators. The report documents the conference proceedings, listing 160 recommendations, with 10 highly prioritized. SRTR will use these recommendations to develop new presentations of information and metrics to support informed decision-making by stakeholders.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Jesse D. Schold, Anne M. Huml, S. Ali Husain, Emilio D. Poggio, R. Blake Buchalter, Rocio Lopez, Bruce Kaplan, Sumit Mohan
Summary: In the United States, over 20% of procured kidneys for transplantation are not utilized. This study examined the factors associated with nonutilization and found that deceased donors from higher distressed communities were more likely to have their kidneys not utilized. The study also found regional variations in kidney nonutilization rates and minimal impact on recipient outcomes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Ogo Egbuna, Brandon Zimmerman, George Manos, Anne Fortier, Madalina C. Chirieac, Leslie A. Dakin, David J. Friedman, Kate Bramham, Kirk Campbell, Bertrand Knebelmann, Laura Barisoni, Ronald J. Falk, Debbie S. Gipson, Michael S. Lipkowitz, Akinlolu Ojo, Mark E. Bunnage, Martin R. Pollak, David Altshuler, Glenn M. Chertow
Summary: “This study found that targeted inhibition of APOL1 channel function with inaxaplin can reduce proteinuria in individuals with APOL1 variants and focal segmental glomerulosclerosis. This provides a new option for treating kidney diseases associated with APOL1 variants.”
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Letter
Urology & Nephrology
Sumit Mohan, Miko Yu, Kristen L. King, S. Ali Husain
KIDNEY INTERNATIONAL REPORTS
(2023)
Editorial Material
Urology & Nephrology
Vimal K. Derebail, Patrick H. Nachman
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
S. Ali Husain, Miko E. Yu, Kristen L. King, Joel T. Adler, Jesse D. Schold, Sumit Mohan
Summary: This study examined disparities in kidney transplant waitlisting among a cohort of young, relatively healthy patients, and found sociodemographic disparities in waitlisting even in the absence of major medical comorbidities. Policy changes are needed to address these barriers to waitlist access.
JAMA INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Rocio Lopez, Sumit Mohan, Jesse D. Schold
Summary: This study on Organ Procurement Organizations (OPOs) found that adjusting for area deprivation and age significantly changed OPO measured performance and tier classifications, suggesting that underlying population characteristics may impact care processes and donation and transplant rates.
Review
Immunology
Petros Nikolopoulos, George Liapis, Panagiotis Giannakopoulos, Ioannis Kotsantis, Konstantinos Drouzas, Sophia Lionaki
Summary: Stimulation of the immune system using immune checkpoint inhibitors (ICIs) has been effective in treating various cancers. However, limited literature exists on the toxicities and nephrotoxicity associated with ICIs. This case study presents a patient with lung cancer who experienced vasculitic skin rash and rapidly deteriorating renal function after receiving atezolizumab, an IgG1 monoclonal antibody. The patient's renal biopsy revealed acute necrotizing pauci-immune vasculitis, but was successfully treated with high-dose glucocorticoids and showed a substantial response to atezolizumab therapy.
Article
Physiology
Evan M. Zeitler, Yuanyuan Li, Madison Schroder, Ronald J. Falk, Susan Sumner
Summary: Obesity causes metabolic changes in kidney tissue, particularly affecting specific pathways such as glycolysis and tryptophan metabolism. This study demonstrates that obesity alters metabolism within the kidney, which may play a crucial role in obesity-related kidney dysfunction.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)